Research Progress in Reproductive Toxicity and Detoxification by Combined Use of Tripterygium wilfordill Hook / 中国中医药信息杂志

Tripterygium wilfordii Hook has the properties of rheumatism dispelling,promoting blood circulation, dredging collaterals, detumescence, pain relieving, anti-parasitism and detoxification. Its common medication forms include Tripterygium wilfordii Hook tablets, Tripterygium wilfordii Hook polygonal tablets, Kunming Shanhaitang tablets,Kunxian Capsules,Tripterygium wilfordii Hook bicolor and Tripterygium wilfordii Hook total terpene tablets. Reproductive toxicity in Tripterygium wilfordii Hook preparations is a side-effect that may deeply impact reproductive-age patients. The combination of single herb or compound can significantly reduce the reproductive toxicity of Tripterygium wilfordii Hook preparations.This article reviewed the recent research in this field and provide references for clinical medication.

Comparison of cell activity from different parts of Tripterygium wilfordill based on xCELLigence system / 中草药

Objective: To compare the bio-activities of different parts of Tripterygium wilfordii from different regions based on RTCA system with HPLC. Methods: Real-time xCELLigence analysis system was established to detect dynamically cellular activity at real-time: The seeding density was 2 × 105 cells/mL, the administration time was about 24 h, and the activity of RBL-2H3 cells from T. wilfordii was detected; The fingerprints of different parts of T. wilfordii were established by HPLC and the common peaks were analyzed. Results: The activity of T. wilfordii from Zhejiang was similar at the same site; The root barks and leaves of T. wilfordii had similar biological activity, and the roots and stems had similar activity; The biological activity for RBL-2H3 cells in root barks and buds was significantly higher than that in roots and stems, especially in the root barks, biological activity was the strongest; The fingerprints showed that the components of different parts were similar but the contents were largely different; The inhibitory rate of chloroform extract on RBL-2H3 cells was significantly higher than that of water extract. Conclusion: At the level of cell biology, the velamen of T. wilfordii and other aerial parts possess value of research and medication, which is deserved to further developed and utilized.