Résumé
We report a 30-day-old baby with subcutaneous fat necrosis and symptomatic hypercalcemia, who developed metastatic calcification in the subcutaneous tissue, kidneys, pericardium and brain. The baby also had anemia, hypertriglyceridemia and hypercholesterolemia. He was managed with intravenous saline, furosemide, oral steroids and bisphosphonates and improved with treatment.
Sujets)
Encéphale/imagerie diagnostique , Calcinose/épidémiologie , Calcinose/anatomopathologie , Humains , Hypercalcémie/épidémiologie , Hypercalcémie/imagerie diagnostique , Nouveau-né , Mâle , Nécrose/épidémiologie , Nécrose/anatomopathologie , Graisse sous-cutanée/anatomopathologie , TomodensitométrieRésumé
Metastatic pulmonary calcification refers to calcium deposition in the normal pulmonary parenchyma and this deposition is secondary to abnormal calcium metabolism. The most common radiologic manifestation consists of poorly-defined nodular opacities that are mainly seen in the upper lung zone. We present here a case of metastatic pulmonary calcification that manifested as atypical, dense, calcium deposition in airspaces within the previously existing consolidation in the bilateral lower lobes, and this process was accelerated by pneumonia-complicated sepsis in a patient with hypercalcemia that was due to hyperparathyroidism.
Sujets)
Femelle , Humains , Adulte d'âge moyen , Calcinose/imagerie diagnostique , Hypercalcémie/étiologie , Hyperparathyroïdie/complications , Maladies pulmonaires/imagerie diagnostique , Parathyroïdectomie , Pneumopathie infectieuse/complications , Choc septique/microbiologie , Tomodensitométrie/méthodesRésumé
Extraosseous metastatic calcification in patients undergoing maintenance hemodialysis results from precipitation of amorphous calcium phosphate and it is characterized by extensive calcifications of periarticular soft tissues, usually around the large joints, manifested clinically by palpable and visible tumors associated with secondary hyperparathyroidism. Extraosseous metastatic calcification can be present in the heart, lungs, stomach, kidneys, skeletal muscle, and around large joints. In the present case, the patient on maintenance hemodialysis has the unusual sites of metastatic calcification, involving both shoulders, the right hip joint, and especially, sternoclavicular joint. To prevent metastatic calcification, we need to decrease calcium, phosphorus, and parathyroid hormone concentration as well as to attenuate calcium phosphorus product.