Glandular Odontogenic Cyst Mimicking Dentigerous Cyst: A Rare Case Report

Background: Glandular odontogenic cyst is an uncommon developmental cyst of odontogenic origin. Till now, around 200 cases have been reported in the English literature, out of which approximately 25 of them are associated with an unerupted tooth. Herein we present a case report of a 7-year-old boy with swelling in the anterior maxillary region which was later diag- nosed as a Glandular odontogenic cyst that mimicked a Dentigerous cyst. Case presentation: A painless swelling was noted in the anterior palatal region. Orthopantamogram was advised which re- vealed a unilocular radiolucency associated with an impacted supernumerary tooth. Provisional diagnosis of Dentigerous cyst was made. The cyst was enucleated in conjunction with peripheral osteotomy. The histopathological examination revealed a cystic capsule with non-keratinized stratified squamous epithelium with 2-4 cell layer thickness, with some areas showing epithelial plaque, microcysts, hobnail cells and few clear cells. Contemplating all the histological features, final diagnosis of Glandular odontogenic cyst was given. Conclusions: The presented case emphasizes the importance of histopathological examination of the unusual and rarely ob- served Glandular odontogenic cyst which can be missed due to similarities with other entities. Recurrence rates being very high, follow up of the cases is imperative.

Cambio de estadio clínico en el cáncer pulmonar no microcítico / Clinical stage change in nonmicrocyst pulmonary cancer

El cambio de estadio clínico del carcinoma pulmonar no microcítico al comparar los períodos pre y posoperatorio puede repercutir negativamente a la hora de definir las estrategias terapéuticas. El objetivo del presente estudio fue evaluar la magnitud de dichos cambios y su efecto sobre el paciente. Se realizó un estudio retrospectivo con una base de datos prospectiva de 259 pacientes tratados entre enero de 2002 y diciembre de 2007. Se excluyeron enfermos con tratamiento neoadyuvante, intervenciones por recidiva o paliativas y neoplasias de células pequeñas. Las variables estudiadas fueron los factores tumor (T), nódulos (N) y metástasis (M), posición y localización del tumor y pulmón afectado. El coeficiente de concordancia permitió evaluar la magnitud del cambio y la prueba de ji al cuadrado, la asociación entre dos variables. Valores de p < 0,05 se consideraron significativos. . El factor T cambió en 91 pacientes (35,1 por ciento), con más frecuencia en lesiones de lóbulos superiores (p = 0,04). La posición no se asoció al cambio (p = 0,110). El factor N se modificó en 50 casos (19,3 por ciento). Se asociaron al cambio: localización lobular (p = 0,001), pulmón afectado (p = 0,002) y factor T (p = 0,013). El cambio del factor M ocurrió en 11 pacientes (4,2 por ciento) y no se asoció a la posición (p = 0,120), localización (p = 0,225) o factor T (p = 0,339). El coeficiente de concordancia fue bajo (k = 0,381; p < 0,001), debido a que el cambio ocurrió en el 49,03 por ciento de los pacientes. CONCLUSIONES. El cambio de estadio clínico fue de magnitud apreciable y, por tanto, tiene el potencial de inducir a la práctica de tratamientos inadecuados, tanto médicos como quirúrgicos(AU)

INTRODUCTION. Change of clinical stage of non-microcyst pulmonary cancer in comparing the pre-postoperative and postoperative periods may to have negative repercussions on the definition of therapeutical strategies. The aim of present paper was to assess the magnitude of such changes and its effect on the patient. METHODS. A retrospective study was conducted with a prospective database of 259 patients treated from January, 2002 to December, 2007. Patients with neoadjuvant therapy, palliative interventions or relapse and small cells neoplasms were excluded. The study variables were: tumor factors (T), nodules (N) and metastasis (M), tumor position and location and involved lung. Agreement coefficient allowed assessing the change magnitude and the Chi² test, the association between the two variables. RESULTS. T factor changed in 91 patients (35,1 percent) more frequent in superior lobules lesions (p = 0,04). Position wasn't associated with the change (p = 0,110). N factor was modified in 50 cases (19,3 percent). Associated with change were: lobular location (p = 0,001), involved lung (p = 0,002) and T factor (p = 0,013). The change in T factor happened in 11 patients (4,2 percent) and wasn't associated with the position (p = 0,120), location (p = 0,225) or T factor (p = 0,339). Agreement coefficient was low (k = 0,381; p < 0,001), because of the change occurred in the 49,03 percent of patients. CONCLUSIONS. The change in clinical stage was of a significant magnitude and thus, has the potential to induce to inappropriate medical and surgical treatments practice(AU)

Spontaneous Resolution of Multiple Fundic Gland Polyps after Cessation of Treatment with Omeprazole / 대한소화기학회지

Fundic gland polyps (FGPs) are the most common type of gastric polyps, found primarily in the fundus and body of stomach. Long term use of proton pump inhibitor (PPI) is known to be associated with certain histological changes of the normal gastric mucosa including parietal cell hyperplasia and fundic gland cysts. We experienced a patient who showed spontaneous resolution of multiple FGPs after the cessation of omeprazole. Two years ago, the patient showed only endoscopically confirmed erosive esophagitis without FGPs. Multiple FGPs developed one year after the use of omeprazole and spontaneously disappeared with the cessation of omeprazole.