Application of Platelet?Rich Fibrin and Freeze?Dried bone Allograft Following Apicoectomy: A Comparative Assessment of Radiographic Healing

Background: Apicoectomy conceptualizes surgically maintaining a tooth with an endodontic lesion that cannot be resolved by conventional endodontic (re?) treatment. To achieve this, continuous improvement in surgical techniques, materials and instruments is being done to enhance the outcome of periapical endodontic surgeries. The purpose of this study was to compare, radiographically, the healing kinetics of platelet?rich fibrin (PRF) and mineralized freeze?dried bone allograft (FDBA) in patients undergoing apicoectomy. Materials and Methods: Nineteen patients (aged 18–40 years) were included in the study and randomly assigned to groups A or B, where they received PRF or FDBA, respectively. Following apicoectomy, PRF gel and FDBA graft were prepared and placed in the osseous defect followed by placement of PRF membrane for graft stabilization and flap closure. Radiographic follow?up was done at the 1st, 3rd, 6th and 12th months for evaluation of healing using Molven’s criteria. Statistical analysis was done with Pearson’s and McNemar’s Chi?square tests. Results: A highly significant difference (P = 0.002) in radiographic healing was observed at 6 months. Complete healing was observed in 50% of cases in Group A whereas in Group B, none of the cases presented with complete radiographic healing. However, at the end of 12 months, complete radiographic healing was observed in both groups. Conclusion: Our data suggest that PRF accelerates bone healing as compared to FDBA and is both time and cost?efficient.

The use of Autologous Concentrated Growth Factors in Osseous Regeneration after Periapical Curettage: A Clinical Study

Introduction: The contemporary research interest inautologous platelet concentrates is backed by an emergingevidence of their promising regenerative potential in numberof clinical applications. Periapical inflammatory lesionsrepresent a chronic pathology of the periapical tissuesthat result in considerable bone resorption and worsen theoverall tooth prognosis. With this background, the presentstudy was designed to evaluate the effect of the most recentplatelet concentrate preparation, concentrated growth factors(CGF) on osseous regeneration after surgical management ofperiapical lesions.Material and methods: A prospective study was done intwenty patients where CGF was used to fill the periapicaldefects after periapical curettage. Area of radiolucency andmean gray values were assessed at baseline, 1 month, 3months and 6 months after surgery using Image J software.Paired t-test was used to evaluate changes occurring betweenbaseline and 1 month and baseline and 6 months.Results: And early and enhanced healing was evident formthe substantial decrease in area of radiolucency, and meangrayscale values indicated a progressive increase in bonedensity during the observational period. These changes werehighly significant (P< 0.05).Conclusion: CGF can be used as an efficacious and costeffective alternative to conventional bone substitutes forpromoting healing after the surgical debridement of periapicaldefects.

Paraendodontic surgery: case report / Cirurgia paraendodôntica: relato de caso

ABSTRACT Paraendodontic surgeries have been increasingly used to solve problems related to failures in conventional endodontic treatment. Better anatomical knowledge of the structures as well as the development of techniques and materials involved has resulted in substantial paraendodontic surgery increase and success. In some cases, teeth endodontic treatment highly benefits treatment accomplishment. This report describes a case of an endodontic treatment complemented by paraendodontic surgery in periapical region of 21, 22 and 23 of a female patient who had been treated at the clinic of the Brazilian Dental Association Dentistry - in the city of Cascavel, State of Parana, Brazil. The case presents a 12-month follow-up for the resolution of painful symptoms, lesion reduction, and bone formation. Literature review was performed regarding paraendodontic surgery in order to assess the determining factors, failure causes and procedure indications/contraindications, as well.

RESUMO A cirurgia paraendodôntica tem sido cada vez mais utilizada para sanar problemas inerentes aos insucessos no tratamento endodôntico convencional. O melhor conhecimento anatômico das estruturas envolvidas bem como a evolução das técnicas e dos materiais proporcionou um aumento significativo da utilização desta técnica e, por conseguinte seu maior sucesso. O tratamento endodôntico primário de um elemento dentário pode atingir altos índices de sucesso. Tornando-se, portanto, imprescindível para se atingir o sucesso do tratamento de alguns casos. Neste trabalho descreve-se um caso de tratamento endodôntico complementado por cirurgia paraendodôntica em região periapical dos elementos dentais 21, 22 e 23 de paciente do gênero feminino que foi tratada na Clínica de Odontologia da Associação Brasileira de Odontologia - Regional de Cascavel, Pr. O caso apresenta acompanhamento de 12 meses com resolução da sintomatologia dolorosa, redução da lesão e neoformação óssea. Foi realizada uma discussão com revisão da literatura sobre a cirurgia paraendodôntica avaliando os fatores determinantes, causas de insucessos, indicações e contraindicações do procedimento.

Clinical efficacy of low level laser therapy in reducing pain and swelling after periapical surgery: a preliminary report / Eficacia clínica de láser terapéutico de bajo nivel de emisión en la reducción de dolor e inflamación posterior a cirugía periapical: reporte preliminar

The objective of this study was to evaluate the efficacy of the low level laser therapy (LLLT) in postoperative pain and swelling associated with periapical surgery. A double-blind, randomized, controlled clinical trial was carried out in 2 groups of 10 patients each, undergoing periapical surgery. The experimental group was treated with an intraoral application of an 810 nm-GaAsAl-laser, having an output power of 100 mW, with overlapping movements over the wound. In the control group, the same procedure was carried out, without therapeutic laser activation. Postoperative pain, swelling, and rescue medication were registered. The experimental group exhibited a decrease in pain intensity after periapical surgery compared with control group (p<0.05). There was not significant statistical difference between the groups in terms of swelling. Six patients of the control group required rescue medication. The use of LLLT in the postoperative management of patients having periapical surgery, using the protocol of this study reduced postoperative pain...

El objetivo del estudio fue evaluar la eficacia del láser terapéutico de bajo nivel de emisión (LTBNE) en el dolor postoperatorio e inflamación asociados con cirugía periapical. Se realizó un ensayo clínico controlado aleatorizado doble ciego en 2 grupos de 10 pacientes cada uno, que requirieron de cirugía periapical. El grupo experimentalfue tratado con una aplicación intraoral de laser de GaAsAl de 810 nm, con una potencia de 100 Mw, con movimientos oscilatorios sobre la herida quirúrgica. En el grupo control, se llevó a cabo el mismo procedimiento, sin la activación del láser terapéutico. Se registraron dolor postoperatorio, inflamación y medicación de rescate. El grupo experimental mostró una disminución en la intensidad del dolor posterior a la cirugía periapical en comparacióncon el grupo control (p<0.05). No se encontró diferencia estadísticamente significativa entre los grupos entérminos de inflamación. Seis pacientes del grupo control requirieron medicación de rescate. El uso de LTBNE en el manejo postoperatorio de pacientes sometidos a cirugíaperiapical, usando el protocolo del presente estudio redujo el dolor postoperatorio...

Monitoring Nonsurgical and Surgical Root Canal Treatment of Teeth with Primary and Secondary Infections

The aim of this study was to monitor nonsurgical and surgical root canal treatment (RCT) of teeth with primary and secondary infections and apical periodontitis (AP). This prospective clinical study comprised the treatment of 80 patients with primary and persistent secondary infections and AP. Of this initial sample, forty patients did not return. Periapical index using cone beam computed tomography scans (CBCTPAI) was used to aid diagnosis, planning and to determine the better therapeutic strategy. Twenty patients (26 teeth) diagnosed with primary infection and AP received conventional RCT and were followed up for 10 to 36 months. Twenty patients (31 teeth) diagnosed with persistent secondary infection were submitted to periapical surgical and followed up for 6 to 30 months. The results showed RCT successful in 19/26 cases with complete AP healing (5/26 with partial repair) in 10-36 months of follow up. For the surgically managed cases, effectiveness of surgical therapy was detected in 10/31 cases with complete healing (10/31 cases with partial repair) within 6-30 months follow up. The return of patients for clinical and radiographic follow-up, and obedience to the proposed time period was very short from ideal. The levels of success in both therapeutic protocols were high. RCT failures were detected even with rigorous standard clinical protocols.

O objetivo do estudo foi monitorar tratamentos de canais radiculares (TCR) convencionais e com auxílio de cirurgia periapical. Este estudo prospectivo constituiu de 80 pacientes portadores de infecções primárias e secundárias persistentes e periodontite apical (PA). O índice periapical utilizando tomografia computadorizada de feixe cônico (CBCTPAI) foi utilizado como auxiliar no diagnóstico, planejamento e para determinar a melhor estratégia terapêutica. Apenas 40 pacientes retornaram para o TCR. Em 20 pacientes (26 dentes) com diagnósticos de infecções primárias e PA foram feitos TCR convencionais e monitoramentos por 10 a 36 meses. Em 20 pacientes (31 dentes) com diagnósticos de infecções secundárias persistentes foram submetidos a procedimentos cirúrgicos e acompanhamentos durante 6 a 30 meses. Os resultados mostraram TCR bem sucedidos em 19 de 26 casos, com curas completas das PA (5 de 26 com reparação parcial) em controles de 10 a 36 meses. Para os casos de tratamentos cirúrgicos foram detectadas eficácias das terapêuticas cirúrgicas em 10 de 31 casos com curas completas (10 de 31 casos com reparação parcial) em controles de 6 a 30 meses. O retorno dos pacientes para controle clínico e radiográfico e a obediência ao período de tempo proposto está muito aquém do ideal. Os níveis de sucesso em ambos os protocolos terapêuticos se mostraram elevados. Fracassos no TCR foram detectados mesmo utilizando protocolo clínico com rigoroso padrão.

O uso da tomografia cone beam no auxílio ao diagnóstico e planejamento de cirúrgia periapical: relato de caso clínico / The use of cone-beam volumetric tomography to help diagnose and plan a periapical surgery: clinical case report

O diagnóstico e o planejamento das intervenções são fundamentais na execução de um tratamento cirúrgico. Um método rotineiramente usado para auxiliar no diagnóstico de lesões periapicais é a radiografia periapical, porém, com essa técnica, estruturas anatômicas tridimensionais são comprimidas em imagens bidimensionais, resultando em superposição de estruturas de interesse diagnóstico. Este artigo relata um caso clínico de um paciente que apresentava uma lesão cística, de dimensões expressivas, na região anterior da maxila cuja cirurgia foi planejada e executada após a visualização das margens da lesão por imagens de tomografia computadorizada Cone Beam (TCCB). Dessa forma, foi possível concluir que a TCCB constitui-se como um método preciso para auxiliar no diagnóstico, propiciando uma maior exatidão no planejamento, pois permite a visualização tridimensional das estruturas.

The diagnosis and planning of interventions are vital for the execution of a surgical treatment. A method used routinely to help diagnose periapical lesions is the periapical radiography. However, with this technique, three-dimensional anatomic structures are compressed into two-dimensional images resulting in the superposition of structures of diagnostic interest. This article reports the clinical case of a patient who presented a cystic lesion of expressive dimensions in the anterior region of the maxilla, and whose surgery was planned and performed after visualization of the lesions? margins by means of Cone Beam Computed Tomography (CBCT). Thus, it is possible to determine that CBCT constitutes a precise method to help diagnosis, providing better accuracy for planning as it allows the three-dimensional visualization of structures.

Propriedades e aspectos biológicos do agregado trióxido mineral: revisão da literatura / Properties and biological aspects of mineral trioxide aggregate: literature review

O material obturador ideal deve apresentar características específicas, como biocompatibilidade, selamento marginal adequado, capacidade de permitir ou induzir o reparo ósseo e facilidade de manipulação e inserção. O agregado trióxido mineral (MTA) foi desenvolvido como um material para obturação retrógrada com melhores propriedades químicas, físicas e biológicas do que os materiais existentes na época, como amálgama, material restaurador intermediário (IRM) e SuperEBA. Atualmente, o MTA é usado como material de preenchimento radicular no selamento apical, no reparo de perfurações e como agente de capeamento pulpar, além de ser usado como material de obturação retrógrada. O objetivo deste artigo foi realizar uma revisão da literatura acerca do agregado trióxido mineral, comparando-o com os principais cimentos endodônticos e materiais obturadores retrógrados disponíveis no mercado para a retrobturação do sistema de canais radiculares, analisando suas propriedades e características biológicas. Concluiu-se que o MTA é um material obturador retrógrado bastante satisfatório do ponto de vista químico-físico-biológico, especialmente por sua biocompatibilidade e seu potencial de ação osteocondutora, osteoindutora e cementocondutora.

The ideal root canal sealer should present specific characteristics, as biological compatibility, appropriate marginal sealing, ability to allow or induce bone repair, and ease of manipulation and insertion. Mineral trioxide aggregate (MTA) was developed such a retro-sealer with better chemistry, physics and biological properties than materials that exist at the time, as amalgam, intermediate restorative material (IRM), and SuperEBA. Actually, MTA is used such a canal filling material to seal root apical, at drilling repair, and as a pulp capping agent; in addition, it is used as a filling retrograde material. The purpose of this study was a literature review about mineral trioxide aggregate, comparing it to the main endodontic cements and retro-sealer materials available at market for root canal filling retrograde filling, analyzing its properties and biological characteristics. It was concluded MTA is a quite satisfactory retro-sealer material, in terms of its chemical-physical-biological properties, especially due to its biocompatibility, and potential actions do conduce and induce the repair of bone and cementum.

A RETROSPECTIVE CLINICAL STUDY OF PERIAPICALLY INFECTED TEETH TREATED WITH PERIAPICAL SURGERY

The effect of non-resorbable barrier membrane on the change of buccal and lingual alveolar bone in immediate implant placement into periapically infected extraction sockets / 대한치주과학회지

PURPOSE: Many researches showed loss of alveolar bone in fresh extraction socket and even in case of immediate implant placement. The aim of this study was to evaluate the effect of non-resorbable barrier membrane on the change of buccal and lingual alveolar bone in immediate implant placement into periapically infected extraction sockets. MATERIALS AND METHODS: Immediate implants were placed into artificially induced periapical lesion of mandibular premolars after complete debridement using buccal bone defect made by a 6mm trephine bur in 4 mongrel dogs. Before flap repositioning, a non-resorbable barrier membrane was placed on the buccal defect in the experimental group. No membrane was placed in the control group. In 12 weeks after placement, the dogs were sacrificed and undecalcified histologic specimens were prepared. The vertical distance from the smooth-rough surface interface(SRI) to gingiva, 1st bone contact and bone crest were measured in buccal and lingual side. The horizontal thicknesses of gingiva and bone at 0, 1, 2 and 3 mm below SRI were measured. RESULTS: The buccal bone was resorbed more than lingual bone in both groups and there was statistical significance(p<0.05). The distances from SRI to 1st bone contact were 2.45+/-2.35 mm in experimental group and 4.49+/-3.10 mm in control group. In all vertical level, lingual bone was thicker than buccal bone(p<0.05). CONCLUSION: Buccal bone was reduced more than lingual bone in immediate implant placement into periapically infected extraction sockets. Placement of non-resorbable barrier membrane reduced the buccal bone resorption. However there was no statistical significance.

Estudo in vitro da infiltração marginal em dentes submetidos a três tipos de secção apical / In vitro study of apical leakage of root canals after different root apex resection techniques

Objetivo: O objetivo deste trabalho foi avaliar in vitro a infiltração marginal apical em dentes submetidos a três tipos de secção apical. Material e métodos: Foram utilizados 30 caninos superiores humanos, instrumentados no terço apical até a lima #40 e escalonados com broca de Gates-Glidden n.º 2, 3 e 4. Posteriormente, os elementos foram obturados pela técnica híbrida de Tagger de termoplastificação, utilizando-se o compactador de McSpadden, e divididos em três grupos distintos (n = 10). O primeiro grupo (GI) foi submetido ao corte apical de 3 mm com broca Endo Z em alta rotação. Os elementos do segundo grupo (GII) tiveram seus ápices desgastados em 3 mm com broca EndoZ em alta rotação, e os elementos do terceiro grupo (GIII) tiveram a região apical seccionada a 3 mm com o laser Er:YAG (500 pulsos, 12 pps a 300 mJ). Após sofrer as secções, cada grupo foi retroobturado com IRM e mantido em tinta nanquim por 5 dias. Decorrido esse tempo, os espécimes foram diafanizados, e a infiltração foi medida com auxílio de um microscópio de mensuração. Resultados: Os resultados mostraram haver diferença estatística significante (p < 0.01) entre GI e os demais grupos. Conclusão: O corte com broca Endo Z proporciona uma menor infiltração apical quando empregado nas apicectomias.

Objective: The aim of the present study was to evaluate in vitro apical arginal leakage of root canals after three root apex resection techniques. Material and methods: Thirty maxillary canines were prepared chemo-mechanically to a size 40 master apical file, and enlarged by using Gates Glidden burs 2, 3 and 4. Teeth were obturated by Tagger thermomechanical compaction technique and then divided into three groups (n = 10). The first group (GI) was 3 mm apicalresected with Endo Z in high speed handpiece. The specimens of second group (GII) were 3 mm apical weared with Endo Z, and the third group (GIII) had 3 mm apical resected with Er:YAG laser (500 impulse, 12 pps and 300 mJ energy). After the apical sections, IRM cement was placed into the root-end cavity and teeth of each group were immersed in India ink for 5 days and submitted to decalcification and clarifying or marginal apical microleakage visualization with microscope. Results: The results showed statistically difference (p < 0.01) between GI and the other groups. Conclusion: The root apex cut using Endo Z promotes the lowest values of microleakage when used in apicoectomy.