Formación de la cultura metrológica desde las potencialidades del deporte y la Educación Física

Este artículo trata la formación de la cultura metrológica, en los estudiantes de la Educación Preuniversitaria, desde las potencialidades del deporte y las clases de Educación Física, como uno de los elementos que debe ser priorizado en el proceso de enseñanza-aprendizaje de la Física y como parte de la preparación de los estudiantes para la vida. El objetivo de este trabajo consistió en diseñar un sistema de tareas docentes integradoras que permita aprovechar las potencialidades del deporte, en general, y las clases de Educación Física, en particular para la formación de la cultura metrológica en los estudiantes de décimo grado. Para el desarrollo de la investigación se utilizaron los métodos: analítico-sintético, inductivo-deductivo, modelación, observación, análisis documental, encuesta, entrevista y estadística descriptiva que permitieron procesar la información referente al tema objeto de investigación; así como determinar las causas de las insuficiencias que se presentan en el proceso de enseñanza-aprendizaje de la Física, para la formación de la cultura metrológica de los estudiantes de décimo grado. El sistema de tareas docentes integradoras propuesto se caracterizó por armonizar núcleos conceptuales básicos para el tratamiento a los contenidos metrológicos como son la estimación y medición de magnitudes y la conversión de unidades de medida; además de aprovechar las potencialidades del deporte y las clases de Educación Física.

Este artigo trata da formação da cultura metrológica em alunos da Educação Pré-Universitária, a partir das potencialidades das aulas de esportes e de Educação Física, como um dos elementos que devem ser priorizados no processo de ensino-aprendizagem de Física e como parte da preparação dos alunos para a vida. O objetivo deste trabalho foi conceber um sistema de tarefas didáticas integradoras que permita aproveitar as potencialidades do esporte, em geral, e das aulas de Educação Física, em particular, para a formação da cultura metrológica em alunos do décimo ano. Para desenvolver a pesquisa foram utilizados os seguintes métodos: analítico-sintético, indutivo-dedutivo, modelagem, observação, análise documental, levantamento, entrevista e estatística descritiva que permitiram o tratamento das informações referentes ao tema sob investigação; bem como determinar as causas das insuficiências que surgem no processo de ensino-aprendizagem de Física, para a formação da cultura metrológica dos alunos do décimo ano. O sistema de tarefas de ensino integrativo proposto caracterizou-se por harmonizar núcleos conceituais básicos para o tratamento de conteúdos metrológicos como a estimativa e medição de grandezas e a conversão de unidades de medida; além de aproveitar o potencial das aulas de esportes e Educação Física.

This article deals with the formation of metrological culture in Pre-University Education students, from the potential of sports and Physical Education classes, as one of the elements that must be prioritized in the teaching-learning process of Physics and as part of preparing students for life. The objective of this work was to design a system of integrative teaching tasks that allows taking advantage of the potential of sport, in general, and Physical Education classes, in particular, for the formation of metrological culture in tenth grade students. To develop the research, the following methods were used: analytical-synthetic, inductive-deductive, modeling, observation, documentary analysis, survey, interview and descriptive statistics that allowed the processing of information regarding the topic under investigation; as well as determine the causes of the insufficiencies that arise in the teaching-learning process of Physics, for the formation of the metrological culture of tenth grade students. The proposed system of integrative teaching tasks was characterized by harmonizing basic conceptual cores for the treatment of metrological content such as the estimation and measurement of magnitudes and the conversion of measurement units; in addition to taking advantage of potential of the sports and Physical Education classes.

Stimulation of mouse hematopoietic stem cells by angiogenin and DNA preparations

Immature hematopoietic progenitors are a constant source for renewal of hemocyte populations and the basic component of the tissue and cell repair apparatus. A unique property of these cells of internalizing extracellular double-stranded DNA has been previously shown. The leukostimulatory effect demonstrated in our pioneering studies was considered to be due to the feature of this cell. In the present research, we have analyzed the effects of DNA genome reconstructor preparation (DNAgr), DNAmix, and human recombinant angiogenin on both hematopoietic stem cells and multipotent progenitors. Treatment with bone marrow cells of experimental mice with these preparations stimulates colony formation by hematopoietic stem cells and proliferation of multipotent descendants. The main lineage responsible for this is the granulocyte-macrophage hematopoietic lineage. Using fluorescent microscopy as well as FACS assay, co-localization of primitive c-Kit- and Sca-1-positive progenitors and the TAMRA-labeled double-stranded DNA has been shown. Human recombinant angiogenin was used as a reference agent. Cells with specific markers were quantified in intact bone marrow and colonies grown in the presence of inducers. Quantitative analysis revealed that a total of 14,000 fragment copies of 500 bp, which is 0.2% of the haploid genome, can be delivered into early progenitors. Extracellular double-stranded DNA fragments stimulated the colony formation in early hematopoietic progenitors from the bone marrow, which assumed their effect on cells in G0. The observed number of Sca1+/c-Kit+ cells in colonies testifies to the possibility of both symmetrical and asymmetrical division of the initial hematopoietic stem cell and its progeny.

Curcumin plays an anti-osteoporosis role by inhibiting NF-κB signaling pathway to reduce oxidative stress damage to osteogenesis / 中国药理学通报

Aim To investigate the mechanism of curcumin inhibition of oxidative stress on osteogenic differentiation and its dose-dependent anti-osteoporosis effect. Methods Cellular oxidative stress models were used, different concentrations of curcumin were added to determinethebone formation markers, and the potential signaling pathways involvedwere detected. Meanwhile, the mouse model of osteoporosis ( ovariecto- mized, 0VX) was used to confirm its effect against osteoporosis. Results In vitro experiments found that low concentrations of curcumin (1-10 μmol · L

The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis

Coronary restenosis is an important cause of poor long-term prognosis in patients with coronary heart disease. Here, we show that lysine methyltransferase SMYD2 expression in the nucleus is significantly elevated in serum- and PDGF-BB-induced vascular smooth muscle cells (VSMCs), and in tissues of carotid artery injury-induced neointimal hyperplasia. Smyd2 overexpression in VSMCs (Smyd2-vTg) facilitates, but treatment with its specific inhibitor LLY-507 or SMYD2 knockdown significantly inhibits VSMC phenotypic switching and carotid artery injury-induced neointima formation in mice. Transcriptome sequencing revealed that SMYD2 knockdown represses the expression of serum response factor (SRF) target genes and that SRF overexpression largely reverses the inhibitory effect of SMYD2 knockdown on VSMC proliferation. HDAC3 directly interacts with and deacetylates SRF, which enhances SRF transcriptional activity in VSMCs. Moreover, SMYD2 promotes HDAC3 expression via tri-methylation of H3K36 at its promoter. RGFP966, a specific inhibitor of HDAC3, not only counteracts the pro-proliferation effect of SMYD2 overexpression on VSMCs, but also inhibits carotid artery injury-induced neointima formation in mice. HDAC3 partially abolishes the inhibitory effect of SMYD2 knockdown on VSMC proliferation in a deacetylase activity-dependent manner. Our results reveal that the SMYD2-HDAC3-SRF axis constitutes a novel and critical epigenetic mechanism that regulates VSMC phenotypic switching and neointimal hyperplasia.

Fundamentos do processo de trabalho em terapia ocupacional: uma abordagem analítica a partir do diálogo entre Terapia Ocupacional Social e Saúde Coletiva Latino-Americana / Labor process foundations of occupational therapy: an analytical approach based on the dialogue between Social Occupational Therapy and Latin American Collective Health / Fundamentos del proceso de trabajo de la terapia ocupacional: una aproximación analítica basada en el dialogo entre Terapia Social Ocupacional y Salud Colectiva Latinoamericana

Resumo Introdução Este artigo apresenta uma abordagem analítica da prática da terapia ocupacional baseada no materialismo histórico dialético, compreendendo que a prática profissional da terapia ocupacional é considerada trabalho no sistema capitalista, podendo ser analisada à luz da Teoria do Processo de Trabalho. Objetivo Propor uma abordagem analítica com o intuito de apoiar o desenvolvimento de práticas de terapia ocupacional emancipatórias, baseadas no diálogo entre a Terapia Ocupacional Social e a Saúde Coletiva Latino-Americana. Método Com base na pesquisa-ação emancipatória, foram realizadas dez oficinas com dez terapeutas ocupacionais visando à produção coletiva de conhecimento. Resultados A atividade humana foi identificada como objeto do processo de trabalho da terapia ocupacional, definida pela categoria trabalho em sua dimensão ontológica. A participação radical foi proposta como o produto intencionado deste processo, sendo entendida como a participação na luta por transformar elementos da determinação social das condições coletivas de trabalho e vida. Os sujeitos desse processo são os terapeutas ocupacionais e os indivíduos, grupos e/ou comunidades acompanhados, todos entendidos como seres sociais em parceria para a transformação social. São identificadas quatro ferramentas teórico-metodológicas: análise emancipatória de atividades humanas, proposição emancipatória de atividades humanas, operacionalização da participação radical e intervenções sobre o tecido social. Conclusão A terapia ocupacional como prática social oferece uma contribuição específica para o desenvolvimento de uma práxis revolucionária coletiva que, voltada para a realização de uma utopia concreta, poderá gerar os meios para produzir uma nova sociedade.

Abstract Introduction This paper presents an analytical approach to occupational therapy practice grounded in historical dialectical materialism. It understands occupational therapy professional practice as work within a capitalist system, and thus subject to analysis through the labor process theory. Objective To propose an analytical approach to occupational therapy practice aimed at supporting the development of an emancipatory practice framework based on the dialogue between Social Occupational Therapy and Latin American Collective Health. Method Utilizing emancipatory action research methodologies, this study conducted 10 workshops with 10 occupational therapists aimed at collective knowledge production. Results Human activity is identified as the object of occupational therapy working process, defined by the category work in its ontological dimension. Radical participation is set as the intended product of this process, which entails engaging in efforts to transform the social determination of collective living conditions. The individuals in this process include occupational therapists and the followed-up individuals, groups, and/or communities, all viewed as social beings collaborating toward social transformation. Four theoretical-methodological tools are identified: emancipatory analysis of human activities, emancipatory proposition of human activities, operationalization of radical participation, and interventions in the social fabric. Conclusion Occupational therapy, as a form of social practice, offers a specific contribution to the development of a collective revolutionary praxis. This praxis, aimed at realizing a concrete utopia, seeks to generate the means to create a new society.

Resumen Introducción Este artículo presenta una aproximación analítica a la práctica de la terapia ocupacional basada en el materialismo histórico dialéctico. Entiende la práctica profesional de terapia ocupacional como trabajo bajo el capitalismo y, como tal, puede ser analizada bajo la teoría del proceso de trabajo. Objetivo Proponer un enfoque analítico de la práctica de la terapia ocupacional con la intención de apoyar el desarrollo posterior de un marco para la práctica de la terapia ocupacional emancipadora basada en el dialogo entre la Terapia Ocupacional Social y la Salud Colectiva Latinoamericana. Método A partir de una investigación acción emancipadora, se realizaron 10 talleres con diez terapeutas ocupacionales con el objetivo de la producción colectiva de conocimiento. Resultados La actividad humana es identificada como objeto del proceso de trabajo de la terapia ocupacional, definida por la categoría trabajo en su dimensión ontológica. La participación radical se establece como el producto previsto del proceso, es decir, la participación en la lucha por los elementos transformadores de la determinación social de las condiciones de vida colectivas. Los sujetos del proceso de trabajo son los terapeutas ocupacionales y los individuos, grupos y/o comunidades acompañados, todos entendidos como seres sociales en colaboración para la transformación social. Se identifican cuatro herramientas teórico-metodológicas: análisis emancipatorio de las actividades humanas, propuesta emancipadora de las actividades humanas, operacionalización de la participación radical e intervenciones en el tejido social. Conclusión La terapia ocupacional como práctica social ofrece una contribución específica al desarrollo de una praxis revolucionaria colectiva que, dirigida a realizar una utopía concreta, puede generar los medios para producir una nueva sociedad.

O nó da terra: a renda da terra como base para análise das questões urbana e agrária / The land knot: land income as basis for analyzing urban and agrarian issues

Resumo: O objetivo deste artigo é discutir a renda da terra como base para análise das questões urbana e agrária. Para isso, realizamos um estudo temático cuja análise seguiu o método materialista histórico-dialético. Debruçamo-nos sobre os estudos desenvolvidos por Marx e Engels, além de elaborarmos uma pesquisa bibliográfica complementar. Buscou-se desvelar o laço que unifica a essência de duas expressões da questão social: a propriedade privada da terra e o processo de sua valorização a partir do trabalho incorporado à terra.

Abstract: This article aims to discuss land rent as a basis for analyzing urban and agrarian issues. To this end, we carried out a thematic study whose analysis followed the historical-dialectic materialist method. We focused on the studies developed by Marx, Engels, as well as complementary bibliographical research. We sought to unveil the bond that unifies the essence of these expressions of the "social issue": private ownership of land and the process of its valorization based on the work incorporated into the land.

Effect of N-acetyl cysteine, rifampicin, and ozone on biofilm formation in pan-resistant Klebsiella pneumoniae: an experimental study

ABSTRACT BACKGROUND: To the best of our knowledge, this is the first study to evaluate the effectiveness of specific concentrations of antibiofilm agents, such as N-acetyl cysteine (NAC), rifampicin, and ozone, for the treatment of pan-resistant Klebsiella pneumoniae (PRKp). OBJECTIVES: We evaluated the effectiveness of antibiofilm agents, such as NAC, rifampicin, and ozone, on biofilm formation in PRKp at 2, 6, 24, and 72 h. DESIGN AND SETTING: This single-center experimental study was conducted on June 15, 2017, and July 15, 2018, at Istanbul Faculty of Medicine, Istanbul University, Turkey. METHODS: Biofilm formation and the efficacy of these agents on the biofilm layer were demonstrated using colony counting and laser-screened confocal microscopy. RESULTS: NAC at a final concentration of 2 μg/mL was administered to bacteria that formed biofilms (24 h), and no significant decrease was detected in the bacterial counts of all isolates (all P > 0.05). Rifampicin with a final concentration of 0.1 μg/mL was administered to bacteria that formed biofilm (24 h), and no significant decrease was detected in bacterial count (all P > 0.05). Notably, ozonated water of even 4.78 mg/L concentration for 72 h decreased the bacterial count by ≥ 2 log10. CONCLUSION: Different approaches are needed for treating PRKp isolates. We demonstrate that PRKp isolates can be successfully treated with higher concentrations of ozone.

PROPUESTA REFLEXIVA CONCEPTUAL SOBRE LA TRASCENDENCIA ESPIRITUAL Y SUS IMPLICACIONES PARA ENFERMERÍA / REFLECTIVE CONCEPTUAL PROPOSAL ON SPIRITUAL TRANSCENDENCE AND ITS IMPLICATIONS FOR NURSING

OBJETIVO: Elaborar una propuesta reflexiva conceptual sobre la trascendencia espiritual y sus implicaciones para enfermería. CONTENIDO: En el presente artículo se realizó una reflexión teórica sobre el fenómeno de la trascendencia espiritual y la construcción interpretativa del concepto destacando revisión de sus atributos que permiten su comprensión. Se incluyen los principales atributos conceptuales y se reflexiona sobre la trascendencia espiritual en enfermería, entendida como una capacidad motivada de manera intrínseca en la persona frente a situaciones vitales, esta capacidad le permite conectar con la situación y buscar sobrepasarla a partir de su sentido de espiritualidad. CONCLUSIONES: La trascendencia espiritual involucra el camino que puede llevar a la persona a una comprensión de situaciones contemplativas y de dificultad y a la vez a contemplar la vida y la existencia de una forma armónica y esta capacidad puede ser promovida en el cuidado de la enfermera.

OBJECTIVE: To elaborate a conceptual reflective proposal on spiritual transcendence and its implications for nursing. CONTENT: In this article, a theoretical reflection on the phenomenon of spiritual transcendence and the interpretative construction of the concept was carried out, highlighting a review of its attributes that further contributed to its understanding. The main conceptual attributes of spiritual transcendence are included and its implications for nursing reflected upon. Spiritual transcendence is understood as an intrinsically motivated capacity in the person in the face of life situations, a capacity that allows him/her to connect with the situation and seek to overcome it based on his/her sense of spirituality. CONCLUSIONS: Spiritual transcendence provides a path that can lead the person to an understanding of difficult situations, while allowing time to contemplate life and existence in a harmonious way. This is a capacity that can be promoted in nursing care.

Age estimation through the development of third molars in a case of multiple dismemberment / Estimación de la edad mediante el desarrollo de terceros molares en un caso de desmembramiento múltiple

El crimen organizado se ha convertido en un flagelo a nivel internacional conformado por grupos al margen de la ley que realizan todo tipo de actividades que involucran desde tráfico de personas, secuestros, extorsiones, narcotráfico y muchos otros delitos. Producto de este fenómeno, la desaparición y ejecución de personas es cada día más frecuente, en muchos casos los cuerpos son quemados o desmembrados para impedir o hacer más difícil la identificación. La odontología forense se ha convertido en una disciplina transcendental en la identificación de cadáveres y restos óseos, además de contar con múltiples métodos para estimar la edad aproximada de una persona. Se presenta el caso de un descuartizamiento múltiple de tres individuos masculinos donde era indispensable identificar si alguno correspondía a una persona menor de 18 años.

Organized crime has become an international scourge made up of outlaw groups that carry out all kinds of activities ranging from human trafficking, kidnapping, extortion, drug trafficking and many more. As a result of this phenomenon, the disappearance and execution of people is becoming more frequent every day, in many cases the bodies are burned or dismembered to prevent or make identification more difficult. Forensic odontology has become a transcendental discipline in the identification of corpses and skeletal remains, in addition to having multiple methods to estimate the approximate age of a person. The case of a multiple dismemberment of three male individuals is presented, where it was essential to identify a person under 18 years of age.

Linguagem enquanto Discurso conforme Michel Foucault: Uma revisão de literatura / El lenguaje como discurso desde Míchel foucault: una revisión delaliterarura / Language as Discourse according to Michel Foucault: Aliterature review

Este estudo se propõe a mostrar que o francês Michel Foucault, em todas as suas obras, oferece ferramentas para que sejam compreendidos, sob diferentes óticas, os problemas da sociedade por meio de interpretações sobre o viver humano. O objetivo dessa revisão de literatura é entender de que forma o discurso organiza as vozes dos sujeitos, como reelabora os discursos proferidos e os faz circular segundo Foucault. Apresenta-se conceitos básicos da Análise de Discurso iniciada na França por Michel Pêcheuxem 1969. O estudo percorre as obras em idas e vindas, com apoio em vários autores como Pêcheux e Mainguineauque ajudam na compreensãoe na aproximação entre método, teoria e prática.Conclui-se que a obra de Michel Foucault assinala que tudo o que é criado como saber oferece inúmeras possibilidades de recriação e está em permanente processo de transformação AU

Este estudio tiene como objetivo mostrar que el francés Michel Foucault, en todas sus obras, ofrece herramientas para comprender, desde diferentes perspectivas, los problemas de la sociedad a través de interpretaciones del vivir humano. El objetivo de esta revisión de la literatura comprender cómo el discurso organiza las voces de los sujetos, cómo reelabora los discursos pronunciados y los hace circular según Foucault. Presenta conceptos básicos del Análisis del Discurso iniciado en Francia por Michel Pêcheux en 1969. El estudio recorre las obras, con el apoyo de varios autores como Pêcheux y Mainguineau que ayudan a comprender y unir método, teoría y práctica. Se concluye que la obra de Michel Foucault destaca que todo lo creado como conocimiento ofrece innumerables posibilidades de recreación y se encuentra en un permanente proceso de transformación AU

This study aims to show that French Foucault, in all his works, offers tools to understand, from different perspectives, the problems of society, through interpretations of human living. The objective of this literature review is to understand how discourse organizes the subjects' voices, how it reworks the speeches given and makes them circulate according to Foucault. It presents basic concepts of Discourse Analysis initiated in France by Michel Pêcheux in 1969. The study goes back and forth through the works, with support from several authors such as Pêcheux and Mainguineau who help in understanding and bringing together method, theory and practice. It is concluded that Michel Foucault's work highlights that everything created as knowledge offers countless possibilities for recreation and is in a permanent process of transformation AU

Manejo das urgências subjetivas nas instituições: que lugar para o serviço-escola? / Maneuvering subjective urgency in institutions: what is the role of psychology school-service? / ¿Manejo de las urgencias subjetivas en las instituiciones: que lugar para el servicio-escuela?

Neste artigo pretende-se discutir a problemática do manejo da urgência subjetiva nas instituições, apoiando-se em uma investigação em andamento no serviço-escola de uma universidade pública. Interroga-se a urgência generalizada, marca de nossos tempos, para situar as coordenadas do manejo da angústia presente nas demandas por assistência em saúde mental dirigidas às instituições. Articula-se, a partir das referências teórico-clínicas dentro da psicanálise de orientação lacaniana, a prática do manejo das urgências em diversos dispositivos de saúde. Pretende-se circunscrever a partir dessa elaboração, o duplo pertencimento dos serviços-escola: lugar de formação e instituição que, de alguma forma, participa da rede de saúde mental. (AU)

This article intends to discuss the problem of maneuvering subjective urgency in institutions, based on ongoing research in development at the school-service of a public university. The widespread urgency is questioned, as a mark of our time, to locate thecoordinates of the management of anxiety present in demands for mental health assistance directed at institutions. It is articulated, through theoretical-clinical references within lacanian oriented psychoanalysis, the practical maneuvering of urgencies in several health devices. It is intended to circumscribe through this elaboration, the double belonging of school-services: place of formation and institution that, in some way, participates in the mental health network. (AU)

En este artículo se pretende discernir la problemática del manejo de la urgencia subjetiva en las instituciones, a partir de una investigación en desarrollo en el servicio-escuela de una universidad pública. Se interroga la urgencia generalizada, marca de nuestra época, para situar las coordinadas del manejo de la angustia presente en las demandas por asistencia en salud mental dirigidas a las instituciones. Desde las referencias teórico-clínicas se articula la práctica del manejo de las urgencias en diversos servicios de salud. Se pretende, a partir de esa discusión, circunscribir la doble pertenencia de los servicios-escuela: lugar de formación que, de alguna forma, participa de la redde salud mental. (AU)

Necesidades de formación de las personas editoras de la Universidad de Costa Rica

El crecimiento de la necesidad de información veraz ha llevado a que las revistas científicas se posicionen como medios de información confiables; lo cual hace que se requiera una necesidad de la profesionalización de esta labor que garantice la confiablidad y rigurosidad de las mismas. El objetivo de este manuscrito fue identificar las necesidades de formación de profesionales a cargo de la gestión editorial de las revistas científicas de la Universidad de Costa Rica. La investigación se realizó desde enero del 2019 hasta junio del 2020, por medio de un enfoque cualitativo de tipo descriptivo, con técnicas de recolección de este mismo enfoque. Se entrevistaron a las personas editoras y directoras de las principales revistas posicionadas en los primeros diez lugares del ranking UCR índex (a la fecha 4 de noviembre del 2019), se utilizó una entrevista semiestructurada con preguntas relacionadas a la identificación de actitudes, habilidades, conocimientos, necesidades de formación y el contexto en el que se desarrollan, estas representan las categorías de análisis utilizadas para el procesamiento de información. Entre los resultados se destacaron necesidades de formación en temáticas afines a los procesos administrativos relacionados con revistas, fundamentos de la gestión editorial, herramientas tecnológicas y el posicionamiento de las revistas; además se evidenciaron las cortas jornadas laborales que poseen los editores de revistas UCR. Se concluye que es imperativo que la UCR atienda estas necesidades de formación, además de fortalecer estos medios de divulgación del conocimiento y que se analice la oportunidad de ofrecer un programa de formación continua o bien una especialidad en gestión editorial.

The growth of the need for reliable information has led scientific journals to position themselves as reliable information media, which entails a need for the professionalization of this work that guarantees the reliability and rigor of this. The objective of this manuscript was to identify the training needs of the professionals in charge of the editorial management of the scientific journals of the University of Costa Rica. The research was carried out from January 2019 to June 2020, through a descriptive qualitative approach, with qualitative collection techniques. The editors and directors of the main journals positioned in the first ten places of the UCR index ranking (November 4th, 2019) were interviewed, a semi-structured interview was used with questions related to the identification of attitudes, skills, knowledge, training needs and the context in which they are developed, these represent the categories of analysis used for the processing of information. The main results shows that, training needs in topics related to the processes were highlighted, administrative issues related to journals, fundamentals of editorial management, technological tools and the positioning of journals; in addition, the short working hours that the editors of UCR magazines have were evidenced. It is concluded that it is imperative that the UCR meets these training needs, in addition to strengthening these means of disseminating knowledge and that the opportunity to offer a continuous training program or a specialty in editorial management be analyzed.

Analysis of the concept of nurses' autonomy in intensive care units: A hybrid model / Análisis del concepto de autonomía de las Unidades de Cuidado Intensivo. Un modelo hídrido / Análise do conceito de autonomia das Unidades de Terapia Intensiva. Um modelo híbrido

Objective. To analyze the concept of autonomy of nurses in Intensive Care Units (ICU). Methods. The hybrid model approach proposed by Schwartz-Barcott and Kim, which includes theoretical, fieldwork and analytical phases, was used for this study. For the theoretical and fieldwork phases, the Graneheim and Lundman stages and the CORE-Q checklist were used, and the results were combined in the final analysis phase. For the theoretical phase, 46 related articles, two instruments and four books were identified after using a search strategy in 7 bibliographic databases in English and one in Persian with the terms MESH: 'nursing', 'autonomy' and 'intensive care'. The information extracted in the theoretical phase served as the basis for the design of the questions used in the semi-structured interviews in the fieldwork phase. Eight nurses with ICU experience working in hospitals affiliated to Isfahan University of Medical Sciences (Iran) participated in the fieldwork phase. Results. The antecedents of the concept of nurse autonomy in ICUs were: empowerment of the workforce, organizational platform, and social and individual views of the profession. Its attributes were professionalism and high personal capabilities. Finally, increased personal competencies, promotion of quality of care, improved attitudes towards the profession and professional outcomes were noted as consequences. Conclusion. The autonomy of nurses in the ICU can facilitate their empowerment, which translates into the promotion of their caring behaviours, followed by the improvement of patient outcomes and quality of care.

Objetivo. Analizar el concepto de autonomía entre las enfermeras de la Unidad de Cuidados Intensivos (UCI).Métodos. Para este estudio se utilizó el enfoque de modelo híbrido propuesto por Schwartz-Barcott y Kim que incluye las fases: teórica, de trabajo de campo y analítica. Para las fases teórica y de trabajo de campo se utilizaron las etapas de Graneheim y Lundman y la lista de comprobación CORE-Q, y los resultados se combinaron en la fase de análisis final. Para la fase teórica se identificaron 46 artículos relacionados, dos instrumentos y cuatro libros tras utilizar una estrategia de búsqueda en 7 bases de datos bibliográficas en inglés y otra en persa con los términos MESH: 'nursing', 'autonomy' e 'intensive care'. La información extraída en la fase teórica sirvió de base para el diseño de las preguntas que se utilizaron en las entrevistas semiestructuradas de la fase de trabajo de campo. En esta última fase participaron ocho enfermeras con experiencia en UCI que trabajaban en hospitales afiliados a la Universidad de Ciencias Médicas de Isfahan (Irán). Resultados. Los antecedentes del concepto de autonomía de las enfermeras en las Unidades de UCI fueron: el empoderamiento de la fuerza de trabajo, la plataforma organizativa y las opiniones sociales e individuales acerca de la profesión. Sus atributos fueron el profesionalismo y las grandes capacidades personales. Por último, se señalaron como consecuencias: el incremento de las competencias personales, la promoción de la calidad de los cuidados, la mejoría de las actitudes hacia la profesión y los resultados profesionales. Conclusión. La autonomía de las enfermeras en las UCI puede facilitar su empoderamiento, lo que se traduce en la promoción de sus conductas asistenciales, seguida de la mejora de los resultados de los pacientes y de la calidad asistencial.

Objetivo. Analisar o conceito de autonomia dos enfermeiros da Unidade de Terapia Intensiva (UTI). Métodos. Este estudo foi realizado utilizando a abordagem do modelo híbrido proposto por Schwartz- Barcott e Kim, que inclui as fases teórica, de campo e analítica. As etapas de Graneheim e Lundman e o checklist CORE-Q foram utilizados nas fases teórica e de trabalho de campo, e os resultados foram combinados na fase de análise final. Para a fase teórica, foram identificados 46 artigos relacionados, dois instrumentos e quatro livros após a utilização de uma estratégia de busca em 7 bases bibliográficas em inglês e outra em persa com os termos MESH: 'nursing', 'autonomy' e 'intensive care'. As informações extraídas na fase teórica serviram de base para o desenho das questões que foram utilizadas nas entrevistas semiestruturadas da fase de trabalho de campo. Participaram desta última fase, oito enfermeiras experientes em UTI trabalhando em hospitais afiliados à Universidade de Ciências Médicas de Isfahan, no Irã.Resultados. Os antecedentes do conceito de autonomia dos enfermeiros nas Unidades de Terapia Intensiva foram: o empoderamento da força de trabalho, a plataforma organizacional e as opiniões sociais e individuais sobre a profissão. Seus atributos eram profissionalismo e grandes habilidades pessoais. Por fim, foram apontadas as seguintes consequências: o aumento das competências pessoais, a promoção da qualidade dos cuidados, a melhoria das atitudes perante a profissão e os resultados profissionais. Conclusão. A autonomia dos enfermeiros na UTI pode facilitar seu empoderamento, que se traduz na promoção de seus comportamentos assistenciais, seguida da melhoria dos resultados dos pacientes e da qualidade da assistência.

Corpo e processos formativos em tempos de pandemia / Body and formative processes in pandemic times / Cuerpo y procesos formativos en tiempos de pandemia

Este artigo discute processos formativos partindo da análise do corpo e do movimento nas artes performativas para pensar um ethos de aprendizagem inventiva. As limitações impostas pela pandemia da COVID-19 compuseram o debate, tornando a investigação uma análise de experiência, na medida em que as pesquisadoras envolveram seu corpo e seu conhecimento, focalizando seu próprio processo formativo em meio ao isolamento social e ao uso das mídias digitais. Utilizou-se a pesquisa-intervenção para acompanhar os processos de transformação aos quais as pesquisadoras estavam sujeitas na medida em que investigavam. Indica-se novos modos de aprender, lançando mão do dispositivo grupal num ethos de aprendizagem inventiva. (AU)

This article discusses formative processes starting from the analysis of the body and movement in the performing arts to think about na ethos of inventive learning. The limitations imposed by the COVID-19 pandemic made up the debate, making the investigation ananalysis of experience, as the researchers involved their bodies and their knowledge, focusing on his own training process amid social isolation and the use of digital media. Research-intervention was used to accompany the transformation processes to which there searchers were subjected as they investigated. New ways of learning are indicated, using the group device in an ethos of inventive learning. (AU)

Este artículo analisa los processos formativos a partir del análisis del cuerpo y el movimento em las artes de performances para pensar en un ethos de aprendizaje inventivo. Las limitaciones impuestas por la pandemia COVID-19 compusieron el debate, convirtiendo la investigación en un análisis de la experiencia, ya que los investigadores involucraron sus cuerpos y sus conocimientos, enfocándose em su próprio processo de formación em médio del aislamiento social y el uso de médios digitales. La investigación de intervención se utilizo para monitorear los processos de transformación a los que estaban sujetos los investigadores mientras investigaban. Se indican nuevas formas de aprendizaje, haciendo uso del dispositivo grupal em um ethos de aprendizaje inventivo. (AU)

Variables, indicadores y criterios de evaluación del servicio médico como escenario de formación de especialistas

La calidad de la educación de posgrado concebida estratégicamente como la integración de la pertinencia social y la excelencia académica, deviene esencial en la gestión de las instituciones docente-asistenciales del sector salud. Sus múltiples dimensiones deben ser contextualizadas y son susceptibles de análisis y perfeccionamiento en cada servicio médico donde se desarrolla el proceso de formación de especialistas. Se utilizaron métodos teóricos y empíricos, para la identificación de las dificultades y la elaboración de la nueva propuesta. Se obtuvieron criterios sobre los servicios médicos como escenarios de formación, en los que se identificaron los problemas relativos a la actividad de posgrado. La propuesta consideró las directrices estratégicas, la población objeto de atención y los diferentes ámbitos temporales y espaciales identificados, con lo que pretende el fortalecimiento y desarrollo de la formación de posgrado en las Universidades de Ciencias Médicas en Cuba.

The quality of postgraduate education, strategically conceived as the integration of social relevance and academic excellence, becomes essential in the management of teaching-assistance institutions in the health sector. Its multiple dimensions must be contextualized and are susceptible to analysis and improvement in each medical service where the specialist formation process takes place. Theoretical and empirical methods were used, for the identification of the difficulties and the elaboration of the new proposal. Criteria on medical services were obtained as training scenarios, in which problems related to postgraduate activity were identified. The objective of the work is to expose a proposal of variables, indicators and evaluation criteria in the service as a scenario the specialist's formation. The proposal was considered the strategic guidelines, the target population and the different temporal and spatial areas identified, with which it intends to strengthen and develop postgraduate training in the Medical Sciences Universities in Cuba.

Narrativas sobre competição esportiva: reflexões e perspectivas / Narratives about sports competition: reflections and perspectives / Narrativas sobre la competición deportiva: reflexiones y perspectivas

Analisar as concepções sobre competição esportiva em publicações acadêmicas brasileiras é o foco deste trabalho. Utilizando-se da revisão sistemática, do tipo estado da arte, foram analisados 175 artigos no recorte temporal 2010-2020 (11 anos) em 14 revistas da área da Educação Física. Há parcimônia dos/as autores/as quanto a complexidade da competição e foram salutares indicativas do rememorar a essência do tema; independente da área de conhecimento específico, foram recorrentes indicativos de um processo respeitoso e pedagógico da competição aos praticantes. Ademais, confirmam que amadores e profissionais; homens e mulheres; idosos e jovens, todos podem (e devem) ter a opção da experiência esportiva no âmbito competitivo (AU).

Analyzing the concepts about sports competition in Brazilian academic publication is the objective of this paper. Using the state-of-art systematic review, 175 articles were considered from 14 Physical Education Journals from 2010 to 2020 (11 years). There is parsimony by the authors regarding the complexity of the competition and greetings indicative of remembering the essence of the theme; regardless of the area of specific knowledge, there were recurrent indicators of a respectful and pedagogical process of the competition for practitioners. Also, it was confirmed that amateurs and professionals; men and women; elderly and young; everyone can (and should) have the possibility of sporting experience in the competitive environment (AU).

Analizar las concepciones sobre la competición deportiva en las publicaciones académicas brasileñas es el foco de este trabajo. Utilizando la revisión sistemática del tipo estado del arte, se buscarán 175 artículos en el período de 2010-2020 en 14 revistas del área de Educación Física. Hay parcimônia a la complejidad de la competición y fueron saludos indicativos de recordar la esencia del tema; independientemente del área de conocimiento específico, fueron recurrentes indicativos para un proceso respetuoso y pedagógico de la competencia por practicantes. También confirman que los atletas aficionados y profesionales; hombres y mujeres; ancianos y jóvenes, todos pueden (y deben) tener la opción de la experiencia deportiva en el entorno competitivo

Mechanism of microRNA-30d-5p regulating osteogenic differentiation of bone marrow stromal cells through glucose-regulated 78 / 解剖学报

Objective To investigate the effect of microRNA(miR)-30d-5p on osteogenic differentiation and apoptosis of bone marrow stromal cells and its mechanism. Methods Bone marrow stromal cells were divided into miR-30d-5p overexpression negative control group, miR-30d-5p overexpression group, miR-30d-5p inhibition negative control group and miR-30d-5p inhibition group. Alkaline phosphatase (ALP) staining was used to identify osteogenesis, alizarin red staining was used to detect calcium nodules precipitation, and TUNEL was used to detect apoptosis. mRNA and protein expression levels were detected by Real-time PCR and Western blotting, and the potential binding sites of miR-30d-5p were predicted by the bioinformatics analysis website Targetscan 7.1. Results After miR-30d-5p overexpression, osteogenic differentiation ability, and mineralization ability of the cells decreased (P<0.05), while apoptosis level increased (P< 0.05). The expression of glucoregulatory protein 78 (GRP78) and osteogenic specific transcription factor Runt related transcription factor 2(RUNX2) decreased significantly (P<0.05). However, miR-30d-5p inhibitor-treated the cells with increased osteogenic differentiation and mineralization ability (P < 0.05), and apoptosis level decreased (P < 0.05). GRP78 and RUNX2 protein levels increased (P<0.05). The miR-30d-5p binding site was located at 142-148 bp of the 3'UTR of the GRP78 gene. Conclusion MiR-30d-5p inhibits osteogenic differentiation and promotes apoptosis of bone marrow stromal cells by down-regulating the expression of GRP78 protein.

Licochalcone A inhibits osteosarcoma proliferation by Akt/ERK signaling pathway / 中国药理学通报

Aim To investigate the effect of licochalcone A (LCA) on proliferation and apoptosis of osteosarcoma HOS and U2OS cells and to explore its possible molecular mechanism. Methods The HOS and U2OS cells were cultured in vitro. MTT assay was used to detect the proliferation of the cells after being treated with different concentrations of LCA at different intervention time. Then HOS and U2OS cells were treated with 0. 1% DMSO, or different concentrations of LCA (5, 10, 20 μmol/L), and flow cytometry was used to assess the cell apoptosis. The expression of apoptosis-related protein cleaved PARP1, Bcl-2, Bax, and Akt, ERK were detected by Western blot. The antitumor effect of LCA was detected on U2OS xenograft mice in vivo. Results LCA could inhibit the proliferation of HOS and U2OS cells in a time-and dose-dependent manner. Flow cytometry showed that LCA treatment could induce cell apoptosis. Western blot results showed that LCA could inhibit the phosphorylation of Akt and ERK, increase the expression of cleaved PARP1 and Bax, and decrease the expression of Bcl-2. In the tumor-bearing mouse models, LCA significantly decreased the tumor volume (P < 0. 05) and weight (P < 0. 01). Conclusions LCA could inhibit the proliferation of HOS and U2OS and induce apoptosis possibly by inhibiting the Akt/ERK signaling pathway.

Effects of Apelin-13/putative receptor protein related to AT1 homodimer on behaviors of human umbilical vein endothelial cells / 中国药理学通报

Aim To explore the effects of putative receptor protein related to ATI (APJ) homodimer on the behaviors-the proliferation, migration and tube formation of human umbilical vein endothelial cells (HU-VECs). Methods HUVECs at logarithmic growth stage were randomly divided into PBS, Apelin-13 + TM1 (APJ monomer group) and Apelin-13 + PBS group (APJ homodimer group). Western blot and Matrix-Assisted Laser Desorption/Ionization Time of Fligh Mass Spectrometry (MALDI-TOF MS) were used to detect the expression of APJ and APJ homodimer in HUVECs, respectively. Real-Time Cell Analyzers (RT-CA) was used to detect the concentration of the maximum effect of Apelin-13. Cell viability was detected by CCK-8. The cell migration ability was detected by scratch test, and the number of tubes formed on matri-gel that made artificial basement membrane was counted. Results Western blot and MALDI-TOF MS showed that APJ and APJ homodimer were expressed in HUVECs. The EC50 of Apelin-13 was 2.26 x 10

Mechanism of scutellarein inhibiting foaming of macrophages by promoting cholesterol efflux pathway / 中国药理学通报

Aim To investigate the effects of scutellarein on the macrophage foam cell formation and cholesterol efflux, and the underlying mechanism. Methods THP-1 cells were differentiated with PMA, and the cell viability was detected by MTT assays. The effects of scutellarein on the cholesterol efflux and macrophage foam cell formation were evaluated by using NBD-la-beled cholesterol and the cholesterol detection kit. The effects of scutellarein on the activation of PPARγ-LXRα-ABCA1 signaling pathway were determined by molecular docking, ELISA, dual-luciferase reporter and Western blot. The effects of PPARγ knowdown on scutellarein-induced cholesterol efflux and inhibiting macrophage foaming were analyzed by siRNA interference. Results Scutellarein dose-dependently inhibited oxLDL-induced cholesterol accumulation, accelerated cholesterol efflux and significantly increased the protein expression of LXRα and ABCA1. At the same time, scutellarein could bind PPARγ and initiate its downstream LXRa-ABCAl signaling pathway. In addition, gene silencing of PPARγ not only significantly inhibited scutellarein-induced LXRα-ABCA1 signaling pathway and cholesterol efflux, but also reversed the inhibitory effect of scutellarein on macrophage foaming. Conclusions Scutellarein could promote the cholesterol efflux by activating PPARγ and initiating the downstream LXR-ABCA1 signaling pathway, thereby prevent the macrophage foam cell formation.