Expression of survivin and programmed cell death 5 in mucoepidermoid carcinoma and their clinical sig-nificance / 实用口腔医学杂志

Objective:To investigate the expression of Survivin and programmed cell death 5(PDCD5)protein in mucoepidermoid carcinoma(MEC).Methods:Survivin and PDCD5 were detected by immunohistochemical staining in 20 cases of normal parotid tis-sue(group A),40 cases of pleomorphic adenoma(group B)and 45 cases of MEC tissues(group C).Results:The positive expres-sion ratio of Survivin in group A,B and C was 10.0%,27.5% and 55.6% respectively(χ2 =14.556,P <0.01),while that of PD-CD5 was 85%,65% and 33.3% respectively (χ2 =17.439,P <0.01).The expression of survivin or PDCD5 was related with dif-ferentiation,lymph node metastasis and TNM staging of MEC.Survivin and PDCD5 showed a negative correlation in MEC(χ2 =4.500,P =0.034,γs =-0.316).Conclusion:Survivin over-expression and PDCD5 down-expression may play a role in the de-velopment and progress of mucoepidermoid carcinoma.

Cytological diagnosis of mucoepidermoid carcinoma of parotid - A diagnostic dilemma.

Mucoepidermoid carcinoma (MEC) of parotid, a rare disease, was diagnosed by fine needle aspiration in a young child and later confirmed on histopathology. Of all salivary gland tumors, mucoepidermoid carcinoma is the most difficult to diagnose by fine needle aspiration cytology due to overlapping cytomorphology with benign lesions. So, fine needle aspiration cytology helps in early diagnosis and management