Résumé
Studies showed that animal model of the so-called simple syndrome currently have corresponding modern medical disease without exception. Even such animal model is called simple syndrome model, its properties is a cer-tain modern medicine disease. There is no specific corresponding relationship between the syndrome-attribution and the syndrome. The signs and symptoms differentiation and abnormal physical and chemical detection indices after pathogen-modeling of traditional Chinese medicine (TCM) cannot be determined since there are no specific corre-sponding relationships. The study on disease-syndrome combination model contains both modern medical modeling method and TCM modeling method. This type of modeling method has its own existing shortcomings. Meanwhile, two modeling methods used in the model establishment have uncertain relationship. The disease-syndrome combination model is usually not established in the comparison among different syndromes of one disease. Therefore, it has no ex-clusive attribute. There are many problems existed in the TCM modeling method, disease-syndrome combination modeling method, and syndrome-attribute evaluation methods. The basic reasons are the wide difference between symptoms and signs for diagnosis in modern medicine disease. There are a few symptoms and signs for diagnosis in modern medicine. But there are much more symptoms and signs for syndrome differentiation of the same disease. Many symptoms for syndrome differentiation are unknown for its source of origin existed in a virtual state. It caused that many virtual syndromes abstracted by virtual symptoms, and was reflected by the relevant standards. It leads to devastating consequences for the development of animal modeling method.