The efficacy of zinc medicine in the treatment of recurrent aphthous ulcers: A Meta analysis / 实用口腔医学杂志

Objective: To evaluate the curative effects of zinc medicine in the treatment of recurrent aphthous ulcers(RAU). Methods: The randomized controlled trials (RCTs) about the zinc medicine in the treatment of RAU were retrieved from PubMed, CENTRAL, EMbase, CNKI and WANFANG from January 1, 1980 to June 1, 2016, the references included in the study were manually selected. After quality evaluation and material extraction by the reviewer, Meta analysis was done according to the documents and materials by software Stata. Results: 4 RCTs involving 156 patients were included in the study, with 74 cases in the zinc medicine treatment group and 82 cases in the placebo control group. Meta analysis showed that zinc medicine was effective in the treatment of RAU(P＜ 0. 05). Conclusion: Zinc medicine is safe and effective in the treatment of RAU. Zinc deficiency is a risk factor of RAU.

Efficacy and adverse reaction of total glucosides of paeony compared with vitamin B2 in recurrent aphthous ulcers / 中国生化药物杂志

Objective To explore and analyze the clinical efficacy and adverse reactions of total glucosides of paeony (TGP) and vitamin B2 in the treatment of recurrent aphthous ulcers (RAU) . Methods 120 patients of RAU were randomly divided into TGP group and vitamin B2 group, 60 cases in each group. The TGP group received TGP capsules after meals, three times a day, 0.6g/d. Vitamin B2 group received vitamin B2 tablets, three times a day, 5mg/d, 8 weeks for one course. The ulcer change, visual analogue scale (VAS) and efficacy were observed. Results After treatment, the VAS scores were significantly reduced in two groups(P<0.05), and the above indicators of TGP group were better than vitamin B2 group(P<0.05). The total efficacy in TGP group was higher than that in vitamin B2 group (P<0.05). There was minor adverse reactions in TGP group and no significant adverse reactions in vitamin B2 group.Conclusion TGP has good efficacy and safety in the treatment of recurrent aphthous ulcers. The TGP has significant effect than that of vitamin B2.

Relationship between IFN-γ+874 A/T site and IL-2-330 T/G site single nucleotide polymorphism with the susceptibility of recurrent aphthous ulcer / 实用口腔医学杂志

Objective:To explore the possible relationship between recurrent aphthous ulcer( RAU) and the single nucleotide polymor-phism(SNP)of IFN-γ+874A/T site and IL-2-330T/G site. Methods:138 RAU patients and the 124 health control subjects were in-cluded. IFN-γand IL-2 serum concentration were detected by ELISA. IFN-γ+874A/T site and IL-2-330T/G site of the whole blood were detected by RFLP-PCR and SSP-PCR. Results:IFN-γand IL-2 levels in serum of the patients were significantly lower than those of the controls(P0. 05). Conclusion: IFN-γ+874A/T site was associated with the risk of RAU. But,IL-2-330T/G site was not.

Luiz Rau creek and the city of Novo Hamburgo, Rio Grande do Sul / O arroio Luiz Rau e a cidade de Novo Hamburgo/RS

This article presents a reflection on the past and current history, uses, and significance of the Luiz Rau creek to the municipality of Novo Hamburgo, Rio Grande do Sul. Its waters have always been important to the region, quenching the thirst of the local population and their livestock and providing venues for shared social interactions, but also as a destination for municipal industrial and household waste, which has polluted the waters of the creek. Our primary objective is to present and discuss these aspects with the purpose of elucidating the historical importance of this watercourse to the city of Novo Hamburgo. Toward that end, we conducted an exploratory survey to obtain the necessary inputs for such a discussion. We also employed texts from the now-defunct Jornal 5 de Abril and from Jornal NH, the highest-circulating newspaper in the region, to illustrate some situations experienced by the community. We found that municipal waste continues to be dumped into the creek, which has made it rather unloved by the local residents, but it remains firmly present in their daily lives.

Resumo Este artigo apresenta uma reflexão a respeito da história, dos usos e dos significados que o Arroio Luiz Rau teve/tem para o município de Novo Hamburgo. Suas águas, desde sempre tiveram grande importância para a região, pois serviram para suprir a sede dos moradores e seus animais, assim como para dividir espaços de sociabilidade, mas também para a liberação dos resíduos industriais e domésticos, oriundos do município, gerando poluição em suas águas. O objetivo principal, então, é apresentar esses aspectos, discuti-los, com o propósito de elucidar a importância histórica desse curso d’água para a cidade de Novo Hamburgo. Para a realização desse propósito, elaboramos uma pesquisa exploratória, a fim de termos subsídios suficientes para essa discussão. Além disso, utilizamos textos jornalísticos, do extinto, Jornal 5 de Abril e do Jornal NH, que tem a maior circulação na região, para ilustrarmos algumas situações vividas pela comunidade. O que observamos, atualmente, é que o arroio continua recebendo dejetos da cidade, tornando-se um espaço pouco querido pelos habitantes, mas ainda muito presente no cotidiano de seus moradores.

Preliminary assessment of pseudo-total and bioavailable metals in depth in the sediment of Luíz Rau stream in Novo Hamburgo (RS) / Avaliação preliminar de metais pseudo-totais e biodisponíveis em profundidade no sedimento do arroio Luíz Rau em Novo Hamburgo (RS)

The Luíz Rau stream is one of the main streams of Novo Hamburgo. In the stream industrial effluents are released from various sectors, from paint and adhesive industries, metallurgy and leather industry, besides receiving a large amount of domestic sewage. The emissions of these pollutants contribute to decrease water and sediment quality. Within this context, this study evaluated the conditions of the Luíz Rau stream bed sediments, with the determination of the metals like cadmium, lead, chromium and nickel, in depth. To perform the evaluation three points were chosen for sampling along the stream course. The sampling sites were identified as Point A, in Roselândia district and this corresponds to one of the springs and therefore considered as reference value, Point B, in Santo Afonso district being a midpoint of the stream, and Point C also located in Santo Afonso district, near the outfall in Rio dos Sinos river. Cadmium was not detected in any point. At the A and C points chromium was the metal observed in higher concentration in the sediment, up to 45.14 mg kg–1 concentration. In the B point, the metal that was observed in the highest amount was nickel in the concentration of 20.69 mg kg–1.

Resumo O arroio Luíz Rau é um dos principais arroios de Novo Hamburgo, e um importante afluente do Rio dos Sinos. Nele são lançados efluentes industriais dos mais diversos setores, desde indústrias de tintas e adesivos, metalurgia e da indústria do couro, além de receber uma grande quantidade de esgoto doméstico. As emissões destes poluentes contribuem para uma diminuição na qualidade da água e dos sedimentos. Dentro deste contexto, este trabalho avaliou as condições do sedimento do arroio Luíz Rau, com a determinação dos metais cádmio, chumbo, cromo e níquel em profundidade, nas formas pseudo-total e biodisponível. Para a realização desta avaliação, foram escolhidos três pontos para coleta de amostras ao longo do percurso do arroio. Os pontos foram identificados por Ponto A, no bairro Roselândia, sendo que este corresponde a uma das nascentes e por isso considerado como ponto branco, o Ponto B, no bairro Santo Afonso, sendo um ponto intermediário do arroio, e o Ponto C, também localizado no bairro Santo Afonso, próximo à foz, junto ao Rio dos Sinos. O cádmio não foi detectado em nenhum dos pontos amostrados. Nos pontos A e C, o cromo foi o metal observado em maior concentração no sedimento, com concentração de até 45,14 mg kg–1. Já no ponto B, o metal que foi observado em maior quantidade foi o níquel na concentração de 20,69 mg kg–1.

For an ecology of scientific work: science, politics and the case of streams Pampa and Luiz Rau in Novo Hamburgo, Brazil / Por uma ecologia do trabalho científico: a ciência e a política e caso dos arroios Pampa e Luiz Rau em Novo Hamburgo, Brasil

If, like Weber writes, every knowledge is objective in terms of evolving the interests of researchers and the agencies, in this article, we investigate that, which has been researched about two streams: Pampa and Luiz Rau. In doing so, in addition to highlighting what has caught the researchers' attention, this paper manages to point out a few gaps and fruitful fields of study which extend beyond the hard sciences. This study is, therefore, characterized as an essay review paper that sets out to use anthropology of science to think about the limitations and advances the studies about the two streams have achieved, as well as their social impact.

Resumo Se como escreve Weber, todo o conhecimento é objetivo na medida em que envolve interesses de pesquisadores e agências nos questionamos nesse texto sobre, quando falamos nos arroios Pampa e Luiz Rau, aquilo que têm sido pesquisado sobre esses dois arroios. Desta feita, além de colocar em evidência o que têm despertado o interesse, seu mérito reside em apontar algumas lacunas e campos profícuos de estudo que vão para além das ciências duras. Esse estudo se caracteriza, portanto, por um estudo bibliográfico e ensaístico que busca através da antropologia ciência pensar os limites e avanços que se obteve nos últimos anos nesse estudos e seu impacto social.

Luiz Rau creek and the city of Novo Hamburgo, Rio Grande do Sul

This article presents a reflection on the past and current history, uses, and significance of the Luiz Rau creek to the municipality of Novo Hamburgo, Rio Grande do Sul. Its waters have always been important to the region, quenching the thirst of the local population and their livestock and providing venues for shared social interactions, but also as a destination for municipal industrial and household waste, which has polluted the waters of the creek. Our primary objective is to present and discuss these aspects with the purpose of elucidating the historical importance of this watercourse to the city of Novo Hamburgo. Toward that end, we conducted an exploratory survey to obtain the necessary inputs for such a discussion. We also employed texts from the now-defunct Jornal 5 de Abril and from Jornal NH, the highest-circulating newspaper in the region, to illustrate some situations experienced by the community. We found that municipal waste continues to be dumped into the creek, which has made it rather unloved by the local residents, but it remains firmly present in their daily lives.

Resumo Este artigo apresenta uma reflexão a respeito da história, dos usos e dos significados que o Arroio Luiz Rau teve/tem para o município de Novo Hamburgo. Suas águas, desde sempre tiveram grande importância para a região, pois serviram para suprir a sede dos moradores e seus animais, assim como para dividir espaços de sociabilidade, mas também para a liberação dos resíduos industriais e domésticos, oriundos do município, gerando poluição em suas águas. O objetivo principal, então, é apresentar esses aspectos, discuti-los, com o propósito de elucidar a importância histórica desse curso dágua para a cidade de Novo Hamburgo. Para a realização desse propósito, elaboramos uma pesquisa exploratória, a fim de termos subsídios suficientes para essa discussão. Além disso, utilizamos textos jornalísticos, do extinto, Jornal 5 de Abril e do Jornal NH, que tem a maior circulação na região, para ilustrarmos algumas situações vividas pela comunidade. O que observamos, atualmente, é que o arroio continua recebendo dejetos da cidade, tornando-se um espaço pouco querido pelos habitantes, mas ainda muito presente no cotidiano de seus moradores.

Preliminary assessment of pseudo-total and bioavailable metals in depth in the sediment of Luíz Rau stream in Novo Hamburgo (RS)

The Luíz Rau stream is one of the main streams of Novo Hamburgo. In the stream industrial effluents are released from various sectors, from paint and adhesive industries, metallurgy and leather industry, besides receiving a large amount of domestic sewage. The emissions of these pollutants contribute to decrease water and sediment quality. Within this context, this study evaluated the conditions of the Luíz Rau stream bed sediments, with the determination of the metals like cadmium, lead, chromium and nickel, in depth. To perform the evaluation three points were chosen for sampling along the stream course. The sampling sites were identified as Point A, in Roselândia district and this corresponds to one of the springs and therefore considered as reference value, Point B, in Santo Afonso district being a midpoint of the stream, and Point C also located in Santo Afonso district, near the outfall in Rio dos Sinos river. Cadmium was not detected in any point. At the A and C points chromium was the metal observed in higher concentration in the sediment, up to 45.14 mg kg1 concentration. In the B point, the metal that was observed in the highest amount was nickel in the concentration of 20.69 mg kg1.

Resumo O arroio Luíz Rau é um dos principais arroios de Novo Hamburgo, e um importante afluente do Rio dos Sinos. Nele são lançados efluentes industriais dos mais diversos setores, desde indústrias de tintas e adesivos, metalurgia e da indústria do couro, além de receber uma grande quantidade de esgoto doméstico. As emissões destes poluentes contribuem para uma diminuição na qualidade da água e dos sedimentos. Dentro deste contexto, este trabalho avaliou as condições do sedimento do arroio Luíz Rau, com a determinação dos metais cádmio, chumbo, cromo e níquel em profundidade, nas formas pseudo-total e biodisponível. Para a realização desta avaliação, foram escolhidos três pontos para coleta de amostras ao longo do percurso do arroio. Os pontos foram identificados por Ponto A, no bairro Roselândia, sendo que este corresponde a uma das nascentes e por isso considerado como ponto branco, o Ponto B, no bairro Santo Afonso, sendo um ponto intermediário do arroio, e o Ponto C, também localizado no bairro Santo Afonso, próximo à foz, junto ao Rio dos Sinos. O cádmio não foi detectado em nenhum dos pontos amostrados. Nos pontos A e C, o cromo foi o metal observado em maior concentração no sedimento, com concentração de até 45,14 mg kg1. Já no ponto B, o metal que foi observado em maior quantidade foi o níquel na concentração de 20,69 mg kg1.

For an ecology of scientific work: science, politics and the case of streams Pampa and Luiz Rau in Novo Hamburgo, Brazil

If, like Weber writes, every knowledge is objective in terms of evolving the interests of researchers and the agencies, in this article, we investigate that, which has been researched about two streams: Pampa and Luiz Rau. In doing so, in addition to highlighting what has caught the researchers' attention, this paper manages to point out a few gaps and fruitful fields of study which extend beyond the hard sciences. This study is, therefore, characterized as an essay review paper that sets out to use anthropology of science to think about the limitations and advances the studies about the two streams have achieved, as well as their social impact.

Resumo Se como escreve Weber, todo o conhecimento é objetivo na medida em que envolve interesses de pesquisadores e agências nos questionamos nesse texto sobre, quando falamos nos arroios Pampa e Luiz Rau, aquilo que têm sido pesquisado sobre esses dois arroios. Desta feita, além de colocar em evidência o que têm despertado o interesse, seu mérito reside em apontar algumas lacunas e campos profícuos de estudo que vão para além das ciências duras. Esse estudo se caracteriza, portanto, por um estudo bibliográfico e ensaístico que busca através da antropologia ciência pensar os limites e avanços que se obteve nos últimos anos nesse estudos e seu impacto social.

The expression of Th1 and Th2 cytokines in serum of patients with recurrent aphthous ulcer / 实用口腔医学杂志

Objective:To explore the possible role and clinical significance of Th1 and Th2 class cytokines in the pathogenesis of re-current aphthous ulcer (RAU).Methods:35 cases with RAU,25 of minor RAU(MiRAU)and 1 0 of major RAU(MaRAU),were enrolled and 24 healthy subjects served as the controls.The expression levels of Th1 type cytokines (IFN-γ,TNF-α,IL-2)and Th2 type cytokines (IL-4,IL-6,IL-1 0)in the serum of peripheral blood were investigated by flow cytometry CBA methods and their rela-tionship with the clinical features of RAU was analyzed by SPSS 1 1 .5.Results:The expression level of IL-4 and IL-1 0 in MiRAU group was higher than that in the controls(P <0.05),and the expression level of IFN-γ,IL-4 and IL-1 0 in MaRAU group was higher than that in the controls(P <0.05).The expression level of IFN-γand IL-1 0 in MaRAU was higher than that in MiRAU.There was a positive correlation between the levels of IFN-γ,IL-4,IL-1 0 and the severity of RAU.Conclusion:Predominant Th2 immune re-sponse plays a role in RAU,and the level of IFN-γ,IL-4 and IL-1 0 is correlated with the severity of RAU.

Haemorrheologicals: a new approach in the treatment of recurrent aphthous ulcer.

Oral ulcers may have a great many causes. Aphthous stomatitis or Recurrent Aphthous Ulceration (RAU) is an extremely common disorder of the oral cavity. The majority of chronic oral ulcers are accounted for by major aphthous ulcers. The diagnosis of RAU is made on clinical grounds and through exclusion criteria .Here we present a case of RAU treated with a different drug regime.

Clinical application of chitosan oral ulcer spray in treatment of recurrent aphthous ulcer / 中国海洋药物

Objective To observe the therapeutic effect of chitosan oral ulcer spray in treatment of recurrent aphthous ulcer(RAU).Methods Sixty patients suffered with RAU were randomly divided into two groups.The test group was treated with chitosan oral ulcer spray,while the control group was given a traditional Chinese medicine named Xileisan.To evaluate the efficacy according to a specialized evaluate standard.Results The disease course of test group was shorter than that of the control group.The test group was more effective in mitigating the pain of RAU than that of the control group.ConclusionThe efficacy of chitosan oral ulcer spray in treatment of RAU is superior to Xileisan.