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La supplémentation en vitamine A (SVA) est une des stratégies de prévention de la carence en vitamine A. L'objectif était d'étudier les déterminants de la SVA au Sénégal. Ils'agissait d'une analyse secondaire de l'enquête démographique et de santé conduite en 2017. Un échantillonnage en grappes à deux degrés était réalisé. La population d'étude était constituée des enfants âgés de 6 à59 mois. La régression logistique a permis l'identification des déterminants de la SVA. L'odds ratio ajusté (ORA) et son intervalle de confiance à 95% (IC95%) étaient calculés. La couverture en SVA était de 63,8%. Ses déterminants étaient le fait de résider dans les régions Sud-Est (ORA = 2,88 ; IC95%= 2,19-3,79), Centre (ORA = 2,77; IC95% = 2,14-3,59) et Nord (ORA =3,57; IC95%= 2,69-7,73), la taille du ménage ≥ 10 (ORA = 1,28 ;IC95%= 1,11-1,49), la taille de la fratrie ≥ 4 (ORA =1,23 ; IC95%= 1,07-1,43), et l'accouchement en établissement sanitaire (ORA = 1,35 ; IC95%= 1,01-1,80), l'utilisation de la radio (ORA = 1,46 ; IC95%= 1,20-1,77), l'utilisation de la télévision (ORA = 1,33; IC95%= 1,12-,157), la tranche d'âge 12-59 mois (ORA = 2,5 ; IC95%=2,14-2,92), la vaccination par le penta3 (ORA =2 ; IC95% :1,53-2,62). La couverture en SVA n'est pas optimale. La SVA à domicile dans la région Ouest, la promotion de l'accouchement institutionnel, la communication de masse, le renforcement des connaissances des vaccinateurs sur la SVA seraient nécessaires.
Vitamin A supplementation (VAS) is one of the strategies to prevent vitamin A deficiency. The objective was to study the determinants of VAS in Senegal. This was a secondary analysis of the Demographic and Health Survey conducted in 2017. Two-stage cluster sampling was used. The study population consisted of children aged 6-59 months. Logistic regression was used to identify the determinants of VAS. The adjusted odds ratio (AOR) and its 95% confidence interval (95% CI) were calculated. VAS coverage was 63.8%. Its determinants were residence in the South-East (AOR = 2.88; 95% CI= 2.19-3.79), Centre (AOR = 2.77; 95% CI= 2.14-3.59) and North (AOR =3.57; 95% CI= 2.69-7.73) regions, household size ≥ 10 (AOR = 1.28; 95% CI95= 1.11-1.49), sibling size ≥ 4 (AOR =1.23 ; CI95%= 1.07-1.43), and delivery in a health facility (AOR= 1.35; 95% CI= 1.01-1.80), radio use (ARO = 1.46; 95% CI= 1.20-1.77), television use (AOR = 1.33; 95% CI= 1.12-.157), age group 12-59 months (AOR = 2.5;95% CI=2.14-2.92), vaccination with penta3 (AOR =2; 95% CI=1,53-2,62). VAS coverage is not optimal. Home-based VAS in the western region, promotion of institutional delivery, mass communication, strengthening of vaccinators' knowledge on VAS would be necessary.
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Compléments alimentairesRésumé
Background: The change in strategy of India's National Program for the prevention and control of nutritional blindness due to Vitamin A deficiency during 2006, aims for all children aged 9 months to 5 years to receive biannual pulse dose of Vitamin A with a total nine mega doses of Vitamin A. Micronutrient initiative (MI) was providing technical assistance to the State Health department of Karnataka in implementing the new bi-annual strategy, in partnership with UNICEF during the period 2006 to 2010.Methods: During July 2006, the Investigator evaluated its coverage in Gulbarga district. This study assessed the factors influencing the uptake of pulse Vitamin A supplementation (VAS) among children from impoverished background. Using oral questionnaires, a total of 30 Parents (Mothers) of these children, 12 childcare workers (AWWs), 12 peripheral health workers (ANMs) were interviewed regarding barriers towards implementing this Program and assessment of the facilities (12 Anganwadi centres) were conducted.Results: Only 28% of the facility had some IEC display regarding VAS. 75% of ANMs were aware that either green leafy vegetables or fish or fruits are the main source of micronutrients. A similar number of ANMs knew that Vitamin A deficiency causes night blindness, >90% of AWW had informed parents about the program during the monthly mother meetings. <20% of parents were aware of the current pulse VAS program and a similar number were aware of the next round of supplementation.Conclusions: Regular interaction with families, monitoring the activities of field level health workers and supportive supervision will enable uptake of VAS Program. Future action should prioritize sub-district level units ' blocks and villages, with higher concentration of poor households.
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@#<p><strong>BACKGROUND:</strong> The dengue vaccine controversy in the Philippines caused significant public anxiety affecting childhood vaccines, as well as other healthcare programs. An assessment of parental perception and attitude on childhood immunization and other government healthcare programs after the dengue vaccine controversy is lacking</p><p><strong>OBJECTIVE:</strong> To determine the perception and attitude of parents on childhood immunization and other government health care programs after the dengue vaccine controversy at a tertiary pediatric hospital.</p><p><strong>METHODOLOGY:</strong> A hospital-based cross-sectional survey was done at a tertiary pediatric hospital. A total of 96 subjects participated in the study. Parents with children ages 9 to 18 years old whose child was either vaccinated or non-vaccinated with dengue vaccine seen in the dengue clinic, outpatient department and private clinics were invited to answer the structured questionnaire. Proportional stratified sampling was employed. Mann Whitney U-test compared the perception and attitude scores between parents of children who were recipients and non-recipients of dengue vaccine. A p-value of</p><p><strong>RESULTS:</strong> The overall perception and attitude of parents on childhood immunization, deworming and vitamin A supplementation did not differ significantly between parents of non-dengue vaccinated children and dengue-vaccinated children. Sociodemographic factors such as gender, marital status, educational attainment, employment, and economic status did not differ significantly in their perception and attitude in terms of childhood immunization, deworming and vitamin A supplementation.</p><p><strong>CONCLUSIONS:</strong> The overall perception and attitude of parents in both groups showed no significant difference toward childhood immunization, deworming and vitamin A supplementation. There is no association with the overall perception and attitude of parents on childhood immunization, deworming and vitamin A supplementation and their sociodemographic factors. RECOMMENDATIONS: Future similar studies may be conducted in other regions to determine parental perception and attitude towards the government's immunization program and other health care programs.</p>
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Humains , Mâle , Femelle , Vaccins contre la dengue , ImmunisationRésumé
Background: Vitamin A deficiency is a common form of micronutrient malnutrition. The estimated relative risks associated with vitamin A deficiency in children were 1.86 (95% CI 1.32–2.59) for measles mortality, 2.15 (95% CI 1.83–2.58) for diarrhoea mortality, 1.78 (95% CI 1.43–2.19) for malaria mortality, 1.13 (95% CI 1.01–1.32) for other infectious disease mortality. Vitamin A supplementation reduces night blindness, child morbidity and mortality.Methods: This paper tries to explore the socio-demographic causes of receipt of vitamin A in selected lower-middle-income and low income countries by analysing the data of the demographic and health surveys from 2012 and 2016 using PASW 18.0 software. Multivariate binary logistic regressions were conducted to explore the role of socio-demographic covariates in the receipt of vitamin A supplementation. In addition, random forest (RF) analyses were conducted using Python 3.6.Results: After adjusting for related socio-economic and demographic factors, mother’s work status and education and among mass media channels, exposure to television seems to play an important role in predicting receipt of vitamin A in the selected countries in Asia, while education of the mother was significantly associated with the receipt of vitamin A in the selected countries of Africa. In all the selected countries, the RF analyses revealed mother’s education followed by wealth index and mass media (TV), as the variable of most importance.Conclusions: It can be concluded that mother’s education and mass media seems to be working well in making the mothers aware about the vitamin A campaign, especially, the exposure to television. It also figures in the variable importance matrix in addition to wealth index.
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Vitamin A deficiency (VAD) among 1-5 yr old children is reported to be widely prevalent in Southeast Asia and some parts of Africa. It is the leading cause of preventable blindness in young children in the low-income countries in the world. Children even with milder signs of VAD have higher risk of morbidity and mortality. Inadequate dietary intakes of vitamin A with poor bioavailability associated with frequent infections are the primary contributory factors. Currently available approaches to control VAD are ensuring adequate intakes of vitamin A in daily diets, fortification of foods consumed regularly particularly among the low-income communities and periodic administration of massive dose of vitamin A supported by public health interventions and reinforced by behaviour change communication. Under the National Programme in India, six monthly administration of mega dose of vitamin A to 6-59 month old children has been implemented since 1970, to prevent particularly blindness due to VAD and control hypovitaminosis A. Despite inadequate coverage and poor implementation of the programme, blindness due to VAD in children has almost disappeared, though subclinical VAD is still widely prevalent. Based on the results of meta-analysis of eight trials, which indicated that vitamin A supplementation to children aged 6-59 months reduced child mortality rates by about 23 per cent, the World Health Organization made a strong recommendation that in areas with VAD as a public health problem, vitamin A supplementation should be given to infants and children of 6-59 months of age as a public health intervention to reduce child morbidity and improve child survival. At present, in India, there is a need for change in policy with respect to the national programme to opt for targeted instead of universal distribution. However, NITI (National Institution for Transforming India) Aayog, which formulates policies and provides technical support to the Government of India, recommends strengthening of the National Programme for control of VAD through six monthly vitamin A supplementation along with health interventions. Eventually, the goal is to implement food based and horticulture-based interventions harmonizing with public health measures, food fortification and capacity building of functionaries for elimination of VAD.
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Vitamin A supplementation (VAS) is presently being undertaken in India among under 5 (U5) children for two possible benefits (i) to prevent nutritional blindness due to Vitamin A deficiency (VAD) and (ii) to reduce U5 mortality. The existing scientific evidence suggests that nutritional blindness due to VAD has been virtually eliminated and also the difference between U5 mortality rate and infant mortality rate is very low for VAS to have any meaningful impact. On the contrary, scientific evidence indicates that there could be side effects of the administration of mega dose of Vitamin A (MDVA). These side effects of MDVA have not been systematically investigated. The universal VAS should be discontinued immediately as there are no likely benefits to U5 children.
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BACKGROUND/OBJECTIVES: It has been shown that vitamin A supplementation has different effects on skeletal health and the antioxidant system. Deficiency or excess of this vitamin can lead to health problems. Vitamin A can work as either an antioxidant or prooxidant depending on its concentration. The present study was conducted to investigate the effects of different doses of vitamin A supplementation on the antioxidant system in rats. MATERIALS/METHODS: Forty Spargue-Dawley male rats were divided into four groups according to the dose of vitamin A received: 0 (A0), 4,000 (A1), 8,000 (A2), and 20,000 (A3) IU retinyl palmitate/kg diet. After a feeding period of 4 wks, lipid peroxide levels, glutathione concentration, antioxidant enzyme activities, and vitamins A and E concentrations were measured. Histopathological changes were observed in rat liver tissue using an optical microscope and transmission electron microscope. RESULTS: Lipid peroxide levels in plasma were significantly decreased in the A1 and A2 groups compared to the A0 rats. Erythrocyte catalase and hepatic superoxide dismutase activities of the A2 group were significantly higher than those of the A0 group. Hepatic glutathione peroxidase activity was significantly lower in the A3 group compared to the other groups. Total glutathione concentrations were significantly higher in the A1 and A2 groups than in the A0 group. Histological examination of liver tissue showed that excessive supplementation of vitamin A might lead to lipid droplet accumulation and nuclear membrane deformation. CONCLUSIONS: These results indicate that appropriate supplementation of vitamin A might have a beneficial effect on the antioxidant system in rats.
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Animaux , Humains , Mâle , Rats , Catalase , Régime alimentaire , Érythrocytes , Glutathion , Glutathione peroxidase , Foie , Enveloppe nucléaire , Plasma sanguin , Superoxide dismutase , Carence en vitamine A , Rétinol , VitaminesRésumé
Vitamin A deficiency is one of the world's three major micronutrient deficiency diseases,and xerophthalmia, night blindness are the only awareness of it in many clinicians'views.However,the advancements of the current study of its effect are far more than the traditional epithelial and ophthalmic parts.In fact,the progress in vitamin A closely associated to the clinic,especially the diarrhea,recurrent respiratory tract infections,anemia etc is more outstanding.Because there are many different factors in suffering from diverse diseases among people all over the world,it needs to consider more considerately and roundly when prevent,diagnose and treat those diseases correlated to vitamin A.Now the progress of this part is reviewed.