Analysis and suggestions on the development trend of drug innovation in China / 中国药科大学学报

@#In order to comprehensivehy evaluate the stage of China in the global drug innovation, to further optimize the environment for drug innovation in China, and to unleash the vitality of drug innovation, this article mainly analyzes through comparison China''s situation of drug innovation in global competition from such perspectives as the current situation of the global drug R&D innovation market, R&D investment, product pipeline, policy support, and development trends, combined with the characteristics of China''s drug innovation development.It can be seen that China''s pharmaceutical innovation is faced with such practical problems as lagging behind some developed countries in terms of innovation development, companies bunching into research and development innovation, sudden research and development rush, and excessive dependence on capital markets for pharmaceutical innovation.Accordingly, this paper puts forward suggestions on continuously improving China''s new drug innovation environment, rationally selecting differentiated competition and new tracks, reasonably formulating drug innovation development strategies, guiding capital to return to innovative research and development, and constructing a "double cycle" strategy for drug innovation.

Development and strategy analysis of Chinese herbal medicine in Germany / 国际中医中药杂志

Germany owns the largest herbal market in Europe and has the world's leading R&D capabilities for herbal medicine products. Chinese herbal medicine (CHM) spreaded to Germany hundreds of years ago. Since the beginning of the 20th century, China and Germany have signed a series of agreements to support traditional medicine cooperation, and the exchange of herbs between China and Germany has become more frequent, bringing opportunities for CHM to enter into Germany. In recent years, China and Germany have gained progress in the fields of CHM research and trade, etc. However, there are differences in the understanding of herbal medicines, quality standard evaluation, usage, and medication rules between the two countries. By doing SWOT analysis of the development of CHM in Germany, this paper suggested to promote Sino-German medical exchanges and build a community of common health for mankind through strengthening the clinical application of CHM, finding new ways of CHM entering into German market, and building an international talent team of traditional Chinese medicine.

Considerations on Clinical Development and Regulatory of the Oversea License-in Anti-tumor Drugs / 中国肺癌杂志

With the boom of China's innovative pharmaceutical industry, licensing-in model has gradually become an important research and development model for innovative pharmaceutical companies. The in-licensed drugs at different stages need different research and development (R&D) strategy in China. The pharmaceutical companies take the responsibility to comprehensively collate the oversea clinical data and conduct a detailed analysis of clinical pharmacology, safety, efficacy and ethnic sensitivity. Clinical R&D strategy should be made based on the results of the above data and analysis. We encourage high-quality drugs which fill unmet clinical needs licensed in, and as early as possible, so as to conduct multi-regional clinical trials (MRCTs). The clinical R&D strategy in China is particularly important for the drug's approval. Guidelines published by the National Medical Products Administration (NMPA) and clinical associations should be followed. Communications about clinical R&D strategy with Center of Drug Evaluation (CDE) are encouraged.
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Current situation and development strategy of health emergency standardization system / 上海预防医学

In recent years， the increasing scale and scope of public health emergencies have brought serious challenges to China's health emergency system. It is in urgent need to develop the existing health emergency system toward the goal of multi-industry， multi-discipline， multi-professional and multi-regional， while the concept of standardization is essential to achieve this goal. This article describes the construction process of health emergency standardization system by the World Health Organization， the International Organization for Standardization， the United States， and China； analyzes the problems of China's health emergency standardization system by comparing the system between China and the United States， proposes the construction dimensions of China's health emergency standard system， and suggests development strategies targeting the shortcomings of China's health emergency standardization.

The strategies for development of endemiology for the "14th Five-Year Plan" / 中华地方病学杂志

According to the general goal of long term development of basic science from 2021 to 2035 and the "14th Five-Year Plan" in China, starting from the reasearch characteristics and the basic situation of endemiology, this study discusses the strategic position, development law, development trend, development status and layout, development goals and realization ways of endemiology, combined with the strategic needs of the discipline, the important interdisciplinary research areas of endemiology are put forward. The purpose of this study is to promote the rapid development of basic research on endemic diseases, to provide reference for the scientific and technological layout and policy formulation of the endemiology, to provide reference for the "14th Five-Year Plan" in China, and to provide guarantee for the people in the sick area to seek health.

Estrategia de desarrollo de requisitos no funcionales en aplicaciones para la salud / Strategy for developing non-functional requirements in health applications

El desarrollo de software para la salud es complejo. Los Requisitos No Funcionales son especialmente importantes en este tipo de sistemas cuyos fallos causan un daño significativo que puede llegar a repercutir en la salud de las personas. Sin embargo, con frecuencia estos requisitos son subestimados debido a que resultan ser más complejos y requieren un mayor nivel de conocimiento y esfuerzo. El presente artículo describe una estrategia de desarrollo de requisitos no funcionales en aplicaciones para la salud, acorde a los requisitos definidos en la norma ISO/IEC 25030 y a los modelos de calidad de producto y procesos ISO/IEC 25010 y CMMI para desarrollo respectivamente. Los principales resultados se relacionan con la definición de acciones, métodos y técnicas que orientan las actividades de desarrollo de estos requisitos cuya puesta en práctica contribuye a mejorar los atributos de calidad de las especificaciones de requisitos de software(AU)

Software development for health is complex. Non-Functional Requirements are especially important in these types of systems whose failures cause significant damage that can reaffect people's health. However, these requirements are often underestimated because they are more complex and require a higher level of knowledge and effort. This article describes a strategy for developing non-functional requirements in health applications, in accordance with the requirements defined in ISO / IEC 25030 and the product quality models and processes ISO / IEC 25010 and CMMI for Development respectively. The main results are the definition of actions, methods and techniques that guide the development activities of these requirements whose implementation contributes to improve the quality attributes of the software requirements specifications(AU)

Ecological Suitability Analysis of Production Areas and Industrial Development Strategy of Dai Medicine / 中国实验方剂学杂志

The suitable production area can guarantee the quality of Dai medicine， but the research on the suitable ecological factors and suitable production area of plant Dai medicine is relatively scarce at present. In this study， gmpgis was used to analyze the ecological suitability of Dai medicine in China. For the first time， the range of ecological factors and main soil types in the main distribution areas of Dai medicine were extracted， such as annual average temperature of 8.6-23.7 ℃， annual average precipitation of 1212-1881 mm， annual average sunshine of 149.7-157.4 W·m-2， the main soil types are strong eluvial soil， alluvial soil， high activity strong acid soil， etc. Based on 179 sampling points， through the analysis of ecological similarity， the largest ecological similarity area of plant Dai medicine in the world was obtained， mainly including China， Brazil， the United States， Myanmar， Laos and other countries. In China， it is mainly concentrated in the West and south of Yunnan， including Xishuangbanna Dai Autonomous Prefecture， Dehong Dai Jingpo Autonomous Prefecture， Pu'er City， Baoshan City and Lincang City， which are suitable for cultivation. In addition， by analyzing the current situation of Dai medicine industry， this paper summarizes the problems such as the lack of talents， the decreasing of Dai medicine resources， the limitation of cultural heritage， and the weakness of scientific research， and puts forward strategies such as training high-quality talents of Dai medicine， the investigation and protection of Dai medicine resources， promoting the collection and arrangement of Dai medicine data and ancient books， and strengthening the basic and applied research of Dai medicine Enter the development of Dai medicine. This study provides a basis for guiding the rational layout， introduction and breeding of plant Dai medicine production base， and lays a foundation for the scientific and standardized production of high-quality Dai medicine.

Research on Development Strategies of Traditional Chinese Medicine Enterprises Based on SWOT Analysis / 中国实验方剂学杂志

Traditional Chinese medicine (TCM), as the unique health resources, huge potential economic resources, scientific and technological resources with original advantages, excellent cultural resources and important ecological resources, has made remarkable achievements in Chinese economic and social development in recent years. However, there are still some problems in the reform and development of TCM, especially the lack of willingness to innovate and low ability in commercialization of research and development findings in such companies. Meanwhile, the globalization level of TCM is not high. All these problems have seriously restricted the overall development of TCM. Taking TCM enterprises as the research object, this paper uses SWOT analysis to carry out comprehensive strategic analysis on its advantages, disadvantages, opportunities and risks. It is concluded that TCM enterprises in China should focus on research and development of classical formula compound preparations and innovative TCM products, and then propose product development and innovation strategies.

Research progress on sedative and hypnotic effect of Sini Powder and strategic analysis of its new drug development / 中草药

Sini Powder is the traditional Chinese medicine compound, which comes from Treatise on Febrile Diseases. It is used to treat the syndrome of yang depression and reversal cold of limbs. Sini Powder has a certain effect on treating insomnia caused by liver depression and spleen deficiency. Lots of researches have shown that Sini Powder has a sedative and hypnotic effect similar to diazepam and plays an important role in improving sleep disorders caused by post-traumatic stress disorder (PTSD). Sini Powder is not included in Chinese Pharmacopoeia (2015 edition). It is probably to develop Sini Powder into a new drug for the clinic. We collated and summarized the literature about the sedative and hypnotic effect and the improvement of sleep disorders caused by PTSD of Sini Powder. Based on the modern research on the sedative and hypnotic effect of Sini Powder, we think the effect of "relieve uneasiness of mind and body tranquilization" adapts the theory of traditional Chinese medicine, so that it can improve the applied range of Sini Powder. Meanwhile, we analyzed the possibility of Sini Powder being selected into the ancient classical prescription and key problem in research and development on drug preparation of Sini Powder according to regulations of traditional Chinese medicine. Then we put forward some suggestions for further research from two aspects which are the development of Sini Powder and new drugs of traditional Chinese medicine, to provide a reference for the development of new Chinese medicine preparation of Sini Powder focus on "expelling pathogen and relieving depression, soothing liver and regulating spleen, tranquilizing mind".

Research and Development of New Traditional Chinese Medicine Based on Experienced Prescriptions of Prestigious Chinese Physicians / 中国实验方剂学杂志

The experienced prescriptions of famous prestigious Chinese physicians are effective prescriptions developed by prestigious Chinese doctors during their long-time clinical practice, which reflect the traditional Chinese medicine (TCM) understanding of the disease development regularity and core pathogenesis. These experienced prescriptions provide valuable experience for medication and prescription regularities, and represent the highest level of TCM treatment and the major sources of new drug research, development and technology innovation. It is of great significance to inherit academic thoughts and clinical experiences of prestigious Chinese physicians, explore and summarize experienced prescriptions, and develop new Chinese drugs. The researches of new drugs based on experienced prescriptions are the major direction encouraged by the government, with the maximum amount of new TCM drug applications but a low approval rate in recent years. The main reason for the low number of approved new TCM drug applications is that researchers know less about evaluation concepts and relevant techniques, leading to problems in research and development strategy. To facilitate a smooth advance of the new drug research and development and take full advantage of the experienced prescriptions, in this paper, we focus on the problems about new drug development of experienced prescriptions, lay emphasis on the new TCM drug research and development concepts of clinical value, history of human application and whole-process quality control, and deeply and systematically analyze concerns in such links as pharmacy, pharmacodynamics, toxicology and clinic application. The purpose of this article is to provide the reference in solving actual problems, the reliable basis of further researches on experienced prescriptions, and the important guarantee for developing more safe, effective and high-quality controllable drugs to meets clinical requirements, so as to achieve the strategy of a healthy China.

Gestión del conocimiento para mejorar los servicios de salud. Una visión para IMIA-LAC / Knowledge management to improve health services. A vision for IMIA-LAC

Introducción: La generación de mecanismos de aplicación del conocimiento en el desarrollo de nuevos productos y procesos e incluso de nuevas formas de organización social es el recurso fundamental en la Sociedad de la Información -Conocimiento. Objetivo: Proponer tareas para concertar, a través de IMIA-LAC, los atributos de las herramientas informáticas y los procesos que caracterizan la Gestión del Conocimiento. Método: Se revisaron los sitios de IMIA e IMIA-LAC para obtener información sobre el desarrollo de esa organización en el mundo. Utilizando estrategias de búsqueda se obtuvo la información necesaria para vincular la estrategia gerencial de gestión del conocimiento con el desarrollo alcanzado, de las aplicaciones informáticas y de los procesos de informatización de los servicios de salud. Resultados: Se argumenta una propuesta de Planes de Acción para potenciar el desarrollo a través de IMIA-LAC: a) Estrategias dirigidas desde la organización, por ejemplo mejorar la identidad corporativa de esta b) Estrategias dirigidas a la búsqueda de mejoras en los servicios de salud, usando los vínculos efectivos con organizaciones claves en el sector Conclusiones: Se proponen un conjunto de acciones para concertar los procesos que caracterizan la Gestión del Conocimiento a través de IMIA-LAC utilizando las herramientas informáticas(AU)

Introduction: Generating mechanisms for applying knowledge in the development of new products, processes and new forms of social organization is the fundamental resource in the Information-Knowledge Society. Objective: Propose tasks to arrange, through IMIA-LAC, the attributes of IT tools and processes that characterize Knowledge Management. Methods: The IMIA and IMIA-LAC sites were reviewed to obtain information about the work of that organization in the world. Using search strategies the necessary information was obtained to link the managerial strategy of knowledge management with the development achieved of the computer applications and of the computerization processes of the health services. Results: A proposal of Plans of Action is argued to promote the development through IMIA-LAC: a) Strategies directed from the organization, for example to improve the corporate identity of this b) Strategies directed to the search of improvements in the health services, using effective links with key organizations in the sector. Conclusions: A set of actions are proposed to coordinate the processes that characterize the Knowledge Management through IMIA-LAC using the computer tools(AU)

Proteção de direitos humanos: o caso das quebradeiras de coco babaçu / Protection of human rights: the case of babaçu coconut breakers / Protección de derechos humanos: el caso de las rompedoras de coco babaçu

O presente estudo tem o objetivo analisar a proteção de direitos humanos dentro de um contexto histórico e desenvolvimentista na Amazônia, utilizando-se do caso das quebradeiras de coco babaçu. Para isso perpassou-se pelos conflitos sociais existentes na Amazônia e decorrentes desta política, analisou-se a proteção multinível e suas dimensões e a necessidade do âmbito subnacional de proteção dos direitos humanos, para, por fim, apresentar o caso das quebradeiras como exemplo de resistência e fortalecimento do protecionismo para com grupos vulnerabilizados dentro do contexto amazônico, junto à atuação em escuta e clínica ampliada, exemplificando a relação transdisciplinar entre Direito e psicologia em favor de uma atuação à proteção subnacional de direitos humanos através da abertura de novos espaços políticos para comunidades locais e movimentos sociais

The present study has the objective of analyzing the protection of human rights within a historical and developmental context in the Amazon, using the case of babaçu coconut breakers. Taking into account that the social conflicts existing in the Amazon region were the result of this strategy, the multilevel protection and its dimensions and the need for the subnational scope of protection of human rights were analyzed, in order to present the case of the breakers as an example of resistance and strengthening of protectionism towards vulnerable groups within the Amazon context, along with the performance in listening and clinical practice, exemplifying the transdisciplinary relationship between Law and Psychology, in favor of an action related to the subnational protection of human rights through the opening of new political spaces for local communities and social movements

El presente estudio tiene el objetivo de analizar la protección de derechos humanos dentro de un contexto histórico y desarrollista en la Amazonia, utilizando el caso de las rompedoras de coco babaçu. Para ello se percató por los conflictos sociales existentes en la Amazonia y derivados de esta política, se analizó la protección multinivel y sus dimensiones y la necesidad del ámbito subnacional de protección de los derechos humanos, para, por fin, presentar el caso de las quebradoras como ejemplo de resistencia y fortalecimiento del proteccionismo hacia grupos vulnerables dentro del contexto amazónico, junto a la actuación en escucha y clínica ampliada, ejemplificando la relación transdisciplinaria entre Derecho y psicología en favor de una actuación a la protección subnacional de derechos humanos a través de la apertura de nuevos espacios políticos para comunidades locales y movimientos sociales

Improvement of nutritional quality of local dishes and their acceptance by children of different ages / Melhoria de pratos típicos: qualidade nutricional e sua aceitação por crianças de várias idades

ABSTRACT Objective Food insecurity and child malnutrition are central topics in many food programs around the world; however, these indices do not diminish. The creation of strategies is necessary to increase the effectiveness of nutritional improvement programs. The objective of this research was to improve the nutritional quality of three local dishes included in the regular diet of the population by adding amaranth and to evaluate their acceptance by children from three communities in Tochimilco, Puebla, Mexico. Methods The study was carried out in three communities of "Tochimilco", Puebla, Mexico, in order to evaluate three local dishes: banana smoothie, beans and corn tortillas, which were chosen by mothers of the region in participative workshops on preparation of local dishes enriched with amaranth. Two sensory tests were applied: paired-comparison and hedonic scale to 208 and 210 children of preschool and scholar age, respectively. Results It was found that consumers showed similar preference for banana smoothie and beans enriched with amaranth compared to non-enriched dishes; while the amaranth enriched tortilla gained more preference in the different statistical tests and it was the dish with higher content of amino acids. Sensory attributes were similarly assessed and there were no significant differences among rural and urban communities and school year. Conclusion Children easily accept the addition of amaranth to the dishes they are accustomed to, as it does not change their food culture. It is possible to improve child nutrition by designing healthier dishes and incorporating them into the daily cooking of those who prepare the food.

RESUMO Objetivo A insegurança alimentar e a desnutrição infantil são temas centrais de muitos programas alimentares ao redor do mundo; no entanto, esses índices não diminuem. É preciso criar estratégias para aumentar a eficácia dos programas de desenvolvimento nutricional. A presente pesquisa teve como objetivo melhorar a qualidade nutricional de três pratos típicos da dieta normal da população local, adicionando amaranto às comidas típicas e avaliando a aceitação dele por crianças de três comunidades em Tochimilco, Puebla, México. Métodos O estudo foi realizado nas três comunidades para avaliar os três pratos típicos desta mesma região: vitamina de banana, feijão e as tortilhas de milho. Estas comidas foram escolhidas por mães da região em oficinas participativas de preparação de pratos locais enriquecidos com amaranto. Dois testes sensoriais foram aplicados: comparação pareada e escala hedônica para 208 e 210 crianças em idade pré-escolar e escolar, respectivamente. Resultados Verificou-se que os consumidores mostraram uma preferência semelhante pela vitamina de banana e feijão enriquecido com amaranto do que os mesmos não enriquecidos; enquanto a tortilha de milho enriquecida com amaranto ganhou mais preferência nos diferentes testes estatísticos e foi o prato com maior teor de aminoácidos. Os atributos sensoriais foram avaliados da mesma forma e não houve diferenças significativas entre as comunidades rurais e urbanas e as notas escolares. Conclusão As crianças aceitam facilmente a incorporação de amaranto nos pratos típicos da dieta delas, pois não repre-sentou nenhuma alteração da sua cultura alimentar. É possível melhorar a nutrição infantil, criando pratos mais saudáveis e incorporando-os na culinária cotidiana daqueles que preparam a comida.

The cultivation and realization of preponderant disciplines in hospital / 医学研究生学报

This paper analyses the Methods of selecting the cultivation direction of hospital′s dominant disciplines and points out that hospitals should analyse the development environment Objective ly, design the discipline distribution scientifically, and harbor the construction thoughts multi-dimensionally. Based on the practical experience of Nanjing General Hospital, this paper expounds vital Methods to develop preponderant disciplines, proposes that "fusion" and "differentiation" are the developing trend and regards the three major factors-leading talents, strong team, and major projects, as the critical points to prompt the cultivation of preponderant discipline. Lastly, the paper further discusses the implementation of cultivation through strengthening the platform construction, enhancing exchange and cooperation, focusing on achievement transformation and highlighting technical features.

Development strategy of nursing assistants in the scenario of elderly care with medical support / 中华医院管理杂志

The huge shortage of nursing assistants in the industry, has made it imperative and feasible to build and develop a team of nursing assistants. This paper studied the present situation and problems of the nursing assistants in China, naming such setbacks as the personnel shortage, low competence, and poor professionalism. In comparison, overseas experiences in teambuilding were introduced with recommendations raised for China. These recommendations include higher social approval of elderly care industry, innovative development mechanism of nursing assistants, appraisal mechanism for nursing assistants performance, and better fund raising mechanisms for their incentives and training.

A SWOT analysis and development thinking on the status of scientific research in county level public hospitals / 中华医学科研管理杂志

Objective This thesis analyze the current situation of scientific research and the proposals of development of the county level public hospitals.Methods Questionnaires were used to collect the data of the scientific research situation of county-level public hospitals,and SWOT analysis was employed to develop a better understanding of the situation and development of scientific research of county-level public hospitals.Results The number of papers published by hospitals is bound up with the number of scientific and technical staff in the county-level public hospitals,the number of laboratories,tissue banks and the proportion of the postgraduate students to the public hospitals.The achievements above municipal level in scientific research are also strongly linked with the professional scientific and management personnel,the number of laboratories and tissue banks and the proportion of postgraduate students to the hospital.There are distinct features of the advantages,disadvantages,plans and challenges of the scientific research work of county-level public hospitals.Conclusions The most important ways of improving the ability of scientific research and the quality of service in country level public hospitals are that:attach great importance to scientific research,intensify the efforts for the introduction and cultivation of scientific research talents,formulate a reasonable reward system,enable professional scientific research management for its delicacy research etc.

Development strategy of Paris based on combination of domestic patent and current resource application and development / 中国中药杂志

Paris is a commonly used traditional Chinese medicine (TCM), and has antitumor, antibacterial, sedative, analgesic and hemostatic effects. It has been used as an ingredient of 81 Chinese patent medicines, with a wide application and large market demand. Based on the data retrieved from state Intellectual Property Office patent database, a comprehensive analysis was made on Paris patents, so as to explore the current features of Paris patents in the aspects of domestic patent output, development trend, technology field distribution, time dimension, technology growth rate and patent applicant, and reveal the development trend of China's Paris industry. In addition, based on the current Paris resource application and development, a sustainable, multi-channel and multi-level industrial development approach was built. According to the results, studies of Paris in China are at the rapid development period, with a good development trend. However, because wild Paris resources tend to be exhausted, the studies for artificial cultivation technology should be strengthened to promote the industrial development.

Strategy programming for acupuncture development along One-Belt-One-Road countries / 中国针灸

Acupuncture has been applied in 183 countries and regions and gradually become a name card as TCM spreads across the world. The international influence of which plays a significant role in enhancing TCM development. The laws and regulations of TCM acupuncture along One-Belt-One-Road countries were compared and analyzed in this article. With comprehensive research and analysis, the international development strategy of acupuncture was rationally proposed. Combined with the historical background of China's national initiative One-Belt-One-Road, the acupuncture was taken as a breakthrough to lead the global spreading of TCM culture and Chinese herbs, so as to enhance China's soft strength, which could further create a fine cultural environment for the economic prosperity of One-Belt-One-Road countries. In addition, the strategy selection for China regarding TCM acupuncture development along One-Belt-One-Road countries was proposed, and the suggestive solution and implementation strategy for the essential missions and significant issues were provided.

Progress of small molecule anti-tumor covalent drugs / 中国药科大学学报

@#Covalent drugs are a type of inhibitors which exert their biological functions by irreversibly binding to the target through covalent bonds. With the marketing of kinase inhibitor covalent drugs against tumor, covalent drugs have regained the attention for drug discovery and have become a recent hotspot of anti-tumor drugs. In this paper, the action mechanisms, pharmacological advantages and the development strategies of modern covalent drugs are discussed and the recent research progress of anti-tumor covalent inhibitors is summarized, which provides a reference for the design of new anti-tumor covalent drugs.

Study on scientific and technological innovation trend based on the analysis of patents in Beijing municipal hospitals / 中华医学科研管理杂志

Objective To analyze the trend of scientific and technological innovation and propose strategies for development by study the general situation,distribution,dominant technology areas and protection conditions of patent applications from Beijing municipal hospitals during 2006-2015.Methods Collect basic patent information in 22 municipal hospitals to analyze the trend of scientific and technological innovation in municipal hospitals using technological development measurement method.Results A total number of 678 patent applications were filed from 22 hospitals from 2006 to 2015,shows patent applications increased a lot during the ten years.There are 390 valid patents among which medical devices,medical materials and preparation methods,enzyme or microbial testing methods are dominant areas of technological innovation.Conclusions The capacity of technological innovation develops rapidly in municipal hospitals.Research management departments should be more active in advancing technological innovation by strengthen patent management and promoting technology transfer.