Research progress of hepatotoxicity mechanism and attenuation of Tripterygium wilfordii glycoside / 药物评价研究

Tripterygium wilfordii glycoside is an effective component extracted from Tripterygium wilfordii Hook.F.It has an effect on immunosuppression and anti-inflammatory which is used to treatments of rheumatic arthritis and nephrotic syndrome on clinic.The liver adverse reactions have been particularly significant in Tripterygium wilfordii glycoside induced adverse reactions.The aim of this article is to summarize the research of hepatotoxicity mechanism of Tripterygium wilfordii glycoside in recent ten years,to analyze toxic material base,and to search for the attenuated drugs and mechanism.For the clinical application of Tripterygium wilfordii glycoside this article provides related literature and theoretical basis research.