Effect of dexmedetomidine on tourniquet-induced skeletal muscle injury

SUMMARY OBJECTIVE: The aim of this study was to investigate whether dexmedetomidine could reduce tourniquet-induced skeletal muscle injury. METHODS: C57BL6 male mice were randomly assigned to sham, ischemia/reperfusion, and dexmedetomidine groups. Mice in the ischemia/reperfusion and dexmedetomidine groups received normal saline solution and dexmedetomidine intraperitoneally, respectively. The sham group underwent the same procedure as the ischemia/reperfusion group, with the exception of tourniquet application. Subsequently, the ultrastructure of the gastrocnemius muscle was observed, and its contractile force was examined. In addition, Toll-like receptor 4 and nuclear factor-κB expression within muscles was detected by Western blot. RESULTS: Dexmedetomidine alleviated myocyte damage and increased the contractility of skeletal muscles. Moreover, dexmedetomidine significantly inhibited the expression of Toll-like receptor 4/nuclear factor-κB in the gastrocnemius muscle. CONCLUSION: Taken together, these results demonstrate that dexmedetomidine administration attenuated tourniquet-induced structural and functional impairment of the skeletal muscle, partly through inactivation of the Toll-like receptor 4/nuclear factor-κB pathway.

Efficacy of different compression methods for hemostasis at the radial artery puncture point after percutaneous coronary intervention / 中国基层医药

Objective:To compare the hemostatic effects and patient comfort of different compression methods for hemostasis after transradial coronary intervention.Methods:A total of 160 patients who received transradial coronary intervention in The Affiliated Hospital of Hangzhou Normal University from October 2018 to February 2020 were included in this study. In group A ( n = 80), patients underwent spiral compression at the puncture point (release for 1 turn at 2 hours after surgery, rotation for 1 circle after 1 hour, and full decompression). In group B ( n = 80), patients underwent spiral compression at the puncture point (release for 1 turn at 2 hours after surgery, rotation for 1 circle after 2 hours, and full decompression). Percutaneous arterial oxygen saturation value in the affected limb, heart rate, and Visual Analog Scale score at different times after surgery, pain and comfort score at 2 and 12 hours post-surgery were compared between the two groups. Results:Percutaneous arterial oxygen saturation value at 4 and 12 hours post-surgery in group A was (96.6 ± 0.7)% and (97.8 ± 0.5)%, respectively, which was significantly higher than that in group B [(96.2 ± 0.6)%, (97.6 ± 0.7)%, t = 3.88, 2.08, both P < 0.05]. There were no significant differences in total score and subscale score of the General Comfort Questionnaire at 2 hours post-surgery between groups A and B (both P < 0.05). At 12 hours post-surgery, scores of psychological and physical subscales and total score of the General Comfort Questionnaire in group A were (23.64 ± 3.02) points, (12.64 ± 2.05) points, (68.25 ± 6.04) points, which were significantly higher than those in group B [(22.20 ± 2.96) points, (11.38 ± 2.47) points, (64.42 ± 6.71) points, t = 3.05, 3.51, 3.79, all P < 0.05]. At 2 hours post-surgery, there was no significant difference in Numerical Rating Scale score between groups A and B ( P > 0.05). At 4 and 12 hours post-surgery, Numerical Rating Scale score in group A was (2.51 ± 0.58) points and (1.75 ± 0.76) points, respectively, which was significantly lower than that in group B [(2.95 ± 0.63) points, (2.31 ± 0.71) points, t = -4.59, -4.82, both P < 0.05). The incidence of complications was significantly lower in group A than in group B (8.75% vs. 20.00%, χ2 = 4.11, P < 0.05). Conclusion:Compression for hemostasis is highly effective by releasing for 1 turn at 2 hours after transradial coronary intervention, rotating for 1 circle after 1 hour, and full compression because it can greatly mitigate pain, ensure the oxygen supply to the affected limbs, and improve patient comfort.

Use of Foley's catheter as a tourniquet for the management of vascular lesion of lip in Mowat-Wilson syndrome

Background: Vascular malformation of lower lip is a very rare anomaly. The lesion leads to facial asymmetry, difficulty in speech and eating and drooling of saliva. Treatment goals include symmetrical reconstruction of the lip with minimal scarring, provide adequate bulk for the reconstruction of vermillion, in toto removal of the lesion and prevent recurrence. The most common complication during surgical removal of these lesions includes blood loss and profuse bleeding which leads to poor visibility, increased operation time and postoperative requirement of blood transfusion. Therefore, the use of sclerosing agent is recommended before surgical removal. This may help in decreasing bleeding during surgery but not in all cases. Case Report: Here, we report the use of Foley's catheter for the management of a high flow lesion of lower lip in a 12-year-old patient diagnosed with Mowat-Wilson syndrome. This technique helped in providing bloodless field which lead to minimal blood loss and good visibility intraoperatively.

Damage control of peripheral vascular trauma - Don't be afraid of axillary or popliteal fosses / Control de daños del trauma vascular periférico - No le tema a la fosa axilar o poplítea

Abstract Peripheral vascular injuries are uncommon in civilian trauma but can threaten the patient's life or the viability of the limb. The definitive control of the vascular injury represents a surgical challenge, especially if the patient is hemodynamically unstable. This article proposes the management of peripheral vascular trauma following damage control surgery principles. It is essential to rapidly identify vascular injury signs and perform temporary bleeding control maneuvers. The surgical approaches according to the anatomical injured region should be selected. We propose two novel approaches to access the axillary and popliteal zones. The priority should be to reestablish limb perfusion via primary repair or damage control techniques (vascular shunt or endovascular approach). Major vascular surgeries should be managed post-operatively in the intensive care unit, which will allow correction of physiological derangement and identification of those developing compartmental syndrome. All permanent or temporary vascular procedures should be followed by a definitive repair within the first 8 hours. An early diagnosis and opportune intervention are fundamental to preserve the function and perfusion of the extremity.

Resumen El trauma vascular periférico no es común en el contexto civil, pero representa una amenaza para la vida del paciente o de la extremidad. El control definitivo de la lesión vascular representa un desafío quirúrgico, especialmente en pacientes con inestabilidad hemodinámica. Este artículo describe la propuesta de manejo del trauma vascular periférico de acuerdo con los principios de la cirugía de control de daños. Se debe identificar los signos sugestivos de lesión vascular y realizar oportunamente maniobras temporales para el control del sangrado. Se debe elegir el abordaje quirúrgico dependiendo del área anatómica lesionada. Se proponen dos nuevas incisiones para acceder a la región axilar y poplítea. La prioridad es restablecer la perfusión de la extremidad mediante el reparo primario o técnicas de control de daños (shunt vascular o abordaje endovascular). Los pacientes sometidos a cirugías vasculares mayores deben ser manejados postoperatoriamente en la unidad de cuidados intensivos para corregir las alteraciones fisiológicas e identificar aquellos que desarrollen un síndrome compartimental. Todos los procedimientos vasculares permanentes o temporales deben contar con un reparo definitivo en las primeras 8 horas. El diagnóstico temprano e intervención oportuna son fundamentales para salvaguardar la perfusión y funcionalidad de la extremidad.

Damage control of peripheral vascular trauma - Don't be afraid of axillary or popliteal fosses / Control de daños del trauma vascular periférico - No le tema a la fosa axilar o poplítea

Abstract Peripheral vascular injuries are uncommon in civilian trauma but can threaten the patient's life or the viability of the limb. The definitive control of the vascular injury represents a surgical challenge, especially if the patient is hemodynamically unstable. This article proposes the management of peripheral vascular trauma following damage control surgery principles. It is essential to rapidly identify vascular injury signs and perform temporary bleeding control maneuvers. The surgical approaches according to the anatomical injured region should be selected. We propose two novel approaches to access the axillary and popliteal zones. The priority should be to reestablish limb perfusion via primary repair or damage control techniques (vascular shunt or endovascular approach). Major vascular surgeries should be managed post-operatively in the intensive care unit, which will allow correction of physiological derangement and identification of those developing compartmental syndrome. All permanent or temporary vascular procedures should be followed by a definitive repair within the first 8 hours. An early diagnosis and opportune intervention are fundamental to preserve the function and perfusion of the extremity.

Resumen El trauma vascular periférico no es común en el contexto civil, pero representa una amenaza para la vida del paciente o de la extremidad. El control definitivo de la lesión vascular representa un desafío quirúrgico, especialmente en pacientes con inestabilidad hemodinámica. Este artículo describe la propuesta de manejo del trauma vascular periférico de acuerdo con los principios de la cirugía de control de daños. Se debe identificar los signos sugestivos de lesión vascular y realizar oportunamente maniobras temporales para el control del sangrado. Se debe elegir el abordaje quirúrgico dependiendo del área anatómica lesionada. Se proponen dos nuevas incisiones para acceder a la región axilar y poplítea. La prioridad es restablecer la perfusión de la extremidad mediante el reparo primario o técnicas de control de daños (shunt vascular o abordaje endovascular). Los pacientes sometidos a cirugías vasculares mayores deben ser manejados postoperatoriamente en la unidad de cuidados intensivos para corregir las alteraciones fisiológicas e identificar aquellos que desarrollen un síndrome compartimental. Todos los procedimientos vasculares permanentes o temporales deben contar con un reparo definitivo en las primeras 8 horas. El diagnóstico temprano e intervención oportuna son fundamentales para salvaguardar la perfusión y funcionalidad de la extremidad.

Tips for Arthroscopic Anterior Cruciate Reconstruction without the Tourniquet / Dicas para reconstrução artroscópica do cruzado anterior sem o garrote

Abstract The arthroscopic reconstruction of the anterior cruciate ligament is a common surgery performed by the orthopedic surgeons willing to restore the knee stability of physically active patients. Despite the fact that it is usually an uneventful procedure, surgeons must always look for better post-operative results; in this scenario, the arthroscopic reconstruction of the anterior cruciate ligament without a tourniquet is a promising alternative. The aim of the present paper is to share with other orthopedic surgeons around the world our experience with this procedure and some technical tips that may be helpful.

Resumo A reconstrução artroscópica do ligamento cruzado anterior é uma cirurgia comum realizada pelos cirurgiões ortopédicos dispostos a restaurar a estabilidade do joelho de pacientes fisicamente ativos. Apesar de ser geralmente um procedimento sem intercorrências, os cirurgiões devem sempre procurar melhores resultados pós-operatórios; neste cenário, a reconstrução artroscópica do ligamento anterior sem torniquete é uma alternativa promissora. O objetivo deste artigo é compartilhar com outros cirurgiões ortopédicos ao redor do mundo nossa experiência com este procedimento e algumas dicas técnicas que podem ser úteis.

Prehospital Damage Control: The Management of Volume, Temperature… and Bleeding! / Control de Daños Prehospitalario: ¡Para Los Cristaloides, Para La Hipotermia Y…! ¡Para El Sangrado!

Abstract Damage control resuscitation should be initiated as soon as possible after a trauma event to avoid metabolic decompensation and high mortality rates. The aim of this article is to assess the position of the Trauma and Emergency Surgery Group (CTE) from Cali, Colombia regarding prehospital care, and to present our experience in the implementation of the "Stop the Bleed" initiative within Latin America. Prehospital care is phase 0 of damage control resuscitation. Prehospital damage control must follow the guidelines proposed by the "Stop the Bleed" initiative. We identified that prehospital personnel have a better perception of hemostatic techniques such as tourniquet use than the hospital providers. The use of tourniquets is recommended as a measure to control bleeding. Fluid management should be initiated using low volume crystalloids, ideally 250 cc boluses, maintaining the principle of permissive hypotension with a systolic blood pressure range between 80- and 90-mm Hg. Hypothermia must be management using warmed blankets or the administration of intravenous fluids warmed prior to infusion. However, these prehospital measures should not delay the transfer time of a patient from the scene to the hospital. To conclude, prehospital damage control measures are the first steps in the control of bleeding and the initiation of hemostatic resuscitation in the traumatically injured patient. Early interventions without increasing the transfer time to a hospital are the keys to increase survival rate of severe trauma patients.

Resumen La resucitación en el control de daños debe iniciarse lo más rápido posible después de presentado el evento traumático para evitar descompensación metabólica y aumento de la mortalidad. El objetivo de este artículo es sustentar nuestro enfoque respecto a la atención prehospitalaria y presentar nuestra experiencia en la implementación de la iniciativa "Stop the Bleed" en Latinoamérica. La atención prehospitalaria es la fase Cero de la resucitación del control de daños. Por medio de la implementación de la iniciativa "Stop the Bleed" se identificó que el personal prehospitalario tiene una mejor percepción sobre el uso de técnicas hemostáticas como el torniquete que el personal hospitalario. Se recomienda el uso de torniquetes como medida de control de sangrado en extremidades. El manejo de líquidos debe realizarse usando cristaloides a bajos volúmenes, con bolos de 250 mL para cumplir el principio de la hipotensión permisiva con un rango entre 80 y 90 mm Hg de presión arterial sistólica. Se deben realizar medidas para evitar la hipotermia como el uso de sábanas térmicas o paso de líquidos calientes. Estas medidas no deben retrasar en ningún momento el tiempo de traslado para recibir la atención hospitalaria. En conclusión, la atención prehospitalaria es el paso inicial para garantizar las primeras medidas de control de sangrado y de resucitación hemostática de los pacientes. Realizar intervenciones tempranas sin acortar el tiempo de traslado a la atención hospitalaria son las claves para aumentar la tasa de supervivencia.

Modelo sintético de baixo custo para treinamento do uso de torniquete / Low-cost synthetic tourniquet training model

RESUMO Objetivo: apresentar um modelo de baixo custo para treinamento de controle de sangramento com o uso de torniquete e os resultados da avaliação do treinamento. Método: foram utilizados materiais de fácil aquisição e de baixo custo, como espuma de estofado, placa de etileno-acetato de vinila (EVA), bomba plástica de propulsão, recipiente de soro fisiológico, água, tinta escolar, equipos de soro, tubo de látex para garrote e manequins comerciais de perna e de braço. Na montagem, foi criado um sistema de simulação de sangramento ativo que só podia ser controlado com aplicação correta do torniquete. O modelo foi submetido à avaliação de profissionais e acadêmicos. Resultados: o modelo teve semelhança com a anatomia humana, mostrou-se prático no treinamento da contenção de sangramento com uso de torniquete e teve baixo custo financeiro. Conclusão: o modelo para treinamento de controle de sangramento teve excelente aceitabilidade, foi considerado viável para fins educacionais do uso de torniquete e teve baixo custo.

ABSTRACT Objective: to present a low-cost model for bleeding control training with the use of a tourniquet and the results of the training evaluation. Method: low-cost and easy-to-purchase materials, such as upholstery foam, ethylene-vinyl acetate (EVA) sheet, plastic propulsion pump, saline container, water, school paint, serum equipment, rubber tubing for tourniquet, and a leg and an arm of a ghost mannequin, were used. In the model assembly, we created an active bleeding simulation system, which could only be controlled with the correct application of the tourniquet. The model was submitted to professional and academic evaluation. Results: the model was similar to human anatomy, proved to be practical in the bleeding control training with the use of a tourniquet, and had low cost. Conclusion: the model for bleeding control training had excellent acceptability, was considered viable for educational purposes of tourniquet use, and had low cost.

Práticas relacionadas ao uso do garrote durante a punção venosa periférica: uma revisão de escopo / Health professionals' practices related with tourniquet use during peripheral venipuncture: a scoping review / Prácticas relacionadas al uso del garrote durante la punción venosa periférica: una revisión de alcance

Objetivos durante a punção venosa periférica, recomenda-se o uso de um garrote acima do local da punção para potencializar a distensão venosa. Dadas as suas características e o uso em ambientes clínicos, os garrotes podem representar uma fonte de disseminação de micro-organismos. Entretanto, os resultados de estudos científicos nessa área estão dispersos na literatura. Esta revisão de escopo tem como objetivo mapear as evidências disponíveis a respeito das práticas dos profissionais de saúde no que concerne ao uso do garrote durante a punção venosa periférica e à contaminação microbiológica associada. Método revisão de escopo de acordo com a metodologia do Instituto Joanna Briggs. Dois revisores independentes analisaram a relevância dos estudos, extraíram e sintetizaram dados. Resultados quinze estudos foram incluídos na revisão. Em geral, os garrotes foram reutilizados sem processos de descontaminação recorrentes. Verificou-se que os profissionais compartilham esses dispositivos entre si e os usaram continuamente por períodos entre duas semanas e sete anos e meio. Conclusão as práticas de enfermagem relacionadas ao uso do garrote durante a punção venosa periférica não são uniformes. A reutilização de garrotes pode colocar em risco a segurança do paciente se o reprocessamento (limpeza e desinfecção/esterilização) não for adequado, dado o tipo de material do garrote e a microbiota encontrada. Novos estudos são necessários para avaliar o impacto de vários tipos de práticas de reprocessamento na descontaminação de garrotes e na segurança do paciente.

Objectives during peripheral venipuncture, health professionals are recommended to use a tourniquet above the puncture site in order to potentiate venous distension. Given its characteristics and use in clinical settings, tourniquets may represent a source of microorganism dissemination. However, the results of scientific studies in this area are scattered in the literature. This scoping review aims to map the available evidence on health professionals' practices related with tourniquet use during peripheral venipuncture and associated microbiological contamination. Methods scoping review following the Joanna Briggs Institute methodology. Two independent reviewers analyzed the relevance of the studies, extracted and synthesized data. Results fifteen studies were included in the review. Overall, tourniquets were reused without being subject to recurring decontamination processes. It has been found that practitioners share these devices among themselves and use them successively for periods between two weeks and seven and half years. Conclusion nursing practices related to tourniquet use during peripheral venipuncture are not standard. Reuse of tourniquets may jeopardize the patient's safety if reprocessing (cleaning and disinfection/sterilization) is not adequate, given the type of tourniquet material and microbiota found. New studies are needed to assess the impact of various types of reprocessing practices on tourniquet decontamination and patient safety.

Objetivos durante la punción venosa periférica, se recomienda el uso de un garrote arriba del sitio de la punción para potenciar la distensión venosa. Dadas sus características y uso en ambientes clínicos, los garrotes pueden representar una fuente de diseminación de microorganismos. Sin embargo, los resultados de estudios científicos en esta área están dispersos en la literatura. Esta revisión de alcance tiene como objetivo mapear las evidencias disponibles acerca de las prácticas de los profesionales de salud en lo que concierne al uso del garrote durante la punción venosa periférica y la contaminación microbiológica asociada. Método revisión de alcance de acuerdo con la metodología del Instituto Joanna Briggs. Dos revisores independientes analizaron la relevancia de los estudios, extrajeron y sintetizaron datos. Resultados quince estudios se incluyeron en la revisión. En general, los garrotes fueron reutilizados sin procesos de descontaminación recurrentes. Se verificó que los profesionales comparten estos dispositivos entre sí y los utilizaron continuamente por períodos entre dos semanas y siete años y medio. Conclusión las prácticas de enfermería relacionadas al uso del garrote durante la punción venosa periférica no son uniformes. La reutilización de garrotes puede poner en riesgo la seguridad del paciente si el reprocesamiento (limpieza y desinfección/esterilización) no es adecuado, dado el tipo de material del garrote y la microbiota encontrada. Nuevos estudios son necesarios para evaluar el impacto de varios tipos de prácticas de reprocesamiento en la descontaminación de garrotes y en la seguridad del paciente.

Achilles tendon reconstruction with a half-width Achilles graft and wrap-around fascial flap

A 70-year-old man complained imbalance while walking, inability to perform ankle flexion, and could not stand on tip-toe 3 months after injury. The ankle looked swollen with loss of Achilles contour and obvious gait disturbance. Magnetic resonance imaging shows a 5-cm Achilles tendon gap. Subsequently, surgery was performed to solve the neglected Achilles tendon rupture. Patient was put under general anesthesia with a regional block. Using a non-tourniquet technique, a reconstructive procedure was performed using a half-width autologous Achilles tendon graft, which was attached to the calcaneal prominence with wire in a double strand Bunnell fashion. As for the proximal stump, double core Bunnell/modified Kessler suturing was carried out to suture the graft to Achilles stump. To increase the vascularization, an ipsilateral gastrocnemius fascial flap with a distally based-pedicle was harvested to wrap around the tendon graft. At a 6-month follow-up, the patient was able to stand on tip-toe and had also regained a normal gait.

The use of tourniquet during total knee replacement in patients with and without popliteal artery calcification / O uso do manguito pneumático em pacientes submetidos a artroplastia total do joelho com ou sem calcificação da artéria poplítea

ABSTRACT Objective: Identify the clinical and surgical complications associated with the use of a tourniquet in total knee arthroplasty in patients with or without calcification of the popliteal artery. Methods: The study was performed retrospectively, analyzing 58 patients with calcification of the popliteal artery and 57 patients as a control group. Results: The case group patients were significantly older than patients in the control group; however, this had no impact on the clinical outcome in the analyzed period.There were no complications during surgery in the groups studied, as there were no statistically significant differences between the incidence of local or systemic intercurrences in the analyzed period. Conclusion: This study found low rates of complications in patients undergoing total knee arthroplasties with use of a tourniquet, with or without calcification of the popliteal artery.

RESUMO Objetivo: Identificar as complicações clínicas e cirúrgicas associadas ao uso de torniquete na artroplastia total de joelho em pacientes com ou sem calcificação da artéria poplítea. Métodos: O estudo foi feito de modo retrospectivo, analisou 64 pacientes com calcificação da artéria poplítea e 57 pacientes como grupo controle. Resultados: Os pacientes do grupo de casos eram significativamente mais velhos do que os pacientes do grupo controle. Entretanto, tal fato não teve repercussão quanto ao desfecho clínico no período analisado. Não houve complicações durante o ato cirúrgico nos grupos estudados, bem como não houve diferenças estatisticamente significantes entre a incidência de intercorrências locais ou sistêmicas no período analisado. Conclusão: O presente estudo observou baixos índices de complicações em pacientes submetidos a artroplastia total do joelho com uso de torniquete com ou sem calcificação da artéria poplítea.

Iatrogenic Sciatic Nerve Injury after Total Knee Arthroplasty / 대한정형외과학회잡지

Sciatic nerve palsy after total knee arthroplasty, accompanied by motor power weakness and electromyographic evidence, is a rare occurrence. In a 78-year-old female, pneumatic tourniquet was used for 72 minutes, with a pressure of 300 mmHg. The time and pressure are generally accepted values. We noticed sciatic nerve palsy showing motor power weakness and electromyographic evidence. One year after the operation, she recovered full motor power, but complained about a tingling sensation below the knee. Given that the nerve injury after using tourniquet was due to neural ischemia, and since our patient had vascular circulation problems such as atrial fibrillation and clip insertion due to internal carotid artery aneurysm, our patient can be considered as a high-risk patient with weakness to neural ischemic damage, even with the use of conventional tourniquet. Therefore, surgeons should be cautious when using tourniquet in patients with vascular circulation problems.

Effects of dexmedetomidine on responses to tourniquet in patients undergoing lower extremity surgery with peripheral nerve block / 中华麻醉学杂志

Objective To evaluate the effects of dexmedetomidine on responses to tourniquet in patients undergoing lower extremity surgery with peripheral nerve block.Methods Eighty American Society of Anesthesiologists physical status Ⅰ or Ⅱ patients of both sexes,aged 22-63 yr,weighing 47-81 kg,scheduled for elective foot surgery under ultrasound-guided popliteal sciatic nerve block combined with saphenous nerve block,were divided into 2 groups (n =40 each) using a random number table method:control group (group C) and dexmedetomidine group (group D).Dexmedetomidine was intravenously infused for 10 min in a dose of 1 μg/kg in group D,and the equal volume of normal saline was given instead in group C.Blood samples were taken from the internal jugular vein before using the tourniquet (T0) and at 30 and 60 min after releasing the tourniquet (T1-2) for determination of the levels of c-reactive protein (CRP),tumor necrosis factor-alpha (TNF-α),methane dicarboxylic aldehyde (MDA) and superoxide dismutase (SOD) in plasma.The time to responses to tourniquet,tourniquet tolerance time and tourniquet tolerance period were recorded.The occurrence of hypotension,bradycardia and nausea and vomiting was also recorded.Results Compared with the baseline at T0,the concentrations of plasma CRP,TNF-α and MDA were significantly increased and the activity of plasma SOD was decreased at T1,2 in the two groups (P＜0.05).Compared with group C,the concentrations of plasma CRP,TNF-α and MDA were significantly decreased and the activity of plasma SOD was increased at T1,2,the time to responses to tourniquet,tourniquet tolerance time and tourniquet tolerance period were prolonged,and the incidence of bradycardia was increased in group D (P＜0.05).Conclusion Dexmedetomidine can reduce responses to tourniquet in patients undergoing lower extremity surgery with peripheral nerve block.

Incidence and risk factors of early deep venous thrombosis after knee arthroscopy operation under conventional tourniquet / 中国骨伤

<p><b>OBJECTIVE</b>To find out the incidence of early DVT in patients after knee arthroscopic surgery with routine use of tourniquet and discuss the associate risk factors.</p><p><b>METHODS</b>Total 1 561 cases undertaken primary knee arthroscopic surgery was reviewed retrospectively from January 2013 to January 2017, including 651 males and 910 females with a mean age of (65.7±8.7) years old ranging from 62 to 81 years old. The cases were divided into DVT group and non-DVT group according to ultrasonic Doppler after surgery. The DVT occurrence rate was calculated and the basic information was analyzed to filter out the risk factors through univariate analysis and multivariate analysis. The cases of DVT group received 6 months anticoagulation therapy and were undertaken a follow-up of 1, 3, 6 months by ultrasonic Doppler.</p><p><b>RESULTS</b>Out of the 1 561 cases, 226(14.5%) developed early DVTs following surgery, 32(2.0%) cases had the proximal DVTs, and 194(12.4%) cases had the isolated distal DVTs. The risk factors include the age(>=73 years), female sex and gastrocnemius vein dilation (GVD), hypertension, longer tourniquet time(>=74 min). The GVD and the length of tourniquet time was considered to be the best predictor of the early DVTs after surgery, with an odds ratio of 2.337 (95% CI, 1.644-3.611) and 2.112 (95%CI, 1.452-3.301). Twelve isolated distal DVTs(6.6%) and 11 proximal DVTs(36.7%) still showed thrombus at 6-month follow-up, but exhibit decreased size and at various stage of resolution.</p><p><b>CONCLUSIONS</b>The incidence of early DVTs after knee arthroscopic surgery is 14.5%. Out of all risk factors, the GVD and the length of tourniquet time have the best power for prediction of DVTs after surgery. Both proximal and distal DVTs received accepted outcomes after formal therapy.</p>

Research progress in hemorrhage control products of U.S.army / 中华创伤杂志

From Vietnam War to Operation Iraqi Freedom and Operation Enduring Freedom,hemorrhage remains the leading cause of combat death.The U.S.army has made great strides in research and development of hemorrhage control products and various tourniquets and hemostatic dressings have been fielded on the battlefield.This paper introduces current status of hemostatic products and hemorrhage control products.Currently,there are extremity tourniquets and junctional tourniquets.The hemostatic products include HemCon bandages,QuciClot granular and gauze,Celox gauze,XStat,etc.Meanwhile,the author summarizes three development trends of US military hemostatic products,ie,prehospital application of tourniquets,emphasis on hemorrhage control in junctional regions,and gauze hemostatic adjuncts preference.This review offers materials for fully understanding war wound treatment of U.S.army.

Blood level changes in total knee arthroplasty with and without a tourniquet / Variação sanguínea nas artroplastias de joelho com e sem o uso de garrote

ABSTRACT OBJECTIVE: To evaluate the difference between the total blood loss in patients undergoing primary total knee arthroplasty with and without the use of tourniquet. METHODS: A retrospective cohort study, with analysis of medical records of patients undergoing primary total knee arthroplasty in 2015, with and without the use of a tourniquet. Comparison was performed of hemoglobin (HB) and hematocrit (HT) variation in the complete blood count (CBC) during the pre- and post-operative period between the two groups. RESULTS: There were 117 patients undergoing primary total knee arthroplasty included, minimum age of 33 and maximum of 86 years, with a mean of 67 years. 64.1% of the surgeries used a tourniquet and 35.9% did not. The mean preoperative HB in Group 1 was 13.08 and 12.97 in Group 2 (p = 0.435). The mean postoperative HB in Group 1 was 11.64 and 10.93 in Group 2 (p = 0.016). The variation of HB in Group 1 was 1.44 and 2.04 in Group 2 (p = 0.025). The mean preoperative HT in Group 1 was 38.96 and 39.01 in Group 2 (p = 0.898). The mean postoperative HT in Group 1 was 34.47 and 32.19 in Group 2 (p = 0.005). The variation of HT in Group 1 was 4.49 and 6.82 in Group 2 (p = 0.001). A total of 21 patients received transfusions RCC (red cell concentrates), as a result of HB below 8 g/dL or clinical symptoms, respectively, representing seven of Group 1 (9.3% of total intra-group) and 14 of Group 2 (33.3% of total intra-group), with p = 0.001. CONCLUSION: In patients undergoing primary total knee arthroplasty using a tourniquet, a lower variance in the hematimetric indices was observed and fewer blood transfusions were necessary.

RESUMO OBJETIVO: Avaliar a diferença entre a perda sanguínea total em pacientes submetidos à artroplastia total do joelho com e sem o uso de garrote. MÉTODOS: Estudo de coorte retrospectivo, com análise dos prontuários de pacientes submetidos a artroplastia primária total de joelho em 2015, com e sem o uso de garrote. Comparou-se a variação de hemoglobina (HB) e hematócrito (HT) no pré- e pós-operatório entre os dois grupos. RESULTADOS: Foram incluídos 117 pacientes submetidos a artroplastia total de joelho primária, idade mínima de 33 e máxima de 86 anos, com média de 67; em 64,1% das cirurgias, foi usado garrote e em 35,9%, não. No pré-operatório, a média da HB no Grupo 1 foi de 13,08; no Grupo 2, 12,97 (p = 0,435). No pós-operatório, a média da HB no Grupo 1 foi de 11,64; no Grupo 2, 10,93 (p = 0,016). A variação da HB no Grupo 1 foi de 1,44; no Grupo 2, de 2,04 (p = 0,025). No pré-operatório, a média do HT no Grupo 1 foi de 38,96; no Grupo 2, de 39,01 (p = 0898). No pós-operatório, a média do HT no Grupo 1 foi de 34,47; no Grupo 2, de 32,19 (p = 0,005). A variação do HT no Grupo 1 foi de 4,49; no Grupo 2, de 6,82 (p = 0,001). Dos pacientes, 21 receberam transfusão de CH (concentração de hemácias), por HB abaixo de 8 ou sintomas clínicos, sete do Grupo 1 (9,3% do total intragrupo) e 14 do Grupo 2 (33,3% do total intragrupo) com p = 0,001. CONCLUSÃO: Nos pacientes submetidos a artroplastia total de joelho primária com o uso de garrote, ocorreu uma menor variância dos índices hematimétricos e um menor número de transfusões sanguíneas foi necessário.

Comparative analysis of pain in patients who underwent total knee replacement regarding the tourniquet pressure / Análise comparativa da dor em pacientes submetidos à artroplastia total do joelho em relação aos níveis pressóricos do torniquete pneumático

ABSTRACT OBJECTIVES: To evaluate through the visual analog scale (VAS) the pain in patients undergoing total knee replacement (TKR) with different pressures of the pneumatic tourniquet. METHODS: An observational, randomized, descriptive study on an analytical basis, with 60 patients who underwent TKR, divided into two groups, which were matched: a group where TKR was performed with tourniquet pressures of 350 mmHg (standard) and the other with systolic blood pressure plus 100 mmHg (P + 100). These patients had their pain assessed by VAS at 48 h, and at the 5th and 15th days after procedure. Secondarily, the following were also measured: range of motion (ROM), complications, and blood drainage volume in each group; the data were subjected to statistical analysis. RESULTS: After data analysis, there was no statistical difference regarding the incidence of complications (p = 0.612), ROM (p = 0.202), bleeding after 24 and 48 h (p = 0.432 and p = 0.254) or in relation to VAS. No correlation was observed between time of ischemia compared to VAS and bleeding. CONCLUSIONS: The use of the pneumatic tourniquet pressure at 350 mmHg or systolic blood pressure plus 100 mmHg did not influence the pain, blood loss, ROM, and complications. Therefore the pressures at these levels are safe and do not change the surgery outcomes; the time of ischemia must be closely observed to avoid major complications.

RESUMO OBJETIVOS: Avaliar, por meio da escala visual analógica (EVA), a dor em pacientes submetidos à artroplastia total do joelho (ATJ) com diferentes pressões do torniquete pneumático. MÉTODOS: Foi feito um estudo observacional, descritivo, de caráter analítico, prospectivo, randomizado, no qual 60 pacientes foram submetidos à ATJ, divididos em dois grupos, os quais foram comparados entre si: um grupo no qual a ATJ foi feita com pressão do torniquete de 350 mmHg (Padrão) e outro com 100 mmHg acima da pressão arterial sistólica (P + 100). Esses pacientes tiveram sua dor aferida pela EVA após 48 horas, no quinto e no 15° dias após o procedimento cirúrgico. Secundariamente, foram medidos também a amplitude de movimento (ADM), o sangramento via dreno suctor e as complicações em cada um dos grupos estudados; os dados foram submetidos à análise estatística. RESULTADOS: Após a análise dos dados, não foi constatada diferença estatisticamente significante em nível de 5% de significância da pressão em relação à incidência de complicações (p = 0,612), ADM (p = 0,202), ao sangramento após 24 e 48 h (p = 0,432 e p = 0,254) e à EVA. Também não foi constatada correlação do tempo de isquemia em relação a EVA e ao sangramento. CONCLUSÕES: As pressões usadas do torniquete pneumático, 350 mmHg ou pressão arterial sistólica + 100 mmHg, não tiveram influência sobre a dor, a perda sanguínea, a amplitude de movimento e as complicações, são pressões seguras que não alteram o resultado final, desde que respeitados o tempo da isquemia e individualizados os casos.

Change of QT variability index during general anesthesia / 대한마취과학회지

BACKGROUND: The QT variability index (QTVI)-a non-invasive measure of beat-to-beat QT interval (QTI) fluctuations-is related to myocardial repolarization lability. The QTVI represents the relationship between QTI and the RR interval. Elevated QTVI is associated with an increased risk of malignant ventricular arrhythmias and sudden death. We investigated the influence of general anesthesia and tourniquets on the QTVI. METHODS: We studied fifty patients who received total knee replacement arthroplasty under sevoflurane anesthesia. We measured QTI, corrected QTI (QTc), T-wave peak-to-end interval (TPE), QTVI, and heart rate variability. All variables were calculated at baseline (B), 30 min after general anesthesia (A), 30 min (TQ1) and 60 min (TQ2) after tourniquet inflation, and at tourniquet deflation (TQR). RESULTS: Prolongation of QTI was detected at all times, and QTc was significantly prolonged TQR. TPE was unchanged during general anesthesia. The QTVI was significantly decreased and more negative during anesthesia and tourniquet inflation. After deflation of the tourniquet, the QTVI was restored to preanesthetic values. Low frequency (LF) was significantly decreased during general anesthesia, but high frequency (HF) was somewhat maintained, except at TQ2. The LF/HF ratio was significantly decreased at A and TQ2. CONCLUSIONS: Sevoflurane based general anesthesia induced repolarization stability and, more negativity of the QTVI, in patients undergoing total knee replacement arthroplasty.

Contaminação de torniquetes para punção intravenosa periférica / Contamination of tourniquets for peripheral intravenous puncture

Objetivo: Identificar a presença de contaminação em torniquetes para punção intravenosa periférica e caracterizar o perfil dos Staphylococcus spp. e leveduras isolados. Métodos Estudo transversal que inseriu análise de 18 torniquetes para punção intravenosa periférica em uso no hospital. Os torniquetes foram imersos em caldo BHI por 24h e cultivados em meios seletivos para isolamento e identificação de Staphylococcus spp. e leveduras. O método disco-difusão foi empregado para analisar o perfil de suscetibilidade dos Staphylococcus spp. aos antimicrobianos. Resultados Treze (72,2%) torniquetes apresentaram crescimento de algum micro-organismo sendo 11 (52,4%) Staphylococcus coagulase-negativo, dois (9,5%) Staphylococcusaureus, quatro (19%) Rodothorulamucilaginosa, três (14,3%) Candidaalbicans. 61,5% dos Staphylococcus spp. apresentaram resistência a oxacilina. Os profissionais da equipe não relataram protocolos para limpeza, desinfecção ou substituição controlada destes materiais na instituição. Conclusão Foi identificada a contaminação de torniquetes por micro-organismos patogênicos com perfil de resistência aos antibióticos muito utilizados em instituições hospitalares.

Objectives: To identify the presence of contamination on tourniquets for peripheral intravenous puncture and to characterize the profile of the Staphylococcus spp. and the isolated yeasts. Methods Cross-sectional study in which 18 tourniquets for peripheral intravenous puncture in use at a hospital were analyzed. The tourniquets were immersed in BHI broth for 24h and cultivated in selective media for isolation and identification of Staphylococcus spp. and yeasts. The disk-diffusion method was employed to analyze the susceptibility profile of the Staphylococcus spp. to the antimicrobial agents. Results The growth of some microorganism was identified on 13 (72.2%) tourniquets: 11 (52.4%) coagulase-negative Staphylococcus, two (9.5%) Staphylococcus aureus, four (19%) Rodothorula mucilaginosa, three (14.3%) Candida albicans. 61.5% of the Staphylococcus spp. were oxacillin-resistant. The team professionals did not mention protocols for cleaning, disinfection or controlled replacement of these materials at the institution. Conclusion The contamination of tourniquets by pathogenic microorganisms was identified, with a resistance profile to the antibiotics that are frequently used in hospitals.

Effect of dexmedetomidine added to ropivacaine administered locally on prevention of tourniquet-related hypertension in patients undergoing total knee arthroplast / 中华麻醉学杂志

Objective To investigate the effect of dexmedetomidine added to ropivacaine administered locally on prevention of tourniquet?related hypertension in the patients undergoing total knee arthroplast. Methods Ninety patients of both sexes, aged 58-74 yr, weighing 60-78 kg, of American Society of Anesthesiologists physical statusⅠ?Ⅲ, scheduled for elective unilateral total knee arthroplast, were randomly divided into 3 groups ( n=30 each) using a random number table: ropivacaine group ( group R) , dexmedetomidine added to ropivacaine administered locally group ( group D + R ) , and dexmedetomidine administered intravenously + ropivacaine group ( group Div+R ) . Femoral nerve block:0.5% ropivacaine 15 ml was injected in group R; the mixture ( 15 ml) of 0. 5% ropivacaine 20 ml plus dexmedetomidine 60 μg was injected in group D+R; 0.5% ropivacaine 15 ml was injected in group Div+R. Lateral femoral cutaneous nerve block: 0.5% ropivacaine 5 ml was injected in group R; the mixture 5 ml was injected in group D+R; 0.5% ropivacaine 5 ml was injected in group Div+R. General anesthesia was induced after the end of nerve block. In group Div+R, dexmedetomidine was infused as a bolus of 0.5 μg∕kg over 10 min starting from anesthesia induction, followed by an infusion of 0.4 μg·kg-1 ·h-1 until 30 min before the end of surgery. A tourniquet was applied and inflated ( 266-304 mmHg) within 90 min. Before induction of anesthesia ( T0 ) , and at 0, 15, 30, 45, 60, 75 and 90 min after the tourniquet was inflated ( T1?7 ) , mean arterial pressure and heart rate were recorded. The occurrence of hypertension, hypotension, tachycardia and bradycardia was recorded when the tourniquet was inflated. Agitation was assessed and scored after removal of the endotracheal tube. The time for recovery of breathing, emergence time, and time for removal of the endotracheal tube were recorded. Results Compared with group R, the mean arterial pressure and heart rate were significantly decreased at T1?7 in D+R and Div+R groups, the incidence of hypertension and tachycardia was decreased, the incidence of bradycardia was increased, and agitation score was decreased in D+R and Div+R groups ( P0.05). There was no significant difference in the time for recovery of breathing, emergence time, and time for removal of the endotracheal tube between the three groups ( P>0.05 ) . Conclusion Dexmedetomidine added to ropivacaine administered locally can exert effect on prevention of tourniquet?related hypertension in the patients undergoing total knee arthroplast, and the effect is similar to that of dexmedetomidine administered intravenously.