The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in rats

Abstract The present study was performed to explore the curative effect of Methylsulfonylmethane (MSM) in an experimental model of myoglobinuric acute renal failure (ARF). In this experimental model, Rats were injected with 50% glycerol (10 mL/kg, im) followed by an hour later and daily in the next six days by MSM (400 mg/kg) or saline. Kidney's function (urea and creatinine), and reduced glutathione were analyzed. A renal failure produced by glycerol injection, with a significant increase of blood urea and serum creatinine was observed. Rats that received MSM in addition to glycerol had significantly lower blood urea and serum creatinine levels compared to those receiving glycerol alone. However, glutathione has markedly increased after MSM treatment. The effect is probably due to the antioxidant activity of MSM. This may provide therapeutic opportunities for treating humans, myoglobinuric ARF.

Úlceras en intestino delgado por glucosamina con MSM: Reporte de un caso / Case report: Ulcers in the small intestine due to glucosamine and methylsulfonylmethane (MSM) use

Reportamos el caso de una paciente con dolor abdominal, anemia por deficiencia de hierro y sangre oculta positiva en materia fecal. Sin sangrado evidente. Historia de osteoartritis en manejo con glucosamina con metilsulfonilmetano. Endoscopia superior y colonoscopia no explican sangrado. Cápsula endoscópica muestra múltiples úlceras circunferenciales algunas de ellas con sangrado activo. Se descarta uso de AINES y enfermedad de Crohn. Al mes de suspender suplemento nutricional hay resolución de síntomas y de anemia con sangre oculta negativa. No hubo recurrencia de síntomas.

We report on the case of a female patient with abdominal pain, iron deficiency anemia who tested positive for fecal occult blood but had no overt gastrointestinal bleeding. Patient had a known history of osteoarthritis and used Glucosamine - MSM. Both upper GI endoscopy and colonoscopy were negative. Capsule endoscopy showed multiple concentric ulcers, several of which were actively bleeding. Patient reported no use of NSAIDs, and there was no evidence of Crohn's disease. Nutritional supplements were stopped. After four weeks abdominal pain improved, patient had anemia and a fecal occult blood test was negative. Symptoms have not recurred.