Therapeutic action of leflunomide on adjuvant arthritis rats and its mechanism / 中国药理学通报

AIM To study the therapeutic action of leflunomide(Lef) on adjuvant arthritis (AA) rats and its mechanisms. METHODS To observe the change of secondary inflammation,immune function on adjuvant arthritis(AA) rats treated with Lef and to detect the effect of A 771726 —the active product of Lef on T cell subgroup in mice in vitro .RESULTS Lef(2,6,18 mg?kg -1 ?12 d) intragastric injection(ig) could signifcantly inhibit secondary reaction (secondary inflammatory swelling、 multiple arthritis) of AA rats.Lef couldnt effect the lowed response of Con A induced splenolytes, and the decreased IL 2 synthesis in AA rats. But lef(2,6,18 mg?kg -1 ) could inhibit the elevated IL 1 released from peritoneal macrophage (PM?) in AA rats. A 771726 —the active product of Lef(0 1,0 5,2 5,12 5,25,100 ?mol?L -1 ) could inhibit Con A induced T h cells but has no effect in Con A induced T s cells in vitro .CONCLUSION Lef has therapeutic action on AA rats which could be related to its immunosuppressory activities——mainly through inhibit cell mediated immunity.

The antiinflammatory and immunomodulatory effects of actarit and its machenism / 中国药理学通报

AIM To study the antiinflammatory and immunomodulatory effects of actarit(Acta). METHODS To abserve the change of primary and secondary inflammation,immune function on adjuvant arthritis(AA) rats treated with Acta and to detect the effect of Acta on T cell subgroup in mice in vitro. RESULTS Acta(10,30,90 mg?kg -1 ) intragastric injection(ig) did not significantly inhibit primary reaction of AA in rats. But Acta(10,30,90 mg?kg -1 ?11 d) ig signifcantly inhibited secondary reaction (secondary inflammatory swelling、 multiple arthritis) of AA rats. The lowered response of ConA induced splenolytes and the decreased IL 2 synthesis were restored to normal in AA rats treated with Acta, while the elevated IL 1 released from peritoneal macrophate (PM?) was reduced. Acta(1～100 ?mol?L -1 ) could inhibit ConA induced T h cells and enhance ConA induced T s cells culture in vitro . CONCLUSION Acta do not show obvious antiinflammatory action. But Acta has therapeutic action on AA rats, which may be related to its immunomodulatory activities,mainly through modulate cell mediated immunity.