RÉSUMÉ
Syndromes-genome research performed eight years ago, has made a series of achievements. At the same time,there are still many problems which have to be solved. Based on the research experience, six major problems were summed up, such as difficult to refine into a sample, difficult to sample, difficult to analysis mass data, difficult to combine TCM with western medicine disease, difficult to dock and function between TCM theory and genes, difficult to apply the result of Syndrome- genomics. In this paper, the author also put forward possible new strategies, such as establishing the characteristics of the gene database, combining with the known gene functions likely to explain the evidence of the mechanism for the realization of the modernization of TCM theory, speeding up the unknown gene research, occupying gene annotation territories.