Oxidative stress status and its correlation with UACR and Uβ2-MG levels in patients with diabetic nephropathy / 公共卫生与预防医学

Objective To analyze oxidative stress status and its correlation with urinary albumin creatinine ratio (UACR) and urinary β2 microglobulin (Uβ2-MG) in patients with diabetic nephropathy (DN), and to provide a theoretical basis for clinical evaluation of oxidative stress status in DN patients. Methods A total of 382 DN patients admitted to our hospital from January 2020 to December 2021 were selected. According to the 24h urinary microalbumin excretion rate (24h UAER), the patients were divided into mild renal injury group (20µg/min 2-MG levels in DN patients (r=-0.462, 0.413, P2-MG levels in DN patients (r=-0.438, -0.459, P2-MG to predict the oxidative stress status of DN patients was 0.689, the sensitivity was 79.84%, and the specificity was 83.45%. Conclusion Oxidative stress in DN patients can accelerate the pathological progression of nephropathy. The oxidative stress status is closely related to the levels of UACR and Uβ2-MG, which can be used to judge the oxidative stress of the body and prevent the pathological progression of nephropathy in DN patients.

The ganglioside treatment and rehabilitation care in early stage after traumatic brain injury / 中国实用护理杂志

Objective To observe ganglioside and rehabilitation care to early rehabilitation of patients with severe traumatic brain injury.Methods 66 patients with brain injury were randomly divided into the control group and the rehabilitation group with 33 cases in each group.Both groups were given conventional medication and ganglioside treatment.The control group was given routine care.In addition to the usual care,the rehabilitation group received the implementation of systematic and standardized early rehabilitation nursing.Oxidative stress status,Barthel index score,and quality of life were compared between two groups.Results Oxidative stress parameters of the two groups showed no significant difference.After hospital treatment,Barthel index score and quality of life in the rehabilitation group were significantly higher than those of the control group.Conclusions Rehabilitation care can reduce disability rates of head injury,and improve the quality of life of patients.