Encrucijadas de la virtualidad. Niñeces y adolescencias en tiempos de incertidumbre y violencias / Crossroads of virtuality. children and adolescences in times of uncertainties and violence / Carrefour de la virtualité. les enfants et les adolescents en temps d'incertitudes et de violence / Encruzilhadas da virtualidade. infância e adolescência em tempos de incertezas e violências

Entre otros efectos, la pandemia produjo en niños y adolescentes un uso casi abusivo de las pantallas, como modo de conectarse con el mundo. Y mientras algunos las utilizaron para sostener redes afectivas, otros se encerraron en ellas y se aislaron del mundo, resultándoles después muy difícil el regreso. Estamos viendo ahora los efectos de esos tiempos de apego a la virtualidad y de ausencia de contacto con pares, tanto en la primera infancia, como en la edad escolar y en la adolescencia. Así, nos encontramos con un recrudecimiento de un modo de ubicarse por parte de los adultos frente a niñas, niños y adolescentes en el que no se toma en cuenta la lógica infantil, no se los escucha y no se toma en cuenta su sufrimiento. Esto lleva a que se supongan pandemias de TEA (Trastorno de Espectro Autista) y de TDAH (Trastorno por déficit de atención con hiperactividad).Los profesionales psi tenemos una enorme responsabilidad en esta época. Somos artífices de futuro. Es decir, podemos cambiar destinos de niñas, niños y adolescentes si entendemos que trabajar con ellos, en el ámbito que fuera, supone un posicionamiento que implica una representación del otro como ser humano, como sujeto merecedor de intercambios simbólicos AU

Among other effects, the pandemic led children and adolescents to an almost abusive use of screens as a way to connect with the world. While some used them to maintain affective relationships, others closed themselves off and isolated from the world, making it very difficult for them to return to in-person relationships afterward. We are now witnessing the effects of those times of attachment to virtuality and lack of contact with peers, both in early childhood, school-age and adolescence. Thus, we find an upsurge of a way for adults to position themselves in relation to children and adolescents, where the child's logic is not considered, they are not heard, and their psychological suffering is not taken into account. This leads to the assumption of pandemics of ASD (Autism Spectrum Disorder) and ADHD (Attention Deficit Hyperactivity Disorder). Psychologists have a huge responsibility in this era. We are architects of the future. That is, we can change the destinies of children and adolescents if we understand that working with them in any context involves a positioning that implies a representation of the other as a human being, as a subject deserving of symbolic exchanges AU

Entre autres effets, la pandémie a produit une utilisation presque abusive des écrans chez les enfants et les adolescents, comme moyen de se connecter avec le monde. Et tandis que certains les utilisaient pour entretenir des réseaux émotionnels, d'autres s'enfermaient et s'isolaient du monde, ce qui rendait très difficile leur retour ultérieur. Nous constatons aujourd'hui les effets de ces périodes d'attachement à la virtualité et d'absence de contact avec les pairs, tant dans la petite enfance qu'à l'âge scolaire et à l'adolescence.Ainsi, on constate une aggravation d'une manière de positionner les adultes envers les filles, les garçons et les adolescents dans laquelle la logique des enfants n'est pas prise en compte, ils ne sont pas écoutés et leurs souffrances ne sont pas prises encompte. Cela conduit à de supposées pandémies de TSA (trouble du spectre autistique) et de TDAH (trouble du déficit de l'attention avec hyperactivité). Nous, les professionnels du psi, avons une énorme responsabilité en cette période. Nous sommes les architectes du futur. Autrement dit, nous pouvons changer le destin des filles, des garçons et des adolescents si nous comprenons que travailler avec eux, quel que soit le domaine, implique un positionnement qui implique une représentation de l'autre comme être humain, comme sujet digne d'échanges symboliques AU

Entre outros efeitos, a pandemia levou crianças e adolescentes a um uso quase abusivo das telas como forma de se conectar com o mundo. Enquanto alguns as utilizavam para manter redes afetivas, outros se fecharam nelas e se isolaram do mundo, tornando difícil o retorno a relações presenciais. Estamos agora testemunhando os efeitos desses tempos de apego à virtualidade e falta de contato com os pares, tanto na primeira infância quanto na idade escolar e na adolescência. Assim, nos deparamos com o recrudescimento de uma forma de posicionamento por parte dos adultos em relação a crianças e adolescentes, em que a lógica infantil não é considerada, eles não são ouvidos, e seu sofrimento psicológico não é levado em conta. Issoleva à suposição de pandemias de Transtorno do Espectro Autista (TEA) e Transtorno do Déficit de Atenção/Hiperatividade (TDAH).Os profissionais da psicologia têm uma enorme responsabilidade nesta época. Somos arquitetos do futuro. Ou seja, podemos mudar os destinos das crianças e adolescentes se compreendermos que trabalhar com e qualquer contexto envolve um posicionamento que implica uma representação do outro como ser humano, como sujeito merecedor de trocas simbólicas AU

Integration-based co-expression network analysis to investigate tumor-associated modules across three cancer types / 生物工程学报

In case/control gene expression data, differential expression (DE) represents changes in gene expression levels across various biological conditions, whereas differential co-expression (DC) represents an alteration of correlation coefficients between gene pairs. Both DC and DE genes have been studied extensively in human diseases. However, effective approaches for integrating DC-DE analyses are lacking. Here, we report a novel analytical framework named DC&DEmodule for integrating DC and DE analyses and combining information from multiple case/control expression datasets to identify disease-related gene co-expression modules. This includes activated modules (gaining co-expression and up-regulated in disease) and dysfunctional modules (losing co-expression and down-regulated in disease). By applying this framework to microarray data associated with liver, gastric and colon cancer, we identified two, five and two activated modules and five, five and one dysfunctional module(s), respectively. Compared with the other methods, pathway enrichment analysis demonstrated the superior sensitivity of our method in detecting both known cancer-related pathways and those not previously reported. Moreover, we identified 17, 69, and 11 module hub genes that were activated in three cancers, which included 53 known and three novel cancer prognostic markers. Random forest classifiers trained by the hub genes showed an average of 93% accuracy in differentiating tumor and adjacent normal samples in the TCGA and GEO database. Comparison of the three cancers provided new insights into common and tissue-specific cancer mechanisms. A series of evaluations demonstrated the framework is capable of integrating the rapidly accumulated expression data and facilitating the discovery of dysregulated processes.