RÉSUMÉ
Xanthomas are localized lipid deposits within organs that may manifest as papules, plaques, or nodules in skin. They are commonly associated with all types of hyperlipidemia. Xanthoma striatum palmare characterized by xanthomas of the palmar creases is a rare but important diagnostic physical sign of dysbetalipoproteinemia, also known as type III hyperlipoproteinemia. Type III hyperlipoproteinemia is characterized by the early onset of cardiovascular disease and peripheral vascular disease. We describe herein the case of a 51-year-old female patient affected by xanthoma striatum palmare associated with elevated plasma levels of triglycerides and cholesterol and a lipoprotein electrophoresis pattern consistent with type III hyperlipoproteinemia.
Sujet(s)
Femelle , Humains , Adulte d'âge moyen , Maladies cardiovasculaires , Cholestérol , Électrophorèse , Hyperlipidémies , Hyperlipoprotéinémie de type III , Lipoprotéines , Maladies vasculaires périphériques , Plasma sanguin , Peau , Triglycéride , XanthomatoseRÉSUMÉ
A 61-year-old female patient presented with the type III hyperlipoproteinemia (HLP) in association with generalized eruptive and tuberous xanthomas. She had hypercholesterolemia and hypertriglyceridemia, and extensive coronary atherosclerosis. Further studies revealed a positive standing plasma test, abnormal beta-very low density lipoprotein (VLDL) on lipoprotein electrophoresis, markedly elevated very low density lipoprotein-cholesterol (VLDL-C) to plasma triglycerides (TG) ratio (0.86) and homozygosity for apolipoprotein E2. After about one year of therapy with lipid-lowering agents and diet restriction, a significant reduction of serum cholesterol and TG was observed and the yellowish orange discolorations of palmar creases disappeared from her palms.
Sujet(s)
Femelle , Humains , Adulte d'âge moyen , Apolipoprotéine E2 , Cholestérol , Citrus sinensis , Maladie des artères coronaires , Régime alimentaire , Électrophorèse , Hypercholestérolémie , Hyperlipoprotéinémie de type III , Hypertriglycéridémie , Lipoprotéines , Plasma sanguin , Triglycéride , XanthomatoseRÉSUMÉ
Generalized plane xanthoma is a group of plane xanthomas that appear as yellow to yellow-brown flat patches or slightly elevated plaques with a wide-spread distribution. The disease is frequently associated with multiple myeloma or other reticulo-endothelial malignancies and monoclonal gammopathy with unknown significance, and when accompanied by these hematologic malignancies, normolipoproteinemia is invariably associated. We present a case of generalized plane xanthoma associated with multiple myeloma and type III hyperlipoproteinemia in a 48 year-old woman, and this is the first report in Korean literature.