Effect of Porcine Large Intestine-processed Dahuang （Radix et Rhizoma Rhei） on Defecation and Colon Pathological Changes in Constipation Model Mice / 中医杂志

ObjectiveTo investigate the effect of porcine large intestine-processed Dahuang （Radix et Rhizoma Rhei） on defecation in constipation model mice and the possible mechanism. MethodsFifty Kunming mice were randomized to blank group （n=10） and model group （n=40）. Loperamide suspension at the dose of 8 mg/（kg·d） was given by gavage for four consecutive days to establish a model of constipation. The 24 successfully modeled mice were randomly divided into model group， processed Dahuang group， lactulose group， raw Dahuang group， with six mice in each group. Moreover， six randomly selected mice were chosen as control group. Since the fifth day， 8 mg/（kg·d） of loperamide suspension by gavage was given to the model group， processed Dahuang group， raw Dahuang group， and lactulose group； two hours later， the processed and raw Dahuang groups were administered with 0.6 g/（kg·d） of processed and raw Dahuang suspension， respectively， while the lactulose group was given 0.6 g/（kg·d） of latulose suspension， and the blank group and the model group were given 0.2 ml/10 g of distilled water by gavage， all for four days. The general condition， body weight after the last gavage， number of fecal particles within six hours， fecal wet weight， fecal water content ratio， intestinal propulsion rate and colonic histology changes by HE staining of each group were detected. ResultsThe body weight of the mice in the raw Dahuang group was significantly lighter than that in the other groups （P＜0.05 or P＜0.01）. The number of fecal particles， fecal wet weight and intestinal propulsion rate of mice significantly decreased in the model group than in the blank group （P＜0.05 or P＜0.01）. Compared to those in the model group， the number of fecal particles and fecal wet weight in the processed Dahuang group， lactulose group and raw Dahuang group significantly increased， and the fecal water content ratio in the raw Dahuang group increased as well （P＜0.05 or P＜0.01）. Compared to those in the processed Dahuang group， the number of fecal particles and fecal wet weight in the raw Dahuang group decreased， while the fecal water content ratio increased （P＜0.05 or P＜0.01）， and the fecal water content ratio in the lactulose group increased significantly （P＜0.05）. The intestinal propulsion rate in the processed Dahuang group was higher than that in the model group， lactulose group and raw Dahuang group （P＜0.05 or P＜0.01）. Histopathological analysis showed that the colonic crypts and goblet cells in the blank group were normal and clear， and the colonic muscular layer was thicker. The colonic crypts of the mice in the model group were damaged， with reduced goblet cells to varying degrees and changed colonic muscularis. In the lactulose group and raw Dahuang group， part of the crypts were broken， and the goblet cells were damaged to varying degrees， while in the processed Dahuang group， still the colonic tissue structure of the mice was relatively clear， and the colonic crypts and goblet cells were relatively normal， with thickened muscular layer of the colon. ConclusionPorcine large intestine-processed Dahuang could improve defecation in constipation model mice， and reduce the drastic purgation function of raw Dahuang， for which the mechanism may be related to the protection of colon histopathological damage.

Effect of poria cocos on gastrointestinal motility in mice / 公共卫生与预防医学

Objective To investigate the regulatory effect of poria cocos on gastrointestinal motility in mice. Methods A total of 130 Kunming mice were randomly divided into negative control group, low-dose and high-dose groups of raw poria cocos powder, low-dose and high-dose groups of cooked poria cocos powder, low-dose and high-dose groups of poria cocos surrogate culture powder, low-dose, medium-dose and high-dose groups of poria cocos water extract, and low-dose, medium-dose and high-dose groups of poria cocos alcohol extract, with 10 mice in each group. The animals were administered by gavage for 7 days, once a day. After the last administration, the intestinal propulsion function test and gastric solid emptying test were conducted to observe the regulating effect of poria cocos on gastrointestinal motility of mice. Results Compared with the negative control group, the small intestine propulsion rate in the low-dose group of poria cocos surrogate culture powder was significantly increased (P<0.01). Except the high-dose group of raw poria cocos powder, the other poria cocos groups had higher gastric residual rate (P<0.05). Conclusion Poria cocos does not promote intestinal propulsion of mice under normal physiological condition, but it can inhibit gastric empting and exert a moderating effect on gastrointestinal function in normal mice.

Medical micro- and nanomotors in the body

Attributed to the miniaturized body size and active mobility, micro- and nanomotors (MNMs) have demonstrated tremendous potential for medical applications. However, from bench to bedside, massive efforts are needed to address critical issues, such as cost-effective fabrication, on-demand integration of multiple functions, biocompatibility, biodegradability, controlled propulsion and in vivo navigation. Herein, we summarize the advances of biomedical MNMs reported in the past two decades, with particular emphasis on the design, fabrication, propulsion, navigation, and the abilities of biological barriers penetration, biosensing, diagnosis, minimally invasive surgery and targeted cargo delivery. Future perspectives and challenges are discussed as well. This review can lay the foundation for the future direction of medical MNMs, pushing one step forward on the road to achieving practical theranostics using MNMs.

Factores de riesgo del síndrome de túnel del carpo en usuarios de sillas de ruedas

Introducción: El síndrome de túnel de carpo es una neuropatía del nervio mediano muy frecuente en la población. Para los usuarios de sillas de ruedas hay mayor riesgo biomecánico por utilizar reiteradamente la muñeca en la propulsión de este vehículo. Objetivo: Analizar los factores biomecánicos de la silla de ruedas que inciden en el desarrollo del síndrome de túnel del carpo. Métodos: Se realizó una revisión sistemática con términos Mesh en bases de datos como Embase, Pubmed, Google Acedemics, Scielo desde 1988 hasta 2021. Se revisaron más de 200 artículos y por su impacto clínico, se seleccionaron 52 para la revisión. Resultados: El 43 % de los usuarios de silla de ruedas presentan dolor en la muñeca y prevalece como diagnóstico el síndrome de túnel del carpo. La posición de la muñeca en la propulsión genera un aumento de presión en el túnel carpiano lo que condiciona la lesión del nervio mediano. Existen factores de riesgo como el género femenino, las pendientes, el terreno irregular, la vibración, la altura del asiento y el peso del paciente. Entender correctamente las fases de la autopropulsión con sus cuatro patrones, más una prescripción adecuada y los aditamentos necesarios para la silla de ruedas pueden disminuir el riesgo de padecer el síndrome de túnel del carpo. Conclusión: Es importante involucrar de manera activa a los profesionales de la salud en la implementación de estrategias para el entrenamiento, prescripción y uso correcto de la silla de ruedas y con ello prevenir el padecimiento de el síndrome de túnel carpiano.

Introduction: Carpal tunnel syndrome is a very common neuropathy of the median nerve in the population. For wheelchair users, there is a greater biomechanical risk for repeatedly using the wrist to propel this vehicle. Objective: To analyze the biomechanical factors of the wheelchair affecting the development of carpal tunnel syndrome. Methods: A systematic review with Mesh terms was carried out in databases such as Embase, Pubmed, Google Acedemics, Scielo from 1988 to 2021. More than 200 articles were reviewed and due to their clinical impact, 52 were selected for the review. Results: 43% of wheelchair users have wrist pain and carpal tunnel syndrome prevails as a diagnosis. The position of the wrist in the propulsion generates an increase in pressure in the carpal tunnel conditioning the injury of the median nerve. There are risk factors such as female gender, angles, uneven terrain, vibration, seat height and patient weight. Proper understanding the phases of self-propulsion with its four patterns, plus correct prescription and necessary wheelchair attachments can decrease the risk of carpal tunnel syndrome. Conclusion: It is important to actively involve health professionals in the implementation of strategies for training, prescription and correct use of the wheelchair and thereby prevent carpal tunnel syndrome.

Propulsion efficiency in wheelchair tennis: a case study on the influence of the racket on the handrim forces

Aims: to evaluate how the act of holding a tennis racket influences the application of forces in the handrim during manual wheelchair propulsion at a self-selected comfortable speed and sprint. Methods: A case study was conducted with an experienced wheelchair tennis player who propelled the wheelchair in a straightforward trajectory at two different velocities (self-selected comfortable speed and sprint) in two different conditions (freehand and holding the racket). Kinetic and temporal data of the pushes were obtained with the SmartWheel system attached in substitution to the conventional rear wheel at the dominant side of the player. Results: holding the racket affects the propulsion pattern mainly when an accelerated movement is required (sprint). Compared to the propulsion at a self-selected speed, propelling the chair as fast as possible with the racket in hands resulted in lower total and tangential forces on the handrim, and decreased push time and increased push frequency. Conclusion: Such influence on both kinetic and temporal propulsion impact the mechanical efficiency of the manual wheelchair propulsion, which may, ultimately, affect the sport´s performance. Special attention should be directed to the propulsion training with the racket in maneuvers and motions that are characteristic of the wheelchair tennis match in an attempt to provide the athlete with proper technique for optimal propulsion efficiency and sports performance.(AU)

Effect of rotating and advancing gluteal superior and inferior perforator artery island flap on gluteal pressure sore / 中华医学美学美容杂志

Objective To explore the clinical effect of gluteal pressure sore repaired by superior and inferior perforating artery island flap with rotation and joint propulsion.Methods From January 2014 to April 2018,37 patients (27 males,10 females,aged 35～79 years) with hip decubitus were admitted to the First People's Hospital of Yulin City for treatment of hip decubitus.According to the situation of the wound surface,the perforating site of superior and inferior perforator arteries and the local soft tissue,the corresponding perforator arteries were selected as the pedicle to form island skin flap,and the wound surface was transferred by rotation and propulsion.Results All the flaps sur vived well.33 cases healed in the first stage,but 4 cases dehisced and infected in the incision.After dressing change,the wounds healed in the second stage and the wounds were locally smooth.Conclusions The rotational combined push type gluteal superior and inferior perforator island flap is a good method to repair gluteal pressure sore.

Adhesión y proliferación de las células troncales mesenquimales de médula ósea en andamios fibrilares de poli (ácido L-láctico) (PLA) / Adhesion and proliferation of bone marrow mesenchymal stem cells onto poli-L lactic acid (PLA) fiber scaffolds

Resumen: Los andamios fibrilares han recibido un enorme interés como futuros biomateriales con potencial aplicación en el campo de la biomedicina regenerativa. En este sentido, hemos optimizado los parámetros para la síntesis de diferentes concentraciones (6, 7, y 10 %) de andamios de ácido poli-láctico (PLA) por la técnica de hilado por propulsión de gas (AJS). Dichos andamios fueron caracterizados por Microscopía Electrónica de Barrido (SEM) y por espectrometría Infrarroja con Transformada de Fourier (FTIR). Nuestros resultados mostraron que los andamios son fibrilares con diámetros en escalas nanométricas. Asimismo; se estudió la biocompatibilidad celular in vitro al realizar ensayos de adhesión, proliferación y de interacción célula-material al cultivar células troncales mesenquimales derivadas de médula ósea. Nuestros datos indican que las membranas fibrilares de PLA aumentan la respuesta celular, no son citotóxicas al compararse con las películas delgadas de PLA. Por lo tanto; el método de síntesis propuesto tiene potencial para la fabricación de membranas hiladas con una facilidad de procesamiento y podría ser un prometedor biomaterial económico con futuras aplicaciones en la regeneración de tejidos.

Abstract: Fiber scaffolds have received increasing interest as promising biomaterials for potential application in the field of tissue regeneration. In this sense, we optimized the parameters for the synthesis of different concentrations (6, 7, and 10 %) of poly-lactic acid (PLA) scaffolds by air jet spinning technology (AJS). The PLA scaffolds were characterized by Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR) analysis. Our results by SEM micrographs showed that scaffolds have a fibrilar morphology with nanoscale diameter of fibers. Biocompatibility assay was observed through an in vitro experiment based on cell attachment, MTT and cell-material interaction assay when culturing bone marrow-derived mesenchymal stem cells onto the PLA spun membrane scaffolds. Our data indicate that fiber membrane of PLA scaffold increase the cellular response, are not cytotoxic when compared to thin films of PLA. Thus; the proposed synthesis method has potential for easy processing of spun fibrilar scaffolds with good biocompatibility and could be a promising economical biomaterial with future potential applications in tissue regeneration.

Upper extremity temporospatial parameters and kinematics of Filipino track and field paralympians during wheelchair Propulsion: An analysis using a Kinect-based markerless motion analysis system

@#<p style="text-align: justify;"><strong>OBJECTIVE:</strong> The potential of a low-cost, novel Kinect?-based markerless motion analysis system as a tool to measure temporospatial parameters, joint and muscle kinematics, and hand trajectory patterns during the propulsion and recovery phase of wheelchair propulsion (WCP) was determined.</p><p style="text-align: justify;"><strong>METHODS:</strong>Twenty (20) adult male track and field paralympians,(mean age = 36 ± 8.47) propelled themselves on a wheelchair ergometer system while their upper extremity motion was recorded by two Kinect? cameras and processed.</p><p style="text-align: justify;"><strong>RESULTS:</strong> The temporospatial parameters, joint kinematics, and hand trajectory patterns during the propulsion and recovery phase of each participant's WCP cycle were determined and averaged. Average cycle time was 1.45s ± 0.19, average cadence was 0.70 cycles/s ± 0.09, and average speed was 0.76m/s ± 0.32. Average shoulder flexion was 30.99° ± 28.38, average elbow flexion was 24.23° ± 12.25, and average wrist flexion was 12.82° ± 26.78. Eighty five percent (85%) of the participants used a semicircular hand trajectory pattern.</p><p style="text-align: justify;"><strong>CONCLUSION:</strong> The low-cost, novel Kinect?-based markerless motion analysis system had the potential to obtain measurable values during independent wheelchair propu

Preliminary study on constituents of extracts from stems and leaves of Aucklandia lappa and their effect of on gastric emptying and intestinal propulsion of mice / 药物评价研究

Objective To investigate the constituents of water and ethanol extracts from the stems and leaves ofAucklandia lappa and their effect on gastric emptying and intestinal propulsion of gastrointestinal normal,hyperthyroidism and inhibited mice.Methods The water,ethanol and aether petrolei extracts from stems and leaves of A.lappa were prepared,and the chemical constituents of the stems and leaves were identified by chemical reaction.The hyperthyroidism state was induced by neostigmine and inhibiting state was induced by atropine.Mice were ig administered with water and ethanol extracts (0.5 g/kg),with the improved phenol red method to determine gastric emptying and intestinal propulsion in gastrointestinal normal,hyperthyroidism and inhibited mice.Results Both water and ethanol extracts significantly improved intestinal propulsion in normal mice (P ＜ 0.05 and 0.01),while significantly decreased the intestinal propulsion in hyperthyroidism mice (P ＜ 0.05) and ethanol extract showed a stronger decreasing effect than that of water extract.The inhibitory effect of atropine on intestinal propulsion was intensified by these two extracts (P ＜ 0.05).The restrained gastric emptying of normal,hyperthyroidism and inhibited mice was also observed.Chemical composition analysis indicated that many kinds of chemical components including protein,sugar,essential oil,flavonoids,lactones,alkaloids,saponins and tannins existed in the leaves and stems of A.lappa.Conclusion The leaves and stems of A.lappa could promote the intestinal propulsion of normal mice and restrain the intestinal propulsion of hyperthyroidism and inhibited mice while inhibit the gastric emptying in any condition tested,and its promoting effect on the gut may be related to the M cholinergic receptor.

Comparative study on three preparation methods of mouse postoperative ileus models / 国际药学研究杂志

Objective By observing the motility changes of the gastrointestinal tract in mouse postoperative ileus (POI) models prepared with three different methods, this study aims to compare the features of three types of models, and judge their suitability for drug evaluation. Methods Three methods were conducted to prepare the mouse POI models: air exposure, friction and extrusion. In the experiment, the gastric emptying rate, intestinal propulsive rate as well as the relatively percent dextran of blue-2000 in intestinal paragraphs were taken down to evaluate the motility of gastrointestinal tract. Meanwhile, the duodenum, jejunum, ileum and colon of mice were stained in HE method to observe the histopathological changes of each layer in mouse intestinal wall. Results When compared with the control group, the gastric emptying rate of the squeeze-only group was significantly suppressed (P < 0.01). The intestinal propulsive rate in the air exposure group, the friction group and the extrusion group were all suppressed, only the friction group and the extrusion group had statistical difference (P < 0.01). The relative percent of dextran blue-2000 in intestinal paragraphs in mice also show that the motility of the mouse gastrointestinal tract in both the friction and extrusion groups was significantly inhibited. Judging from the results of HE staining, the duodenums of mice in the air exposure group, friction group and extrusion group did not show much difference when compared with the control group. While for the jejunum, the intestinal mucosa and submucosa of mice in the squeeze group had a large quantity of hemorrhage and inflammatory cell infiltration. For the ileum and colon, the friction and extrusion groups showed different degrees of inflammatory cell infiltration, and the mice in the extrusion group suffered from ileal hemorrhage. Conclusion All the three preparation methods of mouse POI models can inhibit the intestinal movement of mice. The effect of the air exposure method causes the light injury. The extrusion method, which causes more serious injury, could be used in the study of the pathogenesis of postoperative ileus.The friction method that has a moderate damage to the intestine, is more suitable for drug screening and evaluation.

Protective effects of CMP on 5-Fu-induced intestinal mucositis of mice / 中国药理学通报

Aim To evaluate the mucosal-protective effects of carboxymethylpachyman( CMP) on Fluorou-racil(5-Fu)-induced mice intestinal mucositis and ex-plore its mechanisms. Methods ICR mice were as-signed randomly to four groups:normal group( n=8;re-ceiving pure water orally for 14 d) ,CMP group( n=8;200 mg·kg-1 CMP for 14 d orally),5-Fu group(n=8;25 mg·kg-1 5-Fu for 7 d,intraperitoneally( i. p. ) , and CMP+5-Fu group( n=8;200 mg·kg-1 CMP for 14 d orally and 25 mg·kg-1 5-Fu for 7 d,i. p. ). At day 14the mice were sacrificed. The intestinal propel-ling rate and the colon length were measured. ROS, GSH and IL-1βcontents,and CAT,GSH-Px activities in homogenate supernatant of PPs were measured by kits for observing the effects of CMP on mice lipid peroxida-tion and intestinal mucosal inflammatory induced by 5-Fu. Colon tissues were used for hematoxylin and eosin ( HE ) staining for the determination of the effect of CMP on mice colon histopathology, immunohistochem-istry for the protein levels of NF-κB and p-p38 . Results CMP significantly extended colon lengths,accelerate the intestinal propelling rates, reduced colonic mucosa epithelium goblet cell loss, inflammatory cells infiltra-tion,and crypt depth shallow induced by 5-Fu. CMP obviously reduced ROS and IL-1β contents, and pre-vented reductions in homogenate supernatant of PPs GSH content, CATand GSH-Px activities by 5-Fu ad-ministration,and also reduced the expression of NF-κB and p-p38 in colon tissues. However, CMP alone had no effect on the colon of normal mice. Conclusion The current study demonstrates that CMP may have sig-nificant protective effects against 5-Fu-induced intesti-nal mucositis. Its mechanism may be related to enhan-cing the antioxidant activity,anti-inflammatory and an-ti-apoptotic effects.

Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon

BACKGROUND/AIMS: Neurotensin is a gut-brain peptide with both inhibitory and excitatory actions on the colonic musculature; our objective was to understand the implications of this for motor patterns occurring in the intact colon of the rat. METHODS: The effects of neurotensin with concentrations ranging from 0.1-100 nM were studied in the intact rat colon in vitro, by investigating spatio-temporal maps created from video recordings of colonic motility before and after neurotensin. RESULTS: Low concentration of neurotensin (0.1-1 nM) inhibited propagating long distance contractions and rhythmic propagating motor complexes; in its place a slow propagating rhythmic segmental motor pattern developed. The neurotensin receptor 1 antagonist SR-48692 prevented the development of the segmental motor pattern. Higher concentrations of neurotensin (10 nM and 100 nM) were capable of restoring long distance contraction activity and inhibiting the segmental activity. The slow propagating segmental contraction showed a rhythmic contraction—relaxation cycle at the slow wave frequency originating from the interstitial cells of Cajal associated with the myenteric plexus pacemaker. High concentrations given without prior additions of low concentrations did not evoke the segmental motor pattern. These actions occurred when neurotensin was given in the bath solution or intraluminally. The segmental motor pattern evoked by neurotensin was inhibited by the neural conduction blocker lidocaine. CONCLUSIONS: Neurotensin (0.1-1 nM) inhibits the dominant propulsive motor patterns of the colon and a distinct motor pattern of rhythmic slow propagating segmental contractions develops. This motor pattern has the hallmarks of haustral boundary contractions.

In vitro and in vivo adhesion properties evaluation carbomer six kinds bioadhesive material / 中国药学杂志

OBJECTIVE: To comprehensively evaluate bioadhesive properties these materials by testing adhesion properties in vitro and in vivo. METHODS: Mucin from porcine stomach model, homemade adhesion measuring device and intestinal propulsion were used for in vitro and in vivo evaluation adhesive materials. RESULTS: Carbomer 934P and HPMCK100M with high viscosity had optimal adhesion in their class, besides chitosan can be specifically bound by mucin from porcine stomach and it performed better than other materials in vivo adhesion. CONCLUSION: Above researches indicate that the bioadhesive properties had a positive correlation with viscosity in the same type material, and the relative molecular mass the materials, moisture absorption capacity, specific binding mucin and other factors should be considered in different types materials in the comprehensive evaluation.

Insights in the knowledge of two Argentine medicinal species of the genus Hybanthus (Violaceae) / Contribución al estudio de dos especies medicinales argentinas del género Hybanthus (Violaceae)

A differential morphoanatomical study was performed in two Argentine species: Hybanthus parviflorus and Hybanthus bigibbosus. Fresh material fixed in acetoalcoholic formalin and material from herbarium were employed. Paradermal and longitudinal sections of stems and transversal sections of leaves were prepared and stained with aqueous alcoholic safranin. The hydrochloric fluoroglucyn test was performed. Known and novel characters (distribution of vascular bundles of the primary stem and type and relative length of cover hairs and cuticular ornamentation of the adaxial epidermis, respectively) prove to be of value for the recognition of these species.Furthermore, the intestinal propulsor activity, related to the popular uses of these species was also assessed. Infusions of the whole plant, their roots and the 50 percent EtOH extracts of the aerial parts of H. parviflorus and H. bigibbosus were tested by the activated charcoal method. The extracts of H. parviflorus proved to have a significant activity which would allow validating its popular use.

Se encaró el estudio morfoanatómico diferencial de dos especies argentinas: Hybanthus parviflorus e Hybanthus bigibbosus. Se trabajó con material fresco fijado en formalina aceto-alcohólica y de herbario. Se realizaron preparados paradermales y cortes longitudinales y transversales de tallos y transversales de hoja empleando safranina alcohólico-acuosa y el test de floroglucina clorhídrica. Caracteres conocidos (distribución de haces vasculares en tallo primario) y novedosos (tipología y longitud relativa de tricomas tectores; ornamentación cuticular de la epidermis adaxial) poseen valor diferencial para el reconocimiento de estas especies.Asimismo se determinó la actividad de propulsión intestinal de ambas especies, relacionada con su uso popular. Se ensayaron las infusiones de la raíz y de las partes aéreas y el extracto EtOH 50 por ciento de las partes aéreas de H. parviflorus e H. bigibbosus, empleando el método del carbón activado. Los extractos de H. parviflorus presentaron una actividad significativa que permitiría validar su uso popular.

Evaluación de la oclusión en pacientes con trastornos temporomandibulares y desarmonías oclusales / Occlusion assessment in patients with temporomandibular disorders and occlusal disharmony

Se realizó un estudio para identificar relación que existe entre los trastornos temporomandibulares y las desarmonías oclusales. Se estudiaron 40 pacientes de ambos sexos, con edades comprendidas entre 18 y 45 años, que solicitaron atención en el Servicio de Trastornos Temporomandibulares, del Departamento de Prótesis de la Facultad de Estomatología, que cumplieron los requisitos expresados para este estudio y refirieron signos y síntomas de trastornos temporomandibulares. Se analizó el comportamiento de las interferencias oclusales a los movimientos mandibulares. Se analizaron las interferencias oclusales a dichos movimientos en los modelos de estudios, montados en un articulador semiajustable. Los resultados obtenidos reflejaron un predominio en las interferencias oclusales, en los pacientes analizados con trastornos temporomandibulares. El mayor porcentaje de interferencias se encontró durante el movimiento propulsivo. Las interferencias fueron más frecuentes en el lado de no trabajo para los movimientos analizados y el grupo de molares resultó ser el más afectado, tanto para los movimientos de propulsión como de lateralidad(AU)

A study was conducted to identify the direct relation among the temporomandibular disorders and occlusal disharmonies, which always has been an attention matter by all Stomatology fields. Forty patients of both sexes were studied aged between 18 and 45 seeking care in the temporomandibular disorders service of Prosthesis Department from the Stomatology Faculty who fulfilled the expressed requirements for this type of study and presenting with signs and symptoms of temporomandibular disorders, thus we analyzed the occlusal interferences behavior to mandibular movements in study models, mounted in a semiadjustable articulator. Results obtained demonstrated predominance in occlusal interferences in study patients with temporomandibular disorders; the greater percentage of interferences was found during the propulsion movement which were more frequent in the non functional side for analyzed movements and molars were the more affected ones for propulsion movement and for laterality(AU)

Effect of Runchangtongbian Mixture on Bowel Propulsion in Mice / 中国药房

OBJECTIVE:To study the effect of Runchangtongbian mixture (an agent of loosing bowel to relive constipation) on bowel propulsion in mice. METHODS:The coom propulsion percentages in bowel in Runchangtongbian mixture group, model group (treated with bowel propulsion suppressants) and blank group were computed and compared, and the data were analyzed statistically. RESULTS:As compared with the blank group, bowel propulsion was greatly enhanced in Runchangtongbian mixture group(P

Effect of Zengshiling Oral Liquid on Gastrointestinal Motility of Young Rats / 中国中医药信息杂志

Objective To investigate the influence of Zengshiling oral liquid on gastric emptying,plasma motilin (MOT) and small intestine propulsion of young rat. Methods Experiment animal were divided into five groups randomly:control group,large dose of Zengshiling oral liquid group,normal dose of Zengshiling oral liquid group,small dose of Zengshiling oral liquid group and Motilium group. The rats were gavaged by 0.9% of NaCl and corresponding drug. 7 days later,gastric emptying was assayed by phenol red,plasma MOT levels and carbon powder propelling rate of small intestine were also assayed. Results The rate of gastric emptying of Zengshiling oral liquid groups were significantly higher than control group (P

The Force and Endurance of Wheelchair Propulsion in Persons with Cervical Cord Injuries

OBJECTIVE: This study was carried out to help the comprehensive rehabilitation of cervical cord injuries by measuring propulsion force and endurance on their wheelchair hand- rims, predicting the differences between neurological levels and analysing the factors which contributed to maintain the wheelchair propulsion force. METHOD: The BTE work simulator was used on 17 cervical cord injuries to test the force and endurance during wheel chair propulsion. The 141 large wheel of BTE work simulator and standard wheelchair which was removed handrims was used for simulating wheelchair propulsion. Wilcoxon rank sum test was used to compare force and endurance among the groups. RESULTS: The wheelchair propulsion force and endurance showed significant differences between neurological levels and types of the life style. The lower the level, the higher the strength and endurance (p<0.001). The wheelchair propulsion force of cervical cord injuries showed statistically significant differences between those with and without jobs (p<0.05). The outdoor wheelchair users and wheelchair propulsion exercise group showed significantly high maximum isometric strengths compared to the indoor users and the only ROM exercise group, respectively (p<0.05). CONCLUSION: During the rehabilitation period cervical cord injured persons need the wheelchair propulsion exercise using BTE work simulator to improve the quality of life.

The Changes of Electromyographic Activity of Upper Extremity and Physiologic Cost Index According to Forward and Reverse Wheelchair Propulsion Methods

OBJECTIVE: To compare physiological cost index of the two manual wheel chair propulsion methods: pushing the handrim forward and reversely, and to find out whether the reverse propulsion method will help prevention of the carpal tunnel syndrome in manual wheelchair users. METHOD: The subjects were thirty healthy men in their twenties. All of them performed two manual wheelchair propulsion methods for two days, foreward propulsion on the first day and reverse propulsion the next day. Duration of the wheelchair propulsion was ten minutes. Electromyography (EMG) of wrist extensor groups, biceps brachii, pectoralis major, trapezius, and triceps brachii, and heart rates were recorded. The EMG activity of each individual was transformed to root mean square (RMS), EMG activity appearance time (%), and EMG activity continuance time (%). RESULTS: EMG activity of the wrist extensors in reverse propulsion of the wheelchair was less active compared to forward propulsion. In reverse propulsion method, energy efficiency was not significantly increased, but RMS of wrist extensor groups was significantly reduced. Contractions of trapezius and biceps brachii muscles appeared in earlier phase of propulsion. CONCLUSION: We concluded that reverse propulsion of the wheelchair will be more effective method of wheelchair propulsion compared to forward propulsion in preventing carpal tunnel syndrome in long-term wheelchair users. The reverse propulsion method in this study uses wrist extensor less, which can reduce the wrist extension movement during wheelchair propulsion. It can possibly contribute on the prevention of carpal tunnel syndrome in long-term wheelchair users.

Effect of sandalwood essential oil on isolated ileum smooth muscle of guinea pig and the small intestine movement function of mice / 西安交通大学学报(医学版)

Objective To study the effect of sandalwood essential oil on isolated ileum smooth muscle of guinea pigs and the small intestine movement function of mice.Methods We used the experiment method of isolating ileum smooth muscle of guinea pigs and intestine propulsion of carbon ink in mice.We constructed the models of healthy mice,neostigminetrested mice and adrenaline-loaded mice.Results Sandalwood essential oil had an inhibitory effect on the spontaneous movement of guinea pigs isolated ileum and an antagonistic action on intestinal spasm caused by acetylcholine,histamine and barium chloride(P