RÉSUMÉ
Objective:To investigate the effect of its invasion capacity after the sipB and crp gene deletion strains of Salmonella typhimurium SL1344.Methods:Salmonella typhimurium SL1344 ΔsipB and Δcrp biological characteristics and invasion capacity were studied .Results:The SL1344Δcrp mutant was not able to ferment maltose, lactose, and sorbitol.The growth rate of the mutant was more slowly than SL1344 strain.The dynamic distribution measurement results showed that the number of bacteria in the two experimental groups of mice were isolated from the liver and spleen were lower than in the SL1344 control group .Next HeLa cells infected results showed that lack of the adhesion rate and invasion rate of theΔsipB strain group was lower thanΔcrp strain group and the SL1344 control group .Conclusion: These results showed that the SipB protein play an important role in the process of bacteria infection the body.