Research advances in peripheral blood brain cell-derived extracellular vesicles as the biomarker for central nervous system diseases / 中风与神经疾病杂志

@#Brain cell-derived extracellular vesicles （BCDEVs） are a group of double-layer membrane-structured nanovesicles which are released by all neural cells in the central nervous system （CNS） and contain the heterogeneity of the biological molecules of their originating cells， and under the physiological and pathological conditions of the brain， they are becoming the key media for communication and waste management between neurons， glial cells， and connective tissue. Based on the different specific molecular markers on the surface of BCDEVs， researchers have successfully enriched different subtypes of BCDEVs from peripheral blood， including neuron-derived extracellular vesicles， astrocytes-derived extracellular vesicles，oligodendrocyte-derived extracellular vesicles， microglia-derived extracellular vesicles， pericyte-derived extracellular vesicles，and endotheliocyte-derived extracellular vesicles. This article reviews extracellular vesicles， summarizes the different specific molecular markers used to enrich different BCDEVs from peripheral blood， and introduces the application of peripheral blood BCDEVs in CNS diseases，so as to clarify their potential as a biomarker and the challenges they face in achieving this goal.

Neuro-Sweet's Syndrome with Central Nervous System Involvement / 대한피부과학회지

Sweet's syndrome is an acute reactive condition that is characterized by fever, neutrophilic leukocytosis, erythematous tender edematous plaques or papules, and a dense dermal infiltrate of mature neutrophils. Although the extracutaneous manifestations of Sweet's syndrome are commonly seen in the joints and eyes, the central nervous system is rarely involved. A novel concept designated "Neuro-Sweet's syndrome" has recently been proposed for those cases of Sweet's syndrome that involve the central nervous system. It is essential to evaluate the skin eruptions in patients with recurrent meningoencephalitis of an unknown origin in order to avoid unnecessary empiric therapy. Herein, we report on two men who suffered from acute recurrent meningoencephalitis and they were subsequently diagnosed as having Neuro-Sweet's syndrome.