Successful treatment of allergic conjunctival granuloma by topical tacrolimus: A clinicopathologic case report

Allergic conjunctival granuloma is a rare cause of conjunctival ocular lesions. The aim of this case report was to present a successful treatment of an allergic conjunctival granuloma with topical tacrolimus eye drops. A 20-year-old female presented with bilateral multiple yellow nodules of the bulbar conjunctival epithelium and conjunctival injection. The patient had tearing, photophobia, itching, foreign body sensation, and red eye. The patient's signs and symptoms progressed despite the use of topical steroids. The patient was treated by application of tacrolimus eye drop (0.005%) in her right eye every 6 h while the left eye was put on placebo. Her signs and symptoms were recorded at each visit. After 3 weeks' therapy with topical tacrolimus eye drop, the patient became asymptomatic in her right eye and conjunctival granulomas fully resolved. Topical tacrolimus seems to be an effective therapeutic option for the treatment of allergic conjunctival granulomas.

Botryomycosis mimicking acute abdomen: a case report / Botriomicose simulando um abdome agudo: relato de caso

Botryomycosis is a rare chronic granulomatous bacterial infection affecting mostly the skin and subcutaneous tissues. The nomenclature is a misnomer as the disease is caused by bacteria, not by fungus. This uncommon infection sometimes mimics neoplasia and actinomycosis. Staphylococcus aureus is the most common agent in botryomycosis, followed by Pseudomonas sp. strains. We report an unusual case of invasive umbilical botriomycosis mimicking an acute abdomen. The patient recovered fully after being treated with surgery and antibiotics. This is the first report of umbilical Botryomycosis, which usually affects the skin.

Botriomicose é uma infecção bacteriana granulomatosa crônica rara que afeta principalmente a pele e tecidos subcutâneos. A nomenclatura é imprópria, uma vez que a infecção é causada por bactérias e não por fungos. Esta infecção incomum simula por vezes uma neoplasia ou actinomicose. O Staphylococcus aureus é o agente mais comum na botriomicose, seguido por cepas de Pseudomonas sp. Relatamosum caso incomum de botriomicose umbilical invasiva simulando um abdome agudo. A paciente recuperou-se totalmente após ser tratada com cirurgia e t antibióticos. Essa doença é mais frequente na pele, e este é o primeiro relato deBotriomicose umbilical.

Phenomena in dermatology.

For a better understanding of various dermatoses, it is imperative for any physician practising dermatology to have a good theoretical knowledge of the underlying pathophysiologic processes involved in various systemic diseases involving the skin. For an easy grasp over this topic, we have discussed the various phenomena under three broad categories, like (a) clinical - Meyerson, Meirowsky, pathergy, Renbok, (b) laboratory - LE cell, prozone and (c) histopathology - Splendore-Hoeppli.