Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue

PURPOSE:Toevaluate the effects of nitrofurazone on the correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue in rats.METHODS: A defect in the abdominal wall was created and corrected with polypropylene mesh in 20 rats. They were randomly distributed into four groups: control, fibrous mesh, nitrofurazone and nitrofurazone dip in the mesh. Euthanasia was performed in 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects.RESULTS:All animals had adhesions. However, no statistically significant difference (p>0.05) when compared between groups. Similarly microscopic analysis, in which there was no statistical significance level for the evaluated parameters such as mono and polymorphonuclear lymphocytes, granuloma, fibrosis, necrosis and collagen proliferation.CONCLUSION:There was no significant effect on the abdominal wall defect repair with polypropylene mesh surrounded by fibrous tissue when dipped in nitrofurazone 2%.

Evaluaton of hypoglycaemic and wound healing activities of Tiliacora acuminata.

Natural products particularly plant origin have played a vital role in prevention and mitigation of human diseases. The present study was carried to evaluate the antihyperglycaemic and wound healing activity of the leaf Extracts of Tiliacora acuminate (Lam) on rats, the aqueous leaf extract was found to produce significant reduction of blood glucose concentration between 2-4 h of administration in alloxan induced hyperglycaemic rats at tested dose levels. However, in normoglycaemic animals, the extract at 400mg/kg produced significant reduction of blood glucose between 2-4 h of administration. In the wound healing studies, the leaf juice was found to be more active than the extract.

Wound healing activity of Cleome rutidosperma DC. roots.

The petroleum ether, chloroform, methanol and aqueous extracts of Cleome rutidosperma DC (Family: Capparidaceae) roots were evaluated for their wound healing activities in rats using excision and incision wound models respective-ly. The effects of test samples on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation and wound breaking strength. Nitrofurazone (0.2% w/w) in simple ointment I.P. was used as reference standard for the activity comparison. The results of the study revealed that the animals treated with methanol and aqueous extracts of C. rutidosperma showed faster rate of wound healing compared to other extracts under study. The chloroform extract of the selected plant also produced promising results but the effects are seen to be of lesser extent than the corresponding methanol and aqueous extracts. The petroleum ether extract did not produce significant results. The present work justifies the use of C. rutidosperma roots for wound healing activity as claimed in the folklore literature.

Wound healing activity of Cleome rutidosperma DC. roots.

The petroleum ether, chloroform, methanol and aqueous extracts of Cleome rutidosperma DC (Family: Capparidaceae) roots were evaluated for their wound healing activities in rats using excision and incision wound models respective-ly. The effects of test samples on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation and wound breaking strength. Nitrofurazone (0.2% w/w) in simple ointment I.P. was used as reference standard for the activity comparison. The results of the study revealed that the animals treated with methanol and aqueous extracts of C. rutidosperma showed faster rate of wound healing compared to other extracts under study. The chloroform extract of the selected plant also produced promising results but the effects are seen to be of lesser extent than the corresponding methanol and aqueous extracts. The petroleum ether extract did not produce significant results. The present work justifies the use of C. rutidosperma roots for wound healing activity as claimed in the folklore literature.

Determination of Nitrofurazone in Nitrofurazone and Zinc Oxide Liniment by UV Spectrophotometry / 中国药房

OBJECTIVE: To establish a method for the determination of nitrofurazone in nitrofurazone and zinc oxide liniment. METHODS: The content of nitrofurazone was determined by UV spectrophotometry. The solvent was water and the wavelength was 375nm. RESULTS: There was good linear relationship within the concentration range of 1.05～12.60?g?mL-1(r=0.999 8). The average recovery was 100.9%,RSD=0.07%. CONCLUSION: The method was sensitive, accurate, reliable, reproducible, and suitable for quality control of nitrofurazone in nitrofurazone and zinc oxide liniment.

Avaliação histopatológica de polpas de dentes de cães, submetidas a pulpotomia e tratamento com substâncias à base de PMCC + Furacin / Histopathologic evaluation of pulp tissue of dog teeth subdued to pulpotomy and treatment with CMPC + Furacin materials

No presente trabalho, foi avaliada histologicamente a resposta pulpar de dentes de cães submetidos a pulpotomia e tratamento do remanescente pulpar com misturas de PMCC 3,5:6,5 e 2,5:7,5, associadas ao Furacin, com e sem curativo de demora. Para isso utilizou-se os segundos e terceiros pré-molares superiores e os primeiros, segundos e terceiros pré-molares inferiores, de 12 cães adultos jovens, distribuídos em 4 Grupos: GI - PMCC3,5:6,5 - Furacin com curativo, GII - PMCC 2,5:7,5 - Furacin com curativo, GIII - PMCC 3,5:6,5 - Furacin sem curativo e GIV - PMCC 2,5:7,5 - Furacin sem curativo. Após os períodos experimentais de 7, 45 e 90 dias, os animais foram sacrificados e procedeu-se a confecção de lâminas para a análise histológica. Pela metodologia empregada, encontramos que em todos os grupos, as soluções de PMCC - Furacin mostraram-se irritantes ao tecido conjuntivo pulpar, exibindo morte tecidual, com fenõmeno de fixação, caracterizada pela manutenção apagada das estruturas, sendo maior nos grupos onde se utilizou o curativo de demora de PMCC - Furacin por 5 minutos (GI e GII), .............

In the present study it was performed an histologic evaluation of the response of the pulp tissue of dogs teeth subdued to pulpotomy and treatment of the reminiscent pulp tissue with 3.5:6.5 and 2.5:7.5 CMPC associated to Furacin, with or without dressing. Upper second and third bicuspids and lower first, second and third bicuspids of 12 young adult dogs were used and distributed into 4 groups: GI - 3.5:6.5 CMPC - Furacin with dressing, GII - 2.5:7.5 CMPC - Furacin with dressing, GIII - 3.5:6.5 CMPC - Furacin without dressing and GIV - 2.5:7.5 CMPC - Furacin without dressing. After experimental periods of 7, 45 and 90 days, the subjects were sacrified and the histopathologic analysis was performed. According to the methodology used, we observed that in all groups the CMPC - Furacin solutions were irritative to the pulp connective tissue, showing tissue death, with fixation phenomena characterized by the loss of dye affinity. This finding was higher in the groups in which CMPC - Furacin dressing was used for 5 minutes (GI and GII), when compared to the groups without the dressings....

Comparative Study on the Incidence of Urinary Tract Infection between Nitrofurazone-Coated Urinary Catheter and Silicone Catheter / 감염

PURPOSE: To evaluate the efficacy and safety of nitofurazone-coated urinary catheter in inhibitory activity of catheter associated urinary tract infection (CAUTI). METHODS: From March to September 2001, 177 patients in five university hospitals who were expected to use urinary catheters and be satisfied with the inclusion, exclusion criteria were analyzed. Through urine culture, we compared the incidence rate and onset of CAUTI after catheterization of standard silicone urinary catheters (control group) and nitofurazone-coated catheters (experimental group). CAUTI was defined as over 103 CFU/mL of bacteria in urine culture. The catheter surface was examined by scanning electron microscopy (SEM) to analyze the bacteial biofilms. RESULTS: The incidence rate of CAUTI was lower in experimental group than in control group but there was no statistical significancy. However, in the patients who had indwelling urinary catheters for 5~7 days, the incidence rate of CAUTI was significantly low in experimental group. Depending on catheter insertion period, the incidence onset of CAUTI was analyzed. It was found that the longer the insertion period was, the lower the incidence rate of CAUTI in experimental group was than in control group, but there was no statistical significancy. In the patients who had indwelling urinary catheters for 5~7 days, the incidence rate of CAUTI was significantly low in experimental group. According to the result of this study, patient who was older and had longer insertion- period, had higher incidence rate of CAUTI. SEM showed the formation of bacterial biofilm in silicone catheters throughout the 5~7 days, but deterioration of the bacterial biofilm was visible on the surface of nitofurazone-coated catheters. There was no side-effect in any groups. CONCLUSION: This study suggests that nitofurazone-coated catheters can be useful for inhibition of urinary tract infection, with systemic and local safety, in patients who have indwelling urinary catheter more than 5 days and old-age paitents.

A Case of Allergic Contact Dermatitis to Antiseptics / 대한피부과학회지

Povidone-iodine is one of the most widely used antiseptics and rarely has been reported to produce allergic contact dermatitis. Nitrofurazone has beeo widely used for the prevention and the treatment of the superficial bacterial infection and infrequently causes allergic contact dermatitis. A 48-year-old man was present with a 3-week history of pruritic skin lesion on the right forearm. He had treated the right forearm with antiseptics including Betadine and nitrofurazone and thereafter suffered from the skin lesion. Patch tests with Korean standard antigens, antiseptics and topical antibacterial agents revealed positive reactions to povidone-iodine and nitrofurazone.

A Case of Allergic Contact Dermatitis to Nitrofurazone Ointment / 대한피부과학회지

Nitrofurazone is a well known sensitizer and is widely used particularly in surgical department for the treatment of secondary infection, but the reports of all ergic contact dermatitis to nitrofurazone are rare in Korean literature. We experienced a case of allergic eontact dermatitis to 0.2% nitrofurazone in 31-year-old female after dressing the grafted wound on the left index finger with the gauze embedded with 0.2% nitrofurazone olintmnt. The patch test results revealed a strong positve reaction to 0.2% nitrofurazone ointment after 48 hours.