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Objective:To explore the preparation procedure of pediatric Kechuan black plasters. Methods:A single factor method was used to observe and study the preparation process of pediatric Kechuan black plaster from the following aspects: the selection of matrix raw material and refined equipment, and the temperature of refinery, “Xiadan”, pouring white wax and adding fine material powder in production processing. Results:The best temperature of“Xiadan” for pure sesame oil and mineral orange with the purity a-bove 95% was 313 ℃. The “Xianzha” temperature was 264 ℃, the temperature of “Houxia” was between 180 ℃ and 200 ℃, and white wax instead of the traditional method was used to eliminate fire toxin. Conclusion:The research is helpful to improving the quali-ty of the black plasters. The preparation process is stable and feasible, and suitable for the industrial production.
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OBJECTIVE: To establish the method of the preparation and test for methyl salicylate glycoside (MSG) tablets. METHODS: MSG tablets were prepared with MSG as main drug and microcrystalline cellulose and sodium carboxymethyl starch as exipients. Its detection method was studied. RESULTS: After experimental study, the high performance liquid chromatography method for related substances detection and content determination of MSG tablets were established. CONCLUSION: The prescription is reasonable and the preparation technology is reliable. The HPLC method has high accuracy and sensitivity and can be used for MSG tablets test.
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Objective To study the extraction process of Jiejiu Gankang granules by orthogonal test.Methods With the ethanol extraction rates of the medical materials like ginseng,radix salviae miltiorrhizae,the water extraction rates of the medical materials like hawthorn,and Tanshinone ⅡA as the parameters,the extract conditions of Jiejiu Gankang granules was optimized by orthogonal design.Results The optimal preparation process was as follows:the mixture of medical materials like ginseng and Schisandra chinensis was refluxed twice with total 10 times of 70% alcohol,2.0 hours for each time,and then the mixture of medical materials like hawthorn extracted twice with total 10 times of boiling water,2.0 hours for each time.Conclusion The optimal preparation process is reasonable and with high extraction rate of active components.
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Objective To optimize the preparation process for Fangji Huangqi Granules. Methods With the extraction rates of tetrandrine, fanchinoline, astragaloside Ⅳand solid as the parameters, the extract conditions of Fangji Huangqi Granules were optimized by orthogonal design . Then the anti-inflammation effect of the extracts was observed on the mice and rats. Results The optimal preparation process was as follows:the mixture of medical materials was firstly refluxed twice with total 10 times of 70 %alcohol,1.5 hours for each time, and then extracted twice with total 12 times of boiling water ,1.5 hours for each time. The anti-inflammation effect of the extracts was obvious on the mice and rats. Conclusion The optimal preparation process is reasonable and with high extraction rate of active components.
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Objective: To select the optimum prepartion procedure for Sanhuangweixueping, Capsules. Methods: The optimum conditions were selected with the contents of active components: emodin, berberine, and baicalin as markers. Results: The optimum preparation procedure was: berberine was extracted with 95% alcohol. Rhizoma Bletillae was immersed with water, then precipitated with 70% alcohol. Radix et Rhizoma Rhei, Radix Scutellariae and Radix Glycyrrhizae were decocted, then precipitaed with 60% alcohol. Sanhuangweixueping Capsules prepared with the optimum preparation procedure possessed stronger pharmacological effect. Conclusion: The optimum prepartion procedure is reliable and the extraction ratio of active compoents is high.
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Objective: To establish the optimum preparation procedure for Grub Eye Drops. Methods: The amount of extract abtained from extraction solutions, the contents of glutamic acid and glycine, nitrogen content and TLC spots were used to evaluate the extraction procedure for Grub Eye Drops by orthogonal design. Results: The optimum extraction condition was A 3B 2C 1. That is adding ten times amount of water to soaking for 30min, decocting for 1.5h, filtering to obtain filtrate Ⅰ, adding seven times of water into filter residue, decocting for 1h to obtain filtrate Ⅱ, combining filtrate Ⅰ and Ⅱ. Conclusion: The experimental method is suitable for the productive preparation of Grub Eye Drops.