Impact of HPV infection on vaginal microecology and maternal and neonatal outcomes / 中南大学学报(医学版)

OBJECTIVES@#Human papillomavirus (HPV) is a kind of spherical DNA virus, which is related to many factors such as immune status and pregnancy. Due to the decrease of immunity, pregnant women are more likely to have HPV infection, which causes serious imbalance of vaginal microecology and is not beneficial to pregnancy outcome. Therefore, this study focuses on the impact of HPV infection on vaginal microecology and maternal and neonatal outcomes.@*METHODS@#A total of 140 pregnant women with HPV infection during pregnancy, who received obstetric examination in the First Affiliated Hospital of Hainan Medical College from November 2017 to July 2019, were selected as a HPV infection group, and 150 normal pregnant women with HPV negative in the same period were selected as a control group. Vaginal secretions were collected from all the pregnant women at 28-34 weeks of gestation to evaluate vaginal pH, cleanliness and microecological status, and to record pregnancy outcomes for all pregnant women.@*RESULTS@#The proportions of vaginal pH>4.5, constituent ratio of flora density and diversity of I-II, positive detection rate of vulvovaginal candidiasis (VVC) and bacterial vaginosis (BV) in HPV infected pregnant women were significantly higher than those in the control group (all @*CONCLUSIONS@#Pregnant women with HPV infection during pregnancy are more likely to have vaginal microecological disorders, and can increase the risk of adverse pregnancy outcomes such as premature delivery and chorioamnionitis.

Clinical efficacy of short term intensive insulin pump therapy and biosynthetic human insulin therapy and its effect on maternal and neonatal outcomes in gestational diabetes mellitus / 中国生化药物杂志

Objective To investigate the clinical effect of insulin on gestational diabetes mellitus(GDM).Methods GDM patients were randomly divided into group A and group B,group B were treated with short term intensive insulin pump therapy,and group A were treated with insulin pump in short term combined with biosynthetic human insulin therapy.Results The body mass index and diabetes family history rates pre-pregnancy in group B were significantly higher than group A(P<0.05).Logistic analysis showed that family history of BMI pre-pregnancy and diabetes family history were independent risk factors for GDM drug treatment(P<0.05).Compared with the group B,the improvement of blood glucose levels and the incidence of complications in patients with group A were better than the former(P<0.05).Conclusion Rational application of insulin can improve the efficacy of clinical treatment of GDM, reduce the incidence of complications, with high safety.

The relationship of maternal and neonatal outcomes of pregnant women with early onset severe preeclampsia in different gestational age / 重庆医学

Objective To investigate affect of maternal and neonatal outcomes of pregnant women with early onset severe pre-eclampsia in different gestational age .Methods 70 pregnant women with early onset severe preeclampsia were selected to divided into 28-31 weeks group(n=33) ,32-34 weeks group(n=37) ,then the clinical conditions ,the complications of pregnant women and the perinatal outcomes were compared .Results The termination of pregnancy time (31 .8 ± 0 .9)weeks ,expectant treatment time(12 .4 ± 4 .1)d ,neonatal weight gain (493 .5 ± 20 .3)g of 28 -31 weeks group had significant difference with 32 -34 weeks group[(33 .5 ± 1 .2)weeks ,(8 .1 ± 3 .9)d ,(302 .2 ± 18 .6)g](P<0 .05) .Perinatal outcomes of expectant treatment time over one week was significantly better than expectant treatment time under one week (P<0 .05) .Perinatal mortality (27 .3% ) ,Neonatal in-tensive care unit(NICU ) occupancy rate (36 .4% ) of 28 -31 weeks group were significantly higher than 32 -34 weeks group (8 .1% ,13 .5% )(P< 0 .05).The proportion of renal dysfunction(51 .5% ),HELLP syndrome(6 .1% ),placental dysfunction (45 .5% ) in 28-31 weeks group had significant difference with 32-34 weeks group(21 .6% ,24 .3% ,21 .6% )(P<0 .05) .Conclu-sion Early onset severe preeclampsia can cause high perinatal mortality ,high NICU occupancy ,and prone to complications ,and positive treatment should be taken according to the condition .

The effect of insulin therapy at different periods on pregnancy outcome of gestational diabetes patients / 中华内分泌外科杂志

Objective To discuss the maternal and neonatal outcomes in gestational diabetes patients given insulin therapy at different periods.Methods Clinical data of 52 cases of gestational diabetes patients admitted from May 2011 to June 2013 in The Central Hospital of Ningbo Development Zone were analyzed,among whom 28 cases accepted insulin therapy before 32 weeks of pregnancy(early diagnosis treatment group)and the rest 24 cases accepted insulin therapy after 32 weeks of pregnancy(late diagnosis treatment group).The pregnancy outcome,hemodynamic parameters,incidence of hypertension,and the outcome of neonates were compared.Results The blood glucose of the 52 patients was controlled in the normal range after insulin therapy.However,incidence of preterm and cesarean section was significantly higher in the early diagnosis treatment group than that in the late diagnosis treatment group (P ＜ 0.05).The incidence of neonatal ketosis,fetal distress,and the incidence of macrosomia was significantly lower in the early treatment group than that in late diagnosis treatment group (P ＜ 0.05).The incidence of pregnancy-induced hypertension had not statistical difference between the two groups of pregnant women(P ＞ 0.05).S/D value of the two groups of pregnant women had no statistical significance(P ＞ 0.05).RI and PI value was significantly higher in the late diagnosis treatment group than those in early diagnosis treatment group(P ＜0.05).Conclusions The blood glucose of patients was controlled in the normal range after insulin therapy.Insulin therapy before 32 weeks of pregnancy can improve pregnancy outcomes.However,further research is needed for specific treatment programs.

An Effect of Massive Proteinuria in Pregnancy Induced Hypertension / 대한산부인과학회잡지

OBJECTIVE: This study was investigated on the relationship the degrees of proteinuria with the maternal characteristics, maternal and the neonatal outcomes. The correlation between the result of single urine protein- to-creatinine ratio and the amount of 24 hour urine protein was also investigated. METHODS: From December 1999 to June 2002, 63 patients were enrolled in this study. They were divided into two groups by the degree of proteinuria at 24 hour urine, single urine and dip stick test, respectively. Each two groups was compared with the maternal characteristics, gestational age, the maternal and the neonatal outcomes. The correlation between single urine protein-to-creatinine ratio and the amount of 24 hour urine protein was analyzed statistically. RESULTS: Each two groups of single urine and dip stick test had no differences in maternal characteristics, gestational age, maternal and the neonatal outcomes. However, in two of 24 hour urine, massive proteinuria group had poor maternal and neonatal outcomes compared with control group (p value 0.01). Single urine protein-to-creatine ratio and the amount 24 hour urine protein had borderline correlation (p value 0.064). CONCLUSION: The presence of proteinuria influences on maternal and neonatal outcomes. Moreover, the massive proteinuria group had more maternal and neonatal complication than control group. The result of single urine protein-to-creatine ratio had borderline correlation with the amount of protein in 24 hour urine collection.

Impact of different blood glucose levels in gestational diabetes mellitus on maternal and neonatal outcomes / 重庆医科大学学报

Objective:To evaluate the impact of different glucose levels in women with gestational diabetes mellitus on maternal and neonatal outcomes.Methods:Data of 65 pregnant women with GDM admitted in our hospital from January 2001 to October 2006 were reviewed.A total of 46 GDM women had blood glucose levels under control before delivery and the rest 19 GDM women did not.The impact of different glucose levels on maternal and neonatal outcomes were compared between the two groups.Results:In the group with the glucose level uncontrolled,the incidence of hypertensive disorder complicating pregnancy,premature rupture of membrane,hydramnios,postpartum hemorrhage,premature infant,neonatal asphyxia,fetal macrosomia,and therapy after 34 weeks pregnancy were 42.11%,26.32%,31.58%,21.05%,47.37%,15.79%,36.84%,and 57.89%,respectively.compared with those of the group with glucose level controlled as 15.22%,4.35%,6.52%,2.17%,17.39%,0.00%,10.87%,and 28.26%,respectively.All the rates of the uncontrolled group were markedly higher than those of the controlled group.Conclusion:Gestational diabetes mellitus does great harm to mother and infant.Diagnosing GDM and controlling blood glucose as early as possible can decrease the complications of mother and infant.