Résumé
Saliva is a biological fluid with multifactorial functional applications with regards to themaintenance of general health. Collection of saliva is non-invasive, easy and cost-effective. Xerostomia, a subjective sensation of dry mouth is one of the most common complaints in elderly and patients on polypharmacy as it is proven as a risk factor. Polypharmacy is the simultaneous use of multiple drugs by a patient for more than one systemic disease. Theaim of the study was to assess the salivary changes in patients on polypharmacy. Unstimulated saliva samples were collected from 20 individuals who reported to the Department of Special Care Dentistry at Saveetha Dental College between November to December 2019.The collected samples were then processed for analysis of three salivary parameters-Salivary glucose, amylase and pH. The data were recorded and statistically analyzed. Out of the 20 samples,12 male (60%) and 8 female(40%) with mean age group as 41.2 years. Independent t test showed statistically significant (p<0.05) values for salivary parameters in patients on polypharmacy medication. This study has shown a significant increase in salivary parameters and further studies relating the salivary changes, systemic disease and the medication involved salivary analysis can be suggested as one of the investigations in patients on polypharmacy.
Résumé
Objective To study the expression of inflammatory factors in the saliva and the stability of implants after implant denture repair in pa-tients with dysplasia of the dentition defect ,and to analyze the prognosis of patients with lipid metabolic disorder. Methods The dentition defect patients with lipid metabolism disorder were selected as the experimental group. Patients with lipid defect were selected as the control group. Saliva was collected before implantation,1 month and 3 months after implantation. ELISA method was used to detect IL-6,IL-1βand TNF-α. Osstell ISQTM radio frequency analyzer was used to detect the stability of the implants and the periodontal status was detected by Florida probe. Re-sults There were no significant differences in the depth of implant probing(PD),bleeding index(BI)and ISQ between the two groups by radio frequency analyzer(all P>0.05). The levels of IL-6,IL-1βand TNF-αin the pre-implantation,1 month and 3 months after implantation were sig-nificantly higher than those in the control group(all P0.05). Conclusion The patients with dyslipidemia after implantation have good implant stability as those with normal blood lipid ,and the patients with dyslipidemia can also obtain good prognosis.