Advances of stanniocalcin 2 in tumors / 国际肿瘤学杂志

Stanniocalcin 2,a secreted glycoprotein hormone,has been found to be highly expressed in a variety of human malignancies.Through several signal transdution pathways,stanniocalcin 2 plays important roles in the regulation of many biological events of tumor such as proliferation,apoptosis,invasion and metastasis,hypoxia tolerating and drug resistance,indicating stanniocalcin 2 may be a pivotal node in the molecular regulation network of tumor.Stanniocalcin 2 is expected to become a novel biomarker and therapeutic target for diagnosis and treatment of tumor if the funtional mechanisms of stanniocalcin 2 could be further elaborated.

Surgical treatment and perioperative period management for 182 elderly patients with colonic carcinoma / 中国癌症杂志

Purpose:To explore the problems in the treatment of the elderly patients suffering from colonic carcinoma.Methods:182 cases of elderly patients aged over 70 who received operation for colonic carcinoma during Jan 1994 to Dec 1998 were analyzed retrospectively. Results:176 cases underwent resections (resection rate 96.7%), of which 129 cases(70.9%)had radical resection and 47 cases(25.8%)palliative resection. 6 cases(3.3%)experienced simple colostomy or bypass. Postoperative complications were found in 67 cases (36.8%),of which 8 cases died during perioperation period(mortality rate 4.4%). Conclusions:Old age is not the major determining factor when considering surgical operation as the treatment for colonic carcinoma patients. In order to enhance resection rate especially radical resection rate and survival rate,to diminish postoperative complications and mortality, and thus to improve the quality of life for the elderly colonic carcinoma patients, a series of measures must be taken. First, diagnosis and treatment of the associated conditions must be emphasized. Second, full preoperative preparations with appropriate choice of the time and procedure for operation, as well as exact operation principles must be followed. Finally, intensive monitoring during the perioperative period and prevention and treatment of postoperative complications were also important factors to be considered.