Résumé
Mitomycin-C eyedrops were administered for the prevention of pterygium recurrence after surgical excision.37 primary and 16 recurrent pterygia were postoperatively instil- led 0.2mg/ml or 0.4mg/ml mitomycin-C eyedrops,and 24 primary and 4 recurrent pterygia were given placebo instead to serve as controls.During a follow-up of 3 to 8 months,one(1.89%)of the 53 eyes treated with mitomycin recurred 3 months after the operation while 3 eyes(10.7%)of the 28 controls recurred,the difference being very significant.The authors opinted that mitomy- cin-C eyedrops of low concentration was safe and effective for the prevention of postop- erative pterygium recurrence.
Résumé
The most common cause of glaucoma filtration surgery failure is cicatrization secondary to fibroblast proliferation and of collagen. The high-risk factors for filtration failure include young age, aphakia, inflammation, neovascularization, and previous failure of filtration operation. Studies have shown beneficial effects of a single dose intraoperative mitomycin C,an antimetabolite, in inhibiting fibroblast proliferation and slceral wound cicatrization, thereby promoting success in eyes of poor surgical prognosis. Corneal complications have been minor.