Investigation of Volumetric and Optical Properties of Anti-Emetic Metoclopramide Hydrochloride Drug in Aqueous-Dimethylsulfoxide (DMSO) Solutions At 303.15.

In view of pharmaceutical applications, the density (ρ) and refractive index (nD) of antiemetic metoclopramide hydrochloride monohydrate (MHM) drug in aqueous, aqueous-DMSO and DMSO solutions were measured at 303.15 K in the wide range of concentration of drug. Apparent molar volumes (φv) were calculated from density data and fitted to the Masson relation to determine partial molar volume (φ °v) of drug. Overall, strong drugsolvent interactions with significant structural changes in pure and mixed solvents have been confirmed.

Partial molar vllume of some alkanolamines in water at 298.15 k / Volumen molar parcial de algunas alcanolaminas en agua a 298,15 k / Volume molar paccial de algumas alcanolaminas em água a 298,15 k

Densities of aqueous solutions of 3-amino-1-propanol, 2-amino-1-propanol, 3-amino-1,2-propanediol, and 1,3-diamino-2-propanol were measured at 298.15 K using the vibrating tube technique. The apparent molar volumes of the alkanolamines were determined as a function of composition from experimental data and the solute limiting partial molar volume was obtained through extrapolation. The results are discussed in terms of the effect of the number and the position of polar groups in the molecules.

Las densidades de soluciones acuosas de 3-amino-1-propanol, 2-amino-1-propanol, 3-amino-1,2-propanodiol y 1,3-diamino-2-propanol fueron medidas a 298,15 K usando la técnica del tubo vibrante. Los volúmenes molares aparentes se determinaron en función de la composición a partir de los datos experimentales y los volúmenes molares parciales de los solutos a dilución infinita fueron obtenidos por extrapolación. Los resultados son discutidos en términos del efecto del número y la posición de los grupos polares en las moléculas.

As densidades de soluções aquosas de 3-amino-1-propanol, 2-amino-1-propanol, 3-amino-1,2-propanediol and 1,3-diamino-2-propanol foram medidas a 298 K utilizando a técnica de tubo vibratório. Os volumes molares aparentes das alcanolaminas foram determinados como uma função de composição partindo de dados experimentais e parciais volumes molares de solutos na diluição infinita foram obtidos por extrapolação. Os resultados são discutidos em termos do efeito do número e da posição dos grupos polares nas moléculas.