Influence of several experimental factors on morphine dependence model in rats / 西安交通大学学报(医学版)

Objective To study the influenc e of several experimental factors on morphine dependence in rats. Methods The 130 SD health rats were randomly assigned to control groups and dependence groups. The withdrawal syndromes between control groups and dependen ce groups in different dosage, different time, constant dose administration and increased dose administration were evaluated. Results The differences between control groups and dependen ce groups were significant (P