RÉSUMÉ
Background: Vitamin D deficiency is thought to be common among pregnant women and is associated with adverse maternal and perinatal outcome. Maternal and foetal outcome in pregnant women with standard obstetric care was compared with women with additional vitamin D supplementation.Methods: A randomized comparative study was conducted on 100 patients attending the antenatal clinic at JSS Medical College and Hospital, Mysuru, Karnataka, India who were randomly grouped into group A (50 patients) who received standard obstetric care (500 mg calcium+200 IU vitamin D) and group B (50 patients) who received in addition to standard obstetric care supplementation of Vitamin D 1000 IU/day starting from 14 weeks of gestation till delivery. Vitamin D levels were assessed in both the groups with onset of labour by chemiluminescence immunoassay and obstetric and neonatal outcomes in both groups were compared.Results: High incidence of vitamin D deficiency (96%) in standard care group compared to vitamin D supplemented group ( p= <0.0001) was noted. The study showed significant reduction in risk of Preeclampsia (P=0.004), GDM (P= 0.02) and primary caesarean delivery (0.008) in Vitamin D supplemented group. Significantly high birth weight in vitamin D supplemented group, an increase in 320 grams in birth weight was noted (P <0.0001).Conclusions: There is a high incidence of subnormal vitamin D levels in antenatal women and is associated with maternal and neonatal adverse effects. Measuring Vitamin D levels and appropriate supplementation of higher dose of vitamin D is an effective strategy in prevention of adverse maternal and neonatal outcomes.
RÉSUMÉ
La hipertensión arterial complica 6-8% de todos los embarazos, es una de las causas principales de morbi-mortalidad materna y fetal siendo especialmente fatal en países con bajo nivel socioeconómico. La importancia de su estudio radica en que una atención prenatal adecuada previene o atenúa las alteraciones que provoca. Con el presente trabajo se intento buscar una relación PRONOSTICA entre parámetros laboratoriales tales como: perfil lipidico, ácido úrico, recuento plaquetario en pacientes preeclampticas, la correlación con la severidad del cuadro y los resultados perinatales obtenidos. Para tal efecto se realizó un estudio descriptivo, transversal y prospectivo donde 57 pacientes cumplieron los criterios de inclusión. No se observaron alteraciones en las lipoproteínas de alta y baja densidad, así como del colesterol total, pero se observo que un 35 % de las pacientes presentaron niveles de triglicéridos alterados, de ellas la mayor parte con diagnostico de preeclampsia severa.
The high blood pressure complícate 6-8% of all pregnancy. It is a major cause of mother and fetal morbi mortality, being specially fatal in low developed countries. It is important study because a adecuated pre partum care can prevent or at least attenuate its ateration. In the present work we search a pronostic relationship between laboratorial parameters such as : lipidic profile, uric acid, plateleds count in pre eclamptic patients, the correlation between severity and perinatal outcomes. In order to these we give an descriptive, transversal and prospective study, in which were included 57 patients that accomplished the inclusión criteria. It was not observed alterations on high and low density lipoproteins, neither total cholesterol, it was observed in 35% of patients triglycerides levels alterations, the most of them have been diagnosticated with severe preeclampsia.