RÉSUMÉ
Objective To explore the level changes of proteins related to non-demyelinating diseases in the cerebrospinal fluid and serum in patients with relapsing-remitting multiple sclerosis (RRMS) of different clinical stages.Methods Twenty-three patients with RRMS,10 patients with head pain (controls) and 10 healthy volunteers (healthy controls),admitted to our hospital from July 2011 to December 2012,were selected.The cerebrospinal fluid sample and blood serum sample were selected in observation group at admission (acute stage) and follow-up (remission phase),control group (during headache) to measure the levels of protein tau,S 100 and neurofilament (NF).Expanded disability status scale (EDSS) was employed to detect the dysneuria and the relation with the protein levels were analyzed.Results In the cerebrospinal fluid,the protein levels of tau,S100 and NF in the observation group both in acute phase and remission phase were significantly higher than those in the control group and healthy control group (P＜0.05); and the levels of three protein in acute phase was higher than those in remission phase (P＜0.05).In blood serum:the protein levels oftau and NF in the observation group in both acute phase and remission phase showed no obvious differences as compared with those in the control group and healthy control group (P＞0.05),but the level of S100 in observation group in both acute phase and remission phase was obviously higher than the control group and healthy control group (P＜0.05); and the levels of three protein in acute phase was higher than those in remission phase (P＜0.05).The EDSS scores of observation group in acute phase and remission phase were (6.0 ±1.5) and (2.8 ±0.7) points,respectively; the protein levels of tau,S 100 and NF in mild EDSS scores patients were significantly lower than those of patients of medium and heavy EDSS scores in acute phase; the protein levels of tau,S100,NF in medium EDSS scores patients had no obvious differences as compared with those of heavy ones (P＞0.05).In remission phase,the tau,S100,NF protein levels of mild EDSS acores patients showed no obvious differences as compared with those of medium ones.Conclusion The protein levels of tau,S100 and NF increase in acute phase of patients with RRMS,which correlates with the EDSS scores,and those decrease in remission phase then,indicating that tau,S100 and NF might be the specific protein markers of non-demyelinating diseases.