Résumé
Objective To investigate the effects of pramipexole on serum cystatin C, antioxidant indexes and brain derived neurotrophic factor ( BDNF) in the treatment of patients with Parkinson’s disease.Methods Retrospective a total of 96 patients with Parkinson’s disease were collected and randomly divided into experimental group and control group with 48 cases in each group.Patients in the control group were treated by levodopa,patients in the experimental group were treated on the basis of the control group with pramipexole, movement and non-movement symptoms were assessed by unified Parkinson’ s disease rating scale ( UPDRS), the serum cystatin C, antioxidant indexes and brain derived neurotrophic factor levels were measured, and the clinical efficacy and adverse reactions were compared.Results The effective rate of the control group (68.75%) was lower than the experimental group (87.50%), with statistical significance (P<0.05); compared with the control group, the movement and non-movement symptoms of the experimental group reduced after treatment, after treatment the serum CRP, serum cystatin C decreased, serum BDNF increased, after treatment the glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidate (GPX) levels increased, with statistical significance (P<0.05).Conclusion Pramipexole in the treatment of patients with Parkinson’s disease could reduce serum cystatin C, improve the levels of BDNF and antioxidant capacity, the effect is remarkable.
Résumé
Objective To investigate the effect of povidone iodine irrigation combined with levofloxacin eye drops on the inflammatory indexes, NO and antioxidant indices in serum and tear fluid of patients with diabetic cataract.Methods 50 cases of pati ents with diabetic cataract and admitted into the hospital during January 2013 to January 2015 were selected as the research objects all of whom received cataract surgery.According to the randomized double blind method, the patients were divided into two groups with 20 cases in each group.The control group received levofloxacin eye drops intervention before surgery while the observation group were treated withpovidone iodine irrigation, based on the control group.The inflammatory indexes (IL-2, sIL-2R, IL-6), NO, antioxidant indexes (TAC, SOD, CAT) and condition of postoperative infection were compared between the two groups before and after irrigation.ResuIts In the observation group, the sIL-2R, IL-6 and NO levels in serum and tear fluid after irrigation were significantly lower than those in the control group while IL-2, TAC, SOD and CAT were significantly higher than those in the control group.The differences were statistically significant (P<0.05).The postoperative infection rate of the observation group was 0.0% which was significantly lower than 16.0% of the control group.The difference was statistically significant ( P<0.05 ) .ConcIusion Povidone iodine irrigation combined with levofloxacin eye drops can significantly reduce the inflammatory reactions in patients with diabetic cataract and improve their antioxidant level.