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A garbage bin was developed specifically to defense radiation of nuclear medicinal waste product;by the bin the waste material can be collected and stored during the processes when medical personnel managing radionuclide, such as opening bottles, diluting, dividing, labeling, washing, injecting and administrating the medicine, under these circumstances, the exposure and damage caused by the nuclear radiation to the personnel and their surrounding people can be effectively decreased or avoided compared to those the medical workers taking the nuclear waste material to throw into an ordinary garbage bin.
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Aim To investigate the protective effect of Citrus aurantium L. polysaccharides-B(CALB) on ra-diation induced by 60Co γ-ray in mice. Methods The BALB/c mice were randomly divided into blank control group, radiation model group, CALB administration group (high, medium and low dose), and positive control group(black fungus polysaccharide,HP). The mice were administered orally for 30 days. After the last administration for three hours,the survival rates on the 2nd day and the 14th day of the blank control group and the irradiated mice after the single radioac-tive irradiation (7 Gy) with 60Co γ-ray were meas-ured. In addition, DNA content and micronucleus of bone marrow cells, SOD, GSH-Px activities, MDA content in serum, liver and brain tissues in mice, TChE activity in brain tissues and spleen and thymus index of mice were detected after one-time whole body irradiation with 60Co γ-ray (3 Gy). Results Each dose group of CALB could significantly improve the survival rate of irradiated mice,increase the DNA con-tent of mouse bone marrow cells and reduce the number of micronuclei in bone marrow cells. In addition, CALB could also increase the thymus and spleen index and the levels of SOD and GSH-Px in serum,brain and liver tissues of mice,and reduce the content of MDA. Conclusion CALB has protective effect on radiation injury,which can be used for further development and utilization of Fructus aurantii.
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Objective To design and synthesize novel G protein-coupled lysophosphatidic acid 2(LPA2)receptor agonists with anti-radiation activity. Methods Nine new LPA2 receptor agonists(Ⅰ2-Ⅰ5 andⅡ1-Ⅱ5)were designed and synthesized using DBIBB as the lead compound. The anti-radiation activity was assayed by the MTS method using the human umbilical vein endothelial cells(HUVEC)irradiated with 8.0 Gy 60Coγray. Results and Conclusion Nine target compounds notreported in the literature were synthesized and their structures were confirmed by 1H NMR and MS. The results showed thatⅠ4 andⅡ1 have obvious anti-radiation ac-tivity,indicating that this kind of compounds is worth further studying.
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Objective Using Ex-Rad as lead compound to design and synthesize coumarin benzyl(sulfoxide)sulfone derivatives with anti-radiation activity. Methods The target compounds were synthesized from methyl 2-mercaptoacetate and 4-bromomethylbenzoic acid through three steps. The anti-radiation activity was assayed by the MTT method using the HUVEC cells irradiated with 8Gy 60Co γ ray. Results Sixteen compounds containing a coumarin benzyl sulfoxide or sulfone group were synthesized and the structures were confirmed by 1H NMR and HRMS. Preliminary evaluation of the 16 compounds demonstrated that 6a, 6b, 6c and 6d exhibited potent anti-radiation activities. Conclusion The anti-radiation activities of 6a, 6b, 6c and 6d were significant, indicating that this kind of compounds is worth further study.
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Anti-radiation drugs can prevent humans from radiation injury, reduce the clinical symptoms of radiation sickness and promote early recovery. With the wide application of radiotherapy in the treatment of malignant tumor patients, anti-radiation drugs for radiotherapy have become more and more important. Tradiational anti-radiation drugs include free radical scavengers, superoxide dismutase(SOD) and SOD mimetics, nitroxides, natural antioxidants and cytokines. These drugs have the common disadvantages of serious side effects, narrow therapeutic time window, poor stability and high cost. Therefore, it is particularly important and urgent to discover anti-radiation drugs which are highly efficient, lowly toxic, inexpensive and easy to use. In recent years, with the deepening understanding of cell signaling pathways, angiotensin converting enzyme inhibitors (ACEI) and apoptosis regulators have gradually become a hot spot for anti-radiation drugs research. This review summarizes the advantages and disadvantages as well as the future trends of anti-radiation drugs with proven or potential usefulness in radiotherapy.
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Anti-radiation drugs can prevent humans from radiation injury,reduce the clinical symptoms of radiation sickness and promote early recovery. With the wide application of radiotherapy in the treatment of malignant tumor patients ,anti-radiation drugs for radiotherapy have become more and more important. Tradiational anti-radiation drugs include free radical scavengers,super?oxide dismutase(SOD)and SOD mimetics,nitroxides,natural antioxidants and cytokines. These drugs have the common disadvantag?es of serious side effects,narrow therapeutic time window,poor stability and high cost. Therefore,it is particularly important and ur?gent to discover anti-radiation drugs which are highly efficient,lowly toxic,inexpensive and easy to use. In recent years,with the deepening understanding of cell signaling pathways,angiotensin converting enzyme inhibitors(ACEI)and apoptosis regulators have gradually become a hot spot for anti-radiation drugs research. This review summarizes the advantages and disadvantages as well as the future trends of anti-radiation drugs with proven or potential usefulness in radiotherapy.
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With the progress of science and technology- the development of nuclear industry and the extensive use of cancer adiotherapy - people are exposed on ionizing radiation more frequently than before. Therefore- the research on anti-radiation drugs ias become the hotspot in pharmaceutical industry. However- the synthetic anti-radiation drugs have several side effects- more and nore investigators have focused on the traditional Chinese medicine (TOM) and natural products. This review reports the research idvances in anti-radiation TCM and natureal products.
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With the progress of science and technology, the development of nuclear industry and the extensive use of cancer radiotherapy, people are exposed on ionizing radiation more frequently than before. Therefore, the research on anti-radiation drugs has become the hotspot in pharmaceutical industry. However, the synthetic anti-radiation drugs have several side effects, more and more investigators have focused on the traditional Chinese medicine (TCM) and natural products. This review reports the research advances in anti-radiation TCM and natureal products.
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Objective To investigate the therapeutic effects and mechanism of anti-radiation pneumonia decoction(ARPD) on radiation induced lung fibrosis in rats.Methods One hundred and five male SD rats in a SPF grade were divided into Chinese medicine group,single radiation group and control group by random digits table method,with 35 in each group.After anesthetization,rats in Chinese medicine and single radiation groups were exposed to 6 MV X-rays at the dose of 15Gy.Rats in Chinese medicine group were treated with ARPD at the dosage of 10 ml·kg-1 ·d-1 once a day,but rats in single radiation group did not receive ARPD treatment.Rats in control group were treated with neither irradiation nor drugs.Five rats of each group were killed and the lung tissues and blood samples were collected at 15,30,60,75,90,105 and 140 d.The pathological changes of lung tissues were observed and the tissue protein and gene expressions of TGF-β1,PAI-1 and collagen type Ⅲ(C Ⅲ) were assayed by Western blot and RT-PCR.ELISA was used to detect serum TGF-β1 and plasma PAI-1.Tissue and serum HYP were determined by acid hydrolysis and alkaline hydrolysis methods respectively.Results Inflammation was found in the lung tissues of all the exposed rats.Obvious pathological lung fibrosis was found at 60 d,the inflammation and the fibrosis in treated group were slighter than those in single radiation group.In Chinese medicine group,the protein and gene expression levels of TGF-β1,PAI-1,C Ⅲ 30 d(Protein:t =2.49-3.74,t =2.63-4.57 and t =2.76-3.83;Gene:t =2.59-4.33,t =2.83-4.62 and t =2.83-3.96,P＜0.05),serum TGF-β1 and plasma PAI-1 15 dlater (t =2.85-6.27 and t =3.69-5.27,P＜0.05),and the levels of tissue and serum HYP60 dlater (t=3.65-4.40 and t =6.56-3.75,P＜0.05),all of them were lower than those in single radiation groups.There were significant positive correlations between tissue TGF-β1 and PAI-1 as well as C Ⅲ (Protein expression:r =0.604,0.759,P ＜0.05;Gene expression:r=0.519,0.816,P＜0.05).Conclusions ARPD may inhibit the pulmonary fibrosis by decreasing the levels of TGF-β1,PAI-1 and C Ⅲ.
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'Ozone hole' , which cause a great increment of the UV radiation to the earth surface, is a exclusive phenomena over the Antarctic. After living in high UV radiation for a long time , plankton in the Antarctic have produced many anti-radiation active substances. In this article, the properties, configurations, functions, etc. of anti-radiation active substances in algae, bacteria and fungi in the Antarctic wen: summarized. At the same time, significative illuminations on the studies and utilization of anti-radiation and anti-tumour active substances are expected.