Résumé
Any disease pertaining to skin causes adverse impact on psychological and social well-being results in depression, social isolation, loneliness and reduce quality of life. WHO has classified skin diseases a psycho-cutaneous disease which emphasizes the relation between skin and psyche. Hence skin ailments are given high priority by the patients. Skin diseases are commonly observed thanks to altered lifestyle including improper and altered food habits, mental stress, improper sleeping habits and poor hygiene. In Ayurveda, the majority the skin diseases are incorporated under Kustharoga and are classified as Mahakustha (major skin disorders) and Kshudra kustha (minor skin disorders). Kitibha kustha is explained under Kshudra kustha in Ayurvedic Samhitas. The signs and symptoms of Kitibha kustha are same as that of psoriasis explained in modern science. Aim: The aim was to gauge the importance of Vamana karma (bio-purificatory measures) in Kustha. Materials and Methods: A male patient aged 18 years presented with the signs and symptoms of slightly raised well-defined brownish patches over upper middle back, behind both ears and around both alar nasal sulcus associated with itching diagnosed it as Kitibha kustha and was treated with Vamana karma (emesis) followed by prior Deepan karma and Bahya & Abhyantar snehan (internal & external oiling) followed by Swedan (fomentation). Results: At the conclusion of Vaman, Pittantik vamana was achieved. Patient had significant relief from Kandu (itching), scaling and reduction of erythema after the procedure. Photographic changes were kept for comparison. Conclusion: This present case study revealed the importance of Vamana karma in Kitibha kustha (Psoriasis).
Résumé
Alopecia areata is characterized by circumscribed non-scarring loss of hair in single or multiple patches over the scalp or body hair. Histopathology shows perifollicular and intrafollicular inflammatory cells infiltrate composed mainly of lymphocytes, described as swarm of bees’ appearance. The characteristic lesion is an asymptomatic, smooth bald patch with normal skin within the patch. Fine regular pitting of nails and tachynochia is a common association. When the hair loss involves the entire scalp it is known as alopecia totalis. Khalitya in Ayurveda is a disease in which Pitta combining with Vata and getting into the pores of hairs (hair follicles) cause fall of hair, and then Kapha along with Rakta obstructs the pores of those hairs and makes it impossible for other hair to grow. As it does not destroy the hair follicles the potential for the re-growth is maintained for many years. However growth in alopecia totalis and universalis is limited. Material and Methods: The present clinical study is a case report on the efficacy of Shamana (pacification) medication along with Vamana (therapeutic emesis), Virechana (therapeutic purgation), Basti (therapeutic Enema) and Nasya (therapeutic nasal medication) and Raktamokshan (therapeutic bloodletting) in the management of a patient diagnosed as Alopecia totalis. Results: There was significant re-growth of the hair of the scalp. SALT Score improved from 97.76 to 2. Discussion: The collected data from this study suggests that Ayurvedic Shodhana (Purification) treatment along with Shamana medications can provide an efficient result for managing Alopecia totalis.
Résumé
Psoriasis is one among the wide-spreading, chronic, frequently recurring diseases of the skin. Its worldprevalence varies between 0.09% and 11.4% in 2013 which reported in 2006 as in between 0.5% and 4.6%.In Ayurveda, the description of Kushta-roga viz. Vata-Kaphaja kushta finds similarity with psoriasis. Thecommon sites of occurrence of psoriasis are scalp, elbow, knee, earlobes and sole which are alsoconsidered as the location of Vata and Kapha.The science of Ayurveda has anecdotal accounts of success in the management of psoriasis in theactual clinical practice even though it lacks the evidence-based medical dermatology research data.It observed that the physicians adopt several treatment protocols for the cure of this disease inclinical practice, which was not rigorously evaluating in research settings. This paper/report is oneof on the ‘Thuvaraka rasayana’ is one such component that could improve treatment outcomes inPsoriasis.A pre and post test case report selected of a 36-year-old lady patient who diagnosed as having stablepsoriasis vulgaris for last seven years. She was administered with internal and external therapies alongwith Shodhana therapies (bio-cleansing procedures) and then followed by intake of Thuvaraka rasayana.The total duration of the treatment was 43 days, and the Study subject assessed before treatment, aftertreatment and on follow-up for improvement using PASI scoring, and histo-pathological study. All thesymptoms observed in the beginning were found considerably reduced, and the severity also found mild.On the follow-up, it concluded that the lesions disappeared completely and the skin set back to itsnormal texture. Even though psoriasis is an autoimmune disease where recurrence rate found moreShodhana therapy and Thuvaraka rasayana have a definite role.© 2018 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Publishing Services byElsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Résumé
Leaf extracts of C. vamana, endemic to Kerala state in India, were found to inhibit cell cycle progression in synchronous cultures of P. polycephalum in a concentration and phase-specific manner. Crude alkaloid extract (CAE) elicited maximum cell cycle delays in comparison to soxhletted chloroform, acetone and aqueous extracts. Total alkaloid content of CAE was found to be 64.9 mg/g. CAE showed lowest DPPH radical scavenging activity. Other extracts with higher free radical scavenging activity exhibited lesser cell cycle inhibiting potential. Upto 21% decrease in nuclear DNA was observed in CAE treated samples. However, genotoxicity as evidenced by comet assay was not observed. The extracts were also found to be non-toxic to human RBCs at the highest concentration tested (750 µg/mL). CAE treatment completely suppressed a 63 kDa polypeptide with a concomitant, but weak induction of a 60 kDa polypeptide suggesting that these may be cell cycle related. CAE was found to possess potent antiproliferative activity against PBLs. The study clearly demonstrates the cell cycle inhibitory activity of C. vamana leaf extracts, with CAE being the most potent of them.