Résumé
Objective To learn the relationship between the sale volume of anti - diarrhea drugs and diarrhea cases,and to evaluate the possibility of using the sale volume of anti - diarrhea drugs as an indirect indicator of foodborne disease surveillance. Methods Collect data of sale volume of 10 kinds of anti - diarrhea drugs in Shanghai Pharmacy Company Limited and diarrhea cases of 23 sentinel hospitals in Shanghai in 2015,and correlation analysis was conducted. Results The variation trend of sale volume of anti - diarrhea drugs and diarrhea cases in sentinel hospitals were similar,and there were same peaks in summer and winter. Sale volume of 10 kinds of anti - diarrhea drugs correlated with diarrhea cases,and the Spearman correlation coefficient of compound ancklandia and berberine tablets was the highest and it reached 0. 695. The coefficient of the sum of ten kinds of anti - diarrhea drugs one or two days before diarrhea cases in sentinel hospitals was higher and reached 0. 630 and 0. 597. Conclusion Anti - diarrhea drugs sale volume were correlatd with diarrhea cases in sentinel hospitals in Shanghai . The sale volume of anti - diarrhea drugs one or two days before diarrhea cases in sentinel hospitals could be used as an indirect indicator of surveillance.
Résumé
Objective To examine the association between anti -diarrhea medicine sales volume and the reported cases of intestinal infectious diseases in Hangzhou.Methods Sales data of three over -the -counter drugs including G dysentery Sha,berberine and Smecta from 2006 to 2010 were collected and standardize.Correlations between out -patient cases of infectious and non -infectious diarrheal from 9 hospitals and medicine sales volume were analyzed respectively.Results From 2006 to 2010,berberine had the highest standardized daily drug dose (DDD)with median 1 600.32.The peak of DDD occurred on July in year 2007,2008 and 2012;while on August in year 2006,2009 and 2010.There was positive correlation between medicine sales volume and infectious diarrhea in year 2006,2007,2008 and 2010,the correlation coefficients were 0.635,0.448,0.298 and 0.217 respectively (P <0.01).The same correlation was occurred in non -infectious diarrhea in year 2006 to 2008 as well and the total correlation coefficient of the three years was 0.419 (P <0.01).Conclusion A positive correlation has been found between the anti -diarrheal medicine sales volume and incidence of infectious and non -infectious intestinal diseases,demonstrating that pharmacy monitoring could have a positive effect on early detection of outbreaks of intestinal diseases.