LASS family and tumor / 国际肿瘤学杂志

LASS gene family is a group of highly conserved and longevous gene LASS protein has a ceramide synthase activity,which can synthesize different types of ceramides.Ceramide is a key intermediate in tumor cells growth,signal transduction and other aspects.Thus it is inferred that the expression of LASS gene can suppress the occurrence and development of tumor within a certain range.

Expression of serum TK1 and its relationship with clinical and pathological features in patients with mammary gland invasive ductal carcinoma / 中国基层医药

Objective To investigate the expression of serum thymidine kinase-1 (TK1) and its relationship with clinical and pathological features in patients with mammary gland invasive ductal carcinoma (MGIDC),and the rde of TK1 in the invasion and progression of MGIDC.Methods The clinical data of 60 patients with MGIDC who underwent surgical treatment were retrospectively analyzed,the healthy subjects were considered as control group.The serum TK1 level was detected by chemiluminescence combined with dot blot hybridization.Results The TK1 positive expression rate of breast cancer group was 75.0％,compared with the the control group (6.7％) the difference between the two groups was significant(x2 =23.155,P ＜ 0.05).The TK1 positive expression rate of the tumor diameter ≥5cm group,the TNM stage Ⅲ to Ⅳ group and lymph node metastasis group was significantly higher than the tumor diameter ＜5cm group,the TNM stage Ⅰ to Ⅱ group and without lymph node metastasis group,the difference was significant(P ＜ 0.05).The TK1 positive expression rate was not statistically significant between the different age group and degree of tumor differentiation group (P ＞ 0.05).Conclusion The serum TK1 is high expression in patients with MGIDC,the serum TK1 level is closely related to the tumor size,TNM stage and lymph node metastasis.The high expression of serum TK1 shows the invasion and progression of MGIDC.