Résumé
In this study, naftifine (a topical antifungal drug) loaded poly(vinyl) alcohol (PVA)/sodium alginate (SA) nanofibrous mats were prepared using the single-needle electrospinning technique. The produced nanofibers were crosslinked with glutaraldehyde (GTA) vapor. The morphology and diameter of the electrospun nanofibers were studied by scanning electron microscopy (SEM). SEM images showed the smoothness of the nanofibers and indicated that the fiber diameter increased with crosslinking and drug loading. Atomic force microscopy (AFM) images confirmed the uniform production of the scaffolds, and elemental mapping via energy dispersive X-ray spectroscopy (EDS) showed the uniform distribution of the drug within the nanofibers. An attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy study demonstrated that naftifine has sufficient secondary interactions with the polymer blend. The crosslinking treatment decreased the burst drug release effectively and the release mechanism followed Korsmeyer-Peppas Super Case-II transport. Overall, these findings suggest the potential use of naftifine-loaded PVA/SA nanofibers as a topical antifungal drug delivery system.
Sujets)
Administration par voie topique , Nanofibres/analyse , Spectrométrie d'émission X/instrumentation , Analyse spectrale/instrumentation , Préparations pharmaceutiques/administration et posologie , Systèmes de délivrance de médicaments , Spectroscopie infrarouge à transformée de Fourier/méthodes , Microscopie à force atomique/instrumentation , Alginates/effets indésirables , Libération de médicamentRésumé
Objective:To evaluate the therapeutic effects of compound naftifine cream on experimental dermatophytosis caused by trichophyton purpureatum or candida albicans.Methods:Two dermatophytosis models of 120 guinea pigs were made and divided into 6 groups( n =10) respectively.Topically 2.5%,1.25%,0.625% of compound naftifine cream and 0.5% cream ketoconazole and 2% cream naftifine and control agent were used in all laboratory animals respectively.All were used for 14days.Results:The efficacy of the compound naftifine cream in topically administered animals was better than that in the ketoconazole or nafiifine cream treatment groups ( P
Résumé
OBJECTIVE:To optimize formula for the compound naftifine hydrochloride cream and to study the stability of its finished products.METHOD:The dosage of the hexadecanol,octadecanol,S-40and sodium dodecyl sulfate was taken as variable factor,the orthogonal experimental design method was adopted and L 9 (3 4 )table was chosen for the experiment.RE-SULTS:The optimized formula is composed of4%of hexadecanol,2%of octadecanol,6%of S-40and0.1%of sodium do-decyl sulfate,from which the finished products manufactured had good stability.CONCLUSION:The cream prepared from this optimized formula and method can meet the specification stated in Chinese Pharmacopoeia.