Comprehensive analysis of insulin products complex disulfide bonds structure by high resolution mass spectrum / 药学学报

The correct pairing of disulfide bonds maintains the correct folding mode and high-level structure formation of peptides and protein drugs, which is crucial for the quality control of products. In order to ensure that the disulfide bonds are correctly paired, disulfide bond analysis is an essential part of peptides and protein drug characterization. Mass spectrometry can be used to analyze disulfide bonds. However, insulin and its analogues have two pairs of disulfide bonds without restriction enzyme cutting site. Conventional collision-induced dissociation (CID) and high-energy induced cleavage (HCD) cannot accurately locate the complex disulfide bond. In our study, three methods were used to localize the complex disulfide, including enzyme digestion combined with key peptide fragment in source decay (ISD) fragmentation method, enzyme digestion combined with partial reduction alkylation method, intact protein source ISD and electron transfer dissociation (ETD) cleavage method, The applicability of insulin aspart, insulin lispro and insulin glargine were also investigated. This study provides a new way for the quality control of disulfide bonding mode of insulin and its analogues, and also provides a reference for the disulfide bond localization of peptides or proteins containing this complex disulfide bond.

Staged Treatment with Chinese Herbal Medicine in a Controlled Ovarian Hyperstimulation of In Vitro Fertilization-Embryo Transfer Programme / 中医杂志

It is believed that kidney deficiency is the fundamental pathogenesis while liver constraint and spleen deficiency， and disharmony of chong （thorough vessel， 冲脉）and ren （conception vessel， 任脉） is the key pathogenesis of infertility patients who adopted controlled ovarian hyperstimulation of in vitro fertilization-embryo transfer （IVF-ET） programme. Therefore， the method of tonifying the kidneys dominantly and treating the liver and spleen simultaneously is proposed， and Chinese herbal medicine is suggested to be used in adjuvant treatment of staged IVF-ET controlled ovrian hyperstimulation. In the regulation stage， modified Liuwei Dihuang Pill （六味地黄丸） can be used to tonify kidney and supplement essence， fortify spleen and nourish liver； in the ovulation promotion stage， modified Wenjing Decoction （温经汤） should be used to warm kidney and assist yang， dispel stasis and nourish blood； in the pre-transplantation endothelial preparation stage， modified Shenling Baizhu Powder （参苓白术散） is suggested to fortify spleen and replenish qi， invigorate blood and resolve stasis； after the transplantation stage， modified Shoutai Pill （寿胎丸） or Taiyuan Decoction （胎元饮） can be taken to fortify spleen and tonify kidney， benefit qi and nourish blood.

Analysis on Determination and Quantity Transfer of Standard Decoction of Ginseng Radix et Rhizoma by Fresh and Traditional Cutting / 中国实验方剂学杂志

ObjectiveTo analyze the quantity-quality transfer of standard decoction of Ginseng Radix et Rhizoma（GRR） decoction pieces produced by fresh and traditional cutting， and to provide reference for quality control and application development of the decoction pieces produced by fresh cutting. MethodTen batches of representative GRR decoction pieces produced by fresh and traditional cutting and their standard decoctions were prepared by standard process， and high performance liquid chromatography（HPLC） fingerprint of the standard decoction was established and performed on an Agilent EC-C18 column（4.6 mm×150 mm， 2.7 μm） with acetonitrile（A）-0.1% phosphoric acid aqueous solution（B） as the mobile phase for gradient elution（0-23 min， 18%-21%A； 23-35 min， 21%-28%A； 35-80 min， 28%-32%A）， and the detection wavelength was 203 nm. Then similarity evaluation， principal component analysis（PCA） and partial least squares-discriminant analysis（PLS-DA） of fingerprint of the standard decoction were performed to screen the differential components with variable importance in the projection（VIP） value>1. Quantitative analysis was carried out on the screened known differential components， and combined with the indicators of the dry extract rate and the transfer rate， to explore the differences in the quantity-quality transfer between the standard decoction of GRR decoction pieces produced by fresh and traditional cutting. ResultThe fingerprint similarity of the standard decoction of GRR decoction pieces produced by fresh and traditional cutting was more than 0.950， and 18 common peaks were identified， including 9 identified common peaks. The results of PCA and PLS-DA showed that there were some differences in the contents of index components between the two standard decoctions. The contents of ginsenoside Rg1， Re and Ro in GRR decoction pieces produced by fresh cutting were higher than those in traditional decoction pieces， while the contents of ginsenoside Rb1， Rc ， Rb2 and Rd were lower than those in traditional decoction pieces. The contents of ginsenoside Rg1， Re， Rb1 and Ro in the standard decoction of GRR decoction pieces produced by fresh cutting were higher than those in the standard decoction of traditional decoction pieces， while the contents of ginsenoside Rc ， Rb2 and Rd were comparable between the two standard decoctions. Compared with the standard decoction of the traditional decoction pieces， the average transfer rates of ginsenoside Rg1， Rb1， Rc， Rb2 and dry extract rate of the standard decoction of GRR decoction pieces produced by fresh cutting were significantly increased（P<0.05）， and the average transfer rate of ginsenoside Re and Rd also increased， but the difference was not statistically significant. ConclusionThe dry extract rate， content and transfer rate of index components of standard decoction of GRR decoction pieces produced by fresh cutting are better than those of the standard decoction of traditional decoction pieces， which can provides data support for the subsequent clinical application of fresh cutting products.

Analysis on Determination and Quantity Transfer of Standard Decoction of Ginseng Radix et Rhizoma by Fresh and Traditional Cutting / 中国实验方剂学杂志

ObjectiveTo analyze the quantity-quality transfer of standard decoction of Ginseng Radix et Rhizoma（GRR） decoction pieces produced by fresh and traditional cutting， and to provide reference for quality control and application development of the decoction pieces produced by fresh cutting. MethodTen batches of representative GRR decoction pieces produced by fresh and traditional cutting and their standard decoctions were prepared by standard process， and high performance liquid chromatography（HPLC） fingerprint of the standard decoction was established and performed on an Agilent EC-C18 column（4.6 mm×150 mm， 2.7 μm） with acetonitrile（A）-0.1% phosphoric acid aqueous solution（B） as the mobile phase for gradient elution（0-23 min， 18%-21%A； 23-35 min， 21%-28%A； 35-80 min， 28%-32%A）， and the detection wavelength was 203 nm. Then similarity evaluation， principal component analysis（PCA） and partial least squares-discriminant analysis（PLS-DA） of fingerprint of the standard decoction were performed to screen the differential components with variable importance in the projection（VIP） value>1. Quantitative analysis was carried out on the screened known differential components， and combined with the indicators of the dry extract rate and the transfer rate， to explore the differences in the quantity-quality transfer between the standard decoction of GRR decoction pieces produced by fresh and traditional cutting. ResultThe fingerprint similarity of the standard decoction of GRR decoction pieces produced by fresh and traditional cutting was more than 0.950， and 18 common peaks were identified， including 9 identified common peaks. The results of PCA and PLS-DA showed that there were some differences in the contents of index components between the two standard decoctions. The contents of ginsenoside Rg1， Re and Ro in GRR decoction pieces produced by fresh cutting were higher than those in traditional decoction pieces， while the contents of ginsenoside Rb1， Rc ， Rb2 and Rd were lower than those in traditional decoction pieces. The contents of ginsenoside Rg1， Re， Rb1 and Ro in the standard decoction of GRR decoction pieces produced by fresh cutting were higher than those in the standard decoction of traditional decoction pieces， while the contents of ginsenoside Rc ， Rb2 and Rd were comparable between the two standard decoctions. Compared with the standard decoction of the traditional decoction pieces， the average transfer rates of ginsenoside Rg1， Rb1， Rc， Rb2 and dry extract rate of the standard decoction of GRR decoction pieces produced by fresh cutting were significantly increased（P<0.05）， and the average transfer rate of ginsenoside Re and Rd also increased， but the difference was not statistically significant. ConclusionThe dry extract rate， content and transfer rate of index components of standard decoction of GRR decoction pieces produced by fresh cutting are better than those of the standard decoction of traditional decoction pieces， which can provides data support for the subsequent clinical application of fresh cutting products.

Clinical Efficacy of TCM Multi-channel Intervention Plus Antagonist Regimen on Ovarian Function，TCM Syndromes and Natural Conception in Poor Ovarian Responders Undergoing IVF-ET / 中国实验方剂学杂志

ObjectiveTo objectively analyze the effects of traditional Chinese Medicine （TCM） multi-channel intervention on the ovarian function，TCM syndromes and natural conception of poor ovarian responders（kidney-Yin deficiency，liver depression and blood stasis pattern） who planned to receive another in vitro fertilization embryo transfer（IVF-ET）antagonist regimen. MethodThe 128 low-prognosis patients （kidney Yin deficiency，liver depression and blood stasis pattern） who attended the West China Second University Hospital， Sichuan University and the Hospital of Chengdu University of Traditional Chinese Medicine from August 2020 to February 2023 and met the inclusion criteria were selected，and then divided into the treatment group and the control group according to the random number table，with 64 patients in each group. The control group was treated with oral dehydroepiandrosterone（DHEA），while the treatment group was treated with multi-channel TCM（oral TCM decoction + auricular point sticking + Bushen Huoxue prescription through retention enema）. After 3 menstrual cycles，the relevant indicators for ovarian function evaluation，TCM syndrome scores and natural conception were collected from both groups. ResultCompared with the situation before treatment，the basal follicle stimulating hormone（bFSH），bFSH/basal luteinizing hormone（bLH），basal estradiol（bE2），antral follicle count（AFC），the number of oocytes obtained，the number of normal fertilization，the number of superior embryos and TCM syndrome scores in the treatment group were improved after treatment（P<0.05，P<0.01）. For the control group， the bFSH/bLH and TCM syndrome scores were increased after treatment（P<0.05）， while the bFSH，bFSH/bLH，bE2，AFC，the number of oocytes obtained，the number of normal fertilization，and the number of superior embryos showed no significant difference after treatment. Compared with the control group after treatment，bFSH，bFSH/bLH，bE2，AFC，the number of normal fertilization，the number of superior embryos and TCM syndrome scores in the treatment group were better （P<0.05，P<0.01），while there was no significant difference in the number of oocytes obtained. After treatment，there were 3 cases of natural conception in the treatment group，while there were no natural conception in the control group. ConclusionFor patients with poor ovarian response and kidney Yin deficiency，liver depression and blood stasis pattern，multi-channel intervention of TCM plus the antagonist regimen can reduce bFSH，bFSH/bLH values，improve the levels of bE2，increase AFC，the number of oocytes obtained，the number of normal fertilization and the number of superior embryos，improve ovarian function，menstruation and TCM syndromes，improve their quality of life，and even enable some patients to get pregnant naturally before re-progression and improve their pregnancy outcome.

Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application

Aldehyde oxidase (AOX) is a molybdoenzyme that is primarily expressed in the liver and is involved in the metabolism of drugs and other xenobiotics. AOX-mediated metabolism can result in unexpected outcomes, such as the production of toxic metabolites and high metabolic clearance, which can lead to the clinical failure of novel therapeutic agents. Computational models can assist medicinal chemists in rapidly evaluating the AOX metabolic risk of compounds during the early phases of drug discovery and provide valuable clues for manipulating AOX-mediated metabolism liability. In this study, we developed a novel graph neural network called AOMP for predicting AOX-mediated metabolism. AOMP integrated the tasks of metabolic substrate/non-substrate classification and metabolic site prediction, while utilizing transfer learning from 13C nuclear magnetic resonance data to enhance its performance on both tasks. AOMP significantly outperformed the benchmark methods in both cross-validation and external testing. Using AOMP, we systematically assessed the AOX-mediated metabolism of common fragments in kinase inhibitors and successfully identified four new scaffolds with AOX metabolism liability, which were validated through in vitro experiments. Furthermore, for the convenience of the community, we established the first online service for AOX metabolism prediction based on AOMP, which is freely available at https://aomp.alphama.com.cn.

Transferência de tecnologia para vacina contra COVID-19 no Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz / Transferencia de tecnología para vacuna contra la COVID-19 en el Instituto de Tecnología en Inmunobiológicos (Bio-Manguinhos), Fundación Oswaldo Cruz / Technology transfer for COVID-19 vaccine in the Institute of Technology in Immunobiologicals (Bio-Manguinhos), Oswaldo Cruz Foundation

Resumo: A inovação é um elemento fundamental para o desenvolvimento e crescimento, mas constituída por um processo demorado de acúmulo de conhecimento. Uma das formas de acelerar tal processo é por meio da transferência de tecnologia. Este artigo mapeou as particularidades da transferência de tecnologia para a vacina contra COVID-19, celebrado entre a AstraZeneca e o Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz, bem como reconheceu os seus facilitadores, seus entraves e suas lacunas. Para tanto, foi realizada uma análise desde a etapa da seleção do parceiro mais adequado até a incorporação da nova tecnologia. A metodologia utilizada se baseou em uma ampla revisão bibliográfica sobre o tema, aliada ao estudo de caso. Os resultados apontaram que, apesar de muitas ações ainda precisarem ser realizadas para que os ganhos de capacidade tecnológica sejam potencializados, as lições aprendidas com o processo de transferência de tecnologia servirão de aprendizado e serão utilizadas nos acordos futuros e em andamento.

Resumen: La innovación es un elemento fundamental para el desarrollo y el crecimiento, pero consiste en un proceso de acumulación de conocimiento que requiere mucho tiempo. Una de las formas de acelerar este proceso es mediante la transferencia de tecnología. Este artículo mapeó las particularidades del proceso de transferencia de tecnología para la vacuna contra la COVID-19, celebrado entre AstraZeneca y el Instituto de Tecnología en Inmunobiológicos (Bio-Manguinhos), Fundación Oswaldo Cruz, además de reconocer los facilitadores, obstáculos y brechas. Para ello se realizó un análisis, desde la etapa de selección del socio más adecuado hasta la incorporación de la nueva tecnología. La metodología utilizada se basó en una amplia revisión bibliográfica sobre el tema, combinada con el estudio de caso. Los resultados mostraron que, si bien aún es necesario llevar a cabo muchas acciones para maximizar las ganancias de capacidad tecnológica, las lecciones aprendidas del proceso de transferencia de tecnología servirán como lecciones y se utilizarán en acuerdos futuros y en curso.

Abstract: Innovation is an essential element for development and growth, but it consists of a long process of knowledge accumulation, so technology transfer is used to accelerate this process. This study mapped the particularities of the technology transfer process for the COVID-19 vaccine between AstraZeneca and the Institute of Technology in Immunobiologicals (Bio-Manguinhos), Oswaldo Cruz Foundation, and identified enablers, obstacles, and gaps. Our analysis investigated the process from selection of the most suitable partner to incorporation of the new technology based on a comprehensive literature review on this topic, combined with a case study. The results showed that, although many actions still have to be performed to maximize technology capacity gains, the lessons learned from the technology transfer process will be used in future and ongoing agreements.

Sistema de acciones de orientación educativa para la familia de niño con discapacidad físico-motora

Fundamento: la orientación educativa a las familias de niños con discapacidad físico-motora es esencial para su correcta rehabilitación e inserción en la sociedad. Objetivo: aplicar un sistema de acciones de orientación educativa a la familia de un niño con discapacidad físico-motora. Métodos: se realizó un estudio cualitativo de investigación acción práctica a la familia de un niño con diagnóstico de una parálisis cerebral percibida como una discapacidad físico-motora en el período julio 2021-diciembre 2022, perteneciente al área de salud del Policlínico Docente "Marta Abreu". Los métodos teóricos utilizados fueron: analítico-sintético; inductivo-deductivo y la modelación. Entre los métodos empíricos se aplicaron: la observación participante; entrevista en profundidad; análisis de documentos; diario del investigador y estudio de casos. Resultados: el diagnóstico realizado demostró la necesidad de la preparación de la familia de un niño con discapacidad fisico-motora para afrontar con calidad esta nueva etapa de sus vidas, por lo que se diseñó y aplicó un sistema de acciones el cual fue estructurado en tres subsistemas: primero, acciones para el manejo de las técnicas de aseo; segundo, para las técnicas de alimentación; y tercero, los cuidados posturales y las transferencias. Fue valorado por especialistas vinculados con esta temática, quienes lo consideraron muy pertinente y viable. Conclusiones: el sistema de acciones de orientación a las familias de niños con discapacidad fisico-motora resultó efectivo pues se evidenciaron cambios importantes en cuanto al manejo de este niño por la familia.

Background: educational guidance for families of children with physical-motor disabilities is essential for their correct rehabilitation and insertion into society. Objective: apply a system of educational guidance actions to the family of a child with physical-motor disability. Methods: a qualitative practical action research study was carried out on the family of a child with a diagnosis of cerebral palsy perceived as a physical-motor disability from July 2021 to December 2022, from "Marta Abreu" University Polyclinic health area theoretical methods used were: analytical-synthetic; inductive-deductive and modeling: empirical ones: participant observation; depth interview; document analysis; researcher diary and case study. Results: the diagnosis carried out demonstrated the need to prepare the family of the child with a physical-motor disability to face this new stage of their lives with quality, so a system of actions was designed and applied which was structured in three subsystems: first, actions to manage grooming techniques; second, for feeding techniques; and third, postural care and transfers. It was evaluated by specialists linked to this topic, who considered it very pertinent and viable. Conclusions: the system of guidance actions for the family of a child with a physical-motor disability was effective as important changes were evident in terms of the management of this child by the family.

A randomized clinical trial of transdermal (gel) versus oral estrogen for endometrial preparation in frozen embryo transfer cycle

SUMMARY OBJECTIVE: The aim of this study was to compare endometrial thickness with the use of transdermal estrogen (gel) versus oral estrogen (pills) for endometrial preparation in the frozen embryo transfer cycle and serum estrogen concentrations during the preparation cycle, side effects, and chemical and clinical pregnancy rates. METHODS: This was a prospective, randomized controlled trial of women undergoing endometrial preparation for cryopreserved blastocyst transfer. A total of 88 women were randomized, of which 82 completed the study protocol. Of this group, 44 received 6 mg/day of estradiol valerate orally (pills group) and 38 received 4.5 mg/day of estradiol hemihydrate transdermally (gel group). Endometrial thickness was measured using transvaginal ultrasound between the 7 and 10th day of the cycle. Serum estradiol concentrations were measured on the day of initiating the cycle, on control transvaginal ultrasounds, and on the day of embryo transfer. Side effects were documented at each study visit. p<0.05 were adopted as statistically significant. The groups were compared using Student's t-test for continuous variables and chi-square or Fisher's exact test for categorical variables. RESULTS: There were no significant group differences (p>0.05) in endometrial thickness, biochemical and clinical pregnancy rates, miscarriage rate, blood estradiol concentrations, duration of estradiol administration, or cycle cancellation rates. CONCLUSION: Endometrial preparation with transdermal estrogen yielded similar reproductive outcomes to oral estrogen with fewer side effects.

Repercussions of moving patients on the context of practice: perspectives of the nursing team / Repercusiones de la movilización de pacientes sobre el contexto de práctica: perspectivas del equipo de enfermería / Repercussões da movimentação de pacientes sobre o contexto de prática: perspectivas da equipe de enfermagem

Objective: to examine the nursing team's view of the repercussions of moving patients (admissions, transfers and discharges) on the organization of work and the delivery of care. Method: this is a qualitative study using the focus group technique, conducted with 23 professionals - 12 nurses, eight nurse technicians and three nurse assistants working in three inpatient units at a teaching hospital in the countryside of Sao Paulo. Four meetings took place between November 2021 and March 2022. The reports were analyzed thematically using MAXQDA software. Results: two thematic categories emerged: the influence of structural factors and work organization on the intra-hospital moving of patients; it demands time, generates work overload and interferes with the delivery of care. Conclusion: the volume of moving patient associated with unforeseen demands, care complexity and insufficient staff and resources have a negative impact on the delivery of care, with clinical risks and work overload. The findings make it possible to improve the regulation of patients entering and leaving the units, work organization and care management, avoiding clinical risks, delays, omissions and work overload.

Objetivo: examinar la perspectiva del equipo de enfermería sobre las repercusiones del movimiento de pacientes (admisiones, traslados y altas) en la organización del trabajo y en la prestación de cuidados. Método: estudio cualitativo utilizando la técnica de grupo focal llevado a cabo con 23 profesionales, incluyendo 12 enfermeros, ocho técnicos y tres auxiliares de enfermería de tres unidades de internación de un hospital universitario del interior de São Paulo. Se realizaron cuatro encuentros entre noviembre de 2021 y marzo de 2022. Los relatos fueron analizados en la modalidad temática con la ayuda del software MAXQDA. Resultados: surgieron dos categorías temáticas: la influencia de factores estructurales y de la organización del trabajo en el movimiento intrahospitalario de pacientes; y, el movimiento de pacientes demanda tiempo, genera sobrecarga de trabajo e interfiere en la prestación de cuidados. Conclusión: el volumen de movimientos de pacientes asociado a demandas imprevistas, complejidad asistencial e insuficiencia de personal y de recursos repercute negativamente en la prestación del cuidado con riesgos clínicos y sobrecarga laboral. Los hallazgos permiten mejorar la regulación de las entradas y salidas de pacientes en las unidades, la organización del trabajo y la gestión del cuidado, evitando riesgos clínicos, retrasos, omisiones y sobrecarga laboral.

Objetivo: examinar o olhar da equipe de enfermagem quanto às repercussões da movimentação de pacientes (admissões, transferências e altas) na organização do trabalho e na entrega do cuidado. Método: estudo qualitativo utilizando técnica de grupo focal conduzido junto a vinte e três profissionais sendo doze enfermeiros, oito técnicos e três auxiliares de enfermagem lotados em três unidades de internação de um hospital de ensino do interior de São Paulo. Ocorreram quatro encontros, entre novembro de 2021 e março de 2022. Os relatos foram analisados na modalidade temática com o auxílio do software MAXQDA. Resultados: emergiram duas categorias temáticas: a influência de fatores estruturais e da organização do trabalho na movimentação intra-hospitalar de pacientes; e a movimentação de pacientes demanda tempo, gera sobrecarga de trabalho e interfere na entrega do cuidado. Conclusão: o volume de movimentações de pacientes associado às demandas imprevistas, complexidade assistencial e insuficiência de pessoal e de recursos repercutem negativamente na entrega do cuidar com riscos clínicos e sobrecarga laboral. Os achados possibilitam aprimorar a regulação das entradas e saídas de pacientes nas unidades, organização do trabalho e gestão do cuidado evitando-se riscos clínicos, atrasos, omissões e sobrecarga laboral.

Transição de cuidado de pacientes internados por COVID-19 e sua relação com as características clínicas / Transición de cuidado de pacientes internados por COVID-19 y su relación con las características clínicas / Care transition for patients admitted to hospital due to COVID-19 and its relationship with clinical characteristics

Resumo Objetivo Analisar a transição do cuidado (TC), e sua relação com as características clínicas de pacientes internados por COVID-19. Métodos Estudo transversal, realizado em um hospital geral, com 165 pacientes hospitalizados em decorrência da COVID-19 e que receberam alta para o domicílio. Participaram aqueles que estiveram internados por pelo menos 24hs, maiores de 18 anos, com acesso telefônico após a alta. Excluídos aqueles que receberam alta por transferência, que evoluíram a óbito ou aqueles sem condições cognitivas. Dados coletados entre março a julho de 2021, por meio de questionário sociodemográfico e clínico, bem como o Care Transitions Measure-15. Aplicou-se análise estatística descritiva e inferencial. Resultados A média geral do Care Transitions Measure-15 foi considerada satisfatória (71,8±7,45). O fator Preferências Asseguradas obteve maior média (80,5± 9,84) e o fator Plano de Cuidados a menor (57,5± 11,4). Foram encontradas diferenças estatísticas significativas quando se associou os fatores do CTM-15 com as variáveis clínicas tempo de doença crônica (p<0,03), presença de artefato clínico (p<0,040), uso de medicação contínua (p<0,029) e a reinternação teve diferença significativa nos fatores Preparação para o Autogerenciamento (p<0,045), Preferências Asseguradas (p<0,027) e Plano de Cuidados (p<0,032). Conclusão Os pacientes hospitalizados por COVID-19 avaliaram a TC geral como satisfatória e as variáveis clínicas tempo de doença crônica, artefato clínico, medicação contínua e reinternação interferiram na TC desses pacientes.

Resumen Objetivo Analizar la transición del cuidado (TC) y su relación con las características clínicas de pacientes internados por COVID-19. Métodos Estudio transversal, realizado en un hospital general, con 165 pacientes hospitalizados como consecuencia de COVID-19, que fueron dados de alta para volver a su domicilio. Participaron aquellas personas que estuvieron internadas por lo menos 24 horas, mayores de 18 años, con acceso telefónico después del alta. Se excluyeron aquellas que fueron dadas de alta por transferencia, que fallecieron o que no tenían condiciones cognitivas. Los datos fueron recopilados entre marzo y julio de 2021, mediante cuestionario sociodemográfico y clínico, así como también el Care Transitions Measure-15. Se aplicó análisis estadístico descriptivo e inferencial. Resultados El promedio general del Care Transitions Measure-15 fue considerado satisfactorio (71,8±7,45). El factor Preferencias Aseguradas obtuvo el mayor promedio (80,5± 9,84) y el factor Plan de Cuidados, el menor (57,5± 11,4). Se encontraron diferencias estadísticas significativas cuando se asociaron los factores del CTM-15 con las variables clínicas tiempo de enfermedad crónica (p<0,03), presencia de artefacto clínico (p<0,040), uso de medicación continua (p<0,029). La reinternación tuvo una diferencia significativa en los factores Preparación para la Autogestión (p<0,045), Preferencias Aseguradas (p<0,027) y Plan de Cuidados (p<0,032). Conclusión Los pacientes hospitalizados por COVID-19 evaluaron la TC general como satisfactoria. Las variables clínicas tiempo de enfermedad crónica, artefacto clínico, medicación continua y reinternación interfirieron en la TC de estos pacientes.

Abstract Objective To analyze care transition (CT) and its relationship with the clinical characteristics of patients admitted to hospital due to COVID-19. Methods This is a cross-sectional study, carried out in a general hospital, with 165 patients admitted to hospital due to COVID-19 and who were discharged home. Participants were those who had been admitted to hospital for at least 24 hours, over 18 years of age, with telephone access after discharge. Those who were discharged by transfer, who died or those without cognitive conditions were excluded. Data collected between March and July 2021, using a sociodemographic and clinical questionnaire as well as Care Transitions Measure-15. Descriptive and inferential statistical analysis was applied. Results The overall mean of Care Transitions Measure-15 was considered satisfactory (71.8±7.45). The Important preferences factor obtained the highest mean (80.5± 9.84) and the Care Plan factor the lowest (57.5± 11.4). Significant statistical differences were found when the CTM-15 factors were associated with the clinical variables: duration of chronic disease (p<0.03); presence of clinical artifact (p<0.040); use of continuous medication (p<0.029). Readmission had a significant difference in the factors Health management preparation (p<0.045), Important preferences (p<0.027) and Care plan (p<0.032). Conclusion Patients admitted to hospital due to COVID-19 assessed the general CT as satisfactory and the clinical variables, length of chronic illness, clinical artifact, continuous medication and readmission interfered in the CT of these patients.

Calidad de atención interhospitalaria: Revisión sistemática / Quality of interhospital care: Systematic review / Qualidade do atendimento inter-hospitalar: revisão sistemática

En la actualidad la calidad de atención durante los traslados interhospitalarios de pacientes es una tarea compleja, que desafía la capacidad del personal de salud para mantener un ambiente de cuidado alrededor de estos pacientes. Objetivo. Analizar la calidad de atención interhospitalaria. Metodología. Se realizó una revisión sistemática y se evalúa la calidad de atención interhospitalaria. En la búsqueda de información se utilizaron términos DeCS y operadores boleanos con algoritmos (calidad de atención) AND (Interhospitalaria); (Care quality) AND (Interhospital). Considerando estudios de 2017-2023, en bases de datos como PubMed se obtuvieron 48 artículos, PLoS one 5 artículos, Science Direct 11, Scielo 33 artículos, Sage Journals 6, Elsevier 7, Springer Link 5 artículos. De los 131 artículos en total, se eliminaron 70 en base a resúmenes incompletos y se excluyeron 34 artículos que no tenían información completa; obteniendo 17 artículos para realizar la extracción y el análisis de los datos. Conclusión. Existen estrategias para una adecuada atención interhospitalaria, tales como: oxigenación por membrana extracorpórea como una opción para transportar de forma segura a los pacientes con Síndrome de distrés respiratorio agudo grave, es fundamental garantizar medidas de higiene y el suministro de equipos de protección personal para prevenir propagación de enfermedades; asegurar adecuada comunicación e intercambio de información, a través de medios virtuales, tanto para los familiares y personal; es esencial tener un plan general para prevenir cualquier evento impredecible y agudo, mejoran la eficiencia de la prestación de atención médica, lo que finalmente se traduce en mejores resultados para los pacientes.

Currently, the quality of care during interhospital transfers of patients is a complex task, which challenges the ability of health care personnel to maintain a caring environment around these patients. Objective. To analyze the quality of interhospital care. Methodology. A systematic review was carried out and the quality of interhospital care was evaluated. DeCS terms and Boolean operators with algorithms (Care quality) AND (Interhospital); (Care quality) AND (Interhospital) were used in the information search. Considering studies from 2017-2023, in databases such as PubMed 48 articles were obtained, PLoS one 5 articles, Science Direct 11, Scielo 33 articles, Sage Journals 6, Elsevier 7, Springer Link 5 articles. Of the 131 articles in total, 70 were eliminated based on incomplete abstracts and 34 articles that did not have complete information were excluded; obtaining 17 articles to perform data extraction and analysis. Conclusion. There are strategies for adequate interhospital care, such as: extracorporeal membrane oxygenation as an option to safely transport patients with Severe Acute Respiratory Distress Syndrome, it is essential to ensure hygiene measures and the provision of personal protective equipment to prevent the spread of disease; ensure adequate communication and exchange of information, through virtual means, both for family members and staff; it is essential to have a general plan to prevent any unpredictable and acute event, improve the efficiency of health care delivery, which ultimately translates into better outcomes for patients.

A qualidade do atendimento durante as transferências inter-hospitalares de pacientes é atualmente uma tarefa complexa, que desafia a capacidade da equipe de saúde de manter um ambiente de cuidado em torno desses pacientes. Objetivo. Analisar a qualidade do atendimento interhospitalar. Metodologia. Realizamos uma revisão sistemática e avaliamos a qualidade do atendimento inter-hospitalar. Na busca de informações, foram utilizados termos do DeCS e operadores booleanos com algoritmos (Care quality) AND (Interhospital); (Care quality) AND (Interhospital). Considerando estudos de 2017 a 2023, foram obtidos 48 artigos em bancos de dados como PubMed, 5 artigos em PLoS one, 11 artigos em Science Direct, 33 artigos em Scielo, 6 artigos em Sage Journals, 7 artigos em Elsevier e 5 artigos em Springer Link. Do total de 131 artigos, 70 artigos foram eliminados com base em resumos incompletos e 34 artigos foram excluídos por não terem informações completas, obtendo-se 17 artigos para extração e análise de dados. Conclusões. Existem estratégias para o atendimento inter-hospitalar adequado, tais como oxigenação por membrana extracorpórea como uma opção para o transporte seguro de pacientes com síndrome da angústia respiratória aguda grave; garantia de medidas de higiene e fornecimento de equipamentos de proteção individual para evitar a propagação de doenças; garantia de comunicação e troca de informações adequadas, por meios virtuais, tanto para os familiares quanto para a equipe; ter um plano geral para evitar qualquer evento imprevisível e agudo é essencial para melhorar a eficiência da prestação de serviços de saúde, o que, em última análise, se traduz em melhores resultados para os pacientes.

Percepção do enfermeiro que atua no samu sobre a transferência de cuidado de pacientes / Perception of nurses working in SAMU regarding the transfer of patient care

Objetivo: compreender a percepção do enfermeiro que atua no serviço deatendimento móvel de urgência sobre a transferência de cuidados de pacientes no seu cotidiano de trabalho. Método: pesquisa de campo de natureza qualitativa. Resultados: após as análises das entrevistas emergiram as categorias: Concepção de transferência de cuidados pelos enfermeiros do atendimento pré-hospitalar; O processo de comunicação envolvido na transferência de cuidados no atendimento pré-hospitalar; A visão dos enfermeiros sobre trabalho em equipe na transferência de cuidados no atendimento pré-hospitalar; Avanços e desafios na transferência de cuidados no atendimento pré-hospitalar. Conclusão: A transferência de cuidados, compreendida pelos participantes é percebida nas condutas: trabalho em equipe, comunicação efetiva e cuidado centrado na pessoa. Os entrevistados apresentaram que a troca de informações entre os profissionais do serviço é um momento essencial para a transferência de cuidados para garantir a qualidade e a continuidade da assistência.(AU)

The aim of this study was to understand the perception of nurses working in the mobile emergency care service about the transfer of patient care in their day-to-day work. Method: qualitative field research. Results: After analyzing the interviews, the following categories emerged: Pre-hospital care nurses' concept of transfer of care; The communication process involved in the transfer of care in pre-hospital care; Nurses' view of teamwork in the transfer of care in pre-hospital care; Advances and challenges in the transfer of care in pre-hospital care. Conclusion: The transfer of care, as understood by the participants, is seen in the following behaviors: teamwork, effective communication and person-centered care. The interviewees felt that the exchange of information between service professionals is essential for the transfer of care in order to guarantee the quality and continuity of care. (AU)

El objetivo de este estudio fue conocer la percepción de las enfermeras que trabajan en el servicio móvil de atención de urgências de urgencias móviles sobre la transferencia de cuidados a los pacientes en su trabajo diario. Método: investigación cualitativa de campo. Resultados: Tras el análisis de las entrevistas, surgieron las siguientes categorías: Concepto de los enfermeros de atención prehospitalaria sobre la transferencia de cuidados; Proceso de comunicación implicado en la transferencia de cuidados en la atención prehospitalaria; Visión de los enfermeros sobre el trabajo en equipo en la transferencia de cuidados en la atención prehospitalaria; Avances y retos en la transferencia de cuidados en la atención prehospitalaria. Conclusión: La transferencia de cuidados, tal como la entienden los participantes, se manifiesta en los siguientes comportamientos: trabajo en equipo, comunicación eficaz y cuidados centrados en la persona. Los entrevistados afirmaron que el intercambio de información entre los profesionales del servicio es un momento esencial para que la transferencia de cuidados garantice la calidad y la continuidad de la atención.(AU)

Supervivencia de injerto graso en la lipotransferencia glútea / Survival of fat graft in gluteal lipotransfer

Introducción: El aumento de glúteos tiene como objetivo lograr una apariencia y contorno más joven; así como crear la proporción ideal entre cintura y cadera. Esto se puede lograr mediante la lipoinyección, aunque en este caso existen controversias en cuanto a la viabilidad del tejido injertado y la supervivencia de la grasa. Objetivo: Determinar el porcentaje de supervivencia del injerto de grasa autóloga y su relación con el volumen inyectado en pacientes sometidas a lipotransferencia glútea. Métodos: Se realizó un estudio observacional, descriptivo, de corte longitudinal y prospectivo con una muestra de 44 pacientes sometidas a lipotransferencia glútea en el Servicio de Cirugía Plástica del Hospital Docente Clínico Quirúrgico Dr. Miguel Enríquez en el período comprendido entre marzo de 2018 y junio de 2021. Resultados: El estudio evidencia que, mediante ultrasonido y fórmulas, el volumen promedio y la altura de la de grasa en los glúteos se duplica en el posoperatorio mediato y disminuye en el posoperatorio tardío sin llegar a los valores del preoperatorio. Además, se estableció que cerca de la media del volumen de grasa autóloga injertada en los glúteos sobrevive de manera definitiva en el posoperatorio tardío. Además, quedó establecido que la relación entre el volumen infiltrado y la supervivencia del injerto de grasa autóloga es inversamente proporcional: mientras mayor es el volumen, menor es su supervivencia. Conclusiones: Solo la mitad del volumen de grasa autóloga injertada en los glúteos sobrevive de manera definitiva, y la supervivencia de la grasa es inversamente proporcional al volumen infiltrado(AU)

Introduction: Buttock augmentation aims to achieve a more youthful appearance and contour; as well as creating the ideal proportion between waist and hips. This can be achieved by lipoinjection, although in this case there are controversies regarding the viability of the injected tissue and the survival of the fat. Objective: To determine the percentage of autologous fat graft survival and its relationship with the injected volume in patients undergoing gluteal fat transfer. Methods: An observational, descriptive, longitudinal and prospective study was carried out, with a sample of 44 patients undergoing gluteal lipotransfer, in the plastic surgery service of the Dr. Miguel Enriquez Clinical Surgical Teaching Hospital, in the intermediate period between March 2018 to June 2021. Results: The study shows that through ultrasound and formulas, the average volume and height of fat in the buttocks doubles in the immediate postoperative period, decreasing in the late postoperative period, without reaching preoperative values. Furthermore, it's established that about the mean volume of autologous fat grafted to the buttocks survives definitively in the late postoperative period. In addition, it was established that the relationship between the infiltrated volume and the survival of the autologous fat graft is inversely proportional, the greater the volume, the less its survival. Conclusions: Only half of the volume of autologous fat injected into the buttocks survives definitively, and the survival of the fat is inversely proportional to the volume injected(AU)

Traslado no programado de pacientes pediátricos desde una sala de internación general a una unidad de cuidados intensivos / Unplanned transfer of pediatric patients from the general ward to the intensive care unit

Introducción. Durante la internación, los pacientes pueden presentar un deterioro clínico significativo y requerir el ingreso no programado a la unidad de cuidados intensivos pediátricos (UCIP). Esto puede conllevar un aumento de la morbilidad y la mortalidad. Frecuentemente, estos eventos están precedidos por una fase de deterioro que podría pasar desapercibida. Objetivo. Determinar la frecuencia, analizar las causas, describir las características clínicas y los resultados de los traslados no programados en pacientes pediátricos hospitalizados, desde el área de internación general pediátrica (IGP) a la UCIP, y analizar las diferencias entre traslados urgentes y emergentes. Población y métodos. Estudio descriptivo prospectivo; se analizaron todos los traslados no programados desde IGP a la UCIP ocurridos entre el 1 de enero de 2014 y el 31 de diciembre 2019. Resultados. Se constataron 212 traslados no programados (21 traslados cada 1000 ingresos). El 76 % de los pacientes trasladados presentaban una comorbilidad asociada ­la más frecuente fue la patología oncológica (36 %)­ y llevaban más de 24 horas internados en IGP. Las causas más frecuentes de traslado fueron dificultad respiratoria (43 %), sepsis (20 %) y complicaciones neurológicas/neuroquirúrgicas (20 %). La tasa de mortalidad global fue del 8,96 % (19 pacientes). Conclusiones. El análisis de los traslados no programados es un elemento esencial en la evaluación de la calidad de atención y seguridad del paciente de un área, y debe constituir un indicador integrado al tablero de control. La interpretación de los traslados no programados como un evento prevenible constituye un cambio de paradigma clave.

Introduction. During hospitalization, patients may develop significant clinical deterioration and require unplanned admission to the pediatric intensive care unit (PICU). This may result in increased morbidity and mortality. These events are often preceded by a deterioration phase that may go unnoticed. Objective. To determine the frequency, analyze the causes, and describe the clinical characteristics and outcomes of unplanned transfers of hospitalized pediatric patients from the general pediatric ward (GPW) to the PICU, and analyze the differences between urgent and emergent transfers. Population and methods. Prospective, descriptive study; all unplanned transfers from the GPW to the PICU occurring between January 1st, 2014 and December 31st, 2019 were analyzed. Results. There were 212 unplanned transfers (21 transfers per 1000 admissions). An associated comorbidity was present in 76% of transferred patients ­being cancer the most frequent one (36%)­ and they had been hospitalized for more than 24 hours in the GPW. The most frequent causes of transfer were respiratory distress (43%), sepsis (20%), and neurological/neurosurgical complications (20%). The overall mortality rate was 8.96% (19 patients). Conclusions. The analysis of unplanned transfers is a critical component in the assessment of the quality of care and patient safety of an area, and should be an indicator integrated into the control panel. The interpretation of unplanned transfers as a preventable event is a key paradigm shift.

Rotura del extensor pollicis longus en paciente pediátrico: reporte de caso y revisión de la literatura / Extensor pollicis longus rupture in a pediatric patient: case report and a literature review

Resumen: Introducción: la rotura del tendón extensor pollicis longus (EPL) constituye una patología infrecuente y se presenta normalmente en mujeres adultas en relación con fracturas de radio distal. Material y métodos: se presenta el caso de una paciente adolescente femenino que, tras tratamiento conservador con férula de una fractura fisaria Peterson tipo I en radio, sufre a las seis semanas déficit agudo de extensión del pulgar, diagnosticada mediante examen clínico radiológico de rotura espontánea del extensor pollicis longus. Es tratada por medio de transferencia del extensor propio del índice (EPI) con resultados satisfactorios y recuperación de su actividad habitual al mes postoperatorio. Conclusión: este tipo de lesiones son poco frecuentes en edad pediátrica y casi nunca descritas en un paciente pediátrico con inmadurez esquelética, lo cual hace de este caso algo excepcional. Es necesario tener en cuenta este tipo de complicaciones en pacientes de baja edad aún sin otros factores de riesgo asociados. El tratamiento aplicado más frecuentemente, tanto en adultos como en niños, es la transferencia del extensor propio del índice con buenos resultados a largo plazo.

Abstract: Introduction: the rupture of the extensor pollicis longus (EPL) tendon is a rare pathology and usually occurs in adult women in relation to distal radius fractures. Material and methods: we present the case of an adolescent female patient who, after conservative treatment with splinting of a Peterson type I physeal fracture of the radius, suffered an acute extension deficit of the thumb at six weeks, diagnosed with clinical radiological examination as spontaneous rupture of the extensor pollicis longus (EPL). She was treated with extensor pollicis indicis propius (EIP) transfer with satisfactory results and recovering her usual activity one month after surgery. Conclusion: this kind of injuries are infrequent in pediatric ages and rarely described in a pediatric patient with immature skeleton, what makes this case something exceptional. It is necessary considering these complications in patients of low ages even with no other risk factors. The most frequent treatment applied in adults as in children is the EIP transference with good results in the long term.

Concepción teórica para favorecer la transferencia de la rapidez de movimientos técnicos en el lanzamiento del martillo

El presente artículo se realizó a partir de detectar insuficiencias teórico-metodológicas y prácticas en el proceso de preparación técnica del lanzador de martillo categoría escolar; por tal razón, se propuso como objetivo general elaborar una concepción teórica para favorecer el entrenamiento en la transferencia de la rapidez de movimientos técnicos de los giros al instante final del lanzamiento del martillo, en atletas categoría escolar de la Eide "Pedro Batista Fonseca" de la provincia de Granma. Para el logro del objetivo antes expuesto se emplearon métodos de la investigación científica como los teóricos, el análisis y síntesis, el hipotético-deductivo y el sistémico estructural funcional; dentro de los empíricos, el análisis de documentos, la observación y la medición y como método matemático-estadístico la estadística descriptiva, además, se utilizó como técnica de investigación la entrevista. La propuesta permitió la sistematización de aquellos elementos relacionados directamente con la transferencia en el deporte y el proceso de entrenamiento del lanzador de martillo; de tal manera se previó, con su aplicación, el perfeccionamiento técnico de los atletas implicados en la investigación, así como un incremento en su rendimiento y resultados deportivos.

O presente artigo foi realizado a partir da detecção de insuficiências teórico-metodológicas e práticas no processo de preparação técnica do arremessador de martelos da categoria escola; por esta razão, foi proposto como objetivo geral elaborar uma concepção teórica para favorecer o treinamento na transferência da velocidade dos movimentos técnicos das voltas para o instante final do arremesso do martelo, na categoria escola atletas do Eide "Pedro Batista Fonseca" da província de Granma. Para alcançar o objetivo acima mencionado, foram utilizados métodos de pesquisa científica, tais como métodos teóricos, de análise e síntese, hipotéticos-dedutivos e estruturais-funcionais sistêmicos; dentro dos métodos empíricos, análise de documentos, observação e medição, e estatística descritiva como método matemático-estatístico; além disso, a entrevista foi utilizada como técnica de pesquisa. A proposta permitiu a sistematização daqueles elementos diretamente relacionados com a transferência no esporte e o processo de treinamento do martelo lançador; de tal forma que, com sua aplicação, foi previsto o aperfeiçoamento técnico dos atletas envolvidos na pesquisa, bem como um aumento de seu desempenho e resultados esportivos.

The present article was carried out from the detection of theoretical-methodological and practical insufficiencies in the process of technical preparation of the school category hammer thrower; For this reason, it was proposed as a general objective to develop a theoretical conception to favor training in the transfer of the speed of technical movements of the turns to the final moment of the hammer throw, in school category athletes of the Eide" Pedro Batista Fonseca" of Granma province. To achieve the aforementioned objective, scientific research methods such as theoretical, analysis and synthesis, hypothetical-deductive and structural-functional systemic were used; within the empirical, the analysis of documents, observation and measurement and as a mathematical-statistical method descriptive statistics, in addition, the interview was used as a research technique. The proposal allowed the systematization of those elements directly related to the transfer in sport and the training process of the hammer thrower; In this way, with its application, the technical improvement of the athletes involved in the research was foreseen, as well as an increase in their performance and sports results.

Barriers and Solutions Pertaining to Pradhan Mantri Matru Vandana Yojana (PMMVY) Implementation in a Block of West Bengal: A Mixed-Methods Approach

Introduction: Improvement of maternal health care services will not only put a positive impact on maternal health, but also on the health of the new born. Objectives: This study was conducted to estimate the proportion of eligible beneficiaries who received the benefits provided by the scheme, to identify the barriers faced by the beneficiaries and health providers related to the scheme and to find possible solutions to overcome the barriers found as suggested by them in a block of West Bengal. Method: A cross-sectional study with sequential explanatory mixed-method approach was conducted in a block of West Bengal from January-December 2021. Quantitative data was collected from the digital portal of PMMVY. All beneficiaries who had their Last Menstrual Period (LMP) on and after 1st March 2020 up to 31st December 2020 were included. To identify the barriers faced and suggest possible solutions, Focused Group Discussions (FGDs) were held with the beneficiaries, ANMs and ASHAs and Key-Informant Interviews (KIIs) with the Block Medical Officer and Data Entry Operator. Data were analyzed using SPSS version 25.0. Descriptive statistics were used to summarize quantitative data while qualitative data were analyzed in the form of themes, codes and verbatim. Results: Total eligible beneficiaries for the three installments were 1066, 917 and 708 respectively. About 95.5% beneficiaries received the first installment, 93.0% received the second and 98.3% had received the third installment. The broad themes [codes] generated from the FGDs were challenges during antenatal care [ANC refused, home visit preferred, home ANC difficult, lockdown], challenges related to the PMMVY scheme [documents unavailable, incomplete forms, payment issues], possible solutions [prepare pre-requisites beforehand, provide cash]. Widely two main themes emerged from the KIIs: Form related issues and Payment issues. Conclusion: Coverage of PMMVY scheme in the block was satisfactory. However, speeding the payment process and stricter monitoring of the scheme is required

Spontaneous rupture of the extensor pollicis longus tendon after conservative treatment of a non-displaced distal radius fracture in an adolescent / Rotura espontánea del tendón del extensor largo del pulgar tras el tratamiento conservador de una fractura no desplazada del radio distal en un adolescente

Abstract: A spontaneous rupture of the extensor pollicis longus (EPL) tendon after a fracture of the distal radius is a known complication in adults. In contrast, there are a paucity of reports concerning EPL tendon ruptures in children and adolescents. The authors present a case of a spontaneous rupture of the EPL tendon in a 15-year-old girl after a non-displaced distal radius fracture. The patient had no predisposing factors including rheumatoid arthritis or steroid injection. During surgery, the EPL tendon was found to be ruptured at the extensor retinaculum (third compartment). Extensor indicis proprius (EIP) to EPL transfer was performed. At the 18-month follow-up, the patient was asymptomatic and showed satisfactory thumb function, with normal active extension.

Resumen: La rotura espontánea del tendón del extensor largo del pulgar (EPL) tras una fractura distal del radio es una complicación conocida en adultos. En cambio, son escasos los informes sobre roturas del tendón del EPL en niños y adolescentes. Los autores presentan un caso de rotura espontánea del tendón del EPL en una niña de 15 años tras una fractura distal del radio no desplazada. La paciente no presentaba factores predisponentes como artritis reumatoide o inyección de esteroides. Durante la intervención quirúrgica, se descubrió que el tendón del EPL estaba roto a la altura del retináculo extensor (tercer compartimento). Se realizó una transferencia del extensor indicis proprius (EIP) al EPL. A los 18 meses de seguimiento, el paciente estaba asintomático y mostraba una función satisfactoria del pulgar, con una extensión activa normal.

Política interministerial para la investigación, transferencia y fortalecimiento de la salud en territorio, una experiencia federal / Interministerial Policy for Research, Transfer and Strengthening of Health in the Territory, a Federal Experience

RESUMEN INTRODUCCIÓN: En marzo de 2023, en el marco del "Convenio Marco de Cooperación y Asistencia Técnica Mutua - MSAL/MINCYT", se creó el "Proyecto Federal Interministerial de Investigación, Transferencia y Fortalecimiento para la Salud en Territorio". El objetivo fue presentar un proceso de trabajo innovador entre dos ministerios, que sienta las bases para configurar un modelo de gestión de las políticas de investigación en salud con asiento federal y tendiente a potenciar las funciones y capacidades institucionales de cada sector. MÉTODOS: La coordinación del Proyecto se encuentra a cargo de un Comité Interministerial. En 2023 se realizó la Convocatoria para la presentación de un proyecto anual, que consta de dos componentes: A) Línea de investigación y transferencia; y B) Plan de fortalecimiento de las capacidades institucionales de las áreas de investigación de los ministerios de salud jurisdiccionales agrupadas en la Red Ministerial de Áreas de Investigación en Salud de Argentina. RESULTADOS: Las 24 jurisdicciones presentaron sus proyectos, y todos ellos resultaron aprobados. La estrategia tuvo un impacto en el fortalecimiento de los mecanismos de trabajo conjunto de dos ministerios nacionales, que debieron armonizar modalidades de gestión entre las áreas de investigación en salud y las representaciones de CyT en el ámbito jurisdiccional y entre los decisores en materia sanitaria y los actores del sistema científico. DISCUSIÓN: Esta experiencia contribuye a fortalecer las capacidades estatales, a la vez que permite identificar aspectos que requieren continuar siendo trabajados para consolidar nuevas modalidades de gestión interministeriales.

ABSTRACT INTRODUCTION: In March 2023, within the framework of the "Framework Agreement for Cooperation and Mutual Technical Assistance - MSAL/MINCYT", the "Federal Interministerial Project of Research, Transfer and Strengthening for Health in the Territory" was created. The objective was to present an innovative work process between the Ministry of Health (MSAL) and the Ministry of Science, Technology and Innovation (MINCYT), that lays the foundations for a management model of health research policies with a federal approach and aimed at enhancing the institutional functions and capacities of each sector. METHODS: The Project was coordinated by an Interministerial Committee. In 2023 there was a Call for the presentation of an annual project that consists of two components: A) Line of research and transfer; and B) Plan to strengthen the institutional capacities of the research areas of the jurisdictional health ministries grouped in REMINSA. RESULTS: The 24 jurisdictions presented their projects, and all of them were approved. The strategy strengthened the joint work mechanisms of two national ministries, that had to harmonize management patterns between health research areas and S&T representations at the jurisdictional level and between health decision-makers and the actors of the scientific system. DISCUSSION: This experience contributes to strengthening state capacities, while allowing to identify aspects that require continued work to reinforce new interministerial management patterns.