Transoral thyroid and parathyroid surgery in Brazil: where are we? / Cirurgia transoral de tireóide e paratireóide no Brasil: onde estamos?

ABSTRACT Introduction: thyroid surgery through the transoral vestibular approach is a reality in many countries. While several competing remote access techniques have been developed in the last 20 years, many were not reproducible. Transoral Endoscopic Neck Surgery (TNS) has been shown to be reproducible in different centers around the world, and approximately five years after its description it has been adopted relatively quickly for various reasons. To date, there are at least 7 Brazilian studies published, including a series of more than 400 cases. The aim of this work is to study the progression of Transoral Neck Surgery in Brazil and describe the profile of surgeons involved in this new approach. Methods: this is a retrospective study with descriptive statistics. A REDCap based survey about transoral endoscopic thyroidectomy and parathyroidectomy vestibular approach (TOETVA/TOEPVA) was done with 66 Brazilian surgeons regarding surgeon profile, numbers of cases performed by geographic region, what kind of training was necessary prior to the first case and behavior of the surgeon proposing these new approaches. Results: response rate of this survey was 53%. To date, 1275 TOETVA/TOEPVA cases had been performed in Brazil, 1229 thyroidectomies (96.4%), 42 parathyroidectomies (3.3%) and 4 combined procedures (0.3%). Most of the cases were done in the southeast region (821, 64.4%), 538 (42.2%) cases in the State of São Paulo and 283 (22.2%) cases in the State of Rio de Janeiro. Conclusions: TOETVA is becoming popular in Brazil. Younger surgeons, especially those between 30 and 50 years old were more likely to adopt this approach.

RESUMO Introdução: a cirurgia de tireoide por via transoral vestibular é uma realidade em muitos países. Embora várias outras técnicas de acesso remoto tenham sido desenvolvidas nos últimos 20 anos, muitas não eram reprodutíveis. A cirurgia endoscópica cervical transoral (TNS - Transoral Neck Surgery) tem se mostrado reprodutível em diferentes centros ao redor do mundo sendo que, aproximadamente cinco anos após sua descrição, foi adotada de forma relativamente rápida por vários motivos. Até o momento, existem pelo menos 7 estudos brasileiros publicados, incluindo uma série de mais de 400 casos. O objetivo deste trabalho é estudar a evolução da Cirurgia Transoral do Pescoço (TNS) no Brasil e descrever o perfil dos cirurgiões envolvidos nesta nova abordagem. Métodos: trata-se de um estudo descritivo. Uma pesquisa online hospedada no REDCap sobre tireoidectomia e paratireoidectomia endoscópica transoral por abordagem vestibular (TOETVA/TOEPVA) foi realizada com 66 cirurgiões brasileiros. Foram levantados dados sobre o perfil do cirurgião, número de casos realizados por região geográfica, que tipo de treinamento foi necessário antes do primeiro caso e comportamento do cirurgião durante o relacionamento com o paciente ao abordar essas novas técnicas. Resultados: a taxa de resposta desta pesquisa foi de 53%. Até o momento, 1.275 casos de TOETVA/TOEPVA foram realizados no Brasil, sendo 1.229 tireoidectomias (96,4%), 42 paratireoidectomias (3,3%) e 4 procedimentos combinados (0,3%). A maioria dos casos foi realizada na região sudeste (821, 64,4%), 538 (42,2%) casos no estado de São Paulo e 283 (22,2%) casos no estado do Rio de Janeiro. Conclusões: a TOETVA está se popularizando no Brasil. Cirurgiões mais jovens, especialmente aqueles entre 30 e 50 anos, são mais propensos a adotar essa abordagem.

Vestibular landmarks to minimize injury to the mental nerve during transoral endoscopic thyroidectomy-vestibular approach (TOETVA) procedure: an anatomical study / Puntos de referencia vestibulares para minimizar la lesión del nervio mentoniano durante el procemiento de abordaje vestibular de tiroidectomía endoscópica transoral (TOETVA): un estudio anatómico

SUMMARY: The aim of this study is to reveal the morphometry of the mental nerve to describe a safe zone for minimizing mental nerve damage during transoral endoscopic thyroidectomy-vestibular approach (TOETVA). This study was performed on 12 cadavers. Localization of mental foramen according to teeth, distances of buccogingival sulcus-lip (BG-L), mental foramen-midline (MF-Midline), mental foramen - buccogingival sulcus (MF - BG), commissure - branching point (Cm - Br), branching point - vertical projection of branching point on lower lip (Br - LVP), vertical projection of branching point on lower lip - commissure (LVP - Cm), commissure - midline (Cm - midline), angles of mental (AM), angular (AA) and labial branches (AL) and branching patterns were recorded. Type 1 was mostly found as branching pattern in this study (45.8 %). A new branching pattern (type 9) was found on one cadaver. Mental foramen was mostly located at level of second premolar teeth. According to morphometric results of this study; supero- lateral to course of angular branch and infero-medial to course of mental branch of mental nerve on lower lip after exiting the mental foramen were described as safe zones during surgery for preserving mental nerve and its branches.

RESUMEN: El objetivo de este estudio fue revelar la morfometría del nervio mental o mentoniano para describir una zona segura y de esta manera, minimizar el daño de este nervio durante la tiroidectomía endoscópica transoral-abordaje vestibular (TOETVA). Este estudio se realizó en 12 cadáveres. Se realizó la localización del foramen mentoniano según los dientes, distancias surco gingival-labio (BG-L), foramen mentoniano-línea mediana (MF-Midline), foramen mentoniano-surco gingival (MF-BG), comisura-punto de ramificación (Cm-Br), punto de bifurcación - pro- yección vertical del punto de bifurcación en el labio inferior (Br - LVP), proyección vertical del punto de bifurcación en el labio inferior - comisura (LVP - Cm), comisura - línea mediana (Cm - línea mediana), ángulos del mentón (AM). Se registraron ramos angulares (AA) y labiales (AL) y patrones de ramificación. El tipo 1 se encontró principalmente como patrón de ramificación en el 45,8 %. Se describe un nuevo patrón de ramificación (tipo 9) encontrado en un cadáver. El foramen mentoniano se localizaba mayoritariamente a nivel de los segundos premolares. Según los resultados morfométricos, supero-lateral al curso de la rama angular e infero-medial al curso de la rama mentoniana del nervio mentoniano en el labio inferior, después de salir del foramen mentoniano, se describieron las zonas seguras, para la cirugía y preservación del nervio mentoniano y de sus ramos.

Tiroidectomía endoscópica transoral por abordaje vestibular

Resumen En las últimas dos décadas, distintos tipos de abordajes extracervicales se han ido desarrollando en la cirugía endocrinológica, y principalmente en la tiroidectomía, con el fin de obtener mejores resultados cosméticos. Estos abordajes transfieren la incisión clásica descrita por Kocher, a puntos de acceso más discretos, sin embargo, requieren de disecciones extensas. Fue el desarrollo del abordaje vía vestibular el que cambió el paradigma terapéutico, ya que es el único potencialmente libre de cicatrices cutáneas, que ofrece la seguridad y resultados comparables con técnicas tradicionales. Además, la menor distancia entre el sitio de abordaje y la glándula tiroides, obvia la necesidad de extensas disecciones asociadas a otros tipos de abordajes remotos. La tiroidectomía endoscópica transoral por vía vestibular utiliza un instrumento laparoscópico convencional, vía vestíbulo oral, a través del espacio premandibular insuflado con CO2. Esta técnica se considera segura y reproducible. El presente artículo de revisión pretende describir la técnica quirúrgica, con la finalidad de aportar información que resulte relevante para la práctica clínica diaria.

Abstract In the last two decades, different types of extra-cervical approaches have been described in endocrine surgery, mainly for thyroidectomy, to achieve better cosmetic outcomes. These approaches transfer the classic incision described by Kocher, to inconspicuous locations, yet they necessitate of extensive surgical dissections. It was the development of the vestibular approach that changed the treatment paradigm, as it is the only approach free of visible scars, with a safety profile and overall outcomes comparable to traditional techniques. Furthermore, the shorter distance between the access point and the thyroid gland, obviates the need for extensive dissections, such as those used in other remote approaches. The vestibular transoral endoscopic thyroidectomy uses a conventional laparoscopic instrument via the oral vestibule, through the premandibular space, which is insufflated with CO2. This technique is considered safe and reproducible. This review article aims to describe the surgical technique, in order to provide information relevant to routine clinical practice.

Tiroidectomía transoral endoscópica por abordaje vestibular (TOETVA): primer caso en Perú / Transoral endoscopic thyroidectomy via vestibular approach (TOETVA): first case in Peru

RESUMEN La calidad de vida luego de la cirugía de la glándula tiroides es tan importante como el control de la enfermedad. Para mejorar los resultados cosméticos y la satisfacción del paciente se usan abordajes endoscópicos usando incisiones fuera de la región cervical. La tiroidectomía transoral endoscópica no deja ninguna cicatriz visible en la piel y es una técnica quirúrgica segura. Se presenta el caso de una paciente mujer de 29 años con una tumoración benigna de la glándula tiroides con síntomas compresivos y preocupaciones estéticas, sometida a hemitiroidectomia derecha mediante abordaje transoral vestibular endoscópico en un tiempo de 150 minutos y sangrado mínimo. Los resultados son comparables con la técnica quirúrgica abierta, con un mejor resultado estético y mejora en la calidad de vida.

ABSTRACT Quality of life after thyroid gland surgery is as important as disease control. To improve cosmetic results and patient satisfaction, endoscopic approaches are used using incisions outside the cervical region. Endoscopic transoral thyroidectomy does not leave any visible scarring on the skin. We present the case of a 29-year-old female patient with a benign thyroid gland tumor with compressive symptoms and aesthetic concerns, who underwent a right hemithyroidectomy by means of an endoscopic transoral vestibular approach in a time of 150 minutes and minimal bleeding, without complications in the postoperative period. The transoral endoscopic vestibular approach for endoscopic resection of the thyroid gland is safe and the results are comparable with the open surgical technique, with a better cosmetic result and improved quality of life.

Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA) for thyroid nodules: A series of the first 10 patients in a single institution

Objective@#To present the perioperative data of patients with solitary or multinodular goiter and/ or papillary thyroid carcinoma who underwent Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA) in a single tertiary medical center. @*Methods@#Design: Case series. Setting: Tertiary Government Hospital. Participants: Records of 10 patients who underwent TOETVA from June 2018 to July 2019 (9 thyroid lobectomies, 1 total thyroidectomy) were reviewed. Outcomes and measures included conversion to open surgery, operative time, intraoperative blood loss, size of the thyroid gland, postoperative hospital stay, visual analogue pain scores (VAS), and postoperative complications.@*Results@#None of the 10 patients were converted to an open procedure. The average preoperative thyroid size was 4.73 cm in widest diameter using thyroid ultrasound (±1.88 cm, range 3.6 to 6.5 cm). Mean operative time for thyroid lobectomy and total thyroidectomy was 4 hours and 29 minutes and 4 hours and 15 minutes, respectively. Mean intraoperative blood loss was 140 ml (±47.96 ml, range 80 to 200 ml) for thyroid lobectomy and 100 ml for total thyroidectomy. The average intraoperative size of the thyroid gland measured in widest diameter (larger lobe for total thyroidectomy) was 4.48 cm (±0.919 cm, range 3 to 5.5 cm). Median postoperative hospital stay was 2 days (±1.55 days, range 2 to 12 days). Mean VAS pain scores for postoperative days 1, 2, 3, and 7 were 5, 3, 2, and 0, respectively. Transient recurrent laryngeal nerve injury (of 3 months duration) occurred in 1 patient. Two cases had surgical site infection, 2 had wound dehiscence, 1 had seroma and 1 had skin burn as a complication. None had hypocalcemia or mental nerve injury in the series. @*Conclusions@#TOETVA was replicated in the local setting and a presentation of the perioperative data of all the patients who underwent this novel technique, the indications, as well as surgical and patient outcomes, were described.