Résumé
The etiology of renal cell carcinoma has not been clarified and the familial renal cell carcinoma accompanied with karyotypic abnormalities is very rarely reported in the world literatures. Recently the approaches to evaluate the etiology of renal cell carcinoma are now being tried but it's relationship with the chromosomal abnormalities has not yet been clearly identified. We report two cases of renal cell carcinoma occurred in sister and brother who were treated with radical nephrectomy. And also we studied the pedigree of the family and the karyotype of peripheral leukocytes from four siblings which shows normal chromosomal patterns
Sujets)
Humains , Néphrocarcinome , Aberrations des chromosomes , Caryotype , Leucocytes , Néphrectomie , Pedigree , FratrieRésumé
The etiology of renal cell carcinoma has not been clarified and the familial renal cell carcinoma accompanied with karyotypic abnormalities is very rarely reported in the world literatures. Recently the approaches to evaluate the etiology of renal cell carcinoma are now being tried but it's relationship with the chromosomal abnormalities has not yet been clearly identified. We report two cases of renal cell carcinoma occurred in sister and brother who were treated with radical nephrectomy. And also we studied the pedigree of the family and the karyotype of peripheral leukocytes from four siblings which shows normal chromosomal patterns