Propriedades psicométricas da escala de presença em tecnologias ubíquas / Psychometric properties of presence on ubiquitous technologies' scale / Propiedades psicométricas de la escala de presencia en tecnologías ubicuas

Este estudo teve como objetivo desenvolver uma escala de presença nas tecnologias ubíquas. O processo de desenvolvimento do instrumento teve como etapas 1) a escolha dos atributos comportamentais referentes ao objeto de estudo e à operacionalização do construto, 2) a apresentação a três juízes, dois grupos focais, 3) uma aplicação-piloto em uma amostra reduzida (n = 30) e, por fim, 4) uma aplicação com a 458 participantes. Foram realizadas análises de consistênciainterna, análise fatorial confirmatória e análise fatorial confirmatória multigrupo. A versão final da "Escala de Presença em Tecnologias Ubíquas (EPTU)" conta com 14 itens, agrupados em três fatores independentes (autopresença, presença espacial e presença social), e apresenta um bom índice de consistência interna (α = 0,905) e índices de ajuste aceitáveis (χ2 = 116,83; gl = 74; p < 0,01; CFI = 0,99; RMSEA= 0,035; SRMR = 0,053), com parâmetros psicométricos equivalentes por gênero

This study aimed to develop a scale of presence in ubiquitous technologies. The development process of the instrument had 4 stages: 1) the choice of behavioral attributes related to the object of study and the operation of the construct, 2) the presentation to three judges, two focus groups and a 3) pilot application in a reduced sample (n = 30) and 4) an application with 458 participants. In order to obtain validity and reliability evidences we performed internal consistency analyzes, confirmatory factor analysis and multigroup confirmatory factorial analysis. The final version of the Presence Scale in Ubiquitous Technologies has 14 items, grouped into three independent factors (Self-Presence, Spatial Presence and Social Presence), and has a good internal consistency index (alpha = 0.905) and an acceptable adjustment index (χ2 = 116.83, gl = 74, p <0.01, CFI = 0.99, RMSEA = 0.035, SRMR = 0.053), with equivalent psychometric parameters by gender

Este estudio tuvo como objetivo el desarrollo de una escala de presencia en las tecnologías ubicuas. El proceso de desarrollo del instrumento tuvo como etapas 1) la elección de los atributos comportamentales referentes al objeto de estudio y la operacionalización del constructo, 2) la presentación a tres jueces, dos grupos focales, 3) una aplicación piloto en una muestra reducida (n = 30), y por último, 4) una aplicación con 458 participantes. Se realizaron análisis de consistencia interna, análisis factorial confirmatorio y análisis factorial confirmatorio multigrupo. La versión final de la Escala de Presencia en Tecnologías Ubíquicas cuenta con 14 ítems, agrupados en tres factores independientes (Autopresencia, Presencia Espacial y Presencia Social), y presenta un buen índice de consistencia interna (alfa = 0,905) y un índice de ajuste aceptable (χ2 = 116,83; gl = 74; p < 0,01; CFI = 0,99; RMSEA = 0,035; SRMR = 0,053) con parámetros psicométricos equivalentes por género

AI, big data, and robots for the evolution of biotechnology

Artificial intelligence (AI), big data, and ubiquitous robotic companions —the three most notable technologies of the 4th Industrial Revolution—are receiving renewed attention each day. Technologies that can be experienced in daily life, such as autonomous navigation, real-time translators, and voice recognition services, are already being commercialized in the field of information technology. In the biosciences field in Korea, such technologies have become known to the local public with the introduction of the AI doctor Watson in large number of hospitals. Additionally, AlphaFold, a technology resembling the AI AlphaGo for the game Go, has surpassed the limit on protein folding predictions—the most challenging problems in the field of protein biology. This report discusses the significance of AI technology and big data on the bioscience field. The introduction of automated robots in this field is not just only for the purpose of convenience but a prerequisite for the real sense of AI and the consequent accumulation of basic scientific knowledge.

Smart technologies toward sleep monitoring at home

With progress in sensors and communication technologies, the range of sleep monitoring is extending from professional clinics into our usual home environments. Information from conventional overnight polysomnographic recordings can be derived from much simpler devices and methods. The gold standard of sleep monitoring is laboratory polysomnography, which classifi es brain states based mainly on EEGs. Single-channel EEGs have been used for sleep stage scoring with accuracies of 84.9%. Actigraphy can estimate sleep effi ciency with an accuracy of 86.0%. Sleep scoring based on respiratory dynamics provides accuracies of 89.2% and 70.9% for identifying sleep stages and sleep effi ciency, respectively, and a correlation coeffi cient of 0.94 for apnea–hypopnea detection. Modulation of autonomic balance during the sleep stages are well recognized and widely used for simpler sleep scoring and sleep parameter estimation. This modulation can be recorded by several types of cardiovascular measurements, including ECG, PPG, BCG, and PAT, and the results showed accuracies up to 96.5% and 92.5% for sleep effi ciency and OSA severity detection, respectively. Instead of using recordings for the entire night, less than 5 min ECG recordings have used for sleep effi ciency and AHI estimation and resulted in high correlations of 0.94 and 0.99, respectively. These methods are based on their own models that relate sleep dynamics with a limited number of biological signals. Parameters representing sleep quality and disturbed breathing are estimated with high accuracies that are close to the results obtained by polysomnography. These unconstrained technologies, making sleep monitoring easier and simpler, will enhance qualities of life by expanding the range of ubiquitous healthcare.

Effect of ubiquitous mitochondrial creatine kinase on cisplatin sensitivity of human nasopharyngeal carcinoma cell line CNE-1 / 中华耳鼻咽喉头颈外科杂志

Objective@#To investigate the effect of ubiquitous mitochondrial creatine kinase 1(CKMT1) on the sensitivity of human nasopharyngeal carcinoma cell line CNE-1 to DDP. @*Methods@#CNE-1 cells were transiently transfected with CKMT1 overexpression (CKMT1) or empty vector (EV). The growth curve and DDP IC50 were developed by MTT assay, plate clone formation assay was performed by gradient concentration of DDP treatment, cell cycle and apoptosis were detected by flow cytometry, levels of apoptosis related protein Bax/Bcl-2/C-PARP and the transcription factor p-STAT3-Tyr705 were detected by Western Blot. @*Results@#The transfection efficiencies of CKMT1 and EV were more than 90% with a higher proliferation rate in the CKMT1-transfected cells. However, the CKMT1-transfected cells had a DDP IC50 of 2.76 μmol/L, which was significantly lower than that of 4.60 μmol/L in the EV-transfected cells (P<0.01). With the treatment of certain concentration of DDP, the CKMT1-transfected cells had a lower clone formation rate, the cell cycle arrested more obviously in G2/M phase, and the apoptosis rate was higher (P<0.01), with higher levels of Bax/C-PARP (P<0.05 or P<0.01), but lower levels of Bcl-2 (P<0.01) and p-STAT3-Tyr705 (P<0.01), compare with the EV-transfected cells. @*Conclusions@#CKMT1 may inhibit the activation of STAT3, increasing the sensitivity of CNE-1 to chemotherapeutic drug DDP.

Embedded subject service model of medical library for affiliated hospitals in ubiquitous knowledge environments / 中华医学图书情报杂志

The embedded subject service model in ubiquitous knowledge environments has gradually become an important means to deepen library service and promote its reform.The embedded subject services, established service system, its assessment and its support mechanisms were described, the embedded subject service model of medical library for affiliated hospitals in ubiquitous knowledge environments was elaborated in order to pave the way for improving the future service in college and university library.

Influence of ubiquitous chromatin opening element on the antibody expression in CHO cells / 中国药科大学学报

Ubiquitous chromatin opening element ( UCOE ) , composed of the promoters of human housekeeping genes, prevents transgene from silencing and produces consistent, stable and high-level gene expression irrespec-tive of the chromosomal integration site. The research studied the influence of different UCOE element parts on antibody expression in CHO cells. UCOE 1. 5 kb from chromobox homolog 3 ( CBX3 ) , UCOE 2. 5 kb from the heterogeneous ribonucleoprotein A2/B1 ( HNRPA2 B1 ) and the whole UCOE 4. 0 kb were inserted into the anti-body light and heavy chain vectors, respectively, and transfected into CHO cells using antibiotics-Zeocin and Blasticidin for pressure selection. Four groups of monoclonal cells were harvested and antibody expression of each group was detected. The monoclonal cells with UCOE 1. 5 kb and UCOE 2. 5 kb increased 1. 5 to 2-fold in the level of antibody expression, wheareas, monoclonal cells with UCOE 4. 0 kb increased 3 to 4-fold. The enhance-ment of two housekeeping promoter genes on antibody expression could stack up.

Ubiquitous testing using tablets: its impact on medical student perceptions of and engagement in learning / 한국의학교육

PURPOSE: Ubiquitous testing has the potential to affect medical education by enhancing the authenticity of the assessment using multimedia items. This study explored medical students' experience with ubiquitous testing and its impact on student learning. METHODS: A cohort (n=48) of third-year students at a medical school in South Korea participated in this study. The students were divided into two groups and were given different versions of 10 content-matched items: one in text version (the text group) and the other in multimedia version (the multimedia group). Multimedia items were delivered using tablets. Item response analyses were performed to compare item characteristics between the two versions. Additionally, focus group interviews were held to investigate the students' experiences of ubiquitous testing. RESULTS: The mean test score was significantly higher in the text group. Item difficulty and discrimination did not differ between text and multimedia items. The participants generally showed positive responses on ubiquitous testing. Still, they felt that the lectures that they had taken in preclinical years did not prepare them enough for this type of assessment and clinical encounters during clerkships were more helpful. To be better prepared, the participants felt that they needed to engage more actively in learning in clinical clerkships and have more access to multimedia learning resources. CONCLUSION: Ubiquitous testing can positively affect student learning by reinforcing the importance of being able to understand and apply knowledge in clinical contexts, which drives students to engage more actively in learning in clinical settings.

Feasibility of a smartphone application based action plan and monitoring in asthma

BACKGROUND: Asthma patients may experience acute episodic exacerbation. The guidelines recommend that written action plan should be given to asthma patients. However, no one can predict when and where acute exacerbation will happen. As people carry smart phone almost anytime and anywhere, smartphone application could be a useful tool in asthma care. We evaluated the feasibility of the ubiquitous healthcare system of asthma care using a smartphone application (snuCare) based on the self-management guideline or action plan. METHODS: Forty-four patients including fragile asthmatics were enrolled from Seoul National University Bundang Hospital between December 2011 and February 2012. They were randomly assigned into application user (n = 22) or application nonuser group (n = 22). We evaluated user-satisfaction, and clinical parameters such as asthma control, Quality of Life Questionnaire for Adult Korean Asthmatics, and the adherence of patients. RESULTS: The characteristics were similar at baseline between the 2 groups except those who treated with short-term systemic steroid or increased dose of systemic steroid during previous 8 weeks (user vs. nonuser: 31.8% vs. 4.5%, p = 0.020). Total of 2,226 signals was generated during 8 weeks including 5 risky states. After eight weeks, the users answered that it was very easy to use the application, which was shown in highest scores in terms of satisfaction (mean ± standard deviation, 4.3 ± 0.56). Seventy-three percent of patients answered that the application was very useful for asthma care. User group showed improved the adherence scores (p = 0.017). One patient in application user group could avoid Emergency Department visit owing to the application while a patient in nonuser group visited Emergency Department. CONCLUSION: The ubiquitous healthcare system using a smartphone application (snuCare) based on the self-management guideline or action plan could be helpful in the monitoring and the management of asthma.

Usefulness of ubiquitous-based testing for evaluations in medical education / 한국의학교육

PURPOSE: The purpose of this study was to evaluate the suitability (convenience, objectiveness, and satisfaction) of ubiquitous-based testing (UBT) as a medical education evaluation tool. METHODS: UBT was administered using a smart pad in our medical school in May 2012. A questionnaire was given twice. The pre-UBT questionnaire examined possession of a tablet computer, skillfulness of smart devices, the convenience of UBT, and the usefulness of a medical educational assessment tool. The post-UBT questionnaire evaluated the satisfaction, convenience, and preference of UBT and the usefulness of a medical educational assessment tool, as in the pre-UBT test. The survey was measured on a 4-point scale: 1 is "strongly disagree" and 4 is "strongly agree." RESULTS: One hundred three students (male, 55.3%) participated in the UBT. The mean age was 29.2+/-2.4 years. In the pre-UBT questionnaire analysis, students responded affirmatively to the items about the skillfulness of smart devices, clinical skill assessment, and achievement of educational objectives. The responses to the items on the convenience and satisfaction with the UBT were positive in the post-UBT. The factors that affected the post-UBT questionnaire were as follows: knowledge assessment (p=0.041) and achievement of educational objectives (p=0.015) were significant, based on gender, and satisfaction with the UBT (p=0.002) was significant, based on possession of a tablet computer. The relationship between the ranks of this UBT and the average ranks of the three previous semesters was statistically significant (p<0.001). CONCLUSION: Convenience, objectiveness, knowledge assessment, and composition and completion were useful items in the UBT.

New Directions in Chronic Disease Management

A worldwide epidemic of chronic disease, and complications thereof, is underway, with no sign of abatement. Healthcare costs have increased tremendously, principally because of the need to treat chronic complications of non-communicable diseases including cardiovascular disease, blindness, end-stage renal disease, and amputation of extremities. Current healthcare systems fail to provide an appropriate quality of care to prevent the development of chronic complications without additional healthcare costs. A new paradigm for prevention and treatment of chronic disease and the complications thereof is urgently required. Several clinical studies have clearly shown that frequent communication between physicians and patients, based on electronic data transmission from medical devices, greatly assists in the management of chronic disease. However, for various reasons, these advantages have not translated effectively into real clinical practice. In the present review, we describe current relevant studies, and trends in the use of information technology for chronic disease management. We also discuss limitations and future directions.

Transformation of CDC medical library against the background of ubiquitous knowledge / 中华医学图书情报杂志

Transformation of CDC medical library to wisdom library was elaborated from the target and tactics ac-cording to the connotation and characteristics of ubiquitous knowledge .Suggestions were put forward for CDC medi-cal library to provide knowledge management for the decision-making of public emergencies against the background of ubiquitous knowledge , such as expanding its acquisition of information resources , developing its rich and charac-teristic holdings, mining its recessive knowledge, integrating its information resources, establishing library col-leagues, developing information model of massive data, and pushing personal disease control information.

New normal service in hospital library / 中华医学图书情报杂志

Ubiquitous library and ubiquitous service are the future trend of library.Described in this paper are thus the extended traditional service and multidimensional personal and deepened information service such as sub-ject service, academic conference information service, special subject navigation service, new foreign book transla-tion service, special subject information service, in order to let the readers use the library at any time and at any place and enjoy the library everywhere .

Influence of users' cognition on information retrieval behaviors in ubiquitous knowledge environment / 中华医学图书情报杂志

Users' cognition and information retrieval are faced with great challenges in ubiquitous knowledge environ-ment. The influence of cognitive factors such as personality traits, cognitive style and ability, knowledge structure and ascribed methods on users' information retrieval behaviors was thus analyzed. It was pointed out that different cognitive factors could influence the retrieval, judgment and absorption of its results,users' satisfaction and continuous use in ubiquitous knowledge environment,with suggestions put forward from the aspects of information retrieval education, information service and information users for improving the users ' knowledge system in knowledge assimilating process by working out effective retrieval strategies using the advantages of cognition.

Efficacy of the Smartphone-Based Glucose Management Application Stratified by User Satisfaction

BACKGROUND: We aimed to assess the efficacy of the smartphone-based health application for glucose control and patient satisfaction with the mobile network system used for glucose self-monitoring. METHODS: Thirty-five patients were provided with a smartphone device, and self-measured blood glucose data were automatically transferred to the medical staff through the smartphone application over the course of 12 weeks. The smartphone user group was divided into two subgroups (more satisfied group vs. less satisfied group) based on the results of questionnaire surveys regarding satisfaction, comfort, convenience, and functionality, as well as their willingness to use the smartphone application in the future. The control group was set up via a review of electronic medical records by group matching in terms of age, sex, doctor in charge, and glycated hemoglobin (HbA1c). RESULTS: Both the smartphone group and the control group showed a tendency towards a decrease in the HbA1c level after 3 months (7.7%+/-0.7% to 7.5%+/-0.7%, P=0.077). In the more satisfied group (n=27), the HbA1c level decreased from 7.7%+/-0.8% to 7.3%+/-0.6% (P=0.001), whereas in the less satisfied group (n=8), the HbA1c result increased from 7.7%+/-0.4% to 8.1%+/-0.5% (P=0.062), showing values much worse than that of the no-smartphone control group (from 7.7%+/-0.5% to 7.7%+/-0.7%, P=0.093). CONCLUSION: In addition to medical feedback, device and network-related patient satisfaction play a crucial role in blood glucose management. Therefore, for the smartphone app-based blood glucose monitoring to be effective, it is essential to provide the patient with a well-functioning high quality tool capable of increasing patient satisfaction and willingness to use.

Subject service in Medical Library of Chinese PLA:Its 3-year practical experiences and prospect / 中华医学图书情报杂志

The practical experiences with subject service in Medical Library of Chinese PLA were summarized in terms of the establishment of user information records, accumulation and summation of information, and construc-tion of information platform. Suggestions were put forward for the improvement of subject service in Medical Library of Chinese PLA, such as holding the big information concept in the big data era, using the biomedical data as the target of study, providing various kinds of service, integrating seamless, dynamic and interactive library service into user service. The fact that focus on artificial intelligence, computer, information and coomunication technologies is one of the future directions was pointed out.

Information literacy of medical staff in ubiquitous information society / 中华医学图书情报杂志

After a description of the connotation and features of ubiquitous information society and the connotation and components of information literacy of medical staff in ubiquitous information society, the approaches were put forward for training and improving the information literacy of medical staff in ubiquitous information society.

Modelo arquitetural para geração de alertas aplicado ao monitoramento de pacientes em ambiente hospitalar / Architectural model for generating alerts applied to the monitoring of patients in a hospital environment

O aumento nas demandas por gerenciamento, controle e monitoramento das informações na área da automação hospitalar tem promovido um maior volume de pesquisas que são indutoras do processo de inovação tecnológica na área da saúde. Neste contexto, um aspecto considerado importante na automatização do monitoramento de pacientes consiste na eficiência em detectar e informar em tempo hábil as anomalias encontradas nos sinais vitais dos pacientes. O procedimento de notificar as ocorrências dessas anomalias à equipe médica pode ser implementado por meio da geração e envio de alertas (sonoros ou visuais). Verificando a relevância desse tipo de demanda no ambiente hospitalar, o presente artigo descreve uma arquitetura que tem como fundamento a geração e o envio de alertas, cujos dados são advindos de pacientes internados em Unidades de Terapia Intensiva (UTI). A premissa foi, portanto, otimizar o processo de comunicação das anomalias detectadas de modo que a equipe médica responsável seja notificada de tais eventos de maneira mais eficiente. A arquitetura de comunicação, definida para o ambiente hospitalar, baseou-se em estudos realizados na UTI do Hospital Universitário Onofre Lopes (HUOL). Tais estudos possibilitaram uma análise de requisitos que permitiu definir um gerador de alertas personalizados, e o envio desses para dispositivos móveis das equipes médicas. O processo de envio dos alertas foi baseado em um algoritmo de escalonamento de tempo real, fazendo uso de um middleware e de computação móvel e distribuída, sendo esses os aspectos inovadores dessa arquitetura.

The increase in demand for the management, control and monitoring of information in hospitals has promoted a greater volume of research that induces the process of technological innovation in healthcare. In this context, an important aspect to consider in the automation of patient monitoring is the efficiency to detect and report anomalies in patients’  vital signs in a timely manner. The procedure for notifying the medical staff of these anomalies can be implemented by generating and sending alerts (either audible or visual). Noting the relevance of this demand in the hospital environment, this paper describes an architecture based on the generation and transmission of alerts, whose data are coming from patients hospitalized in intensive care units (ICU). The premise was therefore to optimize the procedure for reporting deficiencies so that the medical staff in charge is notified of such events more efficiently. The communication architecture in hospitals, used in this paper, was based on studies conducted at the ICU of the University Hospital Onofre Lopes (HUOL). These studies allowed an analysis of requirements that lead to the definition of a generator of custom alerts, and the sending of these alerts to mobile devices kept by medical staff. The process of sending those alerts was based on a real time scheduling algorithm making use of a middleware and both mobile and distributed computing, which are the innovative aspects of this architecture.

Diabetes Management System Based on Ubiquitous Healthcare / 임상당뇨병

The rapidly increasing prevalence of chronic disease is an important challenge to healthcare systems worldwide. Ubiquitous healthcare (U-health) systems arising from the fusion of IT and medicine may provide new solutions for addressing chronic disease in the future. Because U-health is based on the constant availability of information, communication networks are being considered as alternatives to mainstream face-to-face healthcare services and also in supportive functions. To improve the quality and efficiency of care for patients with diabetes mellitus, we consider an individualized internet or mobile phone based U-health system of health management. In this paper, we explore the present state of U-health systems in Korea and in other countries, and examine glucose control models in diabetic patients based on u-health systems. Although many problems remain unresolved and the U-health model needs further development and more rigorous study, U-health systems maybe the foundations of medicine's future.

Effects of Nutrition Education Using a Ubiquitous Healthcare (u-Health) Service on Metabolic Syndrome in Male Workers

The objective of this study was to investigate the effects of nutrition education based on ubiquitous healthcare (u-health) service on changes in dietary habits, nutrition intake, and risk factors for metabolic syndrome in male workers. In total, 72 male office workers with at least three risk factors of the National Cholesterol Education Program-Adult Treatment Panel III were recruited as subjects. Anthropometric measurements and biochemical analyses were conducted on all subjects. Dietary habits and nutrient intake were determined by a questionnaire using the 24-hour dietary recall method before and after nutrition education. Subjects measured their body composition, blood pressure, and physical activity more than once per week during the 12 weeks using the u-health care equipment and sent these data to a central database system using a personal computer. Individual nutrition counseling was provided four times on the first, fourth, eight, and twelfth weeks. The results showed significant decreases in abdominal circumference, body fat (%), diastolic blood pressure, serum triglycerides, and serum total cholesterol during the 12 weeks. Subjects with more than 12 measurements showed significant reductions in abdominal circumference, body fat (%), serum triglyceride, and serum total cholesterol. Mean intake of dietary fiber, animal calcium, potassium, vitamin C, and folic acid after nutrition education were higher than those before nutrition education. Participants showed significant increases in the frequencies of consuming protein foods (meat, fish, eggs, beans, tofu, etc.) and vegetables. In conclusion, nutrition education through the u-health service resulted in positive effects on the risk factors for metabolic syndrome, nutrient intake, and dietary habits.