Résumé
@#Tissue engineering has been applied to induce pulp-dentin complex regeneration, and proposed the concept of regenerative endodontics. As a new subject in stomatology, regenerative endodontics promotes root development and pulp regeneration with the combination of dental stem cells, biomaterial scaffolds and growth factors. Clinically, pulp regenerative technique has been used to treat necrosis and periapical periodontitis of immature permanent teeth. Numerous case reports and studies have proved the possibility of pulp regeneration, and regenerative endodontics will become a potential new treatment alternative of dental pulp diseases for dental clinician. In the present paper, we will summarize and analyze the current process and prospective of regenerative endodontics.
Résumé
Here, we describe two dogs in which canine small intestinal submucosa (SIS) was implanted as a biomaterial scaffold during perineal herniorrhaphy. Both dogs had developed severe muscle weakness, unilaterally herniated rectal protrusions, and heart problems with potential anesthetic risks. Areas affected by the perineal hernia (PH) located between the internal obturator and external anal sphincter muscles were reconstructed with naive canine SIS sheets. In 12 months, post-operative complications such as wound infections, sciatic paralysis, rectal prolapse, or recurrence of the hernia were not observed. Symptoms of defecatory tenesmus also improved. Neither case showed any signs of rejection or specific immune responses as determined by complete and differential cell counts. Our findings demonstrate that canine SIS can be used as a biomaterial scaffold for PH repair in dogs.