Clinical effect of laparoscopic splenectomy and pericardial devascularization in portal hypertension patients with Child-Pugh A/B liver function / 临床肝胆病杂志

ObjectiveTo investigate the clinical effect of laparoscopic splenectomy and pericardial devascularization (LSPD) in patients with portal hypertension and the long-term effect of LSPD. MethodsA total of 40 portal hypertension patients with Child-Pugh A/B liver function who received LSPD in The First Hospital of Jilin University from August to December 2017 were enrolled as surgical group, and 44 portal hypertension patients with Child-Pugh A/B liver function who received conservative treatment during the same period of time was enrolled as internal medicine group. The patients were followed up to June 30, 2019, and liver function parameters, upper gastrointestinal bleeding, and portal vein thrombosis were recorded for all patients at each time point. The t-test was used for comparison of normally distributed continuous data between two groups; an analysis of variance was used for comparison between multiple groups, and the Bonferroni test was used for further comparison between two groups. The Kruskal-Wallis H test was used for comparison of continuous data with skewed distribution; between multiple groups, and the Mann-Whitney U test was used for further comparison between two groups. The chi-square test was used for comparison of categorical data between groups. ResultsAt 6, 12, and 24 months after discharge, compared with the internal medicine group, the surgical group had a significantly higher level of cholinesterase (t=3.527, 3.849, and 5.555, all P＜0.05) and a significantly lower Child-Pugh score (t=2.498, 2.138, and 2.081, all P＜0.05). Compared with the internal medicine group at 12 and 24 months after discharge, the surgical group had a significantly higher level of albumin (t=3.120 and 2.587, both P＜0.05) and a significantly lower incidence rate of upper gastrointestinal bleeding (χ2=4.947 and 5.155, both P＜0.05). At 24 months after discharge, the surgical group had a significantly lower number of patients who had a significant increase in alpha-fetoprotein level than the internal medicine group (χ2=4.648, P=0.031). At 12 months after discharge, the surgical group had a significantly higher incidence rate of portal vein thrombosis than the internal medicine group (χ2=4.395, P=0.036). The surgical group had significant improvements in albumin (F=2.959, P=0.013), cholinesterase (F=11.022, P＜0001), prothrombin time (H=94.100, P＜0.001), and Child-Pugh score (F=3.742, P=0.003) from admission to 12 and 24 months after surgery. ConclusionIn portal hypertension patients with Child-Pugh A/B liver function, LSPD can improve liver function and reduce the incidence rate of upper gastrointestinal bleeding, and the high incidence rate of portal vein thrombosis can be effectively reduced by oral aspirin and rivaroxaban.

Esplenectomía Laparoscópica en el Hospital Pediátrico Baca Ortiz, estudio retrospectivo de los últimos 10 años / Laparoscopic splenectomy at Baca Ortiz Pediatric Hospital, a retrospective study of the last 10 years. Observational Study

Introducción: La esplenectomía es un tratamiento estandarizado en niños con trombocitopenia. El método de laparoscopía, en este tratamiento, minimiza los procesos post-operatorios y se ha difundido su aplicación en la comunidad científica. El objetivo del presente estudio es realizar una descripción de la casuística y utilidad de la esplenectomía laparoscópica en los niños con patología hematológica. Métodos: El presente estudio observacional, retrospectivo se realizó en el Hospital Pediátrico Baca Ortiz. Se revisaron expedientes clínicos de los últimos 10 años de pacientes con indicación de esplenectomía quirúrgica. Se analizan variables demográficas, clínicas y de resultados. Se utiliza estadística descriptiva. Resultados: Ingresaron al estudio 14 pacientes que tuvieron una esplenectomía quirúrgica vía laparoscópica. La mayoría de estos pacientes son del sexo femenino, con patologías hematológicas como esferocitosis y púrpura trombocitopénica idiopática (PTI). En el 50% se realizó colecistectomía además de esplenectomía. El tiempo quirúrgico varió de 60 a 120 minutos. Conclusiones: La esplenectomía laparoscópica es considerada una técnica compleja dentro de los procedimientos de laparoscopia, pero es ideal para los pacientes con patología hematológica, por lo que es la técnica de elección. Una ventaja de la esplenectomía laparoscópica es el menor tiempo de recuperación y hospitalización, con heridas quirúrgicas más pequeñas.

Introduction: Splenectomy is a standardized treatment in children with thrombocytopenia. The laparoscopic method, in this treatment, minimizes post-operative processes and its application has become widespread in the scientific community. The objective of this study is to describe the casuistry and usefulness of laparoscopic splenectomy in children with hematological pathology. Methods: This retrospective, observational study was conducted at Baca Ortiz Pediatric Hospital. Medical records of the last 10 years of patients with an indication for surgical splenectomy were reviewed. Demographic, clinical and outcome variables are analyzed. Descriptive statistics are used. Results: Fourteen patients who had a laparoscopic surgical splenectomy entered the study. Most of these patients are female, with hematological pathologies such as spherocytosis and idiopathic thrombocytopenic purpura (ITP). In 50% a cholecystectomy was performed in addition to splenectomy. The surgical time ranged from 60 to 120 minutes. Conclusions: Laparoscopic splenectomy is considered a complex technique within laparoscopic procedures, but it is ideal for patients with hematological pathology, so it is the technique of choice. An advantage of laparoscopic splenectomy is the shorter recovery time and hospitalization, with smaller surgical wounds

Suggestion of grade judgment and selection of surgical methods for splenomegaly / 中国实用外科杂志

Laparoscopic splenectomy(LS) is superior to open splenectomy(OS) because of advantages of minimal invasion,such as small trauma,rapid recovery,and short hospitalizing time,widely used in the resection of normalsized or moderately enlarged spleens. With the wide application of LS,the indications have been extended to the excision of massive spleens. However,there is still a tremendous controversy about the upper limit of splenic size which can be in accord with a requirement of LS and selection of surgical indications. Taking the issues into account,the authors recommended that the splenomegaly should be divided into“four degrees”rather than“three degrees”used today widely in order to guide the selection of appropriate surgical methods.

Resultados del uso de la esplenectomía videolaparoscópica en el Hospital Docente Clínico Quirúrgico "Hermanos Ameijeiras" / Outcomes of videolaparascopic splenectomy at Hermanos Ameijeiras Clinical Surgical Hospital

Introducción: la esplenectomía laparoscópica apareció con el desarrollo de la cirugía de mínimo acceso, se conviertió en la técnica preferida para la exéresis del bazo actualmente. Objetivo: evaluar los resultados de la esplenectomía videolaparoscópica en el tratamiento de las enfermedades hematológicas funcionales benignas. Método: se realizó un estudio descriptivo, longitudinal y prospectivo en 86 pacientes con diagnóstico de enfermedades hematológicas funcionales benignas, atendidos en el Hospital Clínico Quirúrgico Hermanos Ameijeiras desde octubre de 1996 hasta diciembre de 2011. Resultados: en la serie predominó el sexo femenino con 70,9 por ciento y la edad media fue de 40 años (37,8 por ciento). Las enfermedades más frecuentes fueron la púrpura trombocitopénica inmunológica (68,6 por ciento), la anemia hemolítica autoinmune con 23,3 por ciento y la esferocitosis hereditaria con 5,8 por ciento. Requirieron preparación preoperatoria 59,3 por ciento de los pacientes con 50,9 por ciento de respuesta efectiva a esta. El tiempo quirúrgico promedio fue 129 minutos. Como accidentes transoperatorios prevalecieron: la ruptura de la bolsa extractora con 12,8 pr ciento y el sangrado del hilio esplénico con 5,8 por ciento. Esto motivó la conversión a cirugía convencional y la exclusión del seguimiento de 6 pacientes. La complicación posoperatoria más frecuente fue el vómito persistente. El seguimiento de los pacientes se realizó desde los 7 días hasta los 2 años en 78 por ciento de los casos, con un tiempo promedio de 518 días. Hubo remisión total de su enfermedad en 82,7 por ciento de los pacientes, remisión parcial en 15,4 por ciento y solamente 1,9 por ciento no presentó remisión. Conclusiones: la esplenectomía videolaparoscópica es una técnica segura y efectiva en el tratamiento de las enfermedades hematológicas autoinmunes en cirujanos con experiencia en Cirugía de Mínimo Acceso de Avanzada(AU)

Introduction: Laparoscopic splenectomy appeared with the development of minimal access surgery. At the moment, it has become the technique preferred for the spleen exeresis. Objective: To evaluate the outcomes of videolaparoscopic splenectomy in the treatment of benign functional hematological diseases. Method: A descriptive, longitudinal and prospective study was carried out with 86 patients diagnosed with benign functional hematological diseases, attended at Hermanos Ameijeiras Clinical Surgical Hospital, from October 1996 to December 2011. Results: In the series, the female sex predominated (70.9 percent) and the average age was 40 years (37.8 percent). The most frequent diseases were immunological thrombocytopenic purpura (68.6 %), autoimmune hemolytic anemia (23.3 percent), and hereditary spherocytosis (5.8 percent). 59.3 percent of patients required a preoperative preparation, with 50.9 percent of effective response to it. The average surgical time was 129 minutes. The prevailing transoperative accidents were: the rupture of the extractor bag (12.8 percent) and the bleeding of the splenic hilum (5.8 percent). This motivated the change to conventional surgery and the exclusion of the follow-up of 6 patients. The most frequent postoperative complication was persistent vomiting. The follow-up of the patients was carried out from 7 days to 2 years in 78 percent of the cases, with an average time of 518 days. There was total remission of their disease in 82.7 percent of the patients, partial remission in 15.4 percent, and only 1.9 percent did not present any remission. Conclusions: Videolaparoscopic splenectomy is a safe and effective technique in the treatment of autoimmune hematological diseases for surgeons with experience in advanced minimal access surgery(AU)

Multimodal analgesia in laparoscopic splenectomy and pericardial devascularization around perioperative period / 中国现代普通外科进展

Objective:To discuss the clinical reference value of multimodal analgesia in laparoscopic splenectomy and pericardial devascularization around perioperative period (LS+PDA) based on FTS (fast track surgery) concept.Methods:Previously from September 2015 and March 2017,69 patients with portal hypertension were given LS+PDA,37 patients were given traditional perioperative analgesia program (named traditional group),other 32 patients were given multimodal analgesia around perioperative period (named FTS group).The degree of postoperative pain,ambulation time,eating time,anal exhaust time,gastric tube decompression,indwelling time,postoperative 72 hours sleep time,postoperative hospital stay,postoperative adverse reactions were compared between two groups.Results:When operation finished,1,4,8,12,24,48 and 72 hours,pain digital assessment scale of FTS group was significantly lower than traditional group (P＜0.05).FTS group's ambulation,feeding,anal exhaust,gastric tube indwelling and postoperative hospital time all were significantly shorter than traditional group (P＜0.01),its sleeping time after 72 hours was obviously longer than traditional group (P＜0.01).Nausea and vomiting,regurgitation and gastrointestinal reactions,breathing difficulties,splenopyretic incidence of FTS group was significantly lower than traditional group (P＜0.05),and other adverse reactions were no statistical significance between two groups.The all approval rate of postoperative analgesia in FTS group was significantly higher than that in traditional group (P＜0.05).Conclusion:Multimodal analgesia in LS+PDA based on FTS concept has been safe and effective,which nearly can achieve painless surgery.

Postoperative prophylactic anticoagulation in the prevention of portal venous thrombosis in patients after laparoscopic splenectomy: a Meta-analysis / 中华肝胆外科杂志

Objective To study the effectiveness and safety of prophylactic anticoagulation in the prevention of portal venous thrombosis (PVST) in patients after laparoscopic splenectomy.Methods A systematic search of the PubMed,Embase,Cochrane Library,Sinomed,Wangfang,Weipu and CNKI databases was performed to identify studies which compared outcomes in patients with or without prophylactic anticoagulation after laparoscopic splenectomy.The quality of the included studies was assessed using the Cochrane collaboration tool and the Newcastle-Ottawa Scale.Heterogeneity was evaluated using the x2 and I2 tests.The primary outcome was the incidence of postoperative PVST.Results Five studies were included into this review,which involved 206 and 168 patients with or without prophylactic anticoagulation,respectively.The incidence of PVST was significantly reduced with prophylactic anticoagulation with an odds ratio (OR) of 0.32 [95％ confidence interval (CI),0.13 ～0.79,P＜0.05].Conclusion Prophylactic anticoagulation resulted in a significant reduced incidence of PVST after laparoscopic splenectomy.

Comparation of laparoscopic splenectomy for regional portal hypertension using the anterior versus the posterolateral approach / 中华肝胆外科杂志

Objective To study the anterior versus the posterolateral approach for laparoscopic splenectomy for patients with chronic pancreatitis-induced regional portal hypertension (PRPH).Methods The retrospective cohort study was carried out on 62 patients who underwent laparoscopic splenectomy for PRPH at the Peoples' Hospital of Zhengzhou University from Jan 2010 to Jun 2016.The patients were divided into 2 groups:the anterior approach group and the posterolateral approach group,and to compare the differences.Results The operation time,amounts of intraoperative non-splenic blood loss,duration of recovery of intestinal peristalsis,duration of drainage,and duration of postoperative hospital stay were (135.0 ± 12.8) minvs (126.0± 13.1) min,(323.7±50.9) ml vs (245.1 ±35.0) ml,(25.5±2.5) h vs (23.5±3.3) h,(5.7±1.0) dvs (3.2±1.3) dand (9.3±1.5) dvs (7.3±1.2) d in the anterior approach laparoscopic splenectomy group versus the posterolateral approach laparoscopic splenectomy group.These differences were significantly different (all P ＜0.05).On follow-up of the 62 patients,improvements in the varicose veins of the lower esophagus and fundus of stomach at 3 month postoperatively were observed.All these patients recovered well from surgery.Conclusion The posterolateral approach laparoscopic splenectomy approach significantly improved the treatment results in patients with chronic pancreatitis-induced regional portal hypertension.

Laparoscopic splenectomy: a new approach

OBJECTIVES: To introduce a new laparoscopic splenectomy (LS) approach. METHODS: Sixteen patients underwent LS with general anaesthesia and carbon dioxide pneumoperitoneum. The details of the surgery are as follows: 1. The omentum was incised along the greater curvature and retracted as much as possible to expose the pancreatic body and tail. 2. The right arteriovenous root in the gastric omentum was ligated to sufficiently expose the pancreatic body and tail. 3. The pancreatic capsula was opened along the inferior margin of the pancreatic tail, elevated and separated until the superior margin of the pancreas was grasped. The entire splenic pedicle was retracted using a string. The branching blood vessels in the splenic hilus were ligated using clamps and separated. The splenogastric and splenophrenic ligaments were transected proximally using an ultrasonic knife, and the thick short gastric blood vessels were clamped. This procedure allows complete exposure of the area above the pancreatic tail where the splenic hilus is located. The splenoportal vasculature was suspended using a 7-0 silk suture to easily manipulate this tissue. The splenic portal vessels were dissected using an ultrasonic knife, and the portal vessels were isolated individually using vascular clamps and transected. The splenogastric and lienorenal ligaments were also transected. The spleen was then placed into a bag, and the surgical port was slightly enlarged. Finally, the spleen was sectioned for removal. RESULTS: Fifteen surgeries were successfully performed from March 2015 to January 2016. One patient underwent laparotomy. No patients developed postoperative intra-abdominal haemorrhage or infection. One patient developed subcutaneous emphysema, and one developed a wound infection. No deaths occurred. CONCLUSIONS: Active exposure of the area dorsal to the pancreatic tail is a safe and simple splenectomy method.

Primary Giant Splenic and Hepatic Echinococcal Cysts Treated by Laparoscopy

Cystic echinococcosis is a zoonosis caused by the larval stage of Echinococcus granulosus. Liver and lungs are the most commonly affected organs whereas splenic infection is rare and its primary involvement occurs in less than 2% of cases. We report a case of primary giant splenic and hepatic hydatid cyst in a 28-year-old woman who was admitted for upper right quadrant pain. The abdominal ultrasonography and computed tomography showed two cystic tumors with hydatid features in liver and spleen. Total splenectomy was performed for the splenic cyst and partial pericystectomy with drainage for the liver cyst using a laparoscopic approach. One drain was kept in place for two months due to a biliary leak of about 20 ml/day and removed afterward. The patient was discharged on postoperative day 7. Laparoscopic approach for patients with concomitant splenic and hepatic hydatidosis is a safe and effective option.

Laparoscopic Splenectomy for a Patient with Splenomegaly and Hypersplenism due to Idiopathic Portal Hypertension

Idiopathic portal hypertension (IPH) is a rare disorder which is clinically characterized by portal hypertension, splenomegaly, hypersplenism and the absence of liver cirrhosis. Patients with IPH have massive splenomegaly leading to increased portal venous flow and subsequent portal hypertension. In selected IPH patients with splenomegaly and hypersplenism, splenectomy can be regarded as an effective treatment protocol for decreasing portal hypertension. We report a case of a 44-year-old woman who was diagnosed with IPH accompanied by splenomegaly and hypersplenism. She underwent laparoscopic splenectomy and clinical symptoms and hypersplenism resolved. Our study shows that laparoscopic splenectomy can be considered as a procedure for treating patients with splenomegaly and hypersplenism due to IPH.

Impact of obesity and spleen length on laparoscopic splenectomy combined with pericardial devascularization / 中华肝胆外科杂志

Objective To evaluate the impact of obesity and spleen length on laparoscopic splenectomy combined with pericardial devascularization.Methods We retrospectively analyzed 121 patients with portal hypertension who underwent laparoscopic splenectomy combined with pericardial devascularization in our hospital.Using BMI,these patients were classified as the obesity and the non-obesity groups.Using length of the spleen,the patients were divided into two subgroups:spleen AC diameter ＞ 20 cm and spleen AC diameter ≤20 cm.Results (1) For the Obesity group,the operation time,the rate of conversion to open operation and the complication rate after operation were higher than the non-obesity group [(184.0 ± 49.0) min vs (142.0 ±39.0) min,26.1％ vs 8.0％,26.1％ vs 6.7％,respectively,P＜0.05].However,the differences were not significant for mean blood loss,intraperitoneal drainage and complication rate after operation.For patients with massive splenomegaly,the obesity group had higher rates of conversion into open operation and complication (42.9％ vs 11.7％,33.3％ vs 8.8％,respectively,P ＜0.05).For patients with non-massive splenomegaly,the differences were not significant between the obesity and non-obesity groups (P ＞ 0.05).(2) For obesity patients,the spleen AC diameter ＞ 20 cm group had a longer operation time and a higher rate of conversion to open operation [(224.0 ± 42.0) min vs (152.0 ± 44.0) min,42.9％ vs 12.0％,respectively,P ＜ 0.05].The length of spleen had no effect on the operation and its complication (P ＞ 0.05).Conclusions Obesity extended the operation time and increased the rates of conversion to open operation and complication after operation.The spleen length had a major impact on the rates of conversion to open operation and complication after operation for the groups of obesity patients.

Surgical strategy and controversy about upper limit of splenic size for laparoscopic splenectomy / 中华消化外科杂志

Laparoscopic splenectomy (LS) is considered as the standard approach for patients with normal-sized or moderately enlarged spleens because of advantages of minimal invasion.With the improvement of laparoscopic techniques,the previous concept that massive splenomegaly (MS) is a contraindication to LS is being challenged.Nevertheless,there is still a tremendous controversy over this issue.(1) Splenomegaly and MS are not clearly defined.(2) The feasibility,safety and postoperative outcomes of LS for MS are fiercely debated despite much improvement of LS for MS.(3) Whether supporting or opposing LS for MS,the core problem that the upper limit of splenic size can be in accord with a requirement of LS is controversial.Taking these issues into account,authors recommended that the splenomegaly shotdd be divided into four degrees rather than three degrees for the sake of guiding the choice of surgery.

Application of priority processing for splenic pedicle in laparoscopic splenectomy for portal hypertension and splenomegaly / 中华肝胆外科杂志

A retrospective study was conducted based on the clinical data of 42 patients of portal hypertension and splenomegaly who underwent laparoscopic splenectomy.The patients were divided into two groups including pedicle priority group and conventional group by different operative method.The operation time and intraoperative blood loss in the pedicle priority group were significantly lower than those in the conventional group (both P ＜ 0.05),and there was no statistically significant difference on the conversion rate of laparotomy,active time postoperation,exhaust time,postoperative hospitalization stay and the incidence of complications (all P ＞ 0.05).Priority processing for splenic pedicle has obvious advantages in laparoscopic splenectomy for portal hypertension and splenomegaly,and it could reduce the difficulty of operation,shorten the operation time and reduce bleeding.

The applied analysis of amputation of secondary pedicles of the spleen in laparoscopic splenectomy in hypersplenism caused by the schistosoma cirrhosis / 中国医师进修杂志

Objective To investigate the feasibility, efficacy, safety and economy of secondary splenic pedicle trisection method in removing schistosoma cirrhosis caused the splenic function. Methods Thirty patients receiving spleen secondary structure amputation between July 2014 and September 2016 were analyzed. Results Laparoscopic splenectomy with secondary splenic pedicle transaction was successfully performed in 28 patients, whereas two Endo-GIAs were used in 2 patients. The average of operation time was (80 ± 20) min, and operative blood loss was (320 ± 10) ml. The drainage of the splenic fossa was removed (3- 4) days after operation.Postoperative hospital stay was (10.8 ± 1.2) days after operaions. No massive hemorrhage, pancreatic leakage, secondary infection, serious complications such as abscess under diaphragm and recent complication such as infection of incision occurred postoperatively. Platelet of all patients recovered in 4 days postoperatively, and patients with platelet>400 × 109/L was given oral aspirin enteric-coated metformin hydrochloride. All patients were followed up for 6 months postoperatively, and no intestinal obstruction, portal vein thrombosis and other long-term complications occurred in all patients. Conclusions The amputation of secondary structures of the spleen in laparoscopic splenectomy to remove schistosoma cirrhosis caused the splenic function is safe. It could shorten the length of hospital stay and reduce the medical cost. It is a valuable method for clinical promotion.

Laparoscopic versus traditional open splenectomy for hepatocellular carcinoma with hypersplenism / 华中科技大学学报（医学）（英德文版）

This study aimed to examine the efficacy of the laparoscopic vs. traditional open splenectomy for hepatocellular carcinoma (HCC) with hypersplenism. Between 2002 and 2013, 51 Chinese HCC patients with hypersplenism underwent either simultaneous laparoscopic splenectomy plus anticancer therapies (Lap-S&A) (n=25) or traditional open splenectomy plus anti-cancer therapies (TOS&A) (n=26). The outcomes were reviewed during and after the operation. Anti-cancer therapies for HCC included laparoscopic hepatectomy (LH) and laparoscopic microwave ablation (LMA). The results showed that there was no significant difference in the operating time between the two groups, but the blood loss and blood transfusion were less, pain intensity after surgery was weaker, the time to first bowel movement, time to the first flatus and postoperative hospital stay were shorter, and the postoperative complication rate and the readmission rate were lower in the Lap-S&A group than in the TO-S&A group. Two patients in the Lap-S&A group and one patient in the TO-S&A group died 30 days after surgery. However, no significant difference in the mortality rate was noted between the two groups. It was concluded that simultaneous Lap-S&A holds the advantages of more extensive indications, lower complication incidence and less operative expenditure than conventional open approach and it is a feasible and safe approach for HCC with hypersplenism.

Impact of obesity on hand-assisted laparoscopic splenectomy combined with esophagogastric devascularization / 中华肝胆外科杂志

Objective To study the impact of obesity on the perioperative outcomes of hand-assisted laparoscopic splenectomy combined with esophagogastric devascularization (LSED).Methods The clinical data of patients who underwent hand-assisted laparoscopic splenectomy combined with esophagogastric devascularization between Jan.2013 and Nov.2015 were retrospectively analyzed.The patients were classified as obese group A (BMI≥28 kg/m2) or non-obese group B (BMI ＜ 28 kg/m2).Group A was further divided into two subgroups:group A1 massive splenomegaly (diameter ＞ 20 cm) and A2 splenomegaly (diameter ≤20 cm).The conversion rates,operative complications,mortality,length of stay,operative time,and blood loss were analyzed and compared.Results One hundred and sixty patients who underwent hand-assisted LSED were included into this study.54 patients were in group A and 106 in group B.A significantly longer operative time was found in group A (291 min vs.261 min,P ＜ 0.05).The conversion rates,blood loss,length of hospital stay,overall morbidity rates,and mortality rates were similar in the two groups (P ＞0.05).The mean operative time was significantly longer in group A1 (336 min vs.270 min;P ＜0.01)although blood loss,conversion rates,and overall morbidity rates were higher in group A1.However,there were no significant differences (P ＞ 0.05).Conclusions Hand-assisted laparoscopic splenectomy combined with esophagogastric devascularization for obese patients was safe and feasible.However,for patients with massive splenomegaly,LSED should be performed with caution.

Efficacy and feasibility of laparoscopic splenectomy in patients with a low platelet count / 中华肝胆外科杂志

Objective To investigate the feasibility and efficacy of laparoscopic splenectomy (LS) in patients with a low platelet count.Methods To retrospectively analyse the database of 76 ITP patients operated from 2010 to 2014.A low platelet count was defined as a platelet count of less than-30 × 109/L.The patients were divided into three groups:A (0～ 10 × 109/L),B (10～30 × 109/L),C (＞30 × 109/L) based on preoperative platelet counts.The surgical outcomes and hematological outcomes were compared among the three groups after LS.Results The operations on the 76 patients were all successfully carried out.The mean operating time of group A was (198.9 ± 46.2) min,and it was significantly longer when compared with group B (135.6 ±24.1) min and group C (125.4 ±30.0) min (P ＜0.05).The mean intraoperative blood loss of group A was (182.9 ±37.3) ml,which was significantly more when compared with group B (104.1 ±21.4) ml and group C (102.1 ±43.6) ml,(P ＜0.05).There were no significant difference among the three groups in postoperative complication rate and length of postoperative hospital stay,(P ＞ 0.05).All patients were followed up at 2,6 and 12 months after the operation and the hematological outcomes were measured.The successful therapeutic rates after LS in group A was 42.9％,and it was significantly worse when compared with group C (75％) (P ＞0.05);there was no significant difference when compared with group B (64.7％),(P ＜ 0.05).Conclusion Low preoperative platelet counts have an impact on the efficacy and postoperative recovery after laparoscopic splenectomy.LS was safe and feasible for [TP patients with low preoperative platelet counts.

Radiofrequency ablation and laparoscopic splenectomy for the treatment of small hepatocellular carcinoma with hypersplenism / 中国癌症杂志

Background and purpose:Liver cancer resection and splenectomy are the main methods to treat hepatocellular carcinoma and hypersplenism. The aim of this study was to discuss the safety and feasibility of simultaneous radiofrequency ablation (RFA) and laparoscopic splenectomy (LS) for the treatment of small hepatocellular carcinoma with hypersplenism.Methods:Twenty-seven patients with small hepatocellular carcinoma and cirrhotic hypersplenism underwent RFA and LS. The clinical data were also analyzed.Results:The surgery was converted to an open surgery in 1 patient, while laparoscopic splenectomy in a hand-assisted manner was performed in 2 patients. There were 31 liver tumors treated with RFA. Blood loss were 110-900 mL (mean=320 mL). Operation time were 72-127 min (mean=107 min). Subcutaneous emphysema occurred in 1 patient, and pancreatic leakage in another patient. Nine patients developed ascites. one patient suffered from massive haemorrhage, and emergency operation was adopted to stop bleeding. This patient recovered well after operation. No death was found during the hospitalization. Conclusion:Combining RFA with LS for the treatment of liver cancer and hypersplenism is minimally invasive, safe, and feasible.

Does Laparoscopic Splenectomy have the Advantage on Postoperative Pain?

PURPOSE: The aim of this study is to elucidate the fundamental characteristics of the laparoscopic splenectomy and to compare the clinical outcomes and postoperative pain between the laparoscopic splenectomy and the conventional open splenectomy. METHODS: From January 2005 to January 2013, 28 patients underwent a splenectomy at Pusan National University Hospital, South Korea (PNUH). This study was a comparison of the demographic features and clinical results between the laparoscopic splenectomy (n=15) and open splenectomy (n=13). RESULTS: For the two groups of patients, the following were similar: estimated blood loss, transfusion, operative time, duration of patient-controlled analgesia, and the additional administration of painkillers. In the laparoscopic splenectomy group, the postoperative hospital stay (7.9+/-1.6 days versus 5.9+/-1.4 days, p=0.002) and the diet start time (2.7+/-0.3 days versus 1.8+/-0.8 days, p=0.003) were significantly shorter. No significant difference in postoperative pain was observed between the two groups. CONCLUSION: In this study, there was no benefit for postoperative pain in the LS group. However, the laparoscopic splenectomy has several benefits, including a shorter postoperative hospital stay and an earlier diet start time; in addition, it is feasible and safe.

Multimodality imaging of splenic sclerosing angiomatoid nodular transformation

Sclerosing angiomatoid nodular transformation (SANT) is an exceedingly rare, benign and proliferative vascular lesion that arises from the splenic red pulp. It is often an incidental finding on imaging. The diagnosis of SANT is confirmed via histopathological examination of the resected spleen. Herein, we present a case of SANT and describe its typical imaging characteristics. An asymptomatic 39-year-old man was found to have a 3.1 cm × 2.7 cm × 2.3 cm hypoechoic splenic lesion during abdominal ultrasonography, which was performed to investigate his elevated gamma-glutamyl transpeptidase and alanine transaminase levels. Contrast-enhanced computed tomography suggested a vascular splenic lesion, while magnetic resonance imaging demonstrated features consistent with SANT. In view of the increasing size of the lesion on follow-up imaging, the patient elected for splenectomy. Histopathological examination confirmed SANT, and the lesion was completely resected by laparoscopic splenectomy.