Presyrinx Associated with Post-Traumatic Hydrocephalus Successfully Treated by Ventriculoperitoneal Shunt / 대한신경손상학회지

Presyrinx consists of reversible spinal cord swelling without frank cavitation, as observed on T2 weighted magnetic resonance imaging (MRI). The condition may evolve into syringomyelia, but timely surgical interventions have achieved meaningful results. Here, we report the case of a 27-year-old woman who presented with headache, dizziness, and diplopia 2 months after suffering a mild head trauma. On MRI, hydrocephalus, downward herniation of the cerebellar tonsil, and a diffuse high signal change in the cervical spinal cord were detected. After insertion of a ventriculoperitoneal shunt, her neurological symptoms resolved, and she has had no signs of presyrinx recurrence for >4 years.

Effect of NF-?B and I?B on neuronal apoptosis of experimential presyrinx state in rabbits / 基础医学与临床

Objective To investigate the mechanism of NF-?B and I?B on neuronal apoptosis of spinal presyrinx state in rabbits.Methods The experimental model of rabbits were established by intra-cisternal injection of kaolin.Neuronal apoptosis and the expression of NF?B、I?B、BCL-2、BAX were measured wih immunohistochemistry in 1,3,7,14 and(21 d) after operation repectively.Results In Kaolin group animals,neuronal apoptosis was observed in all time points,but was most significant from 7 to 14 day.Comparing with control groups,NF-?B expression in Kaolin group animals increased in 1~(st) day after operation,reached its peak at 3~(th) day,lasted to 7~(th) day,and recoved normal level at 21~(th) day approximately.I?B expression showed negative corelationship with NF-?B at the same time points.BCL-2 expression increased from 1~(st) day,reached its peak at 7~(th) day,lasted to 14~(th) day,and then began to drop.Although BAX expression had the similar trendency to BCL-2,the former was much stronger than the later.Conclusion In presyrinx state of experimental syringomyelia,increasing expression NF-?B's upregulates its target gene BAX and induces neuronal apoptosis in nervous function injury.