Résumé
Objective To offer suggestions for how to administrate irregular usage of drug prescriptions in clinic .Methods The objective reasons and the hidden danger of irregular usage of drug prescriptions were analyzed .The existing international administration experience was searched and descriptive analysis was conducted .Results The existence of off-label use was rational because the drug in-struction had its loophole , and the information usually was lagged updated .However , off-label use could increase risks for both patients and doctors, which should be administrated by the government .International experience includes:set up clinical evidence references , en-courage drug companies to update instructions in time;establish independent drug information organization .Conclusion Irregular usage of drug prescriptions had its rationality and necessity .Relative regulations should be formulated in China as soon as possible .Irregular usage of drug prescriptions should follow certain principles .Active information support should be offered from related organization .Media administration and public education should be focused .