Progress in the development of common experimental animal models of the eye neoplasm and the orbital diseases / 中华实验眼科杂志

The eye neoplasm and the orbital diseases are a class of serious illness which will cause visual function damage and even life threatening.At present,the etiology and pathogenesis of the most eye neoplasm and orbital diseases are still not clear,which has an adverse effect on the treatment.The medical experimental animal models are the ideal model to simulate human diseases.At the same time,the establishment of related animal models with the eye neoplasm and the orbital diseases is a helpful aid in getting to know the etiology and pathogenesis,providing a basis for studying the etiology and pathogenesis of these diseases.Some progress has been achieved some progress in recent years,however,compared to other diseases,the related animal models of these are still few.The progress in the common experimental animal models of the eye neoplasm and the orbital diseases,the animal models of the thyroid-associated ophthalmopathy (TAO),the orbital adenoid cystic carcinoma,the retinoblastoma (RB),the uveal melanoma,and the idiopathic orbital inflammatory pseudotumor were reviewed in this article.

Atividade da mieloperoxidase está aumentada na síndrome hepatopulmonar em ratos / Myeloperoxidase activity is increased in hepatopulmonary syndrome in rats

RACIONAL: A síndrome hepatopulmonar é formada por tríade clínica composta de doença hepática, dilatação vascular intrapulmonar e alterações de gases sanguíneos. Sua patogênese não é bem definida, mas especula-se que uma combinação de fatores, tais como o desequilíbrio das respostas dos receptores de endotelina, remodelação microvascular pulmonar e predisposição genética, leva à translocação bacteriana e dilatação vascular intrapulmonar. OBJETIVO: Avaliar a atividade da mieloperoxidase em modelo experimental de síndrome hepatopulmonar em ratos. MÉTODO: Foram estudados 29 animais divididos em grupos controle, sham e experimental de síndrome hepatopulmonar. O modelo experimental utilizado para induzir a síndrome foi a ligadura de ducto biliar comum. RESULTADOS: Os níveis de mieloperoxidase foram significativamente maiores no grupo ligadura de ducto biliar comum em comparação com os outros grupos. A atividade da mieloperoxidase foi maior no grupo ligadura de ducto biliar comum que o grupo controle (p<0,05) e do grupo sham (p<0,05). CONCLUSÃO: A atividade da mieloperoxidase estava aumentada na síndrome hepatopulmonar experimentais em ratos.

BACKGROUND: Hepatopulmonary syndrome is formed by a triad of liver disease, intrapulmonary vascular dilatation and changes in blood gases. Its pathogenesis is not well defined, but it is speculated that a combination of factors, such as the imbalance of endothelin receptor responses, pulmonary microvascular remodeling, and genetic predisposition, leads to bacterial translocation and intrapulmonary vascular dilatation. AIM: To evaluate the myeloperoxidase activity in hepatopulmonary syndrome in rat model. METHOD: Twenty-nine rats were divided into control, sham and experimental hepatopulmonary syndrome groups. Was evaluated the myeloperoxidase activity and the experimental model used to induce hepatopulmonary syndrome was common bile duct ligation. RESULTS: The myeloperoxidase activity levels were significantly increased in the common bile duct ligation group as compared with the other groups. Myeloperoxidase activity was higher in the common bile duct ligation group than control group (p<0.05) and than sham group (p<0.05). CONCLUSION: The myeloperoxidase activity is increased in experimental hepatopulmonary syndrome in rats.

Experimental Pig Model of OSAHS under the Lower Pressure Condition and Its CT Study / 实用放射学杂志

Objective To produce the experimental pig model of obstructive sleep apnea hypopnea syndrome(OSAHS) through raising pigs in the lower pressure container in order to study the effect of low pressure on morphology of upper respiratory soft tissue in pig.Methods The pigs were living in a container of low pressure for 6 months to make up the pig models of OSAHS.When the symptoms like OSAHS appearing and the pharyngeal respiratory pressure changing like the characteristics of OSAHS,the pigs were scanned by CT and compared with controls.Results The pharyngeal rear wall and soft palate in model pigs were thickened(0.94 cm?0.16 cm and 1.06 cm?0.23 cm respectively),while in control groups were(0.60 cm?0.11 cm and 0.59 cm?0.13 cm respectively).The cross-sectional area of upper airway in anterior,middle and rear parts were(1.49?0.12) cm2,(1.37?0.32) cm2 and(1.00?0.21) cm2 respectively,the narrowest part was in rear area,and in control groups were(1.30?0.14) cm2,(1.57?0.32) cm2 and(2.48?0.42) cm2 respectively.Conclusion The lower pressure condition can be used to produce animal experimental model of OSAHS,the low pressure is the important factor to cause OSAHS.