Résumé
·AIM: To investigate the distribution of serum specific IgE in children with allergic conjunctivitis and associated allergic diseases. ·METHODS: Retrospective analysis of 708 cases of allergic conjunctivitis in children, according to age divided into the infant group (2 months to 1 years old) 232 cases, the children group (>1 years to 3 years old) 255 cases and the preschool group (>3 years to 6 years old) 221 cases. A automatic in vitro detection system was used to detect serum inhaled allergens and food allergen specific IgE by immune capture method. A questionnaire survey was conducted to investigate the associated allergic diseases and consultation with relevant departments. ·RESULTS: The sIgE positive rate was the lowest in the infant group (87.1%). There were significant differences in the number of sIgE positive species in the infant group compared with those in the other two groups (χ2=10. 96, 21. 78; P<0. 01). The most common allergens in all three groups were milk, egg white and household dust mites, and the positive rate of SIgE in milk was higher in the infant group than in the other two groups. The positive rate of sIgE in dust mites, house dust, tree pollen, mulberry, dog fur, egg white, pineapple and mango were higher in the preschool group than in the other two groups. The positive rate of 3-6 grade sIgE in household dust mites and house dust were higher in preschool group than that in the other two groups (P<0. 01). The infant group had the highest proportion of gastrointestinal allergy (28. 9%). The preschool group had the highest proportion of allergic rhinitis. The proportion with more than three kinds of allergic diseases in children group was higher than that of the other two groups(P<0. 01). ·CONCLUSION: With the increase of age, the positive rate and types of allergen in children with allergic conjunctivitis increased gradually. House dust mites become the primary inhalation allergen from infancy. Allergic diseases associated with allergic conjunctivitis in children are consistent with allergic march.
Résumé
BACKGROUND: Little knowledge is available on the characteristic differences between patients with atopic dermatitis (AD) with and without atopic march after childhood. OBJECTIVE: To observe and compare the phenotypes of patients with AD in regards to atopic march tendency at a single point. METHODS: We enrolled patients with AD aged between 10 and 30 years. The patients were divided into the atopic march and non-atopic march groups on the basis of an investigator-designed survey questionnaire, and their serum-specific immunoglobulin E (IgE) levels or results of the skin prick test were compared. RESULTS: In a total of 182 patients enrolled in the study, 93 patients with atopic march and 89 patients with non-atopic march were observed. When their serum-specific IgE levels or results of the skin prick test were compared between the two groups, there was no significant difference, except for a in the atopic march group. Analysis of AD severity, family history of allergic diseases, and total IgE levels between the two groups showed no statistically significant differences. CONCLUSION: Our findings suggest that although no apparent phenotype characteristics could differentiate the presence of atopic march, the history of the patient's allergic diseases should be revalidated, and clinicians should watch out for future developments of atopic march when a patient shows a high-class sensitization rate to dust mite.
Sujets)
Humains , Eczéma atopique , Poussière , Immunoglobuline E , Immunoglobulines , Mites (acariens) , Phénotype , PeauRésumé
While the term atopic march has been used to imply a natural progression of a cascade of symptoms from eczema to asthma and rhinitis through childhood, this developmental profiles at an individual level are not accurate.Only a small proportion of children(7％) follow this profile.There are increasing evidences from longitudinal studies suggesting that there exist other allergic phenotypes.Through the development of internal and external mechanism of allergic disease, we could do something to help earlier diagnosis and facilitate novel approaches to disease prevention, such as human breast milk, solid food, environmental control, pharmacotherapy, etc.This review aims to summarize recently published articles in order to highlight novel research findings,clinical trial results and guidelines to assist in identifying prevention strategies to arrest the atopic march.
Résumé
PURPOSE: It is widely known that allergic diseases progress through an allergic march. However, there have not been any recent reports in Korea on how the diseases progress. METHODS: Parents who visited one of the Pediatric Allergy Clinics of four university hospitals in Seoul with a child under the age of 6 years during the period from May 1-30, 2006 were asked to complete a questionnaire. RESULTS: A total of 229 parents answered the questionnaire about their children, of which 122 were male and 107 were female. The most common allergic disease before 2 years of age was atopic dermatitis (79%). Meanwhile, in 2- to 4-year age group, allergic rhinitis (38%) and asthma (37%) were predominant. The most common allergic disease in the 4- to 6-year age group was asthma (72%), followed by allergic rhinitis (64%). Seventy-three percent of the children had a family history of allergic disease, most often in the fathers (39%). Among patients with allergic rhinitis, 50% had experienced asthma in their earlier days and 30% had experienced atopic dermatitis. In addition, 57% of the children with asthma had suffered from atopic dermatitis. Parents believed that asthma was the most serious allergic disease. CONCLUSION: In the present study, allergic disease showed a tendency to march from atopic dermatitis to asthma and then to allergic rhinitis. Early diagnosis and treatment of atopic dermatitis is, therefore, considered important for prevention of the allergic march.