RÉSUMÉ
Many events can cause the irreversible damage of optical nerve.Conventional treatment of visual nerve damage is medicine therapy.However,each drug shows its advantages and disadvantages.Chitosan is a polysaccharide with positive charge and good biocompatibility,and it prosses the antioxidant,antiapoptosis and antineuritic effects,so it is thought to play a neuroprotective role for multiple causative neuropathies.The progress in neuroprotective mechanism of chitosan was reviewed in this paper.
RÉSUMÉ
Objective: To investigate the protective effect and mechanism of total peaony glycoside (TPG) on calium overloading injury of nerve cells in rat models. Methods: The nerve cells of cerebral cortex of primary rats were subject to tissue culture,and the calcuim-overloading injury models were induced by caffeine,KCl and NMDA respectively. Results:TPG possessed obvious protective effects on the nerve cells in rat models, increased the number of survival nerve cells and reduced the content of LDH released nerve cells.Conclusion: TPG can protect rat nerve cells with calium-overloading injuriy.