Discussion on the Evolution of the Traditional Preparation Process of Pinelliae Rhizoma Fermentata / 广州中医药大学学报

This article discussed the evolution of the traditional preparation process of Pinelliae Rhizoma Fermentata.The production methods for Pinelliae Rhizoma Fermentata in Song Dynasty include cake-making of Pinelliae Rhizoma together with ginger juice and fermentation after cake-making,and the former method of cake-making was the mainstream.The process technology in Jin and Yuan Dynasties inherited from that in Song Dynasty,and the application of Pinelliae Rhizoma Fermentata had certain limitations.The medical practitioners of Ming Dynasty elucidated the mechanism of processing of Pinelliae Rhizoma Fermentata,and proposed the view of"sliced Pinelliae Rhizoma being potent while fermented Pinelliae Rhizoma being mild".In the Ming Dynasty,LI Shi-Zhen defined the cake-making process and fermentation process for Pinelliae Rhizoma,and HAN Mao's Han Shi Yi Tong(Han's Clear View of Medicine)contained five prescriptions for the processing of Pinelliae Rhizoma Fermentata,which had the epoch-making signficance in the expansion of prescriptions for the processing of Pinelliae Rhizoma Fermentata.In the Qing Dynasty,HAN Fei-Xia's ten methods for making Pinelliae Rhizoma Fermentata were summarized on the basis of the methods recorded in Han Shi Yi Tong,and at that time,the processing of Pinelliae Rhizoma Fermentata and the preparation of Massa Medicata Fermentata interacted with each other.After the founding of the People's Republic of China,the local experience in the preparation of Pinelliae Rhizoma Fermentata was deeply influenced by the methods in the Qing Dynasty,and the local preparation technical standards gradually became the same.Moreover,this article also explored the issues of the importance of"Pinelliae Rhizoma"and"ingredients for fermentation",the pre-treatment of Pinelliae Rhizoma,the distinction between cake-making process and fermentation process for Pinelliae Rhizoma,the amount of flour added as well as the timing of adding,the addition of Massa Medicata Fermentata powder,the role of Alum in Pinelliae Rhizoma Fermentata and so on.

Research Progress in Tong Du Tiao Shen of Mental Disorders / 世界科学技术-中医药现代化

Mental disorders are characterized by disturbances in behavior,volition,emotion,and cognition and are considered emotional diseases in traditional Chinese medicine.Acupuncture is one of the most widely used complementary alternative therapies for the treatment of mental disorders.Recently,there has been growing interest in the use of the Tong Du Tiao Shen(Dredging Du meridian to regulate the spirit)as a primary treatment.However,a comprehensive summary of the establishment and related acupuncture methods of Tong Du Tiao Shen is lacking.This paper aims to address this gap by exploring the origin and development of Tong Du Tiao Shen,its application in treating mental disorders,and the modern biological mechanisms involved.Ultimately,this paper seeks to expand the clinical application of Tong Du Tiao Shen acupuncture and provide a scientific basis for future research in this field.

Analysis of LU Keda's Experience in Treating IgA Nephropathy with Yiqi Yangyin Qufeng Prescription / 浙江中医药大学学报

[Objective]To explore Professor LU Keda's clinical experience in treating IgA nephropathy with Yiqi Yangyin Qufeng prescription.[Methods]Through outpatient learning with teacher,consulting IgA nephropathy related literature,Professor LU's clinical experience in treating IgA nephropathy with Yiqi Yangyin Qufeng Prescription was summarized,and one medical case was provided to support the treatment.[Results]Professor LU points out that the early IgA nephropathy patients are deficient in spleen and kidney,and always invaded by wind easily.He applies the thought of syndrome differentiation and prescription called"state target binding"from Academician TONG Xiaolin,taking"Qi and Yin deficiency syndrome"as the state,and the physical and chemical indexes"proteinuria and hematuria"as the target,using Yiqi Yangyin Qufeng Prescription for treatment.The medical case mentioned later was identified as early-stage IgA nephropathy,belonged to Qi and Yin deficiency syndrome.The treatment was to invigorate the spleen and tonify Qi,nourish Yin and promote body fluid and dispel wind.It had great curative effect by using Yiqi Yangyin Qufeng Prescription.[Conclusion]Professor LU's experience in establishing the treatment of IgA nephropathy from the perspective of"state target syndrome differentiation"is worth learning and inheriting.

Network pharmacology-based study on mechanism of Zhi-Huang-Zhi-Tong powder in rheumatoid arthritis treatment / 中国药理学通报

Aim To discover the potential active compounds and possible mechanisms in rheumatoid arthritis (RA) treatment with Zhi-Huang-Zhi-Tong powder (ZHZTP) by using network pharmacology and in vitro study. Methods The active ingredient targets and disease targets of Zhihuang Zhitong Powder were searched and screened by database; they intersected to get a common target; and the "drug-component-target" relationship network diagram was constructed for GO and KEGG enrichment analysis of the overlapping genes; then the core components were docked with the core targets. Finally, based on the inflammation model of HUVECs in vitro, the efficacy and mechanism of Zhihuang Zhitong powder were verified by MTT method, plate scratch test and Western blot. Results Active compounds involved in RA treatment were screened in the present study, and the top two were ursolic acid and emodin, all playing crucial roles in RA treatment with ZHZTP. Additionally, the key target was AKTA, TNF and IL-6. GO and KEGG enrichment analysis revealed that ZHZTP regulated BP, MF and CC, and also focused on regulating AKTA, TNF and IL-6 signaling pathway. Molecular docking showed that interactions between key active compounds and key targets were stable. In vitro ZHZTP significantly inhibited cell viability and migration of TNF-a-stimulated HUVECs, and the involved mechanism may be associated with PI3K/AKT/m-TOR signaling. Conclusions The present study reveals that the potential active compounds of ZHZTP are ursolic acid and emodin, and moreover, the involved mechanisms of ZHZTP for RA treatment are associated with PI3 K/AKT/m-TOR signaling.

Comprehensive chemical profiling and quantitative analysis of ethnicYi medicine Miao-Fu-Zhi-Tong granules using UHPLC-MS/MS / 中国天然药物

Developing analytical methods for the chemical components of natural medicines remains a challenge due to its diversity and complexity. Miao-Fu-Zhi-Tong (MFZT) granules, an ethnic Yi herbal prescription, comprises 10 herbs and has been clinically applied for gouty arthritis (GA) therapy. Herein, a series of chemical profiling strategies including in-house library matching, molecular networking and MS/MS fragmentation behavior validation based on ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) were developed for qualitative analysis of MFZT granules. A total of 207 compounds were identified or characterized in which several rare guanidines were discovered and profiled into alkyl substituted or cyclic subtypes. Moreover, network pharmacology analysis indicated that MFZT's anti-gout mechanism was mostly associated with the nuclear factor kappa-B (NF-κB) signaling, nucleotide oligomerization domain (NOD)-like signaling and rheumatoid arthritis pathways, along with the synergistic effect of 84 potential active compounds. In addition, a quantitative analytical method was developed to simultaneously determine the 29 potential effective components. Among them, berberine, pellodendrine, 3-feruloylquinic acid, neoastilbin, isoacteoside and chlorogenic acid derivatives at higher concentrations were considered as the chemical markers for quality control. These findings provide a holistic chemical basis for MFZT granules and will support the development of effective analytical methods for the herbal formulas of natural medicines.

Discussions on Academician TONG Xiaolin's “Three-level Two-node and Three-segment Holographic Theory” / 中医杂志

This paper reviewed the development of biological holography theory， discussed on the limitations of biological holography law， and explained the theoretical connotation and basis of the “three-level two-node and three-segment holographic theory” innovatively proposed by Academician TONG Xiaolin， aiming at inspiring new thinking on the theoretical research of biological holography. By observing the human body structure， Academician TONG Xiaolin finds that there is a similar law in the head， trunk， limbs， and fingers （toes） that there are two moveable joints （groups） dividing the part into three segments， and each segment contains all the information of the whole part， which is a holographic phenomenon. Accordingly， Academician TONG creatively put forward the “three-level two-node and three-segment holographic theory” of the human body， and “three levels” respectively refer to the original level trunk， the branch level limbs， and the end level extremities. The “two nodes” refer to the two joints （groups） of each level， and “two nodes” can be further divided into “three segments”. Therefore， there are “two nodes” and “three segments” in each level with a similar distribution pattern， which reflects the holographic distribution law that the part reflects the whole and the whole includes the part.

Integration of single-cell RNA sequencing and network disturbance to elucidate cross-talk between multi-components drug and trigeminal ganglia cells in migraine / 中国药理学与毒理学杂志

OBJECTIVE To clarify the mecha-nism of Tou Tong Ning capsule(TTNC)and elu-cidate crosstalk between multi-components drug and trigeminal ganglia cells in migraine.METH-ODS We integrated single-cell RNA sequencing data and a quantitative evaluation algorithm of the disturbance of multi-target drugs on the dis-ease network to explore the specific pathology of TTNC for migraine.Cerebrovascular smooth muscle spasmolytic activity experiment was car-ried out to verify the results of bioinformatics analysis.RESULTS TTNC can effectively regu-late the functions of synaptic signaling,inflamma-tion and immune response,and cerebrovascular smooth muscle.For different cell subtypes of tri-geminal ganglia,TTNC can significantly disturb the robustness on neuronal cell networks and non-neural networks(fibroblast and vascular cells),indicating TTNC vasodilation activity of brain vessels and neural regulation activities of various neuro types.Contraction of cerebrovas-cular smooth muscle of mouse ex vivo confirmed the vasodilation activity of TTNC and active com-pounds(Emodin,Luteolin and Levistilide A).And literature mining confirmed the vasospasmolytic activity and neuroprotective effect activity of TTNC.CONCLUSIONS Integrating single-cell data and network disturbance tools provides a new strategy for the MoA of multi-components drug through cell subtyping.

TONG Xiaolin's Cold-Damp Epidemic Differentiation and Treatment Concepts and Diagnostic and Therapeutic Key Points / 中医杂志

Building on a clear understanding of the diagnosis and treatment patterns for cold-damp epidemics， and incorporating the insights of Academician TONG Xiaolin regarding the differentiation and treatment of such epidemics， this article have distilled the key diagnostic principles. These principles primarily entail observing color and pulse， initially distinguishing between yin and yang， with treatment focusing on dispelling cold and dampness. A comprehensive approach is adopted throughout treatment， with a combination of overall strategies and tailored treatments that evolve in line with the patient's condition. In critical and severe cases， particular attention is given to aspects such as sweating， pulse analysis， and consciousness， preventing the pathogen from penetrating deeply. Efforts are made to open and close organ networks， expelling external pathogens without fixating on resolving constipation. The dosage and efficacy of herbal remedies are adjusted based on individual circumstances and clinical symptoms. The objective is to eliminate pathogens comprehensively， while being vigilant against relapses， ultimately achieving a full recovery. This overview of the thought processes and clinical principles for diagnosing and treating cold-damp epidemics will guide precise clinical practices and provide a theoretical foundation for the involvement of traditional Chinese medicine in epidemic prevention and treatment.

Connotation and Clinical Application of Tong （Dredging） Method in Treatment of Coronary Heart Disease / 中国实验方剂学杂志

Tong （dredging） method in traditional Chinese medicine （TCM） emphasizes soothing the stagnated Qi， blood， and body fluid in zang-fu organs， meridians， and collaterals to remove pathogens， reinforce vital Qi， and balance Yin and Yang of the human body. Tong method can be adopted to disperse sweat pore， attack pathogenic Qi， harmonize Yin and Yang， as well as tonify deficiency， and resolve stagnation. It has been proved effective in treating coronary heart disease （CHD）， which falls into the category of "chest impediment and heart pain" in TCM， with the key pathogenesis lying in blood vessel obstruction. Therefore， dredging blood vessels is the primary therapeutic principle for CHD. Specifically， there are four aspects. The first is dispersing and dredging the sweat pore of the heart. If the sweat pore is occluded by pathogenic cold， which makes Yang-qi undissipated， Cinnamomi Ramulus， Piperis Longi Fructus， Alpiniae Officinarum Rhizoma， and Asari Radix et Rhizoma can be prescribed for warming and dredging heart Yang. If the Yang-qi of the heart and chest stagnated in the body， which hinders Qi and blood to nourish the myocardium， resulting in chest pain， Poria and Alismatis Rhizoma can be prescribed. For CHD due to atherosclerosis and inflammation， heat-clearing， toxin-removing， and inflammation-resisting Chinese medicinal herbs such as Coptidis Rhizoma and Rhei Radix et Rhizoma are recommended. The second is attacking and dredging the collaterals of the heart. Salviae Miltiorrhizae Radix et Rhizoma， Chuanxiong Rhizoma， Notoginseng Radix et Rhizoma， etc. can be prescribed for blood stasis， Trichosanthis Fructus， Allii Macrostemonis Bulbus， Pinelliae Rhizoma， etc. for phlegm， and Aquilariae Lignum Resinatum， Euodiae Fructus， etc. for pathogenic cold. Since the chronic disease can affect collaterals， Moschus and Santali Albi Lignum can be added to promote blood circulation and remove the obstruction of collaterals of the heart. The third is harmonizing and dredging the mind. Cinnamomi Ramulus， Coptidis Rhizoma， Cinnamomi Cortex， etc. are selected for restoring the coordination between the heart and the kidney. According to the specific syndrome， the methods of nourishing the mind and calming the nerves through tranquilizing the mind， calming down the mind， and inducing resuscitation can be selected using such Chinese medicines as Ziziphi Spinosae Semen， Polygalae Radix， and Draconis Ossa. The fourth is tonifying and dredging the Qi and blood of the heart. The deficiency syndrome of CHD is divided into Qi deficiency and kidney deficiency. Invigorating Qi and strengthening the heart are the first essentials for the treatment of CHD. In Qi invigoration， Qi and blood must be strengthened simultaneously to strengthen the heart and clear the pulse. Hence， Bazhentang modified by Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos can be chosen. In kidney Qi tonifying， kidney and heart must be strengthened simultaneously， and the methods of tonifying kidney and activating blood can be used. Ginseng Radix et Rhizoma and Astragali Radix are considered as the first choice for tonifying heart Qi， and Epimedii Folium and Morindae Officinalis Radix for tonifying kidney Qi， which are added with Salviae Miltiorrhizae Radix et Rhizoma and Rehmanniae Radix Praeparata to obtain the kidney-tonifying and blood-activating prescription. It is suitable for treating CHD due to kidney deficiency and blood stasis. Simultaneous treatment of heart and kidney is more suitable for middle-aged and elderly patients and chronically ill patients. Tong method can be used in various clinical diseases as well as CHD.

Efficacy of Wen-Luo-Tong on Peripheral Neuropathy Induced by Chemotherapy or Target Therapy: A Randomized, Double-Blinded, Placebo-Controlled Trial / 中国结合医学杂志

OBJECTIVE@#To evaluate the efficacy of Wen-Luo-Tong Granules (WLT) local administration in the treatment of patients with peripheral neuropathy (PN) induced by chemotherapy or target therapy.@*METHODS@#This study is a randomized, double-blinded, and placebo-controlled trial. Seventy-eight patients with PN induced by chemotherapy or target therapy were enrolled from China-Japan Friendship Hospital between July 2019 and January 2020. They were randomly assigned to WLT (39 cases) and control groups (39 cases) using a block randomization method. The WLT group received WLT (hand and foot bath) plus oral Mecobalamin for 1 week, while the control group received placebo plus oral Mecobalamin. The primary endpoint was PN grade evaluated by the National Cancer Institute-Common Toxicity Criteria for Adverse Events (NCI-CTCAE). The secondary endpoints included quantitative touch-detection threshold, neuropathy symptoms, Quality of Life Questionnaire-Chemotherapy Induced Peripheral Neuropathy (QLQ-CIPN20), and Quality of Life Questionnaire-Core30 (QLQ-C30).@*RESULTS@#After treatment, the PN grade in the WLT group was significantly lower than that in the control group (1.00 ± 0.29 vs. 1.75 ± 0.68, P<0.01). The total effective rate in the WLT group was significantly higher than that in the control group (82.05% vs. 51.28%, P<0.01). Compared with the control group, the touch-detection thresholds at fingertips, neuropathy symptom score, QLQ-CIPN 20 (sensory scale, motor scale, autonomic scale, and sum score), and QLQ-C30 (physical functioning, role functioning, emotional functioning, and global health) in the WLT group significantly improved after treatment (P<0.01 or P<0.05).@*CONCLUSION@#WLT local administration was significantly effective in the treatment of patients with PN induced by chemotherapy or target therapy. (Trial registration No. ChiCTR1900023862).

Effect of Zhitong-Rusheng Decoction on wound healing and serum fibronectin and epidermal growth factor levels after anal fistula operation / 国际中医中药杂志

Objective:To investigate the effect of Zhitong-Rusheng Decoction on wound healing and serum fibronectin (FN) and epidermal growth factor (EGF) levels after anal fistula operation. Methods:A total of 102 patients after anal fistula operation in our hospital from March 2018 to March 2020 were randomly divided into control group (51 cases) and observation group (51 cases) according to the random number table method. The control group was treated with conventional western treatment, while the observation group was treated with Zhitong-Rusheng Decoction on the basis of control group. The two groups were treated for 3 weeks. The clinical symptoms were scored before and after treatment, and the levels of serum FN and EGF were detected by ELISA. The wound healing time, hematochezia disappearance time, wound longitudinal diameter and wound area before and after treatment were observed. The clinical efficacy was evaluated after treatment. Results:The total effective rate was 98.0% (50/51) in the observation group and 72.6% (37/51) in the control group, with significant difference between the two groups ( χ2=13.209, P<0.01). After treatment, the pain degree score, wound exudation score and granulation morphology score of the observation group were significantly lower than those in the control group ( t=15.448, 21.424, 28.641, P<0.001). After treatment, the wound healing time [(6. 04 ± 1.20) d vs. (9.42 ± 1.58) d, t=12.166] and the disappearance time of hematochezia [(15.72 ± 2.86) d vs. (19.95 ± 4.33) d, t=6.862] of the observation group were significantly shorter than thosse of the control group( P<0.01). After treatment, the wound longitudinal diameter [(1.89 ± 0.31) cm vs. (2.82 ± 0.54) cm, t=10.666] and wound area [(3.26 ± 0.54) cm 2vs. (4.98 ± 1.10) cm 2, t=10. 024] of the observation group were significantly less than those in the control group ( P<0.01). The serum FN [(2.92 ± 0.50) mg/L vs. (2.45 ± 0.39) mg/L, t=5.293], EGF [(7.03 ± 1.44) μg/L vs. (5.47 ± 1.03) μg/L, t=6.293] of the observation group were significantly higher than those in the control group ( P<0.01). Conclusion:Zhitong-Rusheng Decoction on the basis of conventional treatment on patients after anal fistula operation has a good efficacy, which is conducive to wound healing, reducing clinical symptoms, and improving serum levels of FN and EGF.

Effects of Tongxie-Yaofang on visceral sensitivity and expression of 5-HT and SERT in IBS-D model rats / 国际中医中药杂志

Objective:To explore the effect of Tongxie-Yaofang on visceral sensitivity in IBS-D and the possible mechanism. Methods:Divided 30 male SD rats (one-day old) into normal group (10 rats) and IBS-D model group (20 rats) randomly. IBS-D was induced by the method of neonatal maternal separation and restraint stress. After successful modeling, the IBS-D model group was randomly divided into model group and Tongxie-Yaofang group, with 10 rats in each group. Tongxie-Yaofang group was given Tongxie-Yaofang formula, 4.92 g/ml by gavage, while the normal and model groups were given the same amount of normal saline, rats were gavaged with 2 ml/100 g body weight once a day for 14 days. The electromyography of the exorectus muscle was used to meature colorectal distension and by using electronic constant pressure apparatus to evaluate visceral sensitivity. The morphology of colon by HE staining and Enzyme-linked immunosorbent assay (ELISA) were used to determine the level of colonic 5-hydroxytryptamine (5-HT), qPCR was used to detect the colonic mRNA expression of serotonin transporter (SERT) and Western blot was used to detect SERT expression in colon and hypothalamus. Results:Compared with the model group, at the expansion pressure of 60 mmHg and 80 mmHg, the electromyographic response [(179.51 ± 18.26)% vs. (226.42 ± 25.78)%; (242.13 ± 15.42)% vs. (306.02 ± 51.51)%] in Tongxie-Yaofang group was significantly decreased ( P<0.05 or P<0.01). The colonic content of 5-HT was significantly lower than that in the model group [(8.85 ± 0.53) ng/mg vs.(12.25 ± 1.95) ng/mg] ( P<0.01), the expression of SERT mRNA (0.85 ± 0.12 vs. 0.38 ± 0.02) and SERT protein (0.53 ± 0.11 vs. 0.36 ± 0.17) in the colon was significantly increased ( P<0.05 or P<0.01), the expression of SERT protein (0.88 ± 0.12 vs. 0.36 ± 0.13) in the hypothalamus was significantly increased ( P<0.05). Conclusion:Tongxie-Yaofang could relieve the visceral hypersensitivity, which may be achieved by regulating the 5-HT and SERT expression.

Clinical pharmacology and adverse reactions of Ge Tong Tong Luo Capsule in treating cerebral infarction / 中国药理学通报

The active ingredient of Ge Tong Tong Luo Capsule is the total flavonoids of Pueraria lobata, which mainly consists of puerarin, daidzein, daidzein-4V and other components. In the treatment of cerebral infarction, Ge Tong Tong Luo Capsule and its main pharmacological components have shown to inhibit the progression of atherosclerotic plaque, scavenge oxygen free radicals, anti-platelet aggregation, and inhibit neuronal apoptosis. In terms of adverse events, most of the studies were obvious adverse reactions caused by drugs. In rare studies, although there were adverse events such as palpitation and dry throat, they were relieved without treatment. This article introduces the pharmacological effects, clinical efficacy and adverse reactions of Ge Tong Tong Luo Capsule and its main pharmacological components, and provides a reference for clinical safe and rational drug use.

Effect of Acupuncture-moxibustion plus Zhi Ge Tong Mai Granules on TCM Syndrome Score, Hcy and Nerve Conduction in Patients with Diabetic Peripheral Neuropathy / 上海针灸杂志

Objective To observe the effect of acupuncture-moxibustion plus Zhi Ge Tong Mai granules on the traditional Chinese medicine (TCM) syndrome score, level of homocysteine (Hcy) and nerve conduction in patients with diabetic peripheral neuropathy (DPN). Method Ninety DPN patients were enrolled and randomized into a control group and an observation group. The control group only received Zhi Ge Tong Mai granules, and the observation group was intervened by acupuncture-moxibustion plus Zhi Ge Tong Mai granules. The clinical efficacy, TCM syndrome score, and levels of Hcy, nerve growth factor (NGF), insulin-like growth factor 1 (IGF-1) and vascular endothelial growth factor (VEGF), and nerve conduction function were observed for the two groups. Result The observation group had a higher total effective rate than the control group (P<0.05); the TCM syndrome score in the observation group was lower than that in the control group after treatment (P<0.05); the levels of Hcy and VEGF in the observation group were lower than those in the control group, and the levels of NGF and IGF-1 in the observation group were higher than those in the control group (P<0.05); after treatment, the motor and sensory conduction velocities of both left and right tibial nerves in the observation group were higher than those in the control group (P<0.05). Conclusion Acupuncture-moxibustion plus Zhi Ge Tong Mai granules can boost the clinical efficacy, and improve the TCM syndrome score, and the levels of factors such as Hcy and VEGF in patients with DPN.It can produce better efficacy than Zhi Ge Tong Mai granules alone.

Inheritance and Development of Banxia Xiexin Decoction in Shang Han Lun by WU Ju-tong from Wen Bing Tiao Bian / 中国中医药信息杂志

Through the study of the changing decoction of Banxia Xiexin Decoction in Wu Ju-tong's Wen Bing Tiao Bian, this article explored the inheritance and development of the application of Banxia Xiexin Decoction inShang Han Lun. Wu Ju-tong changed the Banxia Xiexin Decoction for treatment of seasonal febrile diseases, who learned ZHANG Zhong-jing's academic thoughts, drew YE Tian-shi's prescription essence in Lin Zheng Zhi Nan Yi An, and combined with his own clinical experience, which widened the treatment scope, enriched the specific treatment methods and sublimated its application theory. His prescription is based on changes in the disease, and the use of medicine is very flexible and appropriate, which provides the inspiration for future generations to understand the depth of application of the classical prescriptions in Shang Han Lun.

A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia / 中华医学杂志(英文版)

<p><b>Background</b>Functional dyspepsia (FD) is a common upper gastrointestinal disorder worldwide, but the current treatments for FD are still unsatisfactory. The aims of this study were to investigate the efficacy and safety of Qi-Zhi-Wei-Tong granules in patients with postprandial distress syndrome (PDS)-predominant FD.</p><p><b>Methods</b>The study was conducted as a randomized, double-blinded, multicenter, placebo-controlled design in 197 patients with PDS. All participants received placebo treatment for 1 week. Patients whose total symptom score decreased by <50% after the placebo treatment were recruited into the 4-week treatment period, in which they were randomly assigned to be treated with either Qi-Zhi-Wei-Tong granules or placebo. The patients were then followed for 2 weeks without any treatment. Dyspeptic symptoms were scored at weeks 2 and 4 during the random treatment period and 2 weeks after the treatment. Anxiety and depression symptoms were also scored and compared.</p><p><b>Results</b>(1) The total effective rates in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 during the random treatment period and 2 weeks after treatment were all significantly higher than those in the placebo group (38.82% vs. 8.75%, P < 0.001; 69.14% vs. 16.25%, P < 0.001; 77.65% vs. 21.25%, P < 0.001). (2) The total dyspeptic symptoms scores in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 and 2 weeks after treatment were significantly lower than those in the placebo group. (3) The severity and frequency of each dyspeptic symptom at weeks 2 and 4 and the follow-up period were all significantly lower than those in the placebo group. (4) The anxiety scores in the Qi-Zhi-Wei-Tong granules group were significantly lower than those in the placebo group. (5) Qi-Zhi-Wei-Tong granules did not have more adverse effects than the placebo.</p><p><b>Conclusion</b>Qi-Zhi-Wei-Tong granules offer significant symptomatic improvement in PDS with no more adverse effects than placebo.</p><p><b>Trial Registration</b>https://clinicaltrials.gov/, NCT02460601.</p>

Chemical constituents from fruits of Amomum paratsao-ko / 中草药

Objective: To investigate the chemical constituents of Amomum paratsao-ko. Methods: The chemical constituents were separated and purified consecutively by silica gel, Sephadex LH-20 column chromatography, recrystallization as well as preparative HPLC. Their structures were determined by physicochemical properties and spectral analyses. Results: Fourteen compounds were isolated and identified as 2(E)-2-decene-1,10-di-yl-acetate (1), 2(E)-2-decene-1,10-diol (2), β-sitosterol (3), 3,5-dihydroxy- 7,4’-dimethoxyflavone (4), rhamnocitrin (5), kaempferol (6), rhamnetin (7), kaempferol-3,7,4’-O-trimethylether (8), ombuin (9), quercetin (10), kumatakenin (11), octyl ferulate (12), (E)-decyl-3-(4-hydroxy-3-methoxyphenyl) propenoate (13), and trans-p-hydroxycinnamic acid (14). Conclusion: Compound 1 is a new compound named paratsaokoster, and compounds 2-14 are isolated from this plant for the first time.

Discussion on Theory of Tong Yang in Prevention and Treatment for Tumor with "Analogy" / 中国中医药信息杂志

"Analogy" is one of the core ideological tools of TCM theory, and the conclusion is made by comparing the phenomena of nature with the pathology of human body. Through the "analogy" method and combined with TCM theory "the Unity of Man and Nature" concept, this article explored tumor formation, development and related treatment.

Professor 's experience of acupuncture combined with medication for epilepsy / 中国针灸

Professor 's experience of acupuncture combined with medication for epilepsy is summarized, which is explained from epilepsy's etiology and pathogenesis, diagnosis and treatment of acupuncture and medication, respectively. Besides, the theoretical foundation and use instruction of acupuncture technique "-" for epilepsy are introduced. Professor highly values the adherence to etiology and pathogenesis, pays attention to syndrome differentiation and searches for the primary disease cause. He proposes the wind, phlegm, stasis and deficiency are the pathogenesis of epilepsy, and points out acupuncture could be applied during attack stage and remittent stage, but electroacupuncture should be used with caution. Regulating spirit is the key for treating epilepsy. The combination of acupuncture and medication could regulate the governor vessel and guide to the origin, which have significant curative effect.

Rapid analysis by HPLC in the quality control study of Chinese herbal medicine pseudo-ginseng and its Chinese drugs preparation′s specific chromatogram / 国际中医中药杂志

Objective To study the HPLC rapid analysis method for the 5 kinds of saponins in pseudo-ginseng herbs and its traditional Chinese medicine preparations Xuesaitong injection at different habitats and analyze the fingerprint characteristics. Methods The Waters Nova-Pak-wat044375 flash chromatography column (4.6 mm×150 mm, 4 μm) was as stationary phase, and acetonitrile-0.5％ formic acid solution (v/v) system was as the mobile phase. The gradient elution, column temperature was 30 ℃, and detection wavelength was of 203 nm. Twelve batches of Panax notoginseng in Yunnan, Sichuan, Guangxi, Jiangxi and other places four kinds of Xuesaitong injection from different manufacturers were taken for rapid analysis of HPLC and methodological study. The similarity analysis was carried out by Chinese medicine chromatographic fingerprint similarity evaluation system (2012 edition). Results The establishment of rapid HPLC fingerprints baseline separation occurred within 1 min of detection, and 5 kinds of ingredients were all successfully detected in the 40 min. The similarity of each component was more than 0.9, and with a good precision, stability and reproducibility, RSD within 5％. Conclusions The method of HPLC rapid analysis for Chinese herbal medicine pseudo-ginseng and its Chinese drugs preparation's specific chromatogram is simple, rapid and effective. It can fully reflect the changes of 5 representative components chromatogram in pseudo-ginseng and its preparation, and so it can be as the quality control evaluation of pseudo-ginseng and its preparation.